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PubMed:12351644 JSON TXT

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GlyCosmos6-Glycan-Motif-Image

Id	Subject	Object	Predicate	Lexical cue	image
T1	12-15	Glycan_Motif	denotes	GD3	https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G98544DH\|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81928IQ
T3	79-82	Glycan_Motif	denotes	GD3	https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G98544DH\|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81928IQ
T5	84-87	Glycan_Motif	denotes	GD3	https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G98544DH\|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81928IQ
T7	332-335	Glycan_Motif	denotes	GD3	https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G98544DH\|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81928IQ
T9	724-727	Glycan_Motif	denotes	GD3	https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G98544DH\|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81928IQ
T11	923-926	Glycan_Motif	denotes	GD3	https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G98544DH\|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81928IQ
T13	1035-1038	Glycan_Motif	denotes	GD3	https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G98544DH\|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81928IQ
T15	1314-1317	Glycan_Motif	denotes	GD3	https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G98544DH\|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81928IQ
T17	1486-1489	Glycan_Motif	denotes	GD3	https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G98544DH\|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81928IQ

sentences

Id	Subject	Object	Predicate	Lexical cue
T1	0-66	Sentence	denotes	Ganglioside GD3 sensitizes human hepatoma cells to cancer therapy.
T2	67-218	Sentence	denotes	Ganglioside GD3 (GD3) has emerged as a modulator of cell death pathways due to its ability to interact with mitochondria and disable survival pathways.
T3	219-422	Sentence	denotes	Because NF-kappaB activation contributes to cancer therapy resistance, this study was undertaken to test whether GD3 modulates the response of human hepatoblastoma HepG2 cells to radio- and chemotherapy.
T4	423-603	Sentence	denotes	NF-kappaB was activated in HepG2 cells shortly after therapeutic doses of ionizing radiation or daunorubicin treatment that translated into up-regulation of kappaB-dependent genes.
T5	604-714	Sentence	denotes	These effects were accompanied by minimal killing of HepG2 cells by either ionizing radiation or daunorubicin.
T6	715-868	Sentence	denotes	However, GD3 pretreatment blocked the nuclear translocation of active kappaB members, without effect on Akt phosphorylation, induced by either treatment.
T7	869-1002	Sentence	denotes	The suppression of kappaB-dependent gene induction by GD3 was accompanied by enhanced apoptotic cell death caused by these therapies.
T8	1003-1203	Sentence	denotes	Furthermore, the combination of GD3 plus ionizing radiation stimulated the formation of reactive species followed by the mitochondrial release of cytochrome c and Smac/Diablo and caspase 3 activation.
T9	1204-1342	Sentence	denotes	Pretreatment with cyclosporin A before radiotherapy protected HepG2 cells from the therapeutic combination of GD3 plus ionizing radiation.
T10	1343-1623	Sentence	denotes	These findings underscore a key role of mitochondria in the response of tumor cells to cancer therapy and highlight the potential relevance of GD3 to overcome resistance to cancer therapy by combining its dual action as a mitochondria-interacting and NF-kappaB-inactivating agent.

GlyCosmos6-Glycan-Motif-Structure

Id	Subject	Object	Predicate	Lexical cue
T1	12-15	https://glytoucan.org/Structures/Glycans/G81928IQ	denotes	GD3
T2	12-15	https://glytoucan.org/Structures/Glycans/G98544DH	denotes	GD3
T3	79-82	https://glytoucan.org/Structures/Glycans/G81928IQ	denotes	GD3
T4	79-82	https://glytoucan.org/Structures/Glycans/G98544DH	denotes	GD3
T5	84-87	https://glytoucan.org/Structures/Glycans/G81928IQ	denotes	GD3
T6	84-87	https://glytoucan.org/Structures/Glycans/G98544DH	denotes	GD3
T7	332-335	https://glytoucan.org/Structures/Glycans/G81928IQ	denotes	GD3
T8	332-335	https://glytoucan.org/Structures/Glycans/G98544DH	denotes	GD3
T9	724-727	https://glytoucan.org/Structures/Glycans/G81928IQ	denotes	GD3
T10	724-727	https://glytoucan.org/Structures/Glycans/G98544DH	denotes	GD3
T11	923-926	https://glytoucan.org/Structures/Glycans/G81928IQ	denotes	GD3
T12	923-926	https://glytoucan.org/Structures/Glycans/G98544DH	denotes	GD3
T13	1035-1038	https://glytoucan.org/Structures/Glycans/G81928IQ	denotes	GD3
T14	1035-1038	https://glytoucan.org/Structures/Glycans/G98544DH	denotes	GD3
T15	1314-1317	https://glytoucan.org/Structures/Glycans/G81928IQ	denotes	GD3
T16	1314-1317	https://glytoucan.org/Structures/Glycans/G98544DH	denotes	GD3
T17	1486-1489	https://glytoucan.org/Structures/Glycans/G81928IQ	denotes	GD3
T18	1486-1489	https://glytoucan.org/Structures/Glycans/G98544DH	denotes	GD3

