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c_corpus

Id Subject Object Predicate Lexical cue
T1 55-65 P42858 denotes huntingtin
T2 55-65 P42859 denotes huntingtin
T3 55-65 P51111 denotes huntingtin
T4 55-65 PR:000008840 denotes huntingtin
T5 55-65 P51112 denotes huntingtin
T10 85-105 D006816 denotes Huntington's disease
T11 85-105 D006816 denotes Huntington's disease
T14 115-119 PR:000005054 denotes mice
T16 115-119 O89094 denotes mice
T15 115-119 D051379 denotes mice
T17 115-119 10095 denotes mice
T18 134-141 D004194 denotes disease
T19 134-141 D004194 denotes disease
T20 204-212 UBERON:0002435 denotes striatum
T21 204-212 UBERON:0005383 denotes striatum
T22 217-232 UBERON:0000956 denotes cerebral cortex
T24 252-255 CVCL_D569 denotes CAG
T25 256-262 SO:0001068 denotes repeat
T26 280-284 SO:0000704 denotes gene
T27 294-304 P42858 denotes huntingtin
T28 294-304 P42859 denotes huntingtin
T29 294-304 P51111 denotes huntingtin
T30 294-304 PR:000008840 denotes huntingtin
T31 294-304 P51112 denotes huntingtin
T32 306-310 PR:000005054 denotes Mice
T34 306-310 O89094 denotes Mice
T33 306-310 D051379 denotes Mice
T35 306-310 10095 denotes Mice
T36 320-328 SO:0000109 denotes mutation
T37 353-363 P42858 denotes huntingtin
T38 353-363 P42859 denotes huntingtin
T39 353-363 P51111 denotes huntingtin
T40 353-363 PR:000008840 denotes huntingtin
T41 353-363 P51112 denotes huntingtin
T42 364-368 SO:0000704 denotes gene
T43 379-383 PR:000005054 denotes mice
T45 379-383 O89094 denotes mice
T44 379-383 D051379 denotes mice
T46 379-383 10095 denotes mice
T47 426-431 D006801 denotes human
T48 432-439 D004194 denotes disease
T49 432-439 D004194 denotes disease
T50 487-491 PR:000005054 denotes mice
T52 487-491 O89094 denotes mice
T51 487-491 D051379 denotes mice
T53 487-491 10095 denotes mice
T54 500-503 CVCL_D569 denotes CAG
T70 692-702 GO:0040011 denotes locomotion
T75 744-748 PR:Q9NHD5 denotes span
T76 775-785 D004745 denotes enkephalin
T77 775-785 D004745 denotes enkephalin
T80 786-790 SO:0000234 denotes mRNA
T78 786-790 D012333 denotes mRNA
T79 786-790 CHEBI:33699 denotes mRNA
T99 1017-1027 P42858 denotes huntingtin
T100 1017-1027 P42859 denotes huntingtin
T101 1017-1027 P51111 denotes huntingtin
T102 1017-1027 PR:000008840 denotes huntingtin
T103 1017-1027 P51112 denotes huntingtin
T104 1091-1101 P42858 denotes huntingtin
T105 1091-1101 P42859 denotes huntingtin
T106 1091-1101 P51111 denotes huntingtin
T107 1091-1101 PR:000008840 denotes huntingtin
T108 1091-1101 P51112 denotes huntingtin
T115 1348-1370 UBERON:0027371 denotes striosomal compartment
T116 1378-1386 UBERON:0002435 denotes striatum
T117 1378-1386 UBERON:0005383 denotes striatum
T118 1558-1563 10090 denotes mouse
T119 1558-1563 D051379 denotes mouse
T120 1736-1744 SO:0000109 denotes mutation

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-120 DRI_Background denotes Early motor dysfunction and striosomal distribution of huntingtin microaggregates in Huntington's disease knock-in mice.
T2 121-305 DRI_Challenge denotes Huntington's disease (HD) is characterized by a progressive loss of neurons in the striatum and cerebral cortex and is caused by a CAG repeat expansion in the gene encoding huntingtin.
T3 306-440 DRI_Background denotes Mice with the mutation inserted into their own huntingtin gene (knock-in mice) are, genetically, the best models of the human disease.
T4 441-619 DRI_Outcome denotes Here we show for the first time that knock-in mice with 94 CAG repeats develop a robust and early motor phenotype at 2 months of age, characterized by increased rearing at night.
T5 620-749 DRI_Outcome denotes This initial increase in repetitive movements was followed by decreased locomotion at 4 and 6 months, despite a normal life span.
T6 750-891 DRI_Outcome denotes The decrease in striatal enkephalin mRNA that is known to occur at 4 months was not present at 2 months, when increased rearing was observed.
T7 892-1048 DRI_Outcome denotes Both the hyperactive and hypoactive phases of motor dysfunction preceded the detection of nuclear microaggregates of mutated huntingtin in striatal neurons.
T8 1049-1090 DRI_Background denotes Nuclear microaggregates, defined as small
T9 1091-1118 Token_Label.OUTSIDE denotes huntingtin-positive punctas
T10 1119-1238 DRI_Background denotes detected by light microscopy, were very rare at 4 months but became widely distributed in striatal neurons at 6 months.
T11 1239-1289 DRI_Approach denotes Nuclear inclusions did not appear until 18 months.
T12 1290-1506 DRI_Outcome denotes When present, nuclear microaggregates predominated in the striosomal compartment of the striatum, providing a possible explanation for the different neuronal vulnerability of striatal compartments observed in humans.
T13 1507-1753 DRI_Background denotes The early motor phenotype observed in the knock-in mouse is reminiscent of repetitive movements often observed in early HD and provides a novel opportunity to assess the ability of therapies to prevent the initial effects of the mutation in vivo.

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 121-305 DRI_Challenge denotes Huntington's disease (HD) is characterized by a progressive loss of neurons in the striatum and cerebral cortex and is caused by a CAG repeat expansion in the gene encoding huntingtin.
T2 306-440 DRI_Background denotes Mice with the mutation inserted into their own huntingtin gene (knock-in mice) are, genetically, the best models of the human disease.
T3 441-619 DRI_Outcome denotes Here we show for the first time that knock-in mice with 94 CAG repeats develop a robust and early motor phenotype at 2 months of age, characterized by increased rearing at night.
T4 620-749 DRI_Outcome denotes This initial increase in repetitive movements was followed by decreased locomotion at 4 and 6 months, despite a normal life span.
T5 750-891 DRI_Outcome denotes The decrease in striatal enkephalin mRNA that is known to occur at 4 months was not present at 2 months, when increased rearing was observed.
T6 892-1048 DRI_Outcome denotes Both the hyperactive and hypoactive phases of motor dysfunction preceded the detection of nuclear microaggregates of mutated huntingtin in striatal neurons.
T7 1049-1090 DRI_Background denotes Nuclear microaggregates, defined as small
T8 1119-1238 DRI_Background denotes detected by light microscopy, were very rare at 4 months but became widely distributed in striatal neurons at 6 months.
T9 1239-1289 DRI_Approach denotes Nuclear inclusions did not appear until 18 months.
T10 1290-1506 DRI_Outcome denotes When present, nuclear microaggregates predominated in the striosomal compartment of the striatum, providing a possible explanation for the different neuronal vulnerability of striatal compartments observed in humans.
T11 1507-1753 DRI_Background denotes The early motor phenotype observed in the knock-in mouse is reminiscent of repetitive movements often observed in early HD and provides a novel opportunity to assess the ability of therapies to prevent the initial effects of the mutation in vivo.