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PubMed:12138109 JSONTXT

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CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 88-99 Cell denotes enterocytes http://purl.obolibrary.org/obo/CL:0000584
T2 104-131 Cell denotes intraepithelial lymphocytes http://purl.obolibrary.org/obo/CL:0000793|http://purl.obolibrary.org/obo/CL:0000796|http://purl.obolibrary.org/obo/CL:0000797|http://purl.obolibrary.org/obo/CL:0000801|http://purl.obolibrary.org/obo/CL:0000802|http://purl.obolibrary.org/obo/CL:0000803|http://purl.obolibrary.org/obo/CL:0002496
T9 211-238 Cell denotes Intraepithelial lymphocytes http://purl.obolibrary.org/obo/CL:0000793|http://purl.obolibrary.org/obo/CL:0000796|http://purl.obolibrary.org/obo/CL:0000797|http://purl.obolibrary.org/obo/CL:0000801|http://purl.obolibrary.org/obo/CL:0000802|http://purl.obolibrary.org/obo/CL:0000803|http://purl.obolibrary.org/obo/CL:0002496
T16 240-244 Cell denotes IELs http://purl.obolibrary.org/obo/CL:0000793
T17 512-527 Cell denotes epithelial cell http://purl.obolibrary.org/obo/CL:0000066
T18 537-548 Cell denotes enterocytes http://purl.obolibrary.org/obo/CL:0000584
T19 575-586 Cell denotes enterocytic http://purl.obolibrary.org/obo/CL:0000584
T20 731-742 Cell denotes enterocytes http://purl.obolibrary.org/obo/CL:0000584
T21 1031-1042 Cell denotes enterocytes http://purl.obolibrary.org/obo/CL:0000584
T22 1114-1130 Cell denotes alphabeta T cell http://purl.obolibrary.org/obo/CL:0000789
T23 1124-1130 Cell denotes T cell http://purl.obolibrary.org/obo/CL:0000084
T24 1193-1197 Cell denotes IELs http://purl.obolibrary.org/obo/CL:0000793
T25 1269-1273 Cell denotes IELs http://purl.obolibrary.org/obo/CL:0000793
T26 1476-1480 Cell denotes IELs http://purl.obolibrary.org/obo/CL:0000793
T27 1595-1606 Cell denotes enterocytic http://purl.obolibrary.org/obo/CL:0000584
T28 1817-1840 Cell denotes hematopoietic stem cell http://purl.obolibrary.org/obo/CL:0000037
T29 1831-1840 Cell denotes stem cell http://purl.obolibrary.org/obo/CL:0000034
T30 1859-1867 Cell denotes neuronal http://purl.obolibrary.org/obo/CL:0000540
T31 2203-2207 Cell denotes IELs http://purl.obolibrary.org/obo/CL:0000793
T32 2251-2255 Cell denotes IELs http://purl.obolibrary.org/obo/CL:0000793

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 610-619 Glycan_Motif denotes T antigen https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00031MO

Glycosmos6-GlycoEpitope

Id Subject Object Predicate Lexical cue
T1 610-619 http://www.glycoepitope.jp/epitopes/EP0020 denotes T antigen

