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PubMed:12118012 JSONTXT

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GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 27-30 Glycan_Motif denotes GD3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G98544DH|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81928IQ
T3 214-217 Glycan_Motif denotes GD3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G98544DH|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81928IQ
T5 219-222 Glycan_Motif denotes GD3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G98544DH|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81928IQ
T7 420-423 Glycan_Motif denotes GD3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G98544DH|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81928IQ
T9 539-542 Glycan_Motif denotes GD3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G98544DH|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81928IQ
T11 736-739 Glycan_Motif denotes GD3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G98544DH|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81928IQ
T13 1043-1046 Glycan_Motif denotes GD3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G98544DH|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81928IQ
T15 1194-1210 Glycan_Motif denotes glucosylceramide https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G71142DF
T16 1249-1252 Glycan_Motif denotes GD3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G98544DH|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81928IQ
T18 1334-1337 Glycan_Motif denotes GD3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G98544DH|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81928IQ
T20 1522-1525 Glycan_Motif denotes GD3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G98544DH|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81928IQ

sentences

Id Subject Object Predicate Lexical cue
T1 0-78 Sentence denotes Trafficking of ganglioside GD3 to mitochondria by tumor necrosis factor-alpha.
T2 79-167 Sentence denotes The interaction of mitochondria with proapoptotic proteins activates apoptosis pathways.
T3 168-323 Sentence denotes Previous findings have identified ganglioside GD3 (GD3) as an emerging apoptotic lipid intermediate that targets mitochondria in response to death signals.
T4 324-514 Sentence denotes Using immunoelectron and laser scanning confocal microscopy, we characterize the trafficking of GD3 to mitochondria in response to tumor necrosis factor-alpha (TNF-alpha) in rat hepatocytes.
T5 515-705 Sentence denotes In control hepatocytes, GD3 is present predominantly at the plasma membrane as well as in the endosomal/Golgi network, as verified by its colocalization with the asialoglycoprotein receptor.
T6 706-871 Sentence denotes Following TNF-alpha exposure, GD3 undergoes a rapid cellular redistribution with a gradual loss from the plasma membrane before its colocalization with mitochondria.
T7 872-999 Sentence denotes This process is mimicked by acidic sphingomyelinase and ionizing radiation but not by neutral sphingomyelinase or staurosporin.
T8 1000-1269 Sentence denotes TNF-alpha stimulated the colocalization of GD3 with early and late endosomal markers, Rab 5 and Rab 7, whereas perturbation of plasma membrane cholesterol or actin cytoskeleton or inhibition of glucosylceramide synthase prevented the trafficking of GD3 to mitochondria.
T9 1270-1451 Sentence denotes Finally, prevention of the TNF-alpha-stimulated neosynthesis of GD3, cyclosporin A, and latrunculin A or filipin protected sensitized hepatocytes from TNF-alpha-mediated cell death.
T10 1452-1673 Sentence denotes Thus, the intracellular redistribution and mitochondrial targeting of GD3 during TNF-alpha signaling occurs through actin cytoskeleton vesicular trafficking and contributes to TNF-alpha-mediated hepatocellular cell death.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 27-30 https://glytoucan.org/Structures/Glycans/G81928IQ denotes GD3
T2 27-30 https://glytoucan.org/Structures/Glycans/G98544DH denotes GD3
T3 214-217 https://glytoucan.org/Structures/Glycans/G81928IQ denotes GD3
T4 214-217 https://glytoucan.org/Structures/Glycans/G98544DH denotes GD3
T5 219-222 https://glytoucan.org/Structures/Glycans/G81928IQ denotes GD3
T6 219-222 https://glytoucan.org/Structures/Glycans/G98544DH denotes GD3
T7 420-423 https://glytoucan.org/Structures/Glycans/G81928IQ denotes GD3
T8 420-423 https://glytoucan.org/Structures/Glycans/G98544DH denotes GD3
T9 539-542 https://glytoucan.org/Structures/Glycans/G81928IQ denotes GD3
T10 539-542 https://glytoucan.org/Structures/Glycans/G98544DH denotes GD3
T11 736-739 https://glytoucan.org/Structures/Glycans/G81928IQ denotes GD3
T12 736-739 https://glytoucan.org/Structures/Glycans/G98544DH denotes GD3
T13 1043-1046 https://glytoucan.org/Structures/Glycans/G81928IQ denotes GD3
T14 1043-1046 https://glytoucan.org/Structures/Glycans/G98544DH denotes GD3
T15 1194-1210 https://glytoucan.org/Structures/Glycans/G71142DF denotes glucosylceramide
T16 1249-1252 https://glytoucan.org/Structures/Glycans/G81928IQ denotes GD3
T17 1249-1252 https://glytoucan.org/Structures/Glycans/G98544DH denotes GD3
T18 1334-1337 https://glytoucan.org/Structures/Glycans/G81928IQ denotes GD3
T19 1334-1337 https://glytoucan.org/Structures/Glycans/G98544DH denotes GD3
T20 1522-1525 https://glytoucan.org/Structures/Glycans/G81928IQ denotes GD3
T21 1522-1525 https://glytoucan.org/Structures/Glycans/G98544DH denotes GD3

