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PubMed:12397057 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-138 Sentence denotes Identification of a specific molecular repressor of the peroxisome proliferator-activated receptor gamma Coactivator-1 alpha (PGC-1alpha).
T2 139-278 Sentence denotes The nuclear co-activator PGC-1alpha is a pivotal regulator of numerous pathways controlling both metabolism and overall energy homeostasis.
T3 279-428 Sentence denotes Inappropriate increases in PGC-1alpha activity have been linked to a number of pathological conditions including heart failure and diabetes mellitus.
T4 429-534 Sentence denotes Previous studies (Puigserver, P., Adelmant, G., Wu, Z., Fan, M., Xu, J., O'Malley, B., and Spiegelman, B.
T5 535-663 Sentence denotes M. (1999) Science 286, 1368-1371) have demonstrated an inhibitory domain within PGC-1alpha that limits transcriptional activity.
T6 664-851 Sentence denotes Using this inhibitory domain in a yeast two-hybrid screen, we demonstrate that PGC-1alpha directly associates with the orphan nuclear receptor estrogen-related receptor-alpha (ERR-alpha).
T7 852-939 Sentence denotes The binding of ERR-alpha to PGC-1alpha requires the C-terminal AF2 domain of ERR-alpha.
T8 940-1129 Sentence denotes PGC-1alpha and ERR-alpha have a similar pattern of expression in human tissues, with both being present predominantly in organs with high metabolic needs such as skeletal muscle and kidney.
T9 1130-1260 Sentence denotes Similarly, we show that in mice physiological stimuli such as fasting coordinately induces PGC-1alpha and ERR-alpha transcription.
T10 1261-1476 Sentence denotes We also demonstrate that under normal conditions PGC-1alpha is located within discrete nuclear speckles, whereas the expression of ERR-alpha results in PGC-1alpha redistributing uniformly throughout the nucleoplasm.
T11 1477-1605 Sentence denotes Finally, we show that the expression of ERR-alpha can dramatically and specifically repress PGC-1alpha transcriptional activity.
T12 1606-1761 Sentence denotes These results suggest a novel mechanism of transcriptional control wherein ERR-alpha can function as a specific molecular repressor of PGC-1alpha activity.
T13 1762-1949 Sentence denotes In addition, our results suggest that other co-activators might also have specific repressors, thereby identifying another layer of combinatorial complexity in transcriptional regulation.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 392-397 http://purl.obolibrary.org/obo/MAT_0000036 denotes heart
T2 1102-1117 http://purl.obolibrary.org/obo/MAT_0000302 denotes skeletal muscle
T3 1111-1117 http://purl.obolibrary.org/obo/MAT_0000025 denotes muscle
T4 1122-1128 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 392-405 HP_0001635 denotes heart failure
T2 410-427 HP_0000819 denotes diabetes mellitus

FSU-PRGE

Id Subject Object Predicate Lexical cue
T1 56-124 protein denotes peroxisome proliferator-activated receptor gamma Coactivator-1 alpha
T2 126-136 protein denotes PGC-1alpha
T3 164-174 protein denotes PGC-1alpha
T4 306-316 protein denotes PGC-1alpha
T5 615-625 protein denotes PGC-1alpha
T6 743-753 protein denotes PGC-1alpha
T7 807-838 protein denotes estrogen-related receptor-alpha
T8 840-849 protein denotes ERR-alpha
T9 867-876 protein denotes ERR-alpha
T10 880-890 protein denotes PGC-1alpha
T11 929-938 protein denotes ERR-alpha
T12 940-950 protein denotes PGC-1alpha
T13 955-964 protein denotes ERR-alpha
T14 1221-1231 protein denotes PGC-1alpha
T15 1236-1245 protein denotes ERR-alpha
T16 1310-1320 protein denotes PGC-1alpha
T17 1392-1401 protein denotes ERR-alpha
T18 1413-1423 protein denotes PGC-1alpha
T19 1517-1526 protein denotes ERR-alpha
T20 1569-1579 protein denotes PGC-1alpha
T21 1681-1690 protein denotes ERR-alpha
T22 1741-1751 protein denotes PGC-1alpha

