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PubMed:12493756 JSONTXT

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GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 33-36 Glycan_Motif denotes GD3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G98544DH|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81928IQ
T3 139-142 Glycan_Motif denotes GD3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G98544DH|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81928IQ
T5 188-199 Glycan_Motif denotes sialic acid https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T6 469-472 Glycan_Motif denotes GD3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G98544DH|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81928IQ
T8 591-594 Glycan_Motif denotes GD3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G98544DH|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81928IQ
T10 604-618 Glycan_Motif denotes 9-O-acetyl-GD3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G74121RX
T11 615-618 Glycan_Motif denotes GD3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G98544DH|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81928IQ
T13 716-719 Glycan_Motif denotes GD3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G98544DH|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81928IQ
T15 734-737 Glycan_Motif denotes GD3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G98544DH|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81928IQ
T17 1209-1212 Glycan_Motif denotes GD3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G98544DH|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81928IQ
T19 1277-1280 Glycan_Motif denotes GD3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G98544DH|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81928IQ
T21 1296-1310 Glycan_Motif denotes 9-O-acetyl-GD3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G74121RX
T22 1307-1310 Glycan_Motif denotes GD3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G98544DH|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81928IQ
T24 1347-1350 Glycan_Motif denotes GD3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G98544DH|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81928IQ
T26 1541-1544 Glycan_Motif denotes GD3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G98544DH|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81928IQ
T28 1574-1588 Glycan_Motif denotes 9-O-acetyl-GD3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G74121RX
T29 1585-1588 Glycan_Motif denotes GD3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G98544DH|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81928IQ
T31 1652-1655 Glycan_Motif denotes GD3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G98544DH|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81928IQ
T33 1666-1669 Glycan_Motif denotes GD3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G98544DH|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81928IQ
T35 1674-1688 Glycan_Motif denotes 9-O-acetyl-GD3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G74121RX
T36 1685-1688 Glycan_Motif denotes GD3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G98544DH|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81928IQ
T38 1705-1708 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T40 1788-1791 Glycan_Motif denotes GD3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G98544DH|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81928IQ
T42 1993-1996 Glycan_Motif denotes GD3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G98544DH|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81928IQ
T44 2036-2039 Glycan_Motif denotes GD3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G98544DH|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81928IQ
T46 2251-2263 Glycan_Motif denotes sialic acids https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T47 2303-2315 Glycan_Motif denotes sialic acids https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY

