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PubMed_Structured_Abstracts

Id Subject Object Predicate Lexical cue
T1 89-378 OBJECTIVE denotes We determine the sensitivity and specificity of cytokeratin 20 (CK-20) and mucin 7 (MUC7) gene expression in voided urine samples taken from patients with bladder tumor and from control groups to investigate putative, noninvasive urinary markers for bladder tumor detection and monitoring.
T2 402-898 METHODS denotes Voided urine samples were collected from 50 patients with histologically proven bladder neoplasms (pTaN0M0G1-3 in 19 and pTisN0M0G3-pT4pN1M1G3 in 31), 20 patients with urolithiasis, 20 patients with urinary tract infection, 20 patients with other urological neoplasms and 20 healthy volunteers. Total RNA was extracted from exfoliated cells collected from 200 ml. voided urine. All RNA samples were investigated by a specific CK-20 and MUC7 nested reverse transcriptase polymerase chain reaction.
T3 908-1609 RESULTS denotes The overall sensitivity of CK-20 gene expression in voided urine samples for the detection of bladder neoplasms was 78%. In contrast, voided urine samples from control patients and healthy volunteers showed a high rate of false-positive CK-20 detection resulting in a low specificity of 36%. The overall sensitivity of the MUC7 test for all bladder tumor cases was 66%. The sensitivity for papillary urothelial neoplasms (pTaN0M0G1-3) was 42% whereas analysis of the carcinoma in situ and invasive bladder cancer group (pTisN0M0G3-pT4pN1M1G3) yielded a sensitivity of 81%. The overall specificity of the MUC7 nested reverse transcriptase polymerase chain reaction method in the control groups was 80%.
T4 1623-2063 CONCLUSIONS denotes A high positive CK-20 detection rate was found not only in voided urine samples from patients with bladder tumor, but also in urine specimens from control groups. Therefore, CK-20 is not a reliable urinary tumor marker for bladder neoplasms. In contrast to CK-20, analysis of MUC7 demonstrated a high sensitivity and high specificity for carcinoma in situ and invasive bladder cancer, thus fulfilling the criteria of a urinary tumor marker.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 244-257 HP_0009725 denotes bladder tumor
T2 252-257 HP_0002664 denotes tumor
T3 339-352 HP_0009725 denotes bladder tumor
T4 347-352 HP_0002664 denotes tumor

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
12478110-0#0#7#gene4589 0-7 gene4589 denotes Mucin 7
12478110-0#12#26#gene54474 12-26 gene54474 denotes cytokeratin 20
12478110-0#65#78#diseaseC0005695 65-78 diseaseC0005695 denotes bladder tumor
12478110-12#34#38#gene4589 1899-1903 gene4589 denotes MUC7
12478110-12#127#141#diseaseC0005684 1992-2006 diseaseC0005684 denotes bladder cancer
12478110-12#127#141#diseaseC0699885 1992-2006 diseaseC0699885 denotes bladder cancer
0#7#gene458965#78#diseaseC0005695 12478110-0#0#7#gene4589 12478110-0#65#78#diseaseC0005695 associated_with Mucin 7,bladder tumor
12#26#gene5447465#78#diseaseC0005695 12478110-0#12#26#gene54474 12478110-0#65#78#diseaseC0005695 associated_with cytokeratin 20,bladder tumor
34#38#gene4589127#141#diseaseC0005684 12478110-12#34#38#gene4589 12478110-12#127#141#diseaseC0005684 associated_with MUC7,bladder cancer
34#38#gene4589127#141#diseaseC0699885 12478110-12#34#38#gene4589 12478110-12#127#141#diseaseC0699885 associated_with MUC7,bladder cancer

DisGeNET

Id Subject Object Predicate Lexical cue
T0 173-177 gene:4589 denotes MUC7
T1 339-352 disease:C0005695 denotes bladder tumor
T2 173-177 gene:4589 denotes MUC7
T3 244-257 disease:C0005695 denotes bladder tumor
T4 137-151 gene:54474 denotes cytokeratin 20
T5 244-257 disease:C0005695 denotes bladder tumor
T6 137-151 gene:54474 denotes cytokeratin 20
T7 339-352 disease:C0005695 denotes bladder tumor
T8 153-158 gene:54474 denotes CK-20
T9 244-257 disease:C0005695 denotes bladder tumor
T10 164-171 gene:4589 denotes mucin 7
T11 339-352 disease:C0005695 denotes bladder tumor
T12 164-171 gene:4589 denotes mucin 7
T13 244-257 disease:C0005695 denotes bladder tumor
T14 153-158 gene:54474 denotes CK-20
T15 339-352 disease:C0005695 denotes bladder tumor
T16 935-940 gene:54474 denotes CK-20
T17 1002-1019 disease:C0005695 denotes bladder neoplasms
T18 1231-1235 gene:4589 denotes MUC7
T19 1249-1262 disease:C0005695 denotes bladder tumor
R1 T0 T1 associated_with MUC7,bladder tumor
R2 T2 T3 associated_with MUC7,bladder tumor
R3 T4 T5 associated_with cytokeratin 20,bladder tumor
R4 T6 T7 associated_with cytokeratin 20,bladder tumor
R5 T8 T9 associated_with CK-20,bladder tumor
R6 T10 T11 associated_with mucin 7,bladder tumor
R7 T12 T13 associated_with mucin 7,bladder tumor
R8 T14 T15 associated_with CK-20,bladder tumor
R9 T16 T17 associated_with CK-20,bladder neoplasms
R10 T18 T19 associated_with MUC7,bladder tumor