PubMed:12488800 / 560-922 JSONTXT

{"project":"c_corpus","denotations":[{"id":"T77","span":{"begin":0,"end":3},"obj":"UBERON:0000120"},{"id":"T78","span":{"begin":4,"end":11},"obj":"UBERON:0004111"},{"id":"T105","span":{"begin":60,"end":64},"obj":"CVCL_8262"},{"id":"T119","span":{"begin":125,"end":128},"obj":"CHEBI:340824"},{"id":"T122","span":{"begin":125,"end":128},"obj":"CHEBI:59761"},{"id":"T123","span":{"begin":125,"end":130},"obj":"PR:P50282"},{"id":"T124","span":{"begin":125,"end":130},"obj":"PR:P14780"},{"id":"T125","span":{"begin":125,"end":130},"obj":"P14780"},{"id":"T126","span":{"begin":125,"end":130},"obj":"PR:P41245"},{"id":"T127","span":{"begin":125,"end":130},"obj":"P41246"},{"id":"T128","span":{"begin":125,"end":130},"obj":"P41245"},{"id":"T129","span":{"begin":125,"end":130},"obj":"PR:P52176"},{"id":"T130","span":{"begin":125,"end":130},"obj":"P50282"},{"id":"T132","span":{"begin":125,"end":130},"obj":"PR:000010491"},{"id":"T133","span":{"begin":125,"end":130},"obj":"P52176"},{"id":"T134","span":{"begin":125,"end":130},"obj":"O18733"},{"id":"T131","span":{"begin":125,"end":130},"obj":"GO:0004229"},{"id":"T135","span":{"begin":154,"end":158},"obj":"CVCL_8262"},{"id":"T136","span":{"begin":178,"end":181},"obj":"CHEBI:340824"},{"id":"T139","span":{"begin":178,"end":181},"obj":"CHEBI:59761"},{"id":"T140","span":{"begin":178,"end":183},"obj":"PR:P50282"},{"id":"T141","span":{"begin":178,"end":183},"obj":"PR:P14780"},{"id":"T142","span":{"begin":178,"end":183},"obj":"P14780"},{"id":"T143","span":{"begin":178,"end":183},"obj":"PR:P41245"},{"id":"T144","span":{"begin":178,"end":183},"obj":"P41246"},{"id":"T145","span":{"begin":178,"end":183},"obj":"P41245"},{"id":"T146","span":{"begin":178,"end":183},"obj":"PR:P52176"},{"id":"T147","span":{"begin":178,"end":183},"obj":"P50282"},{"id":"T149","span":{"begin":178,"end":183},"obj":"PR:000010491"},{"id":"T150","span":{"begin":178,"end":183},"obj":"P52176"},{"id":"T151","span":{"begin":178,"end":183},"obj":"O18733"},{"id":"T148","span":{"begin":178,"end":183},"obj":"GO:0004229"},{"id":"T152","span":{"begin":214,"end":217},"obj":"UBERON:0000120"},{"id":"T153","span":{"begin":218,"end":225},"obj":"UBERON:0004111"},{"id":"T154","span":{"begin":263,"end":266},"obj":"CHEBI:340824"},{"id":"T157","span":{"begin":263,"end":266},"obj":"CHEBI:59761"},{"id":"T158","span":{"begin":263,"end":268},"obj":"PR:P50282"},{"id":"T159","span":{"begin":263,"end":268},"obj":"PR:P14780"},{"id":"T160","span":{"begin":263,"end":268},"obj":"P14780"},{"id":"T161","span":{"begin":263,"end":268},"obj":"PR:P41245"},{"id":"T162","span":{"begin":263,"end":268},"obj":"P41246"},{"id":"T163","span":{"begin":263,"end":268},"obj":"P41245"},{"id":"T164","span":{"begin":263,"end":268},"obj":"PR:P52176"},{"id":"T165","span":{"begin":263,"end":268},"obj":"P50282"},{"id":"T167","span":{"begin":263,"end":268},"obj":"PR:000010491"},{"id":"T168","span":{"begin":263,"end":268},"obj":"P52176"},{"id":"T169","span":{"begin":263,"end":268},"obj":"O18733"},{"id":"T166","span":{"begin":263,"end":268},"obj":"GO:0004229"},{"id":"T170","span":{"begin":299,"end":306},"obj":"UBERON:0004111"},{"id":"T171","span":{"begin":314,"end":317},"obj":"UBERON:0000120"}],"text":"BBB opening was identified at 1 h, but had been reversed by 24 h. Reduction in EBA-immunoreactivity occurred at 3 h, whereas MMP-9 was not observed until 24 h. The activation of MMP-9 thus occurred much later than BBB opening, which suggests a different role for MMP-9 when selective and reversible opening of the BBB is produced by pharmacological manipulation."}

{"project":"UseCases_ArguminSci_Discourse","denotations":[{"id":"T5","span":{"begin":0,"end":362},"obj":"DRI_Outcome"}],"text":"BBB opening was identified at 1 h, but had been reversed by 24 h. Reduction in EBA-immunoreactivity occurred at 3 h, whereas MMP-9 was not observed until 24 h. The activation of MMP-9 thus occurred much later than BBB opening, which suggests a different role for MMP-9 when selective and reversible opening of the BBB is produced by pharmacological manipulation."}