sentences

Id Subject Object Predicate Lexical cue
T1 0-132 Sentence denotes A gnotobiotic transgenic mouse model for studying interactions between small intestinal enterocytes and intraepithelial lymphocytes.
T2 133-210 Sentence denotes The mouse intestinal epithelium undergoes continuous renewal throughout life.
T3 211-364 Sentence denotes Intraepithelial lymphocytes (IELs) represent a significant fraction of this epithelium and play an important role in intestinal mucosal barrier function.
T4 365-598 Sentence denotes We have generated a germ-free transgenic mouse model to examine the effects of a genetically engineered proliferative abnormality in the principal epithelial cell lineage (enterocytes) on IEL census and on IEL-enterocytic cross-talk.
T5 599-833 Sentence denotes SV40 large T antigen (TAg(Wt)) or a mutant derivative (TAg(K107/8)) that does not bind pRB was expressed in small intestinal villus enterocytes under the control of elements from the intestinal fatty acid binding protein gene (Fabpi).
T6 834-1274 Sentence denotes Quantitative immunohistochemical and flow cytometric analyses of conventionally raised and germ-free FVB/N Fabpi-TAg(Wt), Fabpi-TAg(K107/8), and nontransgenic mice disclosed that forced reentry of enterocytes into the cell cycle is accompanied by an influx of thymically educated alphabeta T cell receptor (TCR)(+) CD4(+) and alphabeta TCR(+) CD8alphabeta(+) IELs and a decrease in intestinally derived gammadelta TCR(+) CD8alphaalpha IELs.
T7 1275-1693 Sentence denotes Real time quantitative reverse transcriptase-PCR studies of jejunal villus epithelium recovered from germ-free transgenic and normal mice by laser capture microdissection and gammadelta TCR(+) jejunal IELs purified by flow cytometry disclosed that the proliferative abnormality is accompanied by decreased expression of enterocytic interleukin-7 as well as IEL interleukin-7Ralpha and transforming growth factor beta3.
T8 1694-1906 Sentence denotes The analysis also revealed that normal villus epithelium expresses Fms-like tyrosine kinase 3 (Flt3), a known regulator of hematopoietic stem cell proliferation and neuronal cell survival, and its ligand (Flt3L).
T9 1907-2055 Sentence denotes Epithelial expression of this receptor and its ligand is reduced by the proliferative abnormality, whereas IEL expression of Flt3L remains constant.
T10 2056-2292 Sentence denotes Together, these findings demonstrate that changes in the proliferative status of the intestinal epithelium affects maturation of gammadelta TCR(+) IELs and produces an influx of alphabeta TCR(+) IELs even in the absence of a microflora.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 610-619 https://glytoucan.org/Structures/Glycans/G00031MO denotes T antigen

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 71-87 http://purl.obolibrary.org/obo/MAT_0000047 denotes small intestinal
T2 143-153 http://purl.obolibrary.org/obo/MAT_0000043 denotes intestinal
T3 328-338 http://purl.obolibrary.org/obo/MAT_0000043 denotes intestinal
T4 707-723 http://purl.obolibrary.org/obo/MAT_0000047 denotes small intestinal
T5 782-792 http://purl.obolibrary.org/obo/MAT_0000043 denotes intestinal
T6 1216-1228 http://purl.obolibrary.org/obo/MAT_0000043 denotes intestinally
T7 1831-1840 http://purl.obolibrary.org/obo/MAT_0000185 denotes stem cell
T8 1831-1835 http://purl.obolibrary.org/obo/MAT_0000239 denotes stem
T9 2141-2151 http://purl.obolibrary.org/obo/MAT_0000043 denotes intestinal

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 553-556 Disease denotes IEL http://purl.obolibrary.org/obo/MONDO_0015998
T2 571-574 Disease denotes IEL http://purl.obolibrary.org/obo/MONDO_0015998
T3 1632-1635 Disease denotes IEL http://purl.obolibrary.org/obo/MONDO_0015998
T4 2014-2017 Disease denotes IEL http://purl.obolibrary.org/obo/MONDO_0015998

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 610-619 Glycan denotes T antigen https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO

GlyCosmos-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 610-619 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes T antigen http://www.glycoepitope.jp/epitopes/EP0020

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 553-556 Disease denotes IEL http://purl.obolibrary.org/obo/MONDO_0015998
T2 571-574 Disease denotes IEL http://purl.obolibrary.org/obo/MONDO_0015998
T3 1632-1635 Disease denotes IEL http://purl.obolibrary.org/obo/MONDO_0015998
T4 2014-2017 Disease denotes IEL http://purl.obolibrary.org/obo/MONDO_0015998

GlyCosmos15-NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 25-30 OrganismTaxon denotes mouse 10088|10090
T3 137-142 OrganismTaxon denotes mouse 10088|10090
T5 406-411 OrganismTaxon denotes mouse 10088|10090
T7 993-997 OrganismTaxon denotes mice 10088
T8 1408-1412 OrganismTaxon denotes mice 10088

GlyCosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 88-99 Cell denotes enterocytes http://purl.obolibrary.org/obo/CL:0000584
T2 104-131 Cell denotes intraepithelial lymphocytes http://purl.obolibrary.org/obo/CL:0000793|http://purl.obolibrary.org/obo/CL:0000796|http://purl.obolibrary.org/obo/CL:0000797|http://purl.obolibrary.org/obo/CL:0000801|http://purl.obolibrary.org/obo/CL:0000802|http://purl.obolibrary.org/obo/CL:0000803|http://purl.obolibrary.org/obo/CL:0002496
T9 211-238 Cell denotes Intraepithelial lymphocytes http://purl.obolibrary.org/obo/CL:0000793|http://purl.obolibrary.org/obo/CL:0000796|http://purl.obolibrary.org/obo/CL:0000797|http://purl.obolibrary.org/obo/CL:0000801|http://purl.obolibrary.org/obo/CL:0000802|http://purl.obolibrary.org/obo/CL:0000803|http://purl.obolibrary.org/obo/CL:0002496
T16 240-244 Cell denotes IELs http://purl.obolibrary.org/obo/CL:0000793
T17 512-527 Cell denotes epithelial cell http://purl.obolibrary.org/obo/CL:0000066
T18 537-548 Cell denotes enterocytes http://purl.obolibrary.org/obo/CL:0000584
T19 575-586 Cell denotes enterocytic http://purl.obolibrary.org/obo/CL:0000584
T20 731-742 Cell denotes enterocytes http://purl.obolibrary.org/obo/CL:0000584
T21 1031-1042 Cell denotes enterocytes http://purl.obolibrary.org/obo/CL:0000584
T22 1114-1130 Cell denotes alphabeta T cell http://purl.obolibrary.org/obo/CL:0000789
T23 1124-1130 Cell denotes T cell http://purl.obolibrary.org/obo/CL:0000084
T24 1193-1197 Cell denotes IELs http://purl.obolibrary.org/obo/CL:0000793
T25 1269-1273 Cell denotes IELs http://purl.obolibrary.org/obo/CL:0000793
T26 1476-1480 Cell denotes IELs http://purl.obolibrary.org/obo/CL:0000793
T27 1595-1606 Cell denotes enterocytic http://purl.obolibrary.org/obo/CL:0000584
T28 1817-1840 Cell denotes hematopoietic stem cell http://purl.obolibrary.org/obo/CL:0000037
T29 1831-1840 Cell denotes stem cell http://purl.obolibrary.org/obo/CL:0000034
T30 1859-1867 Cell denotes neuronal http://purl.obolibrary.org/obo/CL:0000540
T31 2203-2207 Cell denotes IELs http://purl.obolibrary.org/obo/CL:0000793
T32 2251-2255 Cell denotes IELs http://purl.obolibrary.org/obo/CL:0000793

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 71-87 Body_part denotes small intestinal http://purl.obolibrary.org/obo/UBERON_0002108
T2 120-131 Body_part denotes lymphocytes http://purl.obolibrary.org/obo/CL_0000542
T3 143-164 Body_part denotes intestinal epithelium http://purl.obolibrary.org/obo/UBERON_0001277
T4 227-238 Body_part denotes lymphocytes http://purl.obolibrary.org/obo/CL_0000542
T5 287-297 Body_part denotes epithelium http://purl.obolibrary.org/obo/UBERON_0000483
T6 512-527 Body_part denotes epithelial cell http://purl.obolibrary.org/obo/CL_0000066
T7 713-730 Body_part denotes intestinal villus http://purl.obolibrary.org/obo/UBERON_0001213
T8 1052-1062 Body_part denotes cell cycle http://purl.obolibrary.org/obo/UBERON_2000098
T9 1124-1130 Body_part denotes T cell http://purl.obolibrary.org/obo/CL_0000084
T10 1343-1360 Body_part denotes villus epithelium http://purl.obolibrary.org/obo/UBERON_0013636
T11 1733-1750 Body_part denotes villus epithelium http://purl.obolibrary.org/obo/UBERON_0013636
T12 1817-1840 Body_part denotes hematopoietic stem cell http://purl.obolibrary.org/obo/CL_0000037
T13 2141-2162 Body_part denotes intestinal epithelium http://purl.obolibrary.org/obo/UBERON_0001277

