PubMed:12231232 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/12231232","sourcedb":"PubMed","sourceid":"12231232","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/12231232","text":"The striatum as a target for anti-rigor effects of an antagonist of mGluR1, but not an agonist of group II metabotropic glutamate receptors.\nThe aim of the present study was to find out whether the metabotropic receptor 1 (mGluR1) and group II mGluRs, localized in the striatum, are involved in antiparkinsonian-like effects in rats. Haloperidol (1 mg/kg ip) induced parkinsonian-like muscle rigidity, measured as an increased resistance of a rat's hind foot to passive flexion and extension at the ankle joint. (RS)-1-aminoindan-1,5-dicarboxylic acid (AIDA; 0.5-15 microg/0.5 microl), a potent and selective mGluR1 antagonist, or (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylate (2R,4R-APDC; 7.5-15 microg/0.5 microl), a selective group II agonist, was injected bilaterally into the striatum of haloperidol-treated animals. AIDA in doses of 7.5-15 microg/0.5 microl diminished the haloperidol-induced muscle rigidity. In contrast, 2R,4R-APDC injections were ineffective. The present results may suggest that the blockade of striatal mGluR1, but not the stimulation of group II mGluRs, may ameliorate parkinsonian muscle rigidity.","tracks":[{"project":"bc5cdr-valid-experiment","denotations":[{"id":"T1","span":{"begin":120,"end":129},"obj":"Chemical"},{"id":"T2","span":{"begin":334,"end":345},"obj":"Chemical"},{"id":"T3","span":{"begin":367,"end":379},"obj":"Disease"},{"id":"T4","span":{"begin":385,"end":400},"obj":"Disease"},{"id":"T5","span":{"begin":512,"end":551},"obj":"Chemical"},{"id":"T6","span":{"begin":553,"end":557},"obj":"Chemical"},{"id":"T7","span":{"begin":631,"end":675},"obj":"Chemical"},{"id":"T8","span":{"begin":677,"end":687},"obj":"Chemical"},{"id":"T9","span":{"begin":792,"end":803},"obj":"Chemical"},{"id":"T10","span":{"begin":821,"end":825},"obj":"Chemical"},{"id":"T11","span":{"begin":878,"end":889},"obj":"Chemical"},{"id":"T12","span":{"begin":898,"end":913},"obj":"Disease"},{"id":"T13","span":{"begin":928,"end":938},"obj":"Chemical"},{"id":"T14","span":{"begin":1097,"end":1109},"obj":"Disease"},{"id":"T15","span":{"begin":1110,"end":1125},"obj":"Disease"}],"attributes":[{"subj":"T1","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T2","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T3","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T4","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T5","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T6","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T7","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T8","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T9","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T10","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T11","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T12","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T13","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T14","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T15","pred":"source","obj":"bc5cdr-valid-experiment"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"bc5cdr-valid-experiment","color":"#e7ec93","default":true}]}]}}