PubMed:12167666
Annnotations
GlyCosmos6-Glycan-Motif-Image
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 290-292 | Glycan_Motif | denotes | LN | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G04616ST|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00055MO |
| T3 | 414-422 | Glycan_Motif | denotes | LacdiNAc | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G31736BK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00057MO |
| T5 | 426-429 | Glycan_Motif | denotes | LDN | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G31736BK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00057MO |
| T7 | 482-484 | Glycan_Motif | denotes | LN | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G04616ST|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00055MO |
| T9 | 551-554 | Glycan_Motif | denotes | LDN | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G31736BK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00057MO |
| T11 | 781-784 | Glycan_Motif | denotes | LDN | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G31736BK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00057MO |
| T13 | 1205-1208 | Glycan_Motif | denotes | LDN | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G31736BK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00057MO |
| T15 | 1417-1420 | Glycan_Motif | denotes | LDN | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G31736BK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00057MO |
| T17 | 1684-1687 | Glycan_Motif | denotes | LDN | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G31736BK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00057MO |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-150 | Sentence | denotes | Molecular cloning and enzymatic characterization of a UDP-GalNAc:GlcNAc(beta)-R beta1,4-N-acetylgalactosaminyltransferase from Caenorhabditis elegans. |
| T2 | 151-294 | Sentence | denotes | A common terminal structure in glycans from animal glycoproteins and glycolipids is the lactosamine sequence Gal(beta)4GlcNAc-R (LacNAc or LN). |
| T3 | 295-431 | Sentence | denotes | An alternative sequence that occurs in vertebrate as well as in invertebrate glycoconjugates is GalNAc(beta)4GlcNAc-R (LacdiNAc or LDN). |
| T4 | 432-589 | Sentence | denotes | Whereas genes encoding beta4GalTs responsible for LN synthesis have been reported, the beta4GalNAcT(s) responsible for LDN synthesis has not been identified. |
| T5 | 590-795 | Sentence | denotes | Here we report the identification of a gene from Caenorhabditis elegans encoding a UDP-GalNAc:GlcNAc(beta)-R beta1,4-N-acetylgalactosaminyltransferase (Ce(beta)4GalNAcT) that synthesizes the LDN structure. |
| T6 | 796-932 | Sentence | denotes | Ce(beta)4GalNAcT is a member of the beta4GalT family, and its cDNA is predicted to encode a 383-amino acid type 2 membrane glycoprotein. |
| T7 | 933-1200 | Sentence | denotes | A soluble, epitope-tagged recombinant form of Ce(beta)4GalNAcT expressed in CHO-Lec8 cells was active using UDP-GalNAc, but not UDP-Gal, as a donor toward a variety of acceptor substrates containing terminal beta-linked GlcNAc in both N- and O-glycan type structures. |
| T8 | 1201-1319 | Sentence | denotes | The LDN structure of the product was verified by co-chromatography with authentic standards and (1)H NMR spectroscopy. |
| T9 | 1320-1560 | Sentence | denotes | Moreover, Chinese hamster ovary CHO-Lec8 and CHO-Lec2 cells expressing Ce(beta)4GalNAcT acquired LDN determinants on endogenous glycoprotein N-glycans, demonstrating that the enzyme is active in mammalian cells as an authentic beta4GalNAcT. |
| T10 | 1561-1715 | Sentence | denotes | The identification and availability of this novel enzyme should enhance our understanding of the structure and function of LDN-containing glycoconjugates. |
GlyCosmos6-Glycan-Motif-Structure
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 290-292 | https://glytoucan.org/Structures/Glycans/G04616ST | denotes | LN |
| T2 | 414-422 | https://glytoucan.org/Structures/Glycans/G00057MO | denotes | LacdiNAc |
| T3 | 414-422 | https://glytoucan.org/Structures/Glycans/G31736BK | denotes | LacdiNAc |
| T4 | 426-429 | https://glytoucan.org/Structures/Glycans/G00057MO | denotes | LDN |
| T5 | 426-429 | https://glytoucan.org/Structures/Glycans/G31736BK | denotes | LDN |
| T6 | 482-484 | https://glytoucan.org/Structures/Glycans/G04616ST | denotes | LN |
| T7 | 551-554 | https://glytoucan.org/Structures/Glycans/G00057MO | denotes | LDN |
