| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-121 |
Sentence |
denotes |
Heparan sulfate and development: differential roles of the N-acetylglucosamine N-deacetylase/N-sulfotransferase isozymes. |
| T2 |
122-300 |
Sentence |
denotes |
Heparan sulfates (HSs) are N- and O-sulfated polysaccharide components of proteoglycans, which are important constituents of the cell surface as well as the extracellular matrix. |
| T3 |
301-464 |
Sentence |
denotes |
Heparin, with extensive clinical application as an anticoagulant, is a highly sulfated form of HS present within the granules of connective tissue type mast cells. |
| T4 |
465-713 |
Sentence |
denotes |
The diverse functions of HS, which include the modulation of growth factor/cytokine activity, interaction with matrix proteins and binding of enzymes to cell surfaces, depend greatly on the presence of specific, high affinity regions on the chains. |
| T5 |
714-947 |
Sentence |
denotes |
N-acetylglucosamine N-deacetylase/N-sulfotransferases, NDSTs, are an important group of enzymes in HS biosynthesis, initiating the sulfation of the polysaccharide chains and thus determining the generation of the high affinity sites. |
| T6 |
948-1059 |
Sentence |
denotes |
Here, we review the role of the four vertebrate NDSTs in HS biosynthesis as well as their regulated expression. |
| T7 |
1060-1137 |
Sentence |
denotes |
The main emphasis is the phenotypes of mice lacking one or more of the NDSTs. |
