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PubMed:12167666 JSONTXT

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GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 290-292 Glycan_Motif denotes LN https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G04616ST|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00055MO
T3 414-422 Glycan_Motif denotes LacdiNAc https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G31736BK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00057MO
T5 426-429 Glycan_Motif denotes LDN https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G31736BK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00057MO
T7 482-484 Glycan_Motif denotes LN https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G04616ST|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00055MO
T9 551-554 Glycan_Motif denotes LDN https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G31736BK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00057MO
T11 781-784 Glycan_Motif denotes LDN https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G31736BK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00057MO
T13 1205-1208 Glycan_Motif denotes LDN https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G31736BK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00057MO
T15 1417-1420 Glycan_Motif denotes LDN https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G31736BK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00057MO
T17 1684-1687 Glycan_Motif denotes LDN https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G31736BK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00057MO

sentences

Id Subject Object Predicate Lexical cue
T1 0-150 Sentence denotes Molecular cloning and enzymatic characterization of a UDP-GalNAc:GlcNAc(beta)-R beta1,4-N-acetylgalactosaminyltransferase from Caenorhabditis elegans.
T2 151-294 Sentence denotes A common terminal structure in glycans from animal glycoproteins and glycolipids is the lactosamine sequence Gal(beta)4GlcNAc-R (LacNAc or LN).
T3 295-431 Sentence denotes An alternative sequence that occurs in vertebrate as well as in invertebrate glycoconjugates is GalNAc(beta)4GlcNAc-R (LacdiNAc or LDN).
T4 432-589 Sentence denotes Whereas genes encoding beta4GalTs responsible for LN synthesis have been reported, the beta4GalNAcT(s) responsible for LDN synthesis has not been identified.
T5 590-795 Sentence denotes Here we report the identification of a gene from Caenorhabditis elegans encoding a UDP-GalNAc:GlcNAc(beta)-R beta1,4-N-acetylgalactosaminyltransferase (Ce(beta)4GalNAcT) that synthesizes the LDN structure.
T6 796-932 Sentence denotes Ce(beta)4GalNAcT is a member of the beta4GalT family, and its cDNA is predicted to encode a 383-amino acid type 2 membrane glycoprotein.
T7 933-1200 Sentence denotes A soluble, epitope-tagged recombinant form of Ce(beta)4GalNAcT expressed in CHO-Lec8 cells was active using UDP-GalNAc, but not UDP-Gal, as a donor toward a variety of acceptor substrates containing terminal beta-linked GlcNAc in both N- and O-glycan type structures.
T8 1201-1319 Sentence denotes The LDN structure of the product was verified by co-chromatography with authentic standards and (1)H NMR spectroscopy.
T9 1320-1560 Sentence denotes Moreover, Chinese hamster ovary CHO-Lec8 and CHO-Lec2 cells expressing Ce(beta)4GalNAcT acquired LDN determinants on endogenous glycoprotein N-glycans, demonstrating that the enzyme is active in mammalian cells as an authentic beta4GalNAcT.
T10 1561-1715 Sentence denotes The identification and availability of this novel enzyme should enhance our understanding of the structure and function of LDN-containing glycoconjugates.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 290-292 https://glytoucan.org/Structures/Glycans/G04616ST denotes LN
T2 414-422 https://glytoucan.org/Structures/Glycans/G00057MO denotes LacdiNAc
T3 414-422 https://glytoucan.org/Structures/Glycans/G31736BK denotes LacdiNAc
T4 426-429 https://glytoucan.org/Structures/Glycans/G00057MO denotes LDN
T5 426-429 https://glytoucan.org/Structures/Glycans/G31736BK denotes LDN
T6 482-484 https://glytoucan.org/Structures/Glycans/G04616ST denotes LN
T7 551-554 https://glytoucan.org/Structures/Glycans/G00057MO denotes LDN
T8 551-554 https://glytoucan.org/Structures/Glycans/G31736BK denotes LDN
T9 781-784 https://glytoucan.org/Structures/Glycans/G00057MO denotes LDN
T10 781-784 https://glytoucan.org/Structures/Glycans/G31736BK denotes LDN
T11 1205-1208 https://glytoucan.org/Structures/Glycans/G00057MO denotes LDN
T12 1205-1208 https://glytoucan.org/Structures/Glycans/G31736BK denotes LDN
T13 1417-1420 https://glytoucan.org/Structures/Glycans/G00057MO denotes LDN
T14 1417-1420 https://glytoucan.org/Structures/Glycans/G31736BK denotes LDN
T15 1684-1687 https://glytoucan.org/Structures/Glycans/G00057MO denotes LDN
T16 1684-1687 https://glytoucan.org/Structures/Glycans/G31736BK denotes LDN

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 334-344 http://purl.obolibrary.org/obo/MAT_0000373 denotes vertebrate
T2 359-371 http://purl.obolibrary.org/obo/MAT_0000374 denotes invertebrate

NGLY1-deficiency

Id Subject Object Predicate Lexical cue
PD-NGLY1-deficiency-B_T1 1153-1159 chem:24139 denotes GlcNAc