| T8 | 551-554 | https://glytoucan.org/Structures/Glycans/G31736BK | denotes | LDN |
| T9 | 781-784 | https://glytoucan.org/Structures/Glycans/G00057MO | denotes | LDN |
| T10 | 781-784 | https://glytoucan.org/Structures/Glycans/G31736BK | denotes | LDN |
| T11 | 1205-1208 | https://glytoucan.org/Structures/Glycans/G00057MO | denotes | LDN |
| T12 | 1205-1208 | https://glytoucan.org/Structures/Glycans/G31736BK | denotes | LDN |
| T13 | 1417-1420 | https://glytoucan.org/Structures/Glycans/G00057MO | denotes | LDN |
| T14 | 1417-1420 | https://glytoucan.org/Structures/Glycans/G31736BK | denotes | LDN |
| T15 | 1684-1687 | https://glytoucan.org/Structures/Glycans/G00057MO | denotes | LDN |
| T16 | 1684-1687 | https://glytoucan.org/Structures/Glycans/G31736BK | denotes | LDN |
Glycosmos6-MAT
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 334-344 | http://purl.obolibrary.org/obo/MAT_0000373 | denotes | vertebrate |
| T2 | 359-371 | http://purl.obolibrary.org/obo/MAT_0000374 | denotes | invertebrate |
NGLY1-deficiency
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| PD-NGLY1-deficiency-B_T1 | 1153-1159 | chem:24139 | denotes | GlcNAc |
Anatomy-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 334-344 | Body_part | denotes | vertebrate | http://purl.obolibrary.org/obo/MAT_0000373 |
| T2 | 359-371 | Body_part | denotes | invertebrate | http://purl.obolibrary.org/obo/MAT_0000374 |
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 280-286 | Glycan | denotes | LacNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G66213AR |
| T2 | 391-397 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T3 | 426-429 | Glycan | denotes | LDN | https://api.glycosmos.org/wurcs2image/latest/png/binary/G31736BK |
| T4 | 551-554 | Glycan | denotes | LDN | https://api.glycosmos.org/wurcs2image/latest/png/binary/G31736BK |
| T5 | 781-784 | Glycan | denotes | LDN | https://api.glycosmos.org/wurcs2image/latest/png/binary/G31736BK |
| T6 | 1045-1051 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T7 | 1205-1208 | Glycan | denotes | LDN | https://api.glycosmos.org/wurcs2image/latest/png/binary/G31736BK |
| T8 | 1417-1420 | Glycan | denotes | LDN | https://api.glycosmos.org/wurcs2image/latest/png/binary/G31736BK |
| T9 | 1684-1687 | Glycan | denotes | LDN | https://api.glycosmos.org/wurcs2image/latest/png/binary/G31736BK |
GlyCosmos15-NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 127-149 | OrganismTaxon | denotes | Caenorhabditis elegans | 6239 |
| T2 | 639-661 | OrganismTaxon | denotes | Caenorhabditis elegans | 6239 |
| T3 | 1330-1345 | OrganismTaxon | denotes | Chinese hamster | 10029 |
GlyCosmos15-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 910-918 | Body_part | denotes | membrane | http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158 |
| T4 | 1346-1351 | Body_part | denotes | ovary | http://purl.obolibrary.org/obo/UBERON_0000992 |
GlyCosmos15-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 334-344 | Body_part | denotes | vertebrate | http://purl.obolibrary.org/obo/MAT_0000373 |
| T2 | 359-371 | Body_part | denotes | invertebrate | http://purl.obolibrary.org/obo/MAT_0000374 |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-150 | Sentence | denotes | Molecular cloning and enzymatic characterization of a UDP-GalNAc:GlcNAc(beta)-R beta1,4-N-acetylgalactosaminyltransferase from Caenorhabditis elegans. |
| T2 | 151-294 | Sentence | denotes | A common terminal structure in glycans from animal glycoproteins and glycolipids is the lactosamine sequence Gal(beta)4GlcNAc-R (LacNAc or LN). |
| T3 | 295-431 | Sentence | denotes | An alternative sequence that occurs in vertebrate as well as in invertebrate glycoconjugates is GalNAc(beta)4GlcNAc-R (LacdiNAc or LDN). |
| T4 | 432-589 | Sentence | denotes | Whereas genes encoding beta4GalTs responsible for LN synthesis have been reported, the beta4GalNAcT(s) responsible for LDN synthesis has not been identified. |
| T5 | 590-795 | Sentence | denotes | Here we report the identification of a gene from Caenorhabditis elegans encoding a UDP-GalNAc:GlcNAc(beta)-R beta1,4-N-acetylgalactosaminyltransferase (Ce(beta)4GalNAcT) that synthesizes the LDN structure. |
| T6 | 796-932 | Sentence | denotes | Ce(beta)4GalNAcT is a member of the beta4GalT family, and its cDNA is predicted to encode a 383-amino acid type 2 membrane glycoprotein. |
