> top > docs > PubMed:12393902 > annotations

PubMed:12393902 JSONTXT

Annnotations TAB JSON ListView MergeView

sentences

Id Subject Object Predicate Lexical cue
T1 0-96 Sentence denotes MdmX is a RING finger ubiquitin ligase capable of synergistically enhancing Mdm2 ubiquitination.
T2 97-301 Sentence denotes It has been well documented that Mdm2 and its homologue MdmX not only are critical negative regulators of the tumor suppressor p53 but that both Mdm2 and MdmX interact to affect the function of the other.
T3 302-385 Sentence denotes The mechanisms through which these effects are manifested, however, remain unclear.
T4 386-590 Sentence denotes Although Mdm2 has been established as a RING finger ubiquitin ligase, MdmX has not been shown to possess this activity despite the extensive sequence homology between their respective RING finger domains.
T5 591-742 Sentence denotes Here we demonstrate that MdmX acts as a ubiquitin ligase in vitro, being capable of autoubiquitination, as well as mediating the ubiquitination of p53.
T6 743-873 Sentence denotes The addition of Mdm2 to in vitro ubiquitination assays containing MdmX results in a synergistic increase of ubiquitin conjugation.
T7 874-1000 Sentence denotes Analysis of the resulting ubiquitin conjugates reveals that this observed synergy reflects an increase in Mdm2 ubiquitination.
T8 1001-1237 Sentence denotes This study also suggests that ubiquitination of Mdm2 and MdmX may not serve as a signal for degradation, as we show that each are capable of synthesizing non-lysine 48 polyubiquitin chains and, in fact, utilize multiple lysine linkages.
T9 1238-1379 Sentence denotes Taken together, these findings suggest a more active role for MdmX in the Mdm2-MdmX-p53 regulatory network than has been proposed previously.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 207-212 HP_0002664 denotes tumor

FSU-PRGE

Id Subject Object Predicate Lexical cue
T1 0-4 protein denotes MdmX
T2 10-38 protein denotes RING finger ubiquitin ligase
T3 76-80 protein denotes Mdm2
T4 130-134 protein denotes Mdm2
T5 153-157 protein denotes MdmX
T6 207-227 protein denotes tumor suppressor p53
T7 242-246 protein denotes Mdm2
T8 251-255 protein denotes MdmX
T9 395-399 protein denotes Mdm2
T10 426-454 protein denotes RING finger ubiquitin ligase
T11 456-460 protein denotes MdmX
T12 616-620 protein denotes MdmX
T13 631-647 protein denotes ubiquitin ligase
T14 738-741 protein denotes p53
T15 759-763 protein denotes Mdm2
T16 809-813 protein denotes MdmX
T17 851-860 protein denotes ubiquitin
T18 900-909 protein denotes ubiquitin
T19 980-984 protein denotes Mdm2
T20 1049-1053 protein denotes Mdm2
T21 1058-1062 protein denotes MdmX
T22 1300-1304 protein denotes MdmX
T23 1312-1316 protein denotes Mdm2
T24 1317-1321 protein denotes MdmX
T25 1322-1325 protein denotes p53

PIR-corpus2

Id Subject Object Predicate Lexical cue
T1 0-4 protein denotes MdmX
T2 10-38 protein denotes RING finger ubiquitin ligase
T3 76-80 protein denotes Mdm2
T4 130-134 protein denotes Mdm2
T5 153-157 protein denotes MdmX
T6 207-227 protein denotes tumor suppressor p53
T7 242-246 protein denotes Mdm2
T8 251-255 protein denotes MdmX
T9 395-399 protein denotes Mdm2
T10 426-454 protein denotes RING finger ubiquitin ligase
T11 456-460 protein denotes MdmX
T12 616-620 protein denotes MdmX
T13 631-647 protein denotes ubiquitin ligase
T14 738-741 protein denotes p53
T15 759-763 protein denotes Mdm2
T16 809-813 protein denotes MdmX
T17 851-860 protein denotes ubiquitin
T18 900-909 protein denotes ubiquitin
T19 980-984 protein denotes Mdm2
T20 1049-1053 protein denotes Mdm2
T21 1058-1062 protein denotes MdmX
T22 1169-1189 protein denotes polyubiquitin chains
T23 1300-1304 protein denotes MdmX
T24 1312-1316 protein denotes Mdm2
T25 1317-1321 protein denotes MdmX
T26 1322-1325 protein denotes p53

PIR-corpus1

Id Subject Object Predicate Lexical cue
T1 0-4 protein denotes MdmX
T2 10-38 protein denotes RING finger ubiquitin ligase
T3 76-80 protein denotes Mdm2
T4 130-134 protein denotes Mdm2
T5 153-157 protein denotes MdmX
T6 207-227 protein denotes tumor suppressor p53
T7 242-246 protein denotes Mdm2
T8 251-255 protein denotes MdmX
T9 395-399 protein denotes Mdm2
T10 426-454 protein denotes RING finger ubiquitin ligase
T11 456-460 protein denotes MdmX
T12 616-620 protein denotes MdmX
T13 631-647 protein denotes ubiquitin ligase
T14 738-741 protein denotes p53
T15 759-763 protein denotes Mdm2
T16 809-813 protein denotes MdmX
T17 980-984 protein denotes Mdm2
T18 1049-1053 protein denotes Mdm2
T19 1058-1062 protein denotes MdmX
T20 1300-1304 protein denotes MdmX
T21 1312-1316 protein denotes Mdm2
T22 1317-1321 protein denotes MdmX
T23 1322-1325 protein denotes p53

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 207-212 Phenotype denotes tumor HP:0002664

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 207-212 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 10-21 Body_part denotes RING finger http://purl.obolibrary.org/obo/UBERON_0003624
T2 426-437 Body_part denotes RING finger http://purl.obolibrary.org/obo/UBERON_0003624
T3 570-581 Body_part denotes RING finger http://purl.obolibrary.org/obo/UBERON_0003624