sentences

Id Subject Object Predicate Lexical cue
T1 0-77 Sentence denotes Genes modulated by expression of GD3 synthase in Chinese hamster ovary cells.
T2 78-159 Sentence denotes Evidence that the Tis21 gene is involved in the induction of GD3 9-O-acetylation.
T3 160-292 Sentence denotes 9-O-Acetylation is a common sialic acid modification, expressed in a developmentally regulated and tissue/cell type-specific manner.
T4 293-422 Sentence denotes The relevant 9-O-acetyltransferase(s) have not been isolated or cloned; nor have mechanisms for their regulation been elucidated.
T5 423-619 Sentence denotes We previously showed that transfection of the GD3 synthase (ST8Sia-I) gene into Chinese hamster ovary (CHO)-K1 cells gave expression of not only the disialoganglioside GD3 but also 9-O-acetyl-GD3.
T6 620-857 Sentence denotes We now use differential display PCR between wild type CHO-K1 cells and clones stably expressing GD3 synthase (CHO-GD3 cells) to detect any increased expression of other genes and explore the possible induction of a 9-O-acetyltransferase.
T7 858-1025 Sentence denotes The four CHO mRNAs showing major up-regulation were homologous to VCAM-1, Tis21, the KC-protein-like protein, and a functionally unknown type II transmembrane protein.
T8 1026-1102 Sentence denotes A moderate increase in expression of the FxC1 and SPR-1 genes was also seen.
T9 1103-1253 Sentence denotes Interestingly, these are different from genes observed by others to be up-regulated after transfection of GD3 synthase into a neuroblastoma cell line.
T10 1254-1359 Sentence denotes We also isolated a CHO-GD3 mutant lacking 9-O-acetyl-GD3 following chemical mutagenesis (CHO-GD3-OAc(-)).
T11 1360-1492 Sentence denotes Analysis of the above differential display PCR-derived genes in these cells showed that expression of Tis21 was selectively reduced.
T12 1493-1600 Sentence denotes Transfection of a mouse Tis21 cDNA into the CHO-GD3-OAc(-) mutant cells restored 9-O-acetyl-GD3 expression.
T13 1601-1848 Sentence denotes Since the only major gangliosides expressed by CHO-GD3 cells are GD3 and 9-O-acetyl-GD3 (in addition to GM3, the predominant ganglioside type in wild-type CHO-K1 cells), we conclude that GD3 enhances its own 9-O-acetylation via induction of Tis21.
T14 1849-2006 Sentence denotes This is the first known nuclear inducible factor for 9-O-acetylation and also the first proof that 9-O-acetylation can be directly regulated by GD3 synthase.
T15 2007-2175 Sentence denotes Finally, transfection of CHO-GD3-OAc(-) mutant cells with ST6Gal-I induced 9-O-acetylation specifically on sialylated N-glycans, in a manner similar to wild-type cells.
T16 2176-2329 Sentence denotes This indicates separate machineries for 9-O-acetylation on alpha2-8-linked sialic acids of gangliosides and on alpha2-6-linked sialic acids on N-glycans.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 33-36 https://glytoucan.org/Structures/Glycans/G81928IQ denotes GD3
T2 33-36 https://glytoucan.org/Structures/Glycans/G98544DH denotes GD3
T3 139-142 https://glytoucan.org/Structures/Glycans/G81928IQ denotes GD3
T4 139-142 https://glytoucan.org/Structures/Glycans/G98544DH denotes GD3
T5 188-199 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T6 469-472 https://glytoucan.org/Structures/Glycans/G81928IQ denotes GD3
T7 469-472 https://glytoucan.org/Structures/Glycans/G98544DH denotes GD3
T8 591-594 https://glytoucan.org/Structures/Glycans/G81928IQ denotes GD3
T9 591-594 https://glytoucan.org/Structures/Glycans/G98544DH denotes GD3
T10 604-618 https://glytoucan.org/Structures/Glycans/G74121RX denotes 9-O-acetyl-GD3
T11 615-618 https://glytoucan.org/Structures/Glycans/G81928IQ denotes GD3
T12 615-618 https://glytoucan.org/Structures/Glycans/G98544DH denotes GD3
T13 716-719 https://glytoucan.org/Structures/Glycans/G81928IQ denotes GD3
T14 716-719 https://glytoucan.org/Structures/Glycans/G98544DH denotes GD3
T15 734-737 https://glytoucan.org/Structures/Glycans/G81928IQ denotes GD3
T16 734-737 https://glytoucan.org/Structures/Glycans/G98544DH denotes GD3
T17 1209-1212 https://glytoucan.org/Structures/Glycans/G81928IQ denotes GD3
T18 1209-1212 https://glytoucan.org/Structures/Glycans/G98544DH denotes GD3
T19 1277-1280 https://glytoucan.org/Structures/Glycans/G81928IQ denotes GD3
T20 1277-1280 https://glytoucan.org/Structures/Glycans/G98544DH denotes GD3
T21 1296-1310 https://glytoucan.org/Structures/Glycans/G74121RX denotes 9-O-acetyl-GD3
T22 1307-1310 https://glytoucan.org/Structures/Glycans/G81928IQ denotes GD3
T23 1307-1310 https://glytoucan.org/Structures/Glycans/G98544DH denotes GD3
T24 1347-1350 https://glytoucan.org/Structures/Glycans/G81928IQ denotes GD3
T25 1347-1350 https://glytoucan.org/Structures/Glycans/G98544DH denotes GD3
T26 1541-1544 https://glytoucan.org/Structures/Glycans/G81928IQ denotes GD3
T27 1541-1544 https://glytoucan.org/Structures/Glycans/G98544DH denotes GD3
T28 1574-1588 https://glytoucan.org/Structures/Glycans/G74121RX denotes 9-O-acetyl-GD3
T29 1585-1588 https://glytoucan.org/Structures/Glycans/G81928IQ denotes GD3
T30 1585-1588 https://glytoucan.org/Structures/Glycans/G98544DH denotes GD3
T31 1652-1655 https://glytoucan.org/Structures/Glycans/G81928IQ denotes GD3
T32 1652-1655 https://glytoucan.org/Structures/Glycans/G98544DH denotes GD3
T33 1666-1669 https://glytoucan.org/Structures/Glycans/G81928IQ denotes GD3
T34 1666-1669 https://glytoucan.org/Structures/Glycans/G98544DH denotes GD3
T35 1674-1688 https://glytoucan.org/Structures/Glycans/G74121RX denotes 9-O-acetyl-GD3
T36 1685-1688 https://glytoucan.org/Structures/Glycans/G81928IQ denotes GD3
T37 1685-1688 https://glytoucan.org/Structures/Glycans/G98544DH denotes GD3
T38 1705-1708 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T39 1705-1708 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T40 1788-1791 https://glytoucan.org/Structures/Glycans/G81928IQ denotes GD3
T41 1788-1791 https://glytoucan.org/Structures/Glycans/G98544DH denotes GD3
T42 1993-1996 https://glytoucan.org/Structures/Glycans/G81928IQ denotes GD3
T43 1993-1996 https://glytoucan.org/Structures/Glycans/G98544DH denotes GD3
T44 2036-2039 https://glytoucan.org/Structures/Glycans/G81928IQ denotes GD3
T45 2036-2039 https://glytoucan.org/Structures/Glycans/G98544DH denotes GD3
T46 2251-2263 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acids
T47 2303-2315 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acids

