PubMed:12440604 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/12440604","sourcedb":"PubMed","sourceid":"12440604","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/12440604","text":"Long-term outcome after coronary artery bypass grafting in patients with severe left ventricular dysfunction.\nBACKGROUND: The aim of this study was to define the potential for long-term survival with severe left ventricular dysfunction after coronary bypass and to quantify any improvement in overall functional status.\nMETHODS: Left ventricular dysfunction was confirmed preoperatively and the long-term survival and functional outcome after bypass was determined by follow-up studies obtained during the span of a decade.\nRESULTS: From 1/1990 to 12/1999, 86 patients with severe left ventricular dysfunction (mean ejection fraction, 0.18 +/- 0.03; range, 0.10 to 0.20) underwent coronary artery bypass grafting. There were 10 perioperative deaths (11% mortality). The mean survival was 55 months (standard deviation +/- 34 months; range, 2 to 141 months) with an actual 5-year survival rate of 59% (actuarial 5-year 65%, 10-year 33%). Echocardiography obtained between 1 and 6 months, 6 months and 1 year, 1 and 2 years, 2 and 4 years, 4 and 6 years, and 6 and 11 years showed the ejection fraction improved to 0.29 +/- 0.08 (p \u003c 0.001), 0.31 +/- 0.14 (p \u003c 0.002), 0.35 +/- 0.08 (p \u003c 0.001), 0.27 +/- 0.10 (p = 0.002), 0.36 +/- 0.14 (p = 0.004), and 0.30 +/- 0.11 (p = 0.004), respectively. At 1 to 6 months, 6 months to 1 year, and 1 to 2 years, the diastolic left ventricular dimension was unchanged, but the systolic left ventricular dimension decreased significantly from 5.02 +/- 0.77 cm to 4.26 +/- 0.91 cm (p = 0.046), 3.98 +/- 1.43 cm (p = 0.08), and 4.10 +/- 1.14 cm (p = 0.07). The preoperative New York Heart Association classification for all patients improved from 2.8 +/- 0.8 to 1.6 +/- 0.7 (p \u003c 0.001) after a mean of 53 months (standard deviation +/- 34 months).\nCONCLUSIONS: Patients with severe left ventricular dysfunction can derive long-term benefit from coronary bypass through improved left ventricular contractility as documented by a significantly decreased systolic left ventricular dimension and increased ejection fraction. Successful bypass is associated with a 59% actual 5-year survival rate and significantly improved New York Heart Association functional class.","tracks":[{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":200,"end":223},"obj":"HP_0001711"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubmedHPO"}]},{"project":"LitCoin-PubTator-for-Tuning","denotations":[{"id":"2","span":{"begin":59,"end":67},"obj":"OrganismTaxon"},{"id":"3","span":{"begin":85,"end":108},"obj":"DiseaseOrPhenotypicFeature"},{"id":"11","span":{"begin":212,"end":235},"obj":"DiseaseOrPhenotypicFeature"},{"id":"12","span":{"begin":334,"end":357},"obj":"DiseaseOrPhenotypicFeature"},{"id":"13","span":{"begin":560,"end":568},"obj":"OrganismTaxon"},{"id":"14","span":{"begin":586,"end":609},"obj":"DiseaseOrPhenotypicFeature"},{"id":"15","span":{"begin":1657,"end":1665},"obj":"OrganismTaxon"},{"id":"16","span":{"begin":1794,"end":1802},"obj":"OrganismTaxon"},{"id":"17","span":{"begin":1820,"end":1843},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A13","pred":"tao:has_database_id","subj":"13","obj":"Tax:9606"},{"id":"A14","pred":"tao:has_database_id","subj":"14","obj":"MESH:D018754"},{"id":"A12","pred":"tao:has_database_id","subj":"12","obj":"MESH:D018754"},{"id":"A15","pred":"tao:has_database_id","subj":"15","obj":"Tax:9606"},{"id":"A2","pred":"tao:has_database_id","subj":"2","obj":"Tax:9606"},{"id":"A3","pred":"tao:has_database_id","subj":"3","obj":"MESH:D018754"},{"id":"A11","pred":"tao:has_database_id","subj":"11","obj":"MESH:D018754"},{"id":"A16","pred":"tao:has_database_id","subj":"16","obj":"Tax:9606"},{"id":"A17","pred":"tao:has_database_id","subj":"17","obj":"MESH:D018754"},{"subj":"2","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"3","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"11","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"12","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"13","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"14","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"15","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"16","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"17","pred":"source","obj":"LitCoin-PubTator-for-Tuning"}]},{"project":"LitCoin-Disease-Tuning-1","denotations":[{"id":"T1","span":{"begin":80,"end":108},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":207,"end":235},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":329,"end":357},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":581,"end":609},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":1815,"end":1843},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"ID:","subj":"T1","obj":"D018487"},{"id":"A3","pred":"ID:","subj":"T3","obj":"D018487"},{"id":"A2","pred":"ID:","subj":"T2","obj":"D018487"},{"id":"A4","pred":"ID:","subj":"T4","obj":"D018487"},{"id":"A5","pred":"ID:","subj":"T5","obj":"D018487"},{"subj":"T1","pred":"source","obj":"LitCoin-Disease-Tuning-1"},{"subj":"T2","pred":"source","obj":"LitCoin-Disease-Tuning-1"},{"subj":"T3","pred":"source","obj":"LitCoin-Disease-Tuning-1"},{"subj":"T4","pred":"source","obj":"LitCoin-Disease-Tuning-1"},{"subj":"T5","pred":"source","obj":"LitCoin-Disease-Tuning-1"}]},{"project":"LitEisuke","denotations":[{"id":"T1","span":{"begin":80,"end":108},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":207,"end":235},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":329,"end":357},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":581,"end":609},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":1815,"end":1843},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A4","pred":"#label","subj":"T4","obj":"D018487"},{"id":"A5","pred":"#label","subj":"T5","obj":"D018487"},{"id":"A1","pred":"#label","subj":"T1","obj":"D018487"},{"id":"A2","pred":"#label","subj":"T2","obj":"D018487"},{"id":"A3","pred":"#label","subj":"T3","obj":"D018487"},{"subj":"T1","pred":"source","obj":"LitEisuke"},{"subj":"T2","pred":"source","obj":"LitEisuke"},{"subj":"T3","pred":"source","obj":"LitEisuke"},{"subj":"T4","pred":"source","obj":"LitEisuke"},{"subj":"T5","pred":"source","obj":"LitEisuke"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"PubmedHPO","color":"#93eceb","default":true},{"id":"LitCoin-PubTator-for-Tuning","color":"#ecd193"},{"id":"LitCoin-Disease-Tuning-1","color":"#b793ec"},{"id":"LitEisuke","color":"#93ec9d"}]}]}}