mondo_disease

Id	Subject	Object	Predicate	Lexical cue	mondo_id
T1	33-41	Disease	denotes	hepatoma	http://purl.obolibrary.org/obo/MONDO_0007256
T2	51-57	Disease	denotes	cancer	http://purl.obolibrary.org/obo/MONDO_0004992
T3	263-269	Disease	denotes	cancer	http://purl.obolibrary.org/obo/MONDO_0004992
T4	368-382	Disease	denotes	hepatoblastoma	http://purl.obolibrary.org/obo/MONDO_0007256\|http://purl.obolibrary.org/obo/MONDO_0018666
T6	1415-1420	Disease	denotes	tumor	http://purl.obolibrary.org/obo/MONDO_0005070
T7	1430-1436	Disease	denotes	cancer	http://purl.obolibrary.org/obo/MONDO_0004992
T8	1502-1522	Disease	denotes	resistance to cancer	http://purl.obolibrary.org/obo/MONDO_0036501

HP-phenotype

Id	Subject	Object	Predicate	Lexical cue	hp_id
T1	51-57	Phenotype	denotes	cancer	HP:0002664
T2	263-269	Phenotype	denotes	cancer	HP:0002664
T3	368-382	Phenotype	denotes	hepatoblastoma	HP:0002884
T4	1415-1420	Phenotype	denotes	tumor	HP:0002664
T5	1430-1436	Phenotype	denotes	cancer	HP:0002664
T6	1516-1522	Phenotype	denotes	cancer	HP:0002664

Glycan-GlyCosmos

Id	Subject	Object	Predicate	Lexical cue	image
T1	12-15	Glycan	denotes	GD3	https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T2	79-82	Glycan	denotes	GD3	https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T3	84-87	Glycan	denotes	GD3	https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T4	332-335	Glycan	denotes	GD3	https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T5	724-727	Glycan	denotes	GD3	https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T6	923-926	Glycan	denotes	GD3	https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T7	1035-1038	Glycan	denotes	GD3	https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T8	1314-1317	Glycan	denotes	GD3	https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T9	1486-1489	Glycan	denotes	GD3	https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH

GlyCosmos15-HP

Id	Subject	Object	Predicate	Lexical cue	hp_id
T1	51-57	Phenotype	denotes	cancer	HP:0002664
T2	263-269	Phenotype	denotes	cancer	HP:0002664
T3	368-382	Phenotype	denotes	hepatoblastoma	HP:0002884
T4	1415-1420	Phenotype	denotes	tumor	HP:0002664
T5	1430-1436	Phenotype	denotes	cancer	HP:0002664
T6	1516-1522	Phenotype	denotes	cancer	HP:0002664

GlyCosmos15-MONDO

Id	Subject	Object	Predicate	Lexical cue	mondo_id
T1	33-41	Disease	denotes	hepatoma	http://purl.obolibrary.org/obo/MONDO_0007256
T2	51-57	Disease	denotes	cancer	http://purl.obolibrary.org/obo/MONDO_0004992
T3	263-269	Disease	denotes	cancer	http://purl.obolibrary.org/obo/MONDO_0004992
T4	368-382	Disease	denotes	hepatoblastoma	http://purl.obolibrary.org/obo/MONDO_0007256\|http://purl.obolibrary.org/obo/MONDO_0018666
T6	1415-1420	Disease	denotes	tumor	http://purl.obolibrary.org/obo/MONDO_0005070
T7	1430-1436	Disease	denotes	cancer	http://purl.obolibrary.org/obo/MONDO_0004992
T8	1502-1522	Disease	denotes	resistance to cancer	http://purl.obolibrary.org/obo/MONDO_0036501

GlyCosmos15-NCBITAXON

Id	Subject	Object	Predicate	Lexical cue	db_id
T1	27-32	OrganismTaxon	denotes	human	9606
T2	362-367	OrganismTaxon	denotes	human	9606

