PubMed:12374875 / 0-690 JSONTXT

{"project":"PubMed_Structured_Abstracts","denotations":[{"id":"T1","span":{"begin":88,"end":501},"obj":"BACKGROUND"}],"text":"Endogenous antimicrobial peptides and skin infections in atopic dermatitis.\nBACKGROUND: The innate immune system of human skin contains antimicrobial peptides known as cathelicidins (LL-37) and beta-defensins. In normal skin these peptides are negligible, but they accumulate in skin affected by inflammatory diseases such as psoriasis. We compared the levels of expression of LL-37 and human beta-defensin 2 (HBD-2) in inflamed skin from patients with atopic dermatitis and from those with psoriasis.\nMETHODS: The expression of LL-37 and HBD-2 protein in skin-biopsy specimens from patients with psoriasis, patients with atopic dermatitis, and normal subjects was determined by immunohisto"}

{"project":"DisGeNET5_gene_disease","denotations":[{"id":"12374875-3#40#45#gene820","span":{"begin":377,"end":382},"obj":"gene820"},{"id":"12374875-3#116#133#diseaseC0011615","span":{"begin":453,"end":470},"obj":"diseaseC0011615"},{"id":"12374875-3#116#133#diseaseC0013595","span":{"begin":453,"end":470},"obj":"diseaseC0013595"},{"id":"12374875-4#28#33#gene1673","span":{"begin":539,"end":544},"obj":"gene1673"},{"id":"12374875-4#28#33#gene100289462","span":{"begin":539,"end":544},"obj":"gene100289462"},{"id":"12374875-4#86#95#diseaseC0033860","span":{"begin":597,"end":606},"obj":"diseaseC0033860"}],"relations":[{"id":"40#45#gene820116#133#diseaseC0011615","pred":"associated_with","subj":"12374875-3#40#45#gene820","obj":"12374875-3#116#133#diseaseC0011615"},{"id":"40#45#gene820116#133#diseaseC0013595","pred":"associated_with","subj":"12374875-3#40#45#gene820","obj":"12374875-3#116#133#diseaseC0013595"},{"id":"28#33#gene167386#95#diseaseC0033860","pred":"associated_with","subj":"12374875-4#28#33#gene1673","obj":"12374875-4#86#95#diseaseC0033860"},{"id":"28#33#gene10028946286#95#diseaseC0033860","pred":"associated_with","subj":"12374875-4#28#33#gene100289462","obj":"12374875-4#86#95#diseaseC0033860"}],"text":"Endogenous antimicrobial peptides and skin infections in atopic dermatitis.\nBACKGROUND: The innate immune system of human skin contains antimicrobial peptides known as cathelicidins (LL-37) and beta-defensins. In normal skin these peptides are negligible, but they accumulate in skin affected by inflammatory diseases such as psoriasis. We compared the levels of expression of LL-37 and human beta-defensin 2 (HBD-2) in inflamed skin from patients with atopic dermatitis and from those with psoriasis.\nMETHODS: The expression of LL-37 and HBD-2 protein in skin-biopsy specimens from patients with psoriasis, patients with atopic dermatitis, and normal subjects was determined by immunohisto"}