Glycosmos6-GlycoEpitope

Id Subject Object Predicate Lexical cue
T1 604-618 http://www.glycoepitope.jp/epitopes/EP0064 denotes 9-O-acetyl-GD3
T2 1296-1310 http://www.glycoepitope.jp/epitopes/EP0064 denotes 9-O-acetyl-GD3
T3 1574-1588 http://www.glycoepitope.jp/epitopes/EP0064 denotes 9-O-acetyl-GD3
T4 1674-1688 http://www.glycoepitope.jp/epitopes/EP0064 denotes 9-O-acetyl-GD3

PennBioIE

Id Subject Object Predicate Lexical cue
T1 33-45 protein denotes GD3 synthase
T2 96-101 protein denotes Tis21
T3 139-142 protein denotes GD3
T4 306-330 protein denotes 9-O-acetyltransferase(s)
T5 469-481 protein denotes GD3 synthase
T6 483-491 protein denotes ST8Sia-I
T7 591-594 protein denotes GD3
T8 604-618 protein denotes 9-O-acetyl-GD3
T9 716-728 protein denotes GD3 synthase
T10 835-856 protein denotes 9-O-acetyltransferase
T11 867-870 protein denotes CHO
T12 924-930 protein denotes VCAM-1
T13 932-937 protein denotes Tis21
T14 943-966 protein denotes KC-protein-like protein
T15 987-1024 protein denotes unknown type II transmembrane protein
T16 1067-1071 protein denotes FxC1
T17 1076-1081 protein denotes SPR-1
T18 1209-1221 protein denotes GD3 synthase
T19 1229-1242 protein denotes neuroblastoma
T20 1296-1310 protein denotes 9-O-acetyl-GD3
T21 1462-1467 protein denotes Tis21
T22 1517-1522 protein denotes Tis21
T23 1574-1588 protein denotes 9-O-acetyl-GD3
T24 1666-1669 protein denotes GD3
T25 1674-1688 protein denotes 9-O-acetyl-GD3
T26 1842-1847 protein denotes Tis21
T27 1993-2005 protein denotes GD3 synthase

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 33-36 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T2 139-142 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T3 469-472 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T4 591-594 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T5 606-618 Glycan denotes O-acetyl-GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G74121RX
T6 716-719 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T7 734-737 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T8 1209-1212 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T9 1277-1280 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T10 1298-1310 Glycan denotes O-acetyl-GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G74121RX
T11 1347-1350 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T12 1541-1544 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T13 1576-1588 Glycan denotes O-acetyl-GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G74121RX
T14 1652-1655 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T15 1666-1669 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T16 1676-1688 Glycan denotes O-acetyl-GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G74121RX
T17 1705-1708 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T18 1788-1791 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T19 1993-1996 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T20 2036-2039 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 1229-1242 Phenotype denotes neuroblastoma HP:0003006

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 1229-1242 Disease denotes neuroblastoma http://purl.obolibrary.org/obo/MONDO_0005072

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 33-36 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T2 139-142 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T3 469-472 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T4 591-594 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T5 606-618 Glycan denotes O-acetyl-GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G74121RX
T6 716-719 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T7 734-737 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T8 1209-1212 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T9 1277-1280 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T10 1298-1310 Glycan denotes O-acetyl-GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G74121RX
T11 1347-1350 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T12 1541-1544 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T13 1576-1588 Glycan denotes O-acetyl-GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G74121RX
T14 1652-1655 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T15 1666-1669 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T16 1676-1688 Glycan denotes O-acetyl-GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G74121RX
T17 1705-1708 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T18 1788-1791 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T19 1993-1996 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T20 2036-2039 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH

GlyCosmos-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 604-618 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes 9-O-acetyl-GD3 http://www.glycoepitope.jp/epitopes/EP0064
T2 1296-1310 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes 9-O-acetyl-GD3 http://www.glycoepitope.jp/epitopes/EP0064
T3 1574-1588 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes 9-O-acetyl-GD3 http://www.glycoepitope.jp/epitopes/EP0064
T4 1674-1688 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes 9-O-acetyl-GD3 http://www.glycoepitope.jp/epitopes/EP0064

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 1229-1242 Phenotype denotes neuroblastoma HP:0003006

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 1229-1242 Disease denotes neuroblastoma MONDO:0005072

