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PubMed:12122014 JSONTXT

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PubTator4TogoVar

Id Subject Object Predicate Lexical cue proteinmutation
12122014_0 794-799 ProteinMutation denotes G129R rs774669158
12122014_1 1011-1016 ProteinMutation denotes G129R rs774669158
12122014_2 1401-1406 ProteinMutation denotes G129R rs774669158

sentences

Id Subject Object Predicate Lexical cue
T1 0-135 Sentence denotes Csk homologous kinase (CHK) and ErbB-2 interactions are directly coupled with CHK negative growth regulatory function in breast cancer.
T2 136-394 Sentence denotes Our previous studies demonstrated that Csk homologous kinase (CHK) acts as a negative growth regulator of human breast cancer through inhibition of ErbB-2/neu-mediated Src family kinase activity (Bougeret, C., Jiang, S., Keydar, I., and Avraham, H. (2001) J.
T3 395-400 Sentence denotes Biol.
T4 401-406 Sentence denotes Chem.
T5 407-424 Sentence denotes 276, 33711-33720.
T6 425-568 Sentence denotes The interaction between the CHK SH2 domain and Tyr(P)(1248) of the ErbB-2 receptor has been shown to be specific and critical for CHK function.
T7 569-740 Sentence denotes In this report, we investigated whether the interaction of the CHK SH2 domain and ErbB-2 is directly related to the inhibition of heregulin-stimulated Src kinase activity.
T8 741-877 Sentence denotes We constructed three CHK SH2 domain binding mutants: G129R (enhanced binding), R147K (inhibited binding), and R147A (disrupted binding).
T9 878-1010 Sentence denotes NMR spectra for the domains of each construct were used to evaluate their interaction with a Tyr(P)(1248)-containing ErbB-2 peptide.
T10 1011-1102 Sentence denotes G129R showed enhanced binding to ErbB-2, whereas binding was completely disrupted by R147A.
T11 1103-1290 Sentence denotes The enhanced binding mutant showed chemical shift changes at the same residues as wild-type CHK, indicating that this mutant has the same binding characteristics as the wild-type protein.
T12 1291-1471 Sentence denotes Furthermore, inhibition of heregulin-stimulated Src kinase activity was markedly diminished by R147A, whereas G129R-mediated inhibition was stronger as compared with wild-type CHK.
T13 1472-1629 Sentence denotes These results indicate that the specific interaction of CHK and ErbB-2 via the SH2 domain of CHK is directly related to the growth inhibitory effects of CHK.
T14 1630-1801 Sentence denotes These new CHK high affinity binding constructs may serve as good candidates for inhibition of the ErbB-2/Src transduction pathway in gene therapy studies in breast cancer.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 248-261 HP_0003002 denotes breast cancer
T2 248-261 HP_0100013 denotes breast cancer
T3 255-261 HP_0002664 denotes cancer
T4 1787-1800 HP_0003002 denotes breast cancer
T5 1787-1800 HP_0100013 denotes breast cancer
T6 1794-1800 HP_0002664 denotes cancer

FSU-PRGE

Id Subject Object Predicate Lexical cue
T1 0-21 protein denotes Csk homologous kinase
T2 23-26 protein denotes CHK
T3 32-38 protein denotes ErbB-2
T4 78-81 protein denotes CHK
T5 175-196 protein denotes Csk homologous kinase
T6 198-201 protein denotes CHK
T7 284-290 protein denotes ErbB-2
T8 291-294 protein denotes neu
T9 304-321 protein denotes Src family kinase
T10 453-456 protein denotes CHK
T11 492-498 protein denotes ErbB-2
T12 555-558 protein denotes CHK
T13 632-635 protein denotes CHK
T14 651-657 protein denotes ErbB-2
T15 699-708 protein denotes heregulin
T16 720-730 protein denotes Src kinase
T17 762-765 protein denotes CHK
T18 995-1001 protein denotes ErbB-2
T19 1044-1050 protein denotes ErbB-2
T20 1195-1198 protein denotes CHK
T21 1318-1327 protein denotes heregulin
T22 1339-1349 protein denotes Src kinase
T23 1467-1470 protein denotes CHK
T24 1528-1531 protein denotes CHK
T25 1536-1542 protein denotes ErbB-2
T26 1565-1568 protein denotes CHK
T27 1625-1628 protein denotes CHK
T28 1640-1643 protein denotes CHK
T29 1728-1734 protein denotes ErbB-2
T30 1735-1738 protein denotes Src

