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PubMed:12174906 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-120 Sentence denotes Expression of COX-2 and Wnt pathway genes in adenomas of familial adenomatous polyposis patients treated with meloxicam.
TextSentencer_T2 121-132 Sentence denotes BACKGROUND:
TextSentencer_T3 133-366 Sentence denotes Familial adenomatous polyposis (FAP) is an autosomal, dominantly inherited predisposition to colorectal cancer caused by germline mutations within the adenomatous polyposis coli (APC) gene, a key member of the Wnt signalling pathway.
TextSentencer_T4 367-541 Sentence denotes A new class of non-steroidal anti-inflammatory drugs (NSAIDs), the specific cyclooxygenase 2 (COX-2) inhibitors, have recently been applied for the treatment of FAP patients.
TextSentencer_T5 542-563 Sentence denotes PATIENTS AND METHODS:
TextSentencer_T6 564-854 Sentence denotes The expressions of the Wnt members and targets APC, c-myc, cyclin D1 and COX-2, as measured by real-time quantitative RT-PCR, have been evaluated in fresh samples of normal colorectal mucosa and matched adenoma tissue of six unrelated FAP patients before and after treatment with meloxicam.
TextSentencer_T7 855-863 Sentence denotes RESULTS:
TextSentencer_T8 864-954 Sentence denotes A significant up-regulation of COX-2 in adenomas after treatment with meloxicam was found.
TextSentencer_T9 955-1152 Sentence denotes Furthermore, in adenomas, a down-regulation of APC after treatment and a tight correlation of the expressions of the two Wnt targets, c-myc and cyclin D1, in both stages of treatment were observed.
TextSentencer_T10 1153-1164 Sentence denotes CONCLUSION:
TextSentencer_T11 1165-1317 Sentence denotes A feedback loop mediated by the peroxisome proliferator-activated receptor (PPAR) gamma is discussed as being responsible for the up-regulation of COX-2
T1 0-120 Sentence denotes Expression of COX-2 and Wnt pathway genes in adenomas of familial adenomatous polyposis patients treated with meloxicam.
T2 121-132 Sentence denotes BACKGROUND:
T3 133-366 Sentence denotes Familial adenomatous polyposis (FAP) is an autosomal, dominantly inherited predisposition to colorectal cancer caused by germline mutations within the adenomatous polyposis coli (APC) gene, a key member of the Wnt signalling pathway.
T4 367-541 Sentence denotes A new class of non-steroidal anti-inflammatory drugs (NSAIDs), the specific cyclooxygenase 2 (COX-2) inhibitors, have recently been applied for the treatment of FAP patients.
T5 542-563 Sentence denotes PATIENTS AND METHODS:
T6 564-854 Sentence denotes The expressions of the Wnt members and targets APC, c-myc, cyclin D1 and COX-2, as measured by real-time quantitative RT-PCR, have been evaluated in fresh samples of normal colorectal mucosa and matched adenoma tissue of six unrelated FAP patients before and after treatment with meloxicam.
T7 855-863 Sentence denotes RESULTS:
T8 864-954 Sentence denotes A significant up-regulation of COX-2 in adenomas after treatment with meloxicam was found.
T9 955-1152 Sentence denotes Furthermore, in adenomas, a down-regulation of APC after treatment and a tight correlation of the expressions of the two Wnt targets, c-myc and cyclin D1, in both stages of treatment were observed.
T10 1153-1164 Sentence denotes CONCLUSION:
T11 1165-1317 Sentence denotes A feedback loop mediated by the peroxisome proliferator-activated receptor (PPAR) gamma is discussed as being responsible for the up-regulation of COX-2

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
12174906-0#14#19#gene5743 14-19 gene5743 denotes COX-2
12174906-0#57#87#diseaseC0032580 57-87 diseaseC0032580 denotes familial adenomatous polyposis
12174906-1#151#177#gene324 284-310 gene324 denotes adenomatous polyposis coli
12174906-1#179#182#gene324 312-315 gene324 denotes APC
12174906-1#0#30#diseaseC0032580 133-163 diseaseC0032580 denotes Familial adenomatous polyposis
14#19#gene574357#87#diseaseC0032580 12174906-0#14#19#gene5743 12174906-0#57#87#diseaseC0032580 associated_with COX-2,familial adenomatous polyposis
151#177#gene3240#30#diseaseC0032580 12174906-1#151#177#gene324 12174906-1#0#30#diseaseC0032580 associated_with adenomatous polyposis coli,Familial adenomatous polyposis
179#182#gene3240#30#diseaseC0032580 12174906-1#179#182#gene324 12174906-1#0#30#diseaseC0032580 associated_with APC,Familial adenomatous polyposis

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T61 14-19 gene:5743 denotes COX-2
T62 57-87 disease:C0032580 denotes familial adenomatous polyposis
R1 T61 T62 associated_with COX-2,familial adenomatous polyposis

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 737-754 http://purl.obolibrary.org/obo/UBERON_0013067 denotes colorectal mucosa
PD-UBERON-AE-B_T2 748-754 http://purl.obolibrary.org/obo/UBERON_0000344 denotes mucosa
PD-UBERON-AE-B_T3 775-781 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 737-754 http://purl.obolibrary.org/obo/UBERON_0013067 denotes colorectal mucosa
PD-UBERON-AE-B_T2 748-754 http://purl.obolibrary.org/obo/UBERON_0000344 denotes mucosa
PD-UBERON-AE-B_T3 775-781 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue

DisGeNET

Id Subject Object Predicate Lexical cue
T0 14-19 gene:4513 denotes COX-2
T1 57-87 disease:C0032580 denotes familial adenomatous polyposis
T2 14-19 gene:5743 denotes COX-2
T3 45-53 disease:C0001430 denotes adenomas
T4 14-19 gene:4513 denotes COX-2
T5 45-53 disease:C0001430 denotes adenomas
T6 14-19 gene:5743 denotes COX-2
T7 57-87 disease:C0032580 denotes familial adenomatous polyposis
T8 312-315 gene:324 denotes APC
T9 226-243 disease:C0009402 denotes colorectal cancer
T10 312-315 gene:324 denotes APC
T11 165-168 disease:C0032580 denotes FAP
T12 312-315 gene:324 denotes APC
T13 133-163 disease:C0032580 denotes Familial adenomatous polyposis
T14 284-310 gene:324 denotes adenomatous polyposis coli
T15 133-163 disease:C0032580 denotes Familial adenomatous polyposis
T16 312-315 gene:324 denotes APC
T17 226-243 disease:C1527249 denotes colorectal cancer
T18 461-466 gene:5743 denotes COX-2
T19 528-531 disease:C0032580 denotes FAP
T20 895-900 gene:5743 denotes COX-2
T21 904-912 disease:C0001430 denotes adenomas
R1 T0 T1 associated_with COX-2,familial adenomatous polyposis
R2 T2 T3 associated_with COX-2,adenomas
R3 T4 T5 associated_with COX-2,adenomas
R4 T6 T7 associated_with COX-2,familial adenomatous polyposis
R5 T8 T9 associated_with APC,colorectal cancer
R6 T10 T11 associated_with APC,FAP
R7 T12 T13 associated_with APC,Familial adenomatous polyposis
R8 T14 T15 associated_with adenomatous polyposis coli,Familial adenomatous polyposis
R9 T16 T17 associated_with APC,colorectal cancer
R10 T18 T19 associated_with COX-2,FAP
R11 T20 T21 associated_with COX-2,adenomas