PubMed:12388546
Annnotations
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-125 | Sentence | denotes | Arsenic trioxide promotes histone H3 phosphoacetylation at the chromatin of CASPASE-10 in acute promyelocytic leukemia cells. |
| T2 | 126-299 | Sentence | denotes | Arsenic trioxide (As(2)O(3)) is highly effective for the treatment of acute promyelocytic leukemia, even in patients who are unresponsive to all-trans-retinoic acid therapy. |
| T3 | 300-431 | Sentence | denotes | As(2)O(3) is believed to function primarily by promoting apoptosis, but the underlying molecular mechanisms remain largely unknown. |
| T4 | 432-620 | Sentence | denotes | In this report, using cDNA arrays, we have examined the changes in gene expression profiles triggered by clinically achievable doses of As(2)O(3) in acute promyelocytic leukemia NB4 cells. |
| T5 | 621-689 | Sentence | denotes | CASPASE-10 expression was found to be potently induced by As(2)O(3). |
| T6 | 690-787 | Sentence | denotes | Accordingly, caspase-10 activity also substantially increased in response to As(2)O(3) treatment. |
| T7 | 788-937 | Sentence | denotes | A selective inhibitor of caspase-10, Z-AEVD-FMK, effectively blocked caspase-3 activation and significantly attenuated As(2)O(3)-triggered apoptosis. |
| T8 | 938-1125 | Sentence | denotes | Interestingly, the treatment of NB4 cells with As(2)O(3) markedly increased histone H3 phosphorylation at serine 10, an event that is associated with acetylation of the lysine 14 residue. |
| T9 | 1126-1259 | Sentence | denotes | Chromatin immunoprecipitation assays revealed that As(2)O(3) potently enhances histone H3 phosphoacetylation at the CASPASE-10 locus. |
| T10 | 1260-1503 | Sentence | denotes | These results suggest that the effect of As(2)O(3) on histone H3 phosphoacetylation at the CASPASE-10 gene may play an important role in the induction of apoptosis and thus contribute to its therapeutic effects on acute promyelocytic leukemia. |
PubmedHPO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 196-224 | HP_0004836 | denotes | acute promyelocytic leukemia |
| T2 | 216-224 | HP_0001909 | denotes | leukemia |
| T3 | 581-609 | HP_0004836 | denotes | acute promyelocytic leukemia |
| T4 | 601-609 | HP_0001909 | denotes | leukemia |
| T5 | 1474-1502 | HP_0004836 | denotes | acute promyelocytic leukemia |
| T6 | 1494-1502 | HP_0001909 | denotes | leukemia |
2015-BEL-Sample
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 788-936 | cat(p(HGNC:CASP10)) increases cat(p(HGNC:CASP3)) | denotes | A selective inhibitor of caspase-10, Z-AEVD-FMK, effectively blocked caspase-3 activation and significantly attenuated As(2)O(3)-triggered apoptosis |
2015-BEL-Sample-2
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| BEL:20000438 | 788-936 | cat(p(HGNC:CASP10)) increases cat(p(HGNC:CASP3)) | denotes | A selective inhibitor of caspase-10, Z-AEVD-FMK, effectively blocked caspase-3 activation and significantly attenuated As(2)O(3)-triggered apoptosis |
GlyCosmos15-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 90-118 | Phenotype | denotes | acute promyelocytic leukemia | HP:0004836 |
| T2 | 196-224 | Phenotype | denotes | acute promyelocytic leukemia | HP:0004836 |
| T3 | 251-263 | Phenotype | denotes | unresponsive | HP:0025237 |
| T4 | 581-609 | Phenotype | denotes | acute promyelocytic leukemia | HP:0004836 |
| T5 | 1474-1502 | Phenotype | denotes | acute promyelocytic leukemia | HP:0004836 |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 90-118 | Disease | denotes | acute promyelocytic leukemia | http://purl.obolibrary.org/obo/MONDO_0012883 |
| T2 | 196-224 | Disease | denotes | acute promyelocytic leukemia | http://purl.obolibrary.org/obo/MONDO_0012883 |
| T3 | 581-609 | Disease | denotes | acute promyelocytic leukemia | http://purl.obolibrary.org/obo/MONDO_0012883 |
| T4 | 1474-1502 | Disease | denotes | acute promyelocytic leukemia | http://purl.obolibrary.org/obo/MONDO_0012883 |
Glycosmos15-CL
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 96-109 | Cell | denotes | promyelocytic | http://purl.obolibrary.org/obo/CL:0000836 |
| T2 | 202-215 | Cell | denotes | promyelocytic | http://purl.obolibrary.org/obo/CL:0000836 |
| T3 | 587-600 | Cell | denotes | promyelocytic | http://purl.obolibrary.org/obo/CL:0000836 |
| T4 | 1480-1493 | Cell | denotes | promyelocytic | http://purl.obolibrary.org/obo/CL:0000836 |