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PubMed:12393885 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-160 Sentence denotes Mitochondrial localization of mutant superoxide dismutase 1 triggers caspase-dependent cell death in a cellular model of familial amyotrophic lateral sclerosis.
T2 161-280 Sentence denotes The mutations in superoxide dismutase 1 (SOD1) cause approximately 20% of familial amyotrophic lateral sclerosis cases.
T3 281-404 Sentence denotes A toxic gain of function has been considered to be the cause of the disease, but its molecular mechanism remains uncertain.
T4 405-686 Sentence denotes To determine whether the subcellular localization of mutant SOD1 is crucial to mutant SOD1-mediated cell death, we produced neuronal cell models with accumulation of SOD1 in each subcellular fraction/organelle, such as the cytosol, nucleus, endoplasmic reticulum, and mitochondria.
T5 687-936 Sentence denotes We showed that the localization of mutant SOD1 in the mitochondria triggered the release of mitochondrial cytochrome c followed by the activation of caspase cascade and induced neuronal cell death without cytoplasmic mutant SOD1 aggregate formation.
T6 937-1025 Sentence denotes Nuclear and endoplasmic reticulum localization of mutant SOD1 did not induce cell death.
T7 1026-1202 Sentence denotes These results suggest that the localization of mutant SOD1 in the mitochondria is critical in the pathogenesis of mutant SOD1-associated familial amyotrophic lateral sclerosis.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 142-149 http://purl.obolibrary.org/obo/MAT_0000488 denotes lateral
T2 256-263 http://purl.obolibrary.org/obo/MAT_0000488 denotes lateral
T3 1184-1191 http://purl.obolibrary.org/obo/MAT_0000488 denotes lateral

PennBioIE

Id Subject Object Predicate Lexical cue
T1 37-59 protein denotes superoxide dismutase 1
T2 69-76 protein denotes caspase
T3 178-200 protein denotes superoxide dismutase 1
T4 202-206 protein denotes SOD1
T5 289-305 protein denotes gain of function
T6 465-469 protein denotes SOD1
T7 491-495 protein denotes SOD1
T8 571-575 protein denotes SOD1
T9 729-733 protein denotes SOD1
T10 793-805 protein denotes cytochrome c
T11 836-843 protein denotes caspase
T12 911-915 protein denotes SOD1
T13 994-998 protein denotes SOD1
T14 1080-1084 protein denotes SOD1
T15 1147-1151 protein denotes SOD1

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
12393885-0#37#59#gene6647 37-59 gene6647 denotes superoxide dismutase 1
12393885-0#130#159#diseaseC0002736 130-159 diseaseC0002736 denotes amyotrophic lateral sclerosis
37#59#gene6647130#159#diseaseC0002736 12393885-0#37#59#gene6647 12393885-0#130#159#diseaseC0002736 associated_with superoxide dismutase 1,amyotrophic lateral sclerosis

DisGeNET

Id Subject Object Predicate Lexical cue
T0 37-59 gene:6647 denotes superoxide dismutase 1
T1 121-159 disease:C1862939 denotes familial amyotrophic lateral sclerosis
T2 178-200 gene:6647 denotes superoxide dismutase 1
T3 235-273 disease:C1862939 denotes familial amyotrophic lateral sclerosis
T4 202-206 gene:6647 denotes SOD1
T5 235-273 disease:C1862939 denotes familial amyotrophic lateral sclerosis
T6 1147-1151 gene:6647 denotes SOD1
T7 1163-1201 disease:C1862939 denotes familial amyotrophic lateral sclerosis
T8 1080-1084 gene:6647 denotes SOD1
T9 1163-1201 disease:C1862939 denotes familial amyotrophic lateral sclerosis
R1 T0 T1 associated_with superoxide dismutase 1,familial amyotrophic lateral sclerosis
R2 T2 T3 associated_with superoxide dismutase 1,familial amyotrophic lateral sclerosis
R3 T4 T5 associated_with SOD1,familial amyotrophic lateral sclerosis
R4 T6 T7 associated_with SOD1,familial amyotrophic lateral sclerosis
R5 T8 T9 associated_with SOD1,familial amyotrophic lateral sclerosis

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 130-159 Phenotype denotes amyotrophic lateral sclerosis HP:0007354
T2 244-273 Phenotype denotes amyotrophic lateral sclerosis HP:0007354
T3 1172-1201 Phenotype denotes amyotrophic lateral sclerosis HP:0007354

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 121-159 Disease denotes familial amyotrophic lateral sclerosis http://purl.obolibrary.org/obo/MONDO_0005144
T2 235-273 Disease denotes familial amyotrophic lateral sclerosis http://purl.obolibrary.org/obo/MONDO_0005144
T3 1163-1201 Disease denotes familial amyotrophic lateral sclerosis http://purl.obolibrary.org/obo/MONDO_0005144

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 605-614 Body_part denotes organelle http://purl.obolibrary.org/obo/GO_0043226
T2 628-635 Body_part denotes cytosol http://purl.obolibrary.org/obo/GO_0005829
T3 637-644 Body_part denotes nucleus http://purl.obolibrary.org/obo/GO_0005634|http://purl.obolibrary.org/obo/UBERON_0000125
T5 658-667 Body_part denotes reticulum http://purl.obolibrary.org/obo/UBERON_0007361
T6 892-903 Body_part denotes cytoplasmic http://purl.obolibrary.org/obo/GO_0005737
T7 961-970 Body_part denotes reticulum http://purl.obolibrary.org/obo/UBERON_0007361

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 142-149 Body_part denotes lateral http://purl.obolibrary.org/obo/MAT_0000488
T2 256-263 Body_part denotes lateral http://purl.obolibrary.org/obo/MAT_0000488
T3 1184-1191 Body_part denotes lateral http://purl.obolibrary.org/obo/MAT_0000488

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 529-537 Cell denotes neuronal http://purl.obolibrary.org/obo/CL:0000540
T2 864-872 Cell denotes neuronal http://purl.obolibrary.org/obo/CL:0000540