PIR-corpus2

Id Subject Object Predicate Lexical cue
T1 0-27 protein denotes Csk homologous kinase (CHK)
T2 32-38 protein denotes ErbB-2
T3 78-81 protein denotes CHK
T4 175-202 protein denotes Csk homologous kinase (CHK)
T5 213-238 protein denotes negative growth regulator
T6 284-290 protein denotes ErbB-2
T7 304-321 protein denotes Src family kinase
T8 453-456 protein denotes CHK
T9 492-498 protein denotes ErbB-2
T10 555-558 protein denotes CHK
T11 632-635 protein denotes CHK
T12 651-657 protein denotes ErbB-2
T13 699-719 protein denotes heregulin-stimulated
T14 762-765 protein denotes CHK
T15 995-1001 protein denotes ErbB-2
T16 1044-1050 protein denotes ErbB-2
T17 1195-1198 protein denotes CHK
T18 1318-1349 protein denotes heregulin-stimulated Src kinase
T19 1467-1470 protein denotes CHK
T20 1528-1531 protein denotes CHK
T21 1536-1542 protein denotes ErbB-2
T22 1565-1568 protein denotes CHK
T23 1625-1628 protein denotes CHK
T24 1640-1643 protein denotes CHK
T25 1728-1734 protein denotes ErbB-2
T26 1735-1738 protein denotes Src

