PubMed:12373301 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/12373301","sourcedb":"PubMed","sourceid":"12373301","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/12373301","text":"Sulfotransferase 1A2*2 is a risk factor for early-onset breast cancer.\nThe estrogen-signaling pathway plays an important role in the pathophysiology of breast cancer, and the sulfotransferase 1A (SULT1A) family has been found to be both downstream targets of tamoxifen and a risk factor of breast cancer. We have used PCR-RFLP and direct sequencing methods to determine SULT1A2 polymorphisms in 230 Taiwanese breast cancer patients. The results showed that the frequencies of SULT1A2*1 and SULT1A2*2 occurring were 94.8% and 5.2%, respectively. No SULT1A2*3 allele was found in these patients. In comparison with the frequency of healthy controls (96.0% and 4.0% for SULT1A2*1 and SULT1A2*2, respectively), the allelic frequencies of SULT1A2 polymorphisms in these patients were not statistically significant (p=0.398). However, the SULT1A2*2 allele seems to influence the age of onset among early-onset breast cancer patients (p=0.021, OR=2.74, 95%CI=1.13-6.65).","tracks":[{"project":"DisGeNET","denotations":[{"id":"T0","span":{"begin":0,"end":20},"obj":"gene:6799"},{"id":"T1","span":{"begin":56,"end":69},"obj":"disease:C0006142"},{"id":"T2","span":{"begin":0,"end":20},"obj":"gene:6799"},{"id":"T3","span":{"begin":56,"end":69},"obj":"disease:C0678222"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T0","obj":"T1"},{"id":"R2","pred":"associated_with","subj":"T2","obj":"T3"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"attributes":[{"subj":"T0","pred":"source","obj":"DisGeNET"},{"subj":"T1","pred":"source","obj":"DisGeNET"},{"subj":"T2","pred":"source","obj":"DisGeNET"},{"subj":"T3","pred":"source","obj":"DisGeNET"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"DisGeNET","color":"#eca893","default":true}]}]}}