PIR-corpus2

Id Subject Object Predicate Lexical cue
T1 56-66 protein denotes peroxisome
T2 143-174 protein denotes nuclear co-activator PGC-1alpha
T3 306-316 protein denotes PGC-1alpha
T4 615-625 protein denotes PGC-1alpha
T5 743-753 protein denotes PGC-1alpha
T6 783-850 protein denotes orphan nuclear receptor estrogen-related receptor-alpha (ERR-alpha)
T7 867-876 protein denotes ERR-alpha
T8 880-890 protein denotes PGC-1alpha
T9 929-938 protein denotes ERR-alpha
T10 940-950 protein denotes PGC-1alpha
T11 955-964 protein denotes ERR-alpha
T12 1221-1231 protein denotes PGC-1alpha
T13 1236-1245 protein denotes ERR-alpha
T14 1310-1320 protein denotes PGC-1alpha
T15 1392-1401 protein denotes ERR-alpha
T16 1413-1423 protein denotes PGC-1alpha
T17 1517-1526 protein denotes ERR-alpha
T18 1569-1579 protein denotes PGC-1alpha
T19 1681-1690 protein denotes ERR-alpha
T20 1741-1751 protein denotes PGC-1alpha

PIR-corpus1

Id Subject Object Predicate Lexical cue
T1 29-48 protein denotes molecular repressor
T2 56-66 protein denotes peroxisome
T3 126-136 acronym denotes PGC-1alpha
T4 151-174 protein denotes co-activator PGC-1alpha
T5 306-316 protein denotes PGC-1alpha
T6 615-625 protein denotes PGC-1alpha
T7 743-753 protein denotes PGC-1alpha
T8 783-806 protein denotes orphan nuclear receptor
T9 807-838 protein denotes estrogen-related receptor-alpha
T10 840-849 acronym denotes ERR-alpha
T11 867-876 protein denotes ERR-alpha
T12 880-890 protein denotes PGC-1alpha
T13 929-938 protein denotes ERR-alpha
T14 940-950 protein denotes PGC-1alpha
T15 955-964 protein denotes ERR-alpha
T16 1310-1320 protein denotes PGC-1alpha
T17 1392-1401 protein denotes ERR-alpha
T18 1413-1423 protein denotes PGC-1alpha
T19 1517-1526 protein denotes ERR-alpha
T20 1569-1579 protein denotes PGC-1alpha
T21 1681-1690 protein denotes ERR-alpha
T22 1718-1737 protein denotes molecular repressor
T23 1741-1751 protein denotes PGC-1alpha
T24 1806-1819 protein denotes co-activators
T25 1845-1855 protein denotes repressors

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 392-405 Disease denotes heart failure http://purl.obolibrary.org/obo/MONDO_0005252
T2 410-427 Disease denotes diabetes mellitus http://purl.obolibrary.org/obo/MONDO_0005015

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 392-405 Phenotype denotes heart failure HP:0001635
T2 410-427 Phenotype denotes diabetes mellitus HP:0000819

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 1005-1010 OrganismTaxon denotes human 9606
T2 1157-1161 OrganismTaxon denotes mice 10088

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 392-397 Body_part denotes heart http://purl.obolibrary.org/obo/MAT_0000036
T2 1102-1117 Body_part denotes skeletal muscle http://purl.obolibrary.org/obo/MAT_0000302
T3 1122-1128 Body_part denotes kidney http://purl.obolibrary.org/obo/MAT_0000119

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 392-397 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948|http://purl.obolibrary.org/obo/UBERON_0007100|http://purl.obolibrary.org/obo/UBERON_0015228|http://purl.obolibrary.org/obo/UBERON_0015230
T5 1102-1117 Body_part denotes skeletal muscle http://purl.obolibrary.org/obo/UBERON_0001134|http://purl.obolibrary.org/obo/UBERON_0014892|http://purl.obolibrary.org/obo/UBERON_0014895
T8 1122-1128 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T9 1885-1890 Body_part denotes layer http://purl.obolibrary.org/obo/UBERON_0000119|http://purl.obolibrary.org/obo/UBERON_0022303