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GlyCosmos6-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 36-42 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T2 134-138 Body_part denotes cell http://purl.obolibrary.org/obo/CL_0000000
T3 235-244 Body_part denotes processes http://purl.obolibrary.org/obo/UBERON_0004529
T4 515-521 Body_part denotes testis http://purl.obolibrary.org/obo/UBERON_0000473
T5 523-528 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948|http://purl.obolibrary.org/obo/UBERON_0007100|http://purl.obolibrary.org/obo/UBERON_0015228|http://purl.obolibrary.org/obo/UBERON_0015230
T9 658-664 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T10 844-851 Body_part denotes element http://purl.obolibrary.org/obo/UBERON_0000062
T11 869-876 Body_part denotes element http://purl.obolibrary.org/obo/UBERON_0000062
T12 1159-1164 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636
T14 1460-1464 Body_part denotes cell http://purl.obolibrary.org/obo/CL_0000000

sentences

Id Subject Object Predicate Lexical cue
T1 0-127 Sentence denotes Alternative core promoters regulate tissue-specific transcription from the autoimmune diabetes-related ICA1 (ICA69) gene locus.
T2 128-290 Sentence denotes Islet cell autoantigen 69-kDa (ICA69), protein product of the human ICA1 gene, is one target of the immune processes defining the pathogenesis of Type 1 diabetes.
T3 291-400 Sentence denotes We have characterized the genomic structure and functional promoters within the 5'-regulatory region of ICA1.
T4 401-681 Sentence denotes 5'-RNA ligase-mediated rapid amplification of cDNA ends evaluation of ICA1 transcripts expressed in human islets, testis, heart, and cultured neuroblastoma cells reveals that three 5'-untranslated region exons are variably expressed from the ICA1 gene in a tissue-specific manner.
T5 682-993 Sentence denotes Surrounding the transcription initiation sites are motifs characteristic of non-TATA, non-CAAT, GC-rich promoters, including consensus Sp1/GC boxes, an initiator element, cAMP-responsive element-binding protein (CREB) sites, and clusters of other putative transcription factor sites within a genomic CpG island.
T6 994-1347 Sentence denotes Luciferase reporter constructs demonstrate that the first two ICA1 exon promoters reciprocally stimulate luciferase expression within islet- (RIN 1046-38 cells) and brain-derived (NMB7) cells in culture; the exon A promoter exhibits greater activity in islet cells, whereas the exon B promoter more efficiently activates transcription in neuronal cells.
T7 1348-1471 Sentence denotes Mutation of a CREB site within the ICA1 exon B promoter significantly enhances transcriptional activity in both cell lines.
T8 1472-1828 Sentence denotes Our basic understanding of expression from the functional core promoter elements of ICA1 is an important advance that will not only add to our knowledge of the ICA69 autoantigen but will also facilitate a rational approach to discover the function of ICA69 and to identify relevant ICA1 promoter polymorphisms and their potential associations with disease.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 515-521 http://purl.obolibrary.org/obo/MAT_0000132 denotes testis
T2 523-528 http://purl.obolibrary.org/obo/MAT_0000036 denotes heart
T3 1159-1164 http://purl.obolibrary.org/obo/MAT_0000098 denotes brain

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 86-94 Disease denotes diabetes http://purl.obolibrary.org/obo/MONDO_0005015
T2 274-289 Disease denotes Type 1 diabetes http://purl.obolibrary.org/obo/MONDO_0005147
T3 543-556 Disease denotes neuroblastoma http://purl.obolibrary.org/obo/MONDO_0005072

GlyCosmos6-CLO

Id Subject Object Predicate Lexical cue
T1 134-138 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T2 557-562 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3 853-857 http://purl.obolibrary.org/obo/CLO_0053428 denotes cAMP
T4 1148-1153 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T5 1180-1185 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T6 1235-1243 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T7 1253-1258 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T8 1305-1314 http://purl.obolibrary.org/obo/CLO_0001658 denotes activates
T9 1341-1346 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10 1443-1451 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T11 1460-1464 http://purl.obolibrary.org/obo/GO_0005623 denotes cell

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 190-195 OrganismTaxon denotes human NCBItxid:9606
T2 501-506 OrganismTaxon denotes human NCBItxid:9606

FSU-PRGE

Id Subject Object Predicate Lexical cue
T1 103-107 protein denotes ICA1
T2 109-114 protein denotes ICA69
T3 128-157 protein denotes Islet cell autoantigen 69-kDa
T4 159-164 protein denotes ICA69
T5 196-200 protein denotes ICA1
T6 395-399 protein denotes ICA1
T7 401-414 protein denotes 5'-RNA ligase
T8 471-475 protein denotes ICA1
T9 643-647 protein denotes ICA1
T10 853-892 protein denotes cAMP-responsive element-binding protein
T11 894-898 protein denotes CREB
T12 938-958 protein denotes transcription factor
T13 994-1004 protein denotes Luciferase
T14 1056-1060 protein denotes ICA1
T15 1099-1109 protein denotes luciferase
T16 1362-1366 protein denotes CREB
T17 1383-1387 protein denotes ICA1
T18 1556-1560 protein denotes ICA1
T19 1632-1637 protein denotes ICA69
T20 1723-1728 protein denotes ICA69
T21 1754-1758 protein denotes ICA1

PIR-corpus2

Id Subject Object Predicate Lexical cue
T1 75-107 protein denotes autoimmune diabetes-related ICA1
T2 109-114 protein denotes ICA69
T3 128-165 protein denotes Islet cell autoantigen 69-kDa (ICA69)
T4 196-200 protein denotes ICA1
T5 395-399 protein denotes ICA1
T6 471-475 protein denotes ICA1
T7 643-647 protein denotes ICA1
T8 817-820 protein denotes Sp1
T9 853-892 protein denotes cAMP-responsive element-binding protein
T10 929-958 protein denotes putative transcription factor
T11 1056-1060 protein denotes ICA1
T12 1362-1366 protein denotes CREB
T13 1383-1387 protein denotes ICA1
T14 1556-1560 protein denotes ICA1
T15 1632-1649 protein denotes ICA69 autoantigen
T16 1723-1728 protein denotes ICA69
T17 1754-1758 protein denotes ICA1
T21 190-200 long_form denotes human ICA1

PIR-corpus1

Id Subject Object Predicate Lexical cue
T1 139-157 protein denotes autoantigen 69-kDa
T2 159-164 acronym denotes ICA69
T3 167-182 protein denotes protein product
T4 1099-1109 protein denotes luciferase
T5 1632-1649 protein denotes ICA69 autoantigen
T6 1723-1728 protein denotes ICA69