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 280-286 Glycan denotes LacNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G66213AR
T2 391-397 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T3 426-429 Glycan denotes LDN https://api.glycosmos.org/wurcs2image/latest/png/binary/G31736BK
T4 551-554 Glycan denotes LDN https://api.glycosmos.org/wurcs2image/latest/png/binary/G31736BK
T5 781-784 Glycan denotes LDN https://api.glycosmos.org/wurcs2image/latest/png/binary/G31736BK
T6 1045-1051 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T7 1205-1208 Glycan denotes LDN https://api.glycosmos.org/wurcs2image/latest/png/binary/G31736BK
T8 1417-1420 Glycan denotes LDN https://api.glycosmos.org/wurcs2image/latest/png/binary/G31736BK
T9 1684-1687 Glycan denotes LDN https://api.glycosmos.org/wurcs2image/latest/png/binary/G31736BK
T10 58-64 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T15 677-683 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 334-344 Body_part denotes vertebrate http://purl.obolibrary.org/obo/MAT_0000373
T2 359-371 Body_part denotes invertebrate http://purl.obolibrary.org/obo/MAT_0000374

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 280-286 Glycan denotes LacNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G66213AR
T2 391-397 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T3 426-429 Glycan denotes LDN https://api.glycosmos.org/wurcs2image/latest/png/binary/G31736BK
T4 551-554 Glycan denotes LDN https://api.glycosmos.org/wurcs2image/latest/png/binary/G31736BK
T5 781-784 Glycan denotes LDN https://api.glycosmos.org/wurcs2image/latest/png/binary/G31736BK
T6 1045-1051 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T7 1205-1208 Glycan denotes LDN https://api.glycosmos.org/wurcs2image/latest/png/binary/G31736BK
T8 1417-1420 Glycan denotes LDN https://api.glycosmos.org/wurcs2image/latest/png/binary/G31736BK
T9 1684-1687 Glycan denotes LDN https://api.glycosmos.org/wurcs2image/latest/png/binary/G31736BK

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 910-918 Body_part denotes membrane http://purl.obolibrary.org/obo/UBERON_0000094
T2 1346-1351 Body_part denotes ovary http://purl.obolibrary.org/obo/UBERON_0000992

GlyCosmos15-Taxon

Id Subject Object Predicate Lexical cue db_id
T1 127-149 Organism denotes Caenorhabditis elegans 6239
T2 639-661 Organism denotes Caenorhabditis elegans 6239
T3 1330-1345 Organism denotes Chinese hamster 10029
T4 1515-1524 Organism denotes mammalian 40674

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-150 Sentence denotes Molecular cloning and enzymatic characterization of a UDP-GalNAc:GlcNAc(beta)-R beta1,4-N-acetylgalactosaminyltransferase from Caenorhabditis elegans.
T2 151-294 Sentence denotes A common terminal structure in glycans from animal glycoproteins and glycolipids is the lactosamine sequence Gal(beta)4GlcNAc-R (LacNAc or LN).
T3 295-431 Sentence denotes An alternative sequence that occurs in vertebrate as well as in invertebrate glycoconjugates is GalNAc(beta)4GlcNAc-R (LacdiNAc or LDN).
T4 432-589 Sentence denotes Whereas genes encoding beta4GalTs responsible for LN synthesis have been reported, the beta4GalNAcT(s) responsible for LDN synthesis has not been identified.
T5 590-795 Sentence denotes Here we report the identification of a gene from Caenorhabditis elegans encoding a UDP-GalNAc:GlcNAc(beta)-R beta1,4-N-acetylgalactosaminyltransferase (Ce(beta)4GalNAcT) that synthesizes the LDN structure.
T6 796-932 Sentence denotes Ce(beta)4GalNAcT is a member of the beta4GalT family, and its cDNA is predicted to encode a 383-amino acid type 2 membrane glycoprotein.
T7 933-1200 Sentence denotes A soluble, epitope-tagged recombinant form of Ce(beta)4GalNAcT expressed in CHO-Lec8 cells was active using UDP-GalNAc, but not UDP-Gal, as a donor toward a variety of acceptor substrates containing terminal beta-linked GlcNAc in both N- and O-glycan type structures.
T8 1201-1319 Sentence denotes The LDN structure of the product was verified by co-chromatography with authentic standards and (1)H NMR spectroscopy.
T9 1320-1560 Sentence denotes Moreover, Chinese hamster ovary CHO-Lec8 and CHO-Lec2 cells expressing Ce(beta)4GalNAcT acquired LDN determinants on endogenous glycoprotein N-glycans, demonstrating that the enzyme is active in mammalian cells as an authentic beta4GalNAcT.
T10 1561-1715 Sentence denotes The identification and availability of this novel enzyme should enhance our understanding of the structure and function of LDN-containing glycoconjugates.

GlyCosmos15-FMA

Id Subject Object Predicate Lexical cue db_id
T1 1346-1351 Body_part denotes ovary FMA:7209

GlyCosmos15-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 334-344 Body_part denotes vertebrate http://purl.obolibrary.org/obo/MAT_0000373
T2 359-371 Body_part denotes invertebrate http://purl.obolibrary.org/obo/MAT_0000374

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 127-149 OrganismTaxon denotes Caenorhabditis elegans 6239
T2 639-661 OrganismTaxon denotes Caenorhabditis elegans 6239
T3 1330-1345 OrganismTaxon denotes Chinese hamster 10029

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 910-918 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158
T4 1346-1351 Body_part denotes ovary http://purl.obolibrary.org/obo/UBERON_0000992