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sentences

Id Subject Object Predicate Lexical cue
T1 0-123 Sentence denotes Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1.
T2 124-298 Sentence denotes The Saccharomyces cerevisiae Sir2 protein is an NAD(+)-dependent histone deacetylase that plays a critical role in transcriptional silencing, genome stability, and longevity.
T3 299-407 Sentence denotes A human homologue of Sir2, SIRT1, regulates the activity of the p53 tumor suppressor and inhibits apoptosis.
T4 408-566 Sentence denotes The Sir2 deacetylation reaction generates two products: O-acetyl-ADP-ribose and nicotinamide, a precursor of nicotinic acid and a form of niacin/vitamin B(3).
T5 567-723 Sentence denotes We show here that nicotinamide strongly inhibits yeast silencing, increases rDNA recombination, and shortens replicative life span to that of a sir2 mutant.
T6 724-909 Sentence denotes Nicotinamide abolishes silencing and leads to an eventual delocalization of Sir2 even in G(1)-arrested cells, demonstrating that silent heterochromatin requires continual Sir2 activity.
T7 910-1022 Sentence denotes We show that physiological concentrations of nicotinamide noncompetitively inhibit both Sir2 and SIRT1 in vitro.
T8 1023-1184 Sentence denotes The degree of inhibition by nicotinamide (IC(50) < 50 microm) is equal to or better than the most effective known synthetic inhibitors of this class of proteins.
T9 1185-1336 Sentence denotes We propose a model whereby nicotinamide inhibits deacetylation by binding to a conserved pocket adjacent to NAD(+), thereby blocking NAD(+) hydrolysis.
T10 1337-1438 Sentence denotes We discuss the possibility that nicotinamide is a physiologically relevant regulator of Sir2 enzymes.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 367-372 HP_0002664 denotes tumor

FSU-PRGE

Id Subject Object Predicate Lexical cue
T1 102-106 protein denotes sir2
T2 117-122 protein denotes SIRT1
T3 153-157 protein denotes Sir2
T4 189-208 protein denotes histone deacetylase
T5 320-324 protein denotes Sir2
T6 326-331 protein denotes SIRT1
T7 363-383 protein denotes p53 tumor suppressor
T8 412-416 protein denotes Sir2
T9 711-715 protein denotes sir2
T10 800-804 protein denotes Sir2
T11 895-899 protein denotes Sir2
T12 998-1002 protein denotes Sir2
T13 1007-1012 protein denotes SIRT1
T14 1425-1429 protein denotes Sir2

PIR-corpus2

Id Subject Object Predicate Lexical cue
T1 102-106 protein denotes sir2
T2 117-122 protein denotes SIRT1
T3 153-165 protein denotes Sir2 protein
T4 172-196 protein denotes NAD(+)-dependent histone
T5 320-324 protein denotes Sir2
T6 326-331 protein denotes SIRT1
T7 363-383 protein denotes p53 tumor suppressor
T8 412-416 protein denotes Sir2
T9 711-715 protein denotes sir2
T10 800-804 protein denotes Sir2
T11 895-899 protein denotes Sir2
T12 998-1002 protein denotes Sir2
T13 1007-1012 protein denotes SIRT1
T14 1425-1437 protein denotes Sir2 enzymes
T19 111-122 long_form denotes human SIRT1

PIR-corpus1

Id Subject Object Predicate Lexical cue
T1 153-165 protein denotes Sir2 protein
T2 172-196 protein denotes NAD(+)-dependent histone
T3 307-324 protein denotes homologue of Sir2
T4 326-331 protein denotes SIRT1
T5 363-383 protein denotes p53 tumor suppressor
T6 412-416 protein denotes Sir2
T7 800-804 protein denotes Sir2
T8 895-899 protein denotes Sir2
T9 998-1002 protein denotes Sir2
T10 1007-1012 protein denotes SIRT1
T11 1175-1183 protein denotes proteins
T12 1425-1437 protein denotes Sir2 enzymes

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 367-372 Phenotype denotes tumor HP:0002664

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 367-372 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 111-116 OrganismTaxon denotes human 9606
T2 128-152 OrganismTaxon denotes Saccharomyces cerevisiae 4932
T3 301-306 OrganismTaxon denotes human 9606