GlyCosmos15-CL

Id	Subject	Object	Predicate	Lexical cue	cl_id
T1	1415-1426	Cell	denotes	tumor cells	http://purl.obolibrary.org/obo/CL:0001063

sentences

Id	Subject	Object	Predicate	Lexical cue
T1	0-66	Sentence	denotes	Ganglioside GD3 sensitizes human hepatoma cells to cancer therapy.
T2	67-218	Sentence	denotes	Ganglioside GD3 (GD3) has emerged as a modulator of cell death pathways due to its ability to interact with mitochondria and disable survival pathways.
T3	219-422	Sentence	denotes	Because NF-kappaB activation contributes to cancer therapy resistance, this study was undertaken to test whether GD3 modulates the response of human hepatoblastoma HepG2 cells to radio- and chemotherapy.
T4	423-603	Sentence	denotes	NF-kappaB was activated in HepG2 cells shortly after therapeutic doses of ionizing radiation or daunorubicin treatment that translated into up-regulation of kappaB-dependent genes.
T5	604-714	Sentence	denotes	These effects were accompanied by minimal killing of HepG2 cells by either ionizing radiation or daunorubicin.
T6	715-868	Sentence	denotes	However, GD3 pretreatment blocked the nuclear translocation of active kappaB members, without effect on Akt phosphorylation, induced by either treatment.
T7	869-1002	Sentence	denotes	The suppression of kappaB-dependent gene induction by GD3 was accompanied by enhanced apoptotic cell death caused by these therapies.
T8	1003-1203	Sentence	denotes	Furthermore, the combination of GD3 plus ionizing radiation stimulated the formation of reactive species followed by the mitochondrial release of cytochrome c and Smac/Diablo and caspase 3 activation.
T9	1204-1342	Sentence	denotes	Pretreatment with cyclosporin A before radiotherapy protected HepG2 cells from the therapeutic combination of GD3 plus ionizing radiation.
T10	1343-1623	Sentence	denotes	These findings underscore a key role of mitochondria in the response of tumor cells to cancer therapy and highlight the potential relevance of GD3 to overcome resistance to cancer therapy by combining its dual action as a mitochondria-interacting and NF-kappaB-inactivating agent.

GlyCosmos15-Sentences

Id	Subject	Object	Predicate	Lexical cue
T1	0-66	Sentence	denotes	Ganglioside GD3 sensitizes human hepatoma cells to cancer therapy.
T2	67-218	Sentence	denotes	Ganglioside GD3 (GD3) has emerged as a modulator of cell death pathways due to its ability to interact with mitochondria and disable survival pathways.
T3	219-422	Sentence	denotes	Because NF-kappaB activation contributes to cancer therapy resistance, this study was undertaken to test whether GD3 modulates the response of human hepatoblastoma HepG2 cells to radio- and chemotherapy.
T4	423-603	Sentence	denotes	NF-kappaB was activated in HepG2 cells shortly after therapeutic doses of ionizing radiation or daunorubicin treatment that translated into up-regulation of kappaB-dependent genes.
T5	604-714	Sentence	denotes	These effects were accompanied by minimal killing of HepG2 cells by either ionizing radiation or daunorubicin.
T6	715-868	Sentence	denotes	However, GD3 pretreatment blocked the nuclear translocation of active kappaB members, without effect on Akt phosphorylation, induced by either treatment.
T7	869-1002	Sentence	denotes	The suppression of kappaB-dependent gene induction by GD3 was accompanied by enhanced apoptotic cell death caused by these therapies.
T8	1003-1203	Sentence	denotes	Furthermore, the combination of GD3 plus ionizing radiation stimulated the formation of reactive species followed by the mitochondrial release of cytochrome c and Smac/Diablo and caspase 3 activation.
T9	1204-1342	Sentence	denotes	Pretreatment with cyclosporin A before radiotherapy protected HepG2 cells from the therapeutic combination of GD3 plus ionizing radiation.
T10	1343-1623	Sentence	denotes	These findings underscore a key role of mitochondria in the response of tumor cells to cancer therapy and highlight the potential relevance of GD3 to overcome resistance to cancer therapy by combining its dual action as a mitochondria-interacting and NF-kappaB-inactivating agent.

GlyCosmos15-Glycan

Id	Subject	Object	Predicate	Lexical cue	image
T1	12-15	Glycan	denotes	GD3	https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T2	79-82	Glycan	denotes	GD3	https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T3	84-87	Glycan	denotes	GD3	https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T4	332-335	Glycan	denotes	GD3	https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T5	724-727	Glycan	denotes	GD3	https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T6	923-926	Glycan	denotes	GD3	https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T7	1035-1038	Glycan	denotes	GD3	https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T8	1314-1317	Glycan	denotes	GD3	https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T9	1486-1489	Glycan	denotes	GD3	https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH

NCBITAXON

Id	Subject	Object	Predicate	Lexical cue	db_id
T1	27-32	OrganismTaxon	denotes	human	9606
T2	362-367	OrganismTaxon	denotes	human	9606

CL-cell

Id	Subject	Object	Predicate	Lexical cue	cl_id
T1	1415-1426	Cell	denotes	tumor cells	http://purl.obolibrary.org/obo/CL:0001063