| T7 | 933-1200 | Sentence | denotes | A soluble, epitope-tagged recombinant form of Ce(beta)4GalNAcT expressed in CHO-Lec8 cells was active using UDP-GalNAc, but not UDP-Gal, as a donor toward a variety of acceptor substrates containing terminal beta-linked GlcNAc in both N- and O-glycan type structures. |
| T8 | 1201-1319 | Sentence | denotes | The LDN structure of the product was verified by co-chromatography with authentic standards and (1)H NMR spectroscopy. |
| T9 | 1320-1560 | Sentence | denotes | Moreover, Chinese hamster ovary CHO-Lec8 and CHO-Lec2 cells expressing Ce(beta)4GalNAcT acquired LDN determinants on endogenous glycoprotein N-glycans, demonstrating that the enzyme is active in mammalian cells as an authentic beta4GalNAcT. |
| T10 | 1561-1715 | Sentence | denotes | The identification and availability of this novel enzyme should enhance our understanding of the structure and function of LDN-containing glycoconjugates. |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-150 | Sentence | denotes | Molecular cloning and enzymatic characterization of a UDP-GalNAc:GlcNAc(beta)-R beta1,4-N-acetylgalactosaminyltransferase from Caenorhabditis elegans. |
| T2 | 151-294 | Sentence | denotes | A common terminal structure in glycans from animal glycoproteins and glycolipids is the lactosamine sequence Gal(beta)4GlcNAc-R (LacNAc or LN). |
| T3 | 295-431 | Sentence | denotes | An alternative sequence that occurs in vertebrate as well as in invertebrate glycoconjugates is GalNAc(beta)4GlcNAc-R (LacdiNAc or LDN). |
| T4 | 432-589 | Sentence | denotes | Whereas genes encoding beta4GalTs responsible for LN synthesis have been reported, the beta4GalNAcT(s) responsible for LDN synthesis has not been identified. |
| T5 | 590-795 | Sentence | denotes | Here we report the identification of a gene from Caenorhabditis elegans encoding a UDP-GalNAc:GlcNAc(beta)-R beta1,4-N-acetylgalactosaminyltransferase (Ce(beta)4GalNAcT) that synthesizes the LDN structure. |
| T6 | 796-932 | Sentence | denotes | Ce(beta)4GalNAcT is a member of the beta4GalT family, and its cDNA is predicted to encode a 383-amino acid type 2 membrane glycoprotein. |
| T7 | 933-1200 | Sentence | denotes | A soluble, epitope-tagged recombinant form of Ce(beta)4GalNAcT expressed in CHO-Lec8 cells was active using UDP-GalNAc, but not UDP-Gal, as a donor toward a variety of acceptor substrates containing terminal beta-linked GlcNAc in both N- and O-glycan type structures. |
| T8 | 1201-1319 | Sentence | denotes | The LDN structure of the product was verified by co-chromatography with authentic standards and (1)H NMR spectroscopy. |
| T9 | 1320-1560 | Sentence | denotes | Moreover, Chinese hamster ovary CHO-Lec8 and CHO-Lec2 cells expressing Ce(beta)4GalNAcT acquired LDN determinants on endogenous glycoprotein N-glycans, demonstrating that the enzyme is active in mammalian cells as an authentic beta4GalNAcT. |
| T10 | 1561-1715 | Sentence | denotes | The identification and availability of this novel enzyme should enhance our understanding of the structure and function of LDN-containing glycoconjugates. |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 280-286 | Glycan | denotes | LacNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G66213AR |
| T2 | 391-397 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T3 | 426-429 | Glycan | denotes | LDN | https://api.glycosmos.org/wurcs2image/latest/png/binary/G31736BK |
| T4 | 551-554 | Glycan | denotes | LDN | https://api.glycosmos.org/wurcs2image/latest/png/binary/G31736BK |
| T5 | 781-784 | Glycan | denotes | LDN | https://api.glycosmos.org/wurcs2image/latest/png/binary/G31736BK |
| T6 | 1045-1051 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T7 | 1205-1208 | Glycan | denotes | LDN | https://api.glycosmos.org/wurcs2image/latest/png/binary/G31736BK |
| T8 | 1417-1420 | Glycan | denotes | LDN | https://api.glycosmos.org/wurcs2image/latest/png/binary/G31736BK |
| T9 | 1684-1687 | Glycan | denotes | LDN | https://api.glycosmos.org/wurcs2image/latest/png/binary/G31736BK |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 127-149 | OrganismTaxon | denotes | Caenorhabditis elegans | 6239 |
| T2 | 639-661 | OrganismTaxon | denotes | Caenorhabditis elegans | 6239 |
| T3 | 1330-1345 | OrganismTaxon | denotes | Chinese hamster | 10029 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 910-918 | Body_part | denotes | membrane | http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158 |
| T4 | 1346-1351 | Body_part | denotes | ovary | http://purl.obolibrary.org/obo/UBERON_0000992 |