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PubMed:12412174 JSONTXT

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PubMed_Structured_Abstracts

Id Subject Object Predicate Lexical cue
T1 163-613 BACKGROUND denotes Cell-retained isoforms of vascular endothelial growth factor A (VEGF-A) have been reported to play an essential role in tumor progression through stromal neovascularization in malignant solid tumors. While more than 95% of nonsmall cell lung carcinoma (NSCLC) expresses cell-retained VEGF-A isoform, the clinicopathologic implications of neuropilin (NRP), considered the specific receptor for limited types of VEGF-A isoform, are not well understood.
T2 623-1151 METHODS denotes The authors examined NRP1 and NRP2 mRNA expression in 68 NSCLCs and 15 extraneoplastic tissues by a densitometry-assisted, semi-quantitative reverse transcription-polymerase chain reaction. The authors determined the distinct expression of NRPs using the expression level of NRPs relative by optical density to beta2-microglobulin. The authors also investigated VEGF-A isoforms, their receptors, and the clinical implications. Vascularity of NSCLC was morphologically estimated on sections immunostained with anti-CD34 antibody.
T3 1161-1690 RESULTS denotes Eleven of 15 extraneoplastic specimens showed NRP1 expression (73.3%) and 8 showed NRP2 expression (53.3%). The expression level of NRP1 or NRP2 of neoplasmic tissue was higher than that of extraneoplastic tissues (P < 0.01, Mann-Whitney U test). Fifty-five and 44 NSCLCs expressed NRP1 and NRP2, respectively. Forty patients co-expressing NRP1 and NRP2 showed significantly poorer prognosis and increased vessel counts as compared to those 28 cases without co-expression (P < 0.05, log-rank test; P < 0.05, Mann-Whitney U test).
T4 1704-1956 CONCLUSIONS denotes The co-expression of NRP1 and NRP2 genes is significantly correlated with tumor progression through neovascularization in NSCLC. These results suggest that both NRP1 and NRP2 are key molecules for stromal vascularization by cell-retained VEGF in NSCLC.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 283-288 HP_0002664 denotes tumor
T2 355-361 HP_0002664 denotes tumors

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
12412174-0#0#12#gene8829 0-12 gene8829 denotes Neuropilin 1
12412174-0#17#29#gene8828 17-29 gene8828 denotes neuropilin 2
12412174-0#135#149#diseaseC0684249 135-149 diseaseC0684249 denotes lung carcinoma
12412174-1#26#62#gene7422 189-225 gene7422 denotes vascular endothelial growth factor A
12412174-1#64#70#gene7422 227-233 gene7422 denotes VEGF-A
12412174-1#120#137#diseaseC0178874 283-300 diseaseC0178874 denotes tumor progression
12412174-1#186#198#diseaseC0280100 349-361 diseaseC0280100 denotes solid tumors
12412174-1#120#137#diseaseC0178874 283-300 diseaseC0178874 denotes tumor progression
12412174-1#186#198#diseaseC0280100 349-361 diseaseC0280100 denotes solid tumors
12412174-11#21#25#gene8829 1725-1729 gene8829 denotes NRP1
12412174-11#30#34#gene8828 1734-1738 gene8828 denotes NRP2
12412174-11#74#91#diseaseC0178874 1778-1795 diseaseC0178874 denotes tumor progression
0#12#gene8829135#149#diseaseC0684249 12412174-0#0#12#gene8829 12412174-0#135#149#diseaseC0684249 associated_with Neuropilin 1,lung carcinoma
17#29#gene8828135#149#diseaseC0684249 12412174-0#17#29#gene8828 12412174-0#135#149#diseaseC0684249 associated_with neuropilin 2,lung carcinoma
26#62#gene7422120#137#diseaseC0178874 12412174-1#26#62#gene7422 12412174-1#120#137#diseaseC0178874 associated_with vascular endothelial growth factor A,tumor progression
26#62#gene7422186#198#diseaseC0280100 12412174-1#26#62#gene7422 12412174-1#186#198#diseaseC0280100 associated_with vascular endothelial growth factor A,solid tumors
26#62#gene7422120#137#diseaseC0178874 12412174-1#26#62#gene7422 12412174-1#120#137#diseaseC0178874 associated_with vascular endothelial growth factor A,tumor progression
26#62#gene7422186#198#diseaseC0280100 12412174-1#26#62#gene7422 12412174-1#186#198#diseaseC0280100 associated_with vascular endothelial growth factor A,solid tumors
64#70#gene7422120#137#diseaseC0178874 12412174-1#64#70#gene7422 12412174-1#120#137#diseaseC0178874 associated_with VEGF-A,tumor progression
64#70#gene7422186#198#diseaseC0280100 12412174-1#64#70#gene7422 12412174-1#186#198#diseaseC0280100 associated_with VEGF-A,solid tumors
64#70#gene7422120#137#diseaseC0178874 12412174-1#64#70#gene7422 12412174-1#120#137#diseaseC0178874 associated_with VEGF-A,tumor progression
64#70#gene7422186#198#diseaseC0280100 12412174-1#64#70#gene7422 12412174-1#186#198#diseaseC0280100 associated_with VEGF-A,solid tumors
21#25#gene882974#91#diseaseC0178874 12412174-11#21#25#gene8829 12412174-11#74#91#diseaseC0178874 associated_with NRP1,tumor progression
30#34#gene882874#91#diseaseC0178874 12412174-11#30#34#gene8828 12412174-11#74#91#diseaseC0178874 associated_with NRP2,tumor progression

DisGeNET

Id Subject Object Predicate Lexical cue
T0 17-29 gene:8828 denotes neuropilin 2
T1 135-149 disease:C0684249 denotes lung carcinoma
T2 0-12 gene:8829 denotes Neuropilin 1
T3 135-149 disease:C0684249 denotes lung carcinoma
T4 227-233 gene:7422 denotes VEGF-A
T5 349-361 disease:C0280100 denotes solid tumors
T6 227-233 gene:7422 denotes VEGF-A
T7 283-300 disease:C0178874 denotes tumor progression
T8 189-225 gene:7422 denotes vascular endothelial growth factor A
T9 349-361 disease:C0280100 denotes solid tumors
T10 189-225 gene:7422 denotes vascular endothelial growth factor A
T11 283-300 disease:C0178874 denotes tumor progression
R1 T0 T1 associated_with neuropilin 2,lung carcinoma
R2 T2 T3 associated_with Neuropilin 1,lung carcinoma
R3 T4 T5 associated_with VEGF-A,solid tumors
R4 T6 T7 associated_with VEGF-A,tumor progression
R5 T8 T9 associated_with vascular endothelial growth factor A,solid tumors
R6 T10 T11 associated_with vascular endothelial growth factor A,tumor progression