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
12122014-0#0#21#gene4145 0-21 gene4145 denotes Csk homologous kinase
12122014-0#23#26#gene4145 23-26 gene4145 denotes CHK
12122014-0#32#38#gene2064 32-38 gene2064 denotes ErbB-2
12122014-0#78#81#gene4145 78-81 gene4145 denotes CHK
12122014-0#121#134#diseaseC0006142 121-134 diseaseC0006142 denotes breast cancer
12122014-0#121#134#diseaseC0678222 121-134 diseaseC0678222 denotes breast cancer
12122014-0#121#134#diseaseC0006142 121-134 diseaseC0006142 denotes breast cancer
12122014-0#121#134#diseaseC0678222 121-134 diseaseC0678222 denotes breast cancer
12122014-0#121#134#diseaseC0006142 121-134 diseaseC0006142 denotes breast cancer
12122014-0#121#134#diseaseC0678222 121-134 diseaseC0678222 denotes breast cancer
12122014-0#121#134#diseaseC0006142 121-134 diseaseC0006142 denotes breast cancer
12122014-0#121#134#diseaseC0678222 121-134 diseaseC0678222 denotes breast cancer
0#21#gene4145121#134#diseaseC0006142 12122014-0#0#21#gene4145 12122014-0#121#134#diseaseC0006142 associated_with Csk homologous kinase,breast cancer
0#21#gene4145121#134#diseaseC0678222 12122014-0#0#21#gene4145 12122014-0#121#134#diseaseC0678222 associated_with Csk homologous kinase,breast cancer
0#21#gene4145121#134#diseaseC0006142 12122014-0#0#21#gene4145 12122014-0#121#134#diseaseC0006142 associated_with Csk homologous kinase,breast cancer
0#21#gene4145121#134#diseaseC0678222 12122014-0#0#21#gene4145 12122014-0#121#134#diseaseC0678222 associated_with Csk homologous kinase,breast cancer
0#21#gene4145121#134#diseaseC0006142 12122014-0#0#21#gene4145 12122014-0#121#134#diseaseC0006142 associated_with Csk homologous kinase,breast cancer
0#21#gene4145121#134#diseaseC0678222 12122014-0#0#21#gene4145 12122014-0#121#134#diseaseC0678222 associated_with Csk homologous kinase,breast cancer
0#21#gene4145121#134#diseaseC0006142 12122014-0#0#21#gene4145 12122014-0#121#134#diseaseC0006142 associated_with Csk homologous kinase,breast cancer
0#21#gene4145121#134#diseaseC0678222 12122014-0#0#21#gene4145 12122014-0#121#134#diseaseC0678222 associated_with Csk homologous kinase,breast cancer
23#26#gene4145121#134#diseaseC0006142 12122014-0#23#26#gene4145 12122014-0#121#134#diseaseC0006142 associated_with CHK,breast cancer
23#26#gene4145121#134#diseaseC0678222 12122014-0#23#26#gene4145 12122014-0#121#134#diseaseC0678222 associated_with CHK,breast cancer
23#26#gene4145121#134#diseaseC0006142 12122014-0#23#26#gene4145 12122014-0#121#134#diseaseC0006142 associated_with CHK,breast cancer
23#26#gene4145121#134#diseaseC0678222 12122014-0#23#26#gene4145 12122014-0#121#134#diseaseC0678222 associated_with CHK,breast cancer
23#26#gene4145121#134#diseaseC0006142 12122014-0#23#26#gene4145 12122014-0#121#134#diseaseC0006142 associated_with CHK,breast cancer
23#26#gene4145121#134#diseaseC0678222 12122014-0#23#26#gene4145 12122014-0#121#134#diseaseC0678222 associated_with CHK,breast cancer
23#26#gene4145121#134#diseaseC0006142 12122014-0#23#26#gene4145 12122014-0#121#134#diseaseC0006142 associated_with CHK,breast cancer
23#26#gene4145121#134#diseaseC0678222 12122014-0#23#26#gene4145 12122014-0#121#134#diseaseC0678222 associated_with CHK,breast cancer
32#38#gene2064121#134#diseaseC0006142 12122014-0#32#38#gene2064 12122014-0#121#134#diseaseC0006142 associated_with ErbB-2,breast cancer
32#38#gene2064121#134#diseaseC0678222 12122014-0#32#38#gene2064 12122014-0#121#134#diseaseC0678222 associated_with ErbB-2,breast cancer
32#38#gene2064121#134#diseaseC0006142 12122014-0#32#38#gene2064 12122014-0#121#134#diseaseC0006142 associated_with ErbB-2,breast cancer
32#38#gene2064121#134#diseaseC0678222 12122014-0#32#38#gene2064 12122014-0#121#134#diseaseC0678222 associated_with ErbB-2,breast cancer
32#38#gene2064121#134#diseaseC0006142 12122014-0#32#38#gene2064 12122014-0#121#134#diseaseC0006142 associated_with ErbB-2,breast cancer
32#38#gene2064121#134#diseaseC0678222 12122014-0#32#38#gene2064 12122014-0#121#134#diseaseC0678222 associated_with ErbB-2,breast cancer
32#38#gene2064121#134#diseaseC0006142 12122014-0#32#38#gene2064 12122014-0#121#134#diseaseC0006142 associated_with ErbB-2,breast cancer
32#38#gene2064121#134#diseaseC0678222 12122014-0#32#38#gene2064 12122014-0#121#134#diseaseC0678222 associated_with ErbB-2,breast cancer
78#81#gene4145121#134#diseaseC0006142 12122014-0#78#81#gene4145 12122014-0#121#134#diseaseC0006142 associated_with CHK,breast cancer
78#81#gene4145121#134#diseaseC0678222 12122014-0#78#81#gene4145 12122014-0#121#134#diseaseC0678222 associated_with CHK,breast cancer
78#81#gene4145121#134#diseaseC0006142 12122014-0#78#81#gene4145 12122014-0#121#134#diseaseC0006142 associated_with CHK,breast cancer
78#81#gene4145121#134#diseaseC0678222 12122014-0#78#81#gene4145 12122014-0#121#134#diseaseC0678222 associated_with CHK,breast cancer
78#81#gene4145121#134#diseaseC0006142 12122014-0#78#81#gene4145 12122014-0#121#134#diseaseC0006142 associated_with CHK,breast cancer
78#81#gene4145121#134#diseaseC0678222 12122014-0#78#81#gene4145 12122014-0#121#134#diseaseC0678222 associated_with CHK,breast cancer
78#81#gene4145121#134#diseaseC0006142 12122014-0#78#81#gene4145 12122014-0#121#134#diseaseC0006142 associated_with CHK,breast cancer
78#81#gene4145121#134#diseaseC0678222 12122014-0#78#81#gene4145 12122014-0#121#134#diseaseC0678222 associated_with CHK,breast cancer