GlyCosmos15-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 71-87 Body_part denotes small intestinal http://purl.obolibrary.org/obo/MAT_0000047
T2 143-153 Body_part denotes intestinal http://purl.obolibrary.org/obo/MAT_0000043
T3 328-338 Body_part denotes intestinal http://purl.obolibrary.org/obo/MAT_0000043
T4 707-723 Body_part denotes small intestinal http://purl.obolibrary.org/obo/MAT_0000047
T5 782-792 Body_part denotes intestinal http://purl.obolibrary.org/obo/MAT_0000043
T6 1216-1228 Body_part denotes intestinally http://purl.obolibrary.org/obo/MAT_0000043
T7 1831-1840 Body_part denotes stem cell http://purl.obolibrary.org/obo/MAT_0000185
T8 2141-2151 Body_part denotes intestinal http://purl.obolibrary.org/obo/MAT_0000043

sentences

Id Subject Object Predicate Lexical cue
T1 0-132 Sentence denotes A gnotobiotic transgenic mouse model for studying interactions between small intestinal enterocytes and intraepithelial lymphocytes.
T2 133-210 Sentence denotes The mouse intestinal epithelium undergoes continuous renewal throughout life.
T3 211-364 Sentence denotes Intraepithelial lymphocytes (IELs) represent a significant fraction of this epithelium and play an important role in intestinal mucosal barrier function.
T4 365-598 Sentence denotes We have generated a germ-free transgenic mouse model to examine the effects of a genetically engineered proliferative abnormality in the principal epithelial cell lineage (enterocytes) on IEL census and on IEL-enterocytic cross-talk.
T5 599-833 Sentence denotes SV40 large T antigen (TAg(Wt)) or a mutant derivative (TAg(K107/8)) that does not bind pRB was expressed in small intestinal villus enterocytes under the control of elements from the intestinal fatty acid binding protein gene (Fabpi).
T6 834-1274 Sentence denotes Quantitative immunohistochemical and flow cytometric analyses of conventionally raised and germ-free FVB/N Fabpi-TAg(Wt), Fabpi-TAg(K107/8), and nontransgenic mice disclosed that forced reentry of enterocytes into the cell cycle is accompanied by an influx of thymically educated alphabeta T cell receptor (TCR)(+) CD4(+) and alphabeta TCR(+) CD8alphabeta(+) IELs and a decrease in intestinally derived gammadelta TCR(+) CD8alphaalpha IELs.
T7 1275-1693 Sentence denotes Real time quantitative reverse transcriptase-PCR studies of jejunal villus epithelium recovered from germ-free transgenic and normal mice by laser capture microdissection and gammadelta TCR(+) jejunal IELs purified by flow cytometry disclosed that the proliferative abnormality is accompanied by decreased expression of enterocytic interleukin-7 as well as IEL interleukin-7Ralpha and transforming growth factor beta3.
T8 1694-1906 Sentence denotes The analysis also revealed that normal villus epithelium expresses Fms-like tyrosine kinase 3 (Flt3), a known regulator of hematopoietic stem cell proliferation and neuronal cell survival, and its ligand (Flt3L).
T9 1907-2055 Sentence denotes Epithelial expression of this receptor and its ligand is reduced by the proliferative abnormality, whereas IEL expression of Flt3L remains constant.
T10 2056-2292 Sentence denotes Together, these findings demonstrate that changes in the proliferative status of the intestinal epithelium affects maturation of gammadelta TCR(+) IELs and produces an influx of alphabeta TCR(+) IELs even in the absence of a microflora.

