> top > docs > PubMed:12131367 > annotations

PubMed:12131367 JSONTXT

Annnotations TAB JSON ListView MergeView

PubMed_Structured_Abstracts

Id Subject Object Predicate Lexical cue
T1 154-418 OBJECTIVE denotes We provide the necessary tools to study the biology of bone metastasis using renal cell carcinoma as a model. A relevant renal cell carcinoma cell line developed from a human bone metastasis is described and an experimental model in the nude mouse was established.
T2 442-833 METHODS denotes The novel cell line RBM1 was developed from bone metastasis from a patient with renal cell carcinoma. In vitro methods used to study the cell line included karyotype analysis, reverse-transcriptase polymerase chain reaction, ribonuclease protection assay and Western blot analysis. An intratibial injection model in the nude mouse resulted in bone lesions similar to those in human patients.
T3 843-1395 RESULTS denotes Chromosomal analysis of this cell line revealed characteristic cytogenetic abnormalities common in renal cell carcinoma. RBM1 cells expressed parathyroid hormone parathyroid hormone related peptide, interleukin-6 and macrophage colony-stimulating factor, which are cytokines involved in osteoclast activation and subsequent bone resorption. Western blot analysis revealed the presence of high levels of epidermal growth factor receptor and c-MET. Reproducible osteolytic lesions developed in the nude mouse after injecting 1 x 106 cells into the tibia.
T4 1409-1534 CONCLUSIONS denotes This cell line and animal model may allow further study of the biology and mechanism of renal cell carcinoma bone metastasis.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 231-251 HP_0005584 denotes renal cell carcinoma
T2 275-295 HP_0005584 denotes renal cell carcinoma

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
12131367-3#20#24#gene56267 462-466 gene56267 denotes RBM1
12131367-3#20#24#gene494115 462-466 gene494115 denotes RBM1
12131367-3#20#24#gene5940 462-466 gene5940 denotes RBM1
12131367-3#20#24#gene378949 462-466 gene378949 denotes RBM1
12131367-3#20#24#gene56267 462-466 gene56267 denotes RBM1
12131367-3#20#24#gene494115 462-466 gene494115 denotes RBM1
12131367-3#20#24#gene5940 462-466 gene5940 denotes RBM1
12131367-3#20#24#gene378949 462-466 gene378949 denotes RBM1
12131367-3#44#59#diseaseC0153690 486-501 diseaseC0153690 denotes bone metastasis
12131367-3#80#100#diseaseC0007134 522-542 diseaseC0007134 denotes renal cell carcinoma
20#24#gene5626744#59#diseaseC0153690 12131367-3#20#24#gene56267 12131367-3#44#59#diseaseC0153690 associated_with RBM1,bone metastasis
20#24#gene5626780#100#diseaseC0007134 12131367-3#20#24#gene56267 12131367-3#80#100#diseaseC0007134 associated_with RBM1,renal cell carcinoma
20#24#gene49411544#59#diseaseC0153690 12131367-3#20#24#gene494115 12131367-3#44#59#diseaseC0153690 associated_with RBM1,bone metastasis
20#24#gene49411580#100#diseaseC0007134 12131367-3#20#24#gene494115 12131367-3#80#100#diseaseC0007134 associated_with RBM1,renal cell carcinoma
20#24#gene594044#59#diseaseC0153690 12131367-3#20#24#gene5940 12131367-3#44#59#diseaseC0153690 associated_with RBM1,bone metastasis
20#24#gene594080#100#diseaseC0007134 12131367-3#20#24#gene5940 12131367-3#80#100#diseaseC0007134 associated_with RBM1,renal cell carcinoma
20#24#gene37894944#59#diseaseC0153690 12131367-3#20#24#gene378949 12131367-3#44#59#diseaseC0153690 associated_with RBM1,bone metastasis
20#24#gene37894980#100#diseaseC0007134 12131367-3#20#24#gene378949 12131367-3#80#100#diseaseC0007134 associated_with RBM1,renal cell carcinoma
20#24#gene5626744#59#diseaseC0153690 12131367-3#20#24#gene56267 12131367-3#44#59#diseaseC0153690 associated_with RBM1,bone metastasis
20#24#gene5626780#100#diseaseC0007134 12131367-3#20#24#gene56267 12131367-3#80#100#diseaseC0007134 associated_with RBM1,renal cell carcinoma
20#24#gene49411544#59#diseaseC0153690 12131367-3#20#24#gene494115 12131367-3#44#59#diseaseC0153690 associated_with RBM1,bone metastasis
20#24#gene49411580#100#diseaseC0007134 12131367-3#20#24#gene494115 12131367-3#80#100#diseaseC0007134 associated_with RBM1,renal cell carcinoma
20#24#gene594044#59#diseaseC0153690 12131367-3#20#24#gene5940 12131367-3#44#59#diseaseC0153690 associated_with RBM1,bone metastasis
20#24#gene594080#100#diseaseC0007134 12131367-3#20#24#gene5940 12131367-3#80#100#diseaseC0007134 associated_with RBM1,renal cell carcinoma
20#24#gene37894944#59#diseaseC0153690 12131367-3#20#24#gene378949 12131367-3#44#59#diseaseC0153690 associated_with RBM1,bone metastasis
20#24#gene37894980#100#diseaseC0007134 12131367-3#20#24#gene378949 12131367-3#80#100#diseaseC0007134 associated_with RBM1,renal cell carcinoma

PubCasesHPO

Id Subject Object Predicate Lexical cue
TI1 22-42 HP:0005584 denotes renal cell carcinoma
AB1 231-251 HP:0005584 denotes renal cell carcinoma
AB2 275-295 HP:0005584 denotes renal cell carcinoma
AB3 522-542 HP:0005584 denotes renal cell carcinoma
AB4 942-962 HP:0005584 denotes renal cell carcinoma
AB5 1497-1517 HP:0005584 denotes renal cell carcinoma

DisGeNET

Id Subject Object Predicate Lexical cue
T0 462-466 gene:494115 denotes RBM1
T1 486-501 disease:C0153690 denotes bone metastasis
T2 462-466 gene:56267 denotes RBM1
T3 486-501 disease:C0153690 denotes bone metastasis
T4 462-466 gene:5940 denotes RBM1
T5 486-501 disease:C0153690 denotes bone metastasis
T6 462-466 gene:494115 denotes RBM1
T7 522-542 disease:C0007134 denotes renal cell carcinoma
T8 462-466 gene:56267 denotes RBM1
T9 522-542 disease:C0007134 denotes renal cell carcinoma
T10 462-466 gene:5940 denotes RBM1
T11 522-542 disease:C0007134 denotes renal cell carcinoma
R1 T0 T1 associated_with RBM1,bone metastasis
R2 T2 T3 associated_with RBM1,bone metastasis
R3 T4 T5 associated_with RBM1,bone metastasis
R4 T6 T7 associated_with RBM1,renal cell carcinoma
R5 T8 T9 associated_with RBM1,renal cell carcinoma
R6 T10 T11 associated_with RBM1,renal cell carcinoma