GlyCosmos15-Taxon

Id Subject Object Predicate Lexical cue db_id
T1 49-64 Organism denotes Chinese hamster 10029
T2 503-518 Organism denotes Chinese hamster 10029
T3 1511-1516 Organism denotes mouse 10088|10090

GlyCosmos15-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 604-618 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes 9-O-acetyl-GD3 http://www.glycoepitope.jp/epitopes/EP0064
T2 1296-1310 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes 9-O-acetyl-GD3 http://www.glycoepitope.jp/epitopes/EP0064
T3 1574-1588 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes 9-O-acetyl-GD3 http://www.glycoepitope.jp/epitopes/EP0064
T4 1674-1688 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes 9-O-acetyl-GD3 http://www.glycoepitope.jp/epitopes/EP0064

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-77 Sentence denotes Genes modulated by expression of GD3 synthase in Chinese hamster ovary cells.
T2 78-159 Sentence denotes Evidence that the Tis21 gene is involved in the induction of GD3 9-O-acetylation.
T3 160-292 Sentence denotes 9-O-Acetylation is a common sialic acid modification, expressed in a developmentally regulated and tissue/cell type-specific manner.
T4 293-422 Sentence denotes The relevant 9-O-acetyltransferase(s) have not been isolated or cloned; nor have mechanisms for their regulation been elucidated.
T5 423-619 Sentence denotes We previously showed that transfection of the GD3 synthase (ST8Sia-I) gene into Chinese hamster ovary (CHO)-K1 cells gave expression of not only the disialoganglioside GD3 but also 9-O-acetyl-GD3.
T6 620-857 Sentence denotes We now use differential display PCR between wild type CHO-K1 cells and clones stably expressing GD3 synthase (CHO-GD3 cells) to detect any increased expression of other genes and explore the possible induction of a 9-O-acetyltransferase.
T7 858-1025 Sentence denotes The four CHO mRNAs showing major up-regulation were homologous to VCAM-1, Tis21, the KC-protein-like protein, and a functionally unknown type II transmembrane protein.
T8 1026-1102 Sentence denotes A moderate increase in expression of the FxC1 and SPR-1 genes was also seen.
T9 1103-1253 Sentence denotes Interestingly, these are different from genes observed by others to be up-regulated after transfection of GD3 synthase into a neuroblastoma cell line.
T10 1254-1359 Sentence denotes We also isolated a CHO-GD3 mutant lacking 9-O-acetyl-GD3 following chemical mutagenesis (CHO-GD3-OAc(-)).
T11 1360-1492 Sentence denotes Analysis of the above differential display PCR-derived genes in these cells showed that expression of Tis21 was selectively reduced.
T12 1493-1600 Sentence denotes Transfection of a mouse Tis21 cDNA into the CHO-GD3-OAc(-) mutant cells restored 9-O-acetyl-GD3 expression.
T13 1601-1848 Sentence denotes Since the only major gangliosides expressed by CHO-GD3 cells are GD3 and 9-O-acetyl-GD3 (in addition to GM3, the predominant ganglioside type in wild-type CHO-K1 cells), we conclude that GD3 enhances its own 9-O-acetylation via induction of Tis21.
T14 1849-2006 Sentence denotes This is the first known nuclear inducible factor for 9-O-acetylation and also the first proof that 9-O-acetylation can be directly regulated by GD3 synthase.
T15 2007-2175 Sentence denotes Finally, transfection of CHO-GD3-OAc(-) mutant cells with ST6Gal-I induced 9-O-acetylation specifically on sialylated N-glycans, in a manner similar to wild-type cells.
T16 2176-2329 Sentence denotes This indicates separate machineries for 9-O-acetylation on alpha2-8-linked sialic acids of gangliosides and on alpha2-6-linked sialic acids on N-glycans.

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 65-70 Body_part denotes ovary http://purl.obolibrary.org/obo/UBERON_0000992
T2 259-265 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T3 519-524 Body_part denotes ovary http://purl.obolibrary.org/obo/UBERON_0000992

GlyCosmos15-FMA

Id Subject Object Predicate Lexical cue db_id
T1 65-70 Body_part denotes ovary FMA:7209
T2 259-265 Body_part denotes tissue FMA:9637
T3 519-524 Body_part denotes ovary FMA:7209

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 49-64 OrganismTaxon denotes Chinese hamster 10029
T2 503-518 OrganismTaxon denotes Chinese hamster 10029
T3 1511-1516 OrganismTaxon denotes mouse 10088|10090

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 65-70 Body_part denotes ovary http://purl.obolibrary.org/obo/UBERON_0000992
T2 259-265 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T3 519-524 Body_part denotes ovary http://purl.obolibrary.org/obo/UBERON_0000992
T4 1003-1016 Body_part denotes transmembrane http://purl.obolibrary.org/obo/GO_0016020