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-132 Sentence denotes A gnotobiotic transgenic mouse model for studying interactions between small intestinal enterocytes and intraepithelial lymphocytes.
T2 133-210 Sentence denotes The mouse intestinal epithelium undergoes continuous renewal throughout life.
T3 211-364 Sentence denotes Intraepithelial lymphocytes (IELs) represent a significant fraction of this epithelium and play an important role in intestinal mucosal barrier function.
T4 365-598 Sentence denotes We have generated a germ-free transgenic mouse model to examine the effects of a genetically engineered proliferative abnormality in the principal epithelial cell lineage (enterocytes) on IEL census and on IEL-enterocytic cross-talk.
T5 599-833 Sentence denotes SV40 large T antigen (TAg(Wt)) or a mutant derivative (TAg(K107/8)) that does not bind pRB was expressed in small intestinal villus enterocytes under the control of elements from the intestinal fatty acid binding protein gene (Fabpi).
T6 834-1274 Sentence denotes Quantitative immunohistochemical and flow cytometric analyses of conventionally raised and germ-free FVB/N Fabpi-TAg(Wt), Fabpi-TAg(K107/8), and nontransgenic mice disclosed that forced reentry of enterocytes into the cell cycle is accompanied by an influx of thymically educated alphabeta T cell receptor (TCR)(+) CD4(+) and alphabeta TCR(+) CD8alphabeta(+) IELs and a decrease in intestinally derived gammadelta TCR(+) CD8alphaalpha IELs.
T7 1275-1693 Sentence denotes Real time quantitative reverse transcriptase-PCR studies of jejunal villus epithelium recovered from germ-free transgenic and normal mice by laser capture microdissection and gammadelta TCR(+) jejunal IELs purified by flow cytometry disclosed that the proliferative abnormality is accompanied by decreased expression of enterocytic interleukin-7 as well as IEL interleukin-7Ralpha and transforming growth factor beta3.
T8 1694-1906 Sentence denotes The analysis also revealed that normal villus epithelium expresses Fms-like tyrosine kinase 3 (Flt3), a known regulator of hematopoietic stem cell proliferation and neuronal cell survival, and its ligand (Flt3L).
T9 1907-2055 Sentence denotes Epithelial expression of this receptor and its ligand is reduced by the proliferative abnormality, whereas IEL expression of Flt3L remains constant.
T10 2056-2292 Sentence denotes Together, these findings demonstrate that changes in the proliferative status of the intestinal epithelium affects maturation of gammadelta TCR(+) IELs and produces an influx of alphabeta TCR(+) IELs even in the absence of a microflora.

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 610-619 Glycan denotes T antigen https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO

GlyCosmos15-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 610-619 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes T antigen http://www.glycoepitope.jp/epitopes/EP0020

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 25-30 OrganismTaxon denotes mouse 10088|10090
T3 137-142 OrganismTaxon denotes mouse 10088|10090
T5 406-411 OrganismTaxon denotes mouse 10088|10090
T7 993-997 OrganismTaxon denotes mice 10088
T8 1408-1412 OrganismTaxon denotes mice 10088

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 71-87 Body_part denotes small intestinal http://purl.obolibrary.org/obo/UBERON_0002108
T2 120-131 Body_part denotes lymphocytes http://purl.obolibrary.org/obo/CL_0000542
T3 143-164 Body_part denotes intestinal epithelium http://purl.obolibrary.org/obo/UBERON_0001277
T4 227-238 Body_part denotes lymphocytes http://purl.obolibrary.org/obo/CL_0000542
T5 287-297 Body_part denotes epithelium http://purl.obolibrary.org/obo/UBERON_0000483
T6 512-527 Body_part denotes epithelial cell http://purl.obolibrary.org/obo/CL_0000066
T7 713-730 Body_part denotes intestinal villus http://purl.obolibrary.org/obo/UBERON_0001213
T8 1052-1062 Body_part denotes cell cycle http://purl.obolibrary.org/obo/UBERON_2000098
T9 1124-1130 Body_part denotes T cell http://purl.obolibrary.org/obo/CL_0000084
T10 1343-1360 Body_part denotes villus epithelium http://purl.obolibrary.org/obo/UBERON_0013636
T11 1733-1750 Body_part denotes villus epithelium http://purl.obolibrary.org/obo/UBERON_0013636
T12 1817-1840 Body_part denotes hematopoietic stem cell http://purl.obolibrary.org/obo/CL_0000037
T13 2141-2162 Body_part denotes intestinal epithelium http://purl.obolibrary.org/obo/UBERON_0001277

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 71-87 Body_part denotes small intestinal http://purl.obolibrary.org/obo/MAT_0000047
T2 143-153 Body_part denotes intestinal http://purl.obolibrary.org/obo/MAT_0000043
T3 328-338 Body_part denotes intestinal http://purl.obolibrary.org/obo/MAT_0000043
T4 707-723 Body_part denotes small intestinal http://purl.obolibrary.org/obo/MAT_0000047
T5 782-792 Body_part denotes intestinal http://purl.obolibrary.org/obo/MAT_0000043
T6 1216-1228 Body_part denotes intestinally http://purl.obolibrary.org/obo/MAT_0000043
T7 1831-1840 Body_part denotes stem cell http://purl.obolibrary.org/obo/MAT_0000185
T8 2141-2151 Body_part denotes intestinal http://purl.obolibrary.org/obo/MAT_0000043