PIR-corpus1

Id Subject Object Predicate Lexical cue
T1 0-21 protein denotes Csk homologous kinase
T2 23-26 acronym denotes CHK
T3 32-38 protein denotes ErbB-2
T4 78-81 protein denotes CHK
T5 175-196 protein denotes Csk homologous kinase
T6 198-201 acronym denotes CHK
T7 284-321 protein denotes ErbB-2/neu-mediated Src family kinase
T8 492-498 protein denotes ErbB-2
T9 555-558 protein denotes CHK
T10 651-657 protein denotes ErbB-2
T11 699-719 protein denotes heregulin-stimulated
T12 1044-1050 protein denotes ErbB-2
T13 1195-1198 protein denotes CHK
T14 1282-1289 protein denotes protein
T15 1318-1349 protein denotes heregulin-stimulated Src kinase
T16 1467-1470 protein denotes CHK
T17 1528-1531 protein denotes CHK
T18 1536-1542 protein denotes ErbB-2
T19 1565-1568 protein denotes CHK
T20 1625-1628 protein denotes CHK
T21 1728-1738 protein denotes ErbB-2/Src

DisGeNET

Id Subject Object Predicate Lexical cue
T0 0-21 gene:4145 denotes Csk homologous kinase
T1 121-134 disease:C0006142 denotes breast cancer
T2 0-21 gene:4145 denotes Csk homologous kinase
T3 121-134 disease:C0678222 denotes breast cancer
T4 23-26 gene:4145 denotes CHK
T5 121-134 disease:C0006142 denotes breast cancer
T6 23-26 gene:4145 denotes CHK
T7 121-134 disease:C0678222 denotes breast cancer
T8 32-38 gene:2064 denotes ErbB-2
T9 121-134 disease:C0006142 denotes breast cancer
T10 32-38 gene:2064 denotes ErbB-2
T11 121-134 disease:C0678222 denotes breast cancer
T12 78-81 gene:4145 denotes CHK
T13 121-134 disease:C0678222 denotes breast cancer
T14 78-81 gene:4145 denotes CHK
T15 121-134 disease:C0006142 denotes breast cancer
T16 175-196 gene:4145 denotes Csk homologous kinase
T17 248-261 disease:C0006142 denotes breast cancer
T18 175-196 gene:4145 denotes Csk homologous kinase
T19 248-261 disease:C0678222 denotes breast cancer
T20 198-201 gene:4145 denotes CHK
T21 248-261 disease:C0006142 denotes breast cancer
T22 198-201 gene:4145 denotes CHK
T23 248-261 disease:C0678222 denotes breast cancer
R1 T0 T1 associated_with Csk homologous kinase,breast cancer
R2 T2 T3 associated_with Csk homologous kinase,breast cancer
R3 T4 T5 associated_with CHK,breast cancer
R4 T6 T7 associated_with CHK,breast cancer
R5 T8 T9 associated_with ErbB-2,breast cancer
R6 T10 T11 associated_with ErbB-2,breast cancer
R7 T12 T13 associated_with CHK,breast cancer
R8 T14 T15 associated_with CHK,breast cancer
R9 T16 T17 associated_with Csk homologous kinase,breast cancer
R10 T18 T19 associated_with Csk homologous kinase,breast cancer
R11 T20 T21 associated_with CHK,breast cancer
R12 T22 T23 associated_with CHK,breast cancer

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 121-134 Phenotype denotes breast cancer HP:0003002
T2 248-261 Phenotype denotes breast cancer HP:0003002
T3 1787-1800 Phenotype denotes breast cancer HP:0003002

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 121-134 Disease denotes breast cancer http://purl.obolibrary.org/obo/MONDO_0007254
T2 248-261 Disease denotes breast cancer http://purl.obolibrary.org/obo/MONDO_0007254
T3 1787-1800 Disease denotes breast cancer http://purl.obolibrary.org/obo/MONDO_0007254

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 242-247 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 121-127 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310
T2 248-254 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310
T3 1787-1793 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310