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c_corpus

Id Subject Object Predicate Lexical cue
T1 0-3 CHEBI:340824 denotes MMP
T4 0-3 CHEBI:59761 denotes MMP
T5 0-5 PR:P50282 denotes MMP-9
T6 0-5 PR:P14780 denotes MMP-9
T7 0-5 P14780 denotes MMP-9
T8 0-5 PR:P41245 denotes MMP-9
T9 0-5 P41246 denotes MMP-9
T10 0-5 P41245 denotes MMP-9
T11 0-5 PR:P52176 denotes MMP-9
T12 0-5 P50282 denotes MMP-9
T14 0-5 PR:000010491 denotes MMP-9
T15 0-5 P52176 denotes MMP-9
T16 0-5 O18733 denotes MMP-9
T13 0-5 GO:0004229 denotes MMP-9
T19 37-47 7895 denotes papaverine
T17 37-47 D010208 denotes papaverine
T18 37-47 CHEBI:28241 denotes papaverine
T20 37-47 D010208 denotes papaverine
T21 57-64 UBERON:0004111 denotes opening
T22 72-91 UBERON:0000120 denotes blood-brain barrier
T25 135-139 CHEBI:23888 denotes drug
T26 179-186 UBERON:0004111 denotes opening
T27 194-213 UBERON:0000120 denotes blood-brain barrier
T30 215-218 UBERON:0000120 denotes BBB
T31 254-270 CL:0000115 denotes endothelial cell
T32 288-315 C114781 denotes endothelial barrier antigen
T33 288-315 C114781 denotes endothelial barrier antigen
T37 337-340 UBERON:0000120 denotes BBB
T38 357-363 UBERON:0027368 denotes matrix
T40 357-383 P14780 denotes matrix metalloproteinase-9
T41 357-383 P41246 denotes matrix metalloproteinase-9
T42 357-383 P41245 denotes matrix metalloproteinase-9
T43 357-383 P50282 denotes matrix metalloproteinase-9
T44 357-383 PR:000010491 denotes matrix metalloproteinase-9
T45 357-383 P52176 denotes matrix metalloproteinase-9
T46 357-383 O18733 denotes matrix metalloproteinase-9
T39 357-383 D020780 denotes matrix metalloproteinase-9
T47 385-388 CHEBI:340824 denotes MMP
T50 385-388 CHEBI:59761 denotes MMP
T51 385-390 PR:P50282 denotes MMP-9
T52 385-390 PR:P14780 denotes MMP-9
T53 385-390 P14780 denotes MMP-9
T54 385-390 PR:P41245 denotes MMP-9
T55 385-390 P41246 denotes MMP-9
T56 385-390 P41245 denotes MMP-9
T57 385-390 PR:P52176 denotes MMP-9
T58 385-390 P50282 denotes MMP-9
T60 385-390 PR:000010491 denotes MMP-9
T61 385-390 P52176 denotes MMP-9
T62 385-390 O18733 denotes MMP-9
T59 385-390 GO:0004229 denotes MMP-9
T64 396-416 GO:0031012 denotes extracellular matrix
T65 410-416 UBERON:0027368 denotes matrix
T66 417-425 CHEBI:25367 denotes molecule
T67 462-465 UBERON:0000120 denotes BBB
T68 466-473 UBERON:0004111 denotes opening
T69 519-526 UBERON:0005396 denotes carotid
T72 540-550 7895 denotes papaverine
T70 540-550 D010208 denotes papaverine
T71 540-550 CHEBI:28241 denotes papaverine
T73 540-550 D010208 denotes papaverine
T74 554-558 10118 denotes rats
T75 554-558 10116 denotes rats
T76 554-558 D051381 denotes rats
T77 560-563 UBERON:0000120 denotes BBB
T78 564-571 UBERON:0004111 denotes opening
T105 620-624 CVCL_8262 denotes 24 h
T119 685-688 CHEBI:340824 denotes MMP
T122 685-688 CHEBI:59761 denotes MMP
T123 685-690 PR:P50282 denotes MMP-9
T124 685-690 PR:P14780 denotes MMP-9
T125 685-690 P14780 denotes MMP-9
T126 685-690 PR:P41245 denotes MMP-9
T127 685-690 P41246 denotes MMP-9
T128 685-690 P41245 denotes MMP-9
T129 685-690 PR:P52176 denotes MMP-9
T130 685-690 P50282 denotes MMP-9
T132 685-690 PR:000010491 denotes MMP-9
T133 685-690 P52176 denotes MMP-9
T134 685-690 O18733 denotes MMP-9
T131 685-690 GO:0004229 denotes MMP-9
T135 714-718 CVCL_8262 denotes 24 h
T136 738-741 CHEBI:340824 denotes MMP
T139 738-741 CHEBI:59761 denotes MMP
T140 738-743 PR:P50282 denotes MMP-9
T141 738-743 PR:P14780 denotes MMP-9
T142 738-743 P14780 denotes MMP-9
T143 738-743 PR:P41245 denotes MMP-9
T144 738-743 P41246 denotes MMP-9
T145 738-743 P41245 denotes MMP-9
T146 738-743 PR:P52176 denotes MMP-9
T147 738-743 P50282 denotes MMP-9
T149 738-743 PR:000010491 denotes MMP-9
T150 738-743 P52176 denotes MMP-9
T151 738-743 O18733 denotes MMP-9
T148 738-743 GO:0004229 denotes MMP-9
T152 774-777 UBERON:0000120 denotes BBB
T153 778-785 UBERON:0004111 denotes opening
T154 823-826 CHEBI:340824 denotes MMP
T157 823-826 CHEBI:59761 denotes MMP
T158 823-828 PR:P50282 denotes MMP-9
T159 823-828 PR:P14780 denotes MMP-9
T160 823-828 P14780 denotes MMP-9
T161 823-828 PR:P41245 denotes MMP-9
T162 823-828 P41246 denotes MMP-9
T163 823-828 P41245 denotes MMP-9
T164 823-828 PR:P52176 denotes MMP-9
T165 823-828 P50282 denotes MMP-9
T167 823-828 PR:000010491 denotes MMP-9
T168 823-828 P52176 denotes MMP-9
T169 823-828 O18733 denotes MMP-9
T166 823-828 GO:0004229 denotes MMP-9
T170 859-866 UBERON:0004111 denotes opening
T171 874-877 UBERON:0000120 denotes BBB

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-92 DRI_Approach denotes MMP-9 and EBA immunoreactivity after papaverine mediated opening of the blood-brain barrier.
T2 93-220 DRI_Background denotes Papaverine is a non-specific vasodilatory drug, which was found to unexpectedly cause opening of the blood-brain barrier (BBB).
T3 221-474 DRI_Approach denotes We studied the expression of two endothelial cell related markers, endothelial barrier antigen (EBA) as a marker of BBB intactness, and matrix metalloproteinase-9 (MMP-9), an extracellular matrix molecule, the activation of which results in BBB opening.
T4 475-559 DRI_Background denotes Immunoreactivity was quantified after intra-carotid injection of papaverine in rats.
T5 560-922 DRI_Outcome denotes BBB opening was identified at 1 h, but had been reversed by 24 h. Reduction in EBA-immunoreactivity occurred at 3 h, whereas MMP-9 was not observed until 24 h. The activation of MMP-9 thus occurred much later than BBB opening, which suggests a different role for MMP-9 when selective and reversible opening of the BBB is produced by pharmacological manipulation.