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 27-30 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T2 214-217 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T3 219-222 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T4 420-423 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T5 539-542 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T6 736-739 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T7 1043-1046 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T8 1249-1252 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T9 1334-1337 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T10 1522-1525 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 50-55 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T2 455-460 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 50-55 Phenotype denotes tumor HP:0002664
T2 455-460 Phenotype denotes tumor HP:0002664

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 27-30 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T2 214-217 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T3 219-222 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T4 420-423 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T5 539-542 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T6 736-739 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T7 1043-1046 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T8 1249-1252 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T9 1334-1337 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T10 1522-1525 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 50-55 Phenotype denotes tumor HP:0002664
T2 455-460 Phenotype denotes tumor HP:0002664

GlyCosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 502-513 Cell denotes hepatocytes http://purl.obolibrary.org/obo/CL:0000182
T2 526-537 Cell denotes hepatocytes http://purl.obolibrary.org/obo/CL:0000182
T3 1404-1415 Cell denotes hepatocytes http://purl.obolibrary.org/obo/CL:0000182

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 502-513 Body_part denotes hepatocytes http://purl.obolibrary.org/obo/CL_0000182
T2 526-537 Body_part denotes hepatocytes http://purl.obolibrary.org/obo/CL_0000182
T3 575-590 Body_part denotes plasma membrane http://purl.obolibrary.org/obo/GO_0005886
T4 619-624 Body_part denotes Golgi http://purl.obolibrary.org/obo/GO_0005794
T5 811-826 Body_part denotes plasma membrane http://purl.obolibrary.org/obo/GO_0005886
T6 1127-1142 Body_part denotes plasma membrane http://purl.obolibrary.org/obo/GO_0005886
T7 1158-1176 Body_part denotes actin cytoskeleton http://purl.obolibrary.org/obo/GO_0015629
T8 1404-1415 Body_part denotes hepatocytes http://purl.obolibrary.org/obo/CL_0000182
T9 1462-1475 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622
T10 1568-1586 Body_part denotes actin cytoskeleton http://purl.obolibrary.org/obo/GO_0015629

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 50-55 Disease denotes tumor MONDO:0005070
T2 455-460 Disease denotes tumor MONDO:0005070

GlyCosmos15-Taxon

Id Subject Object Predicate Lexical cue db_id
T1 498-501 Organism denotes rat 10114|10116

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-78 Sentence denotes Trafficking of ganglioside GD3 to mitochondria by tumor necrosis factor-alpha.
T2 79-167 Sentence denotes The interaction of mitochondria with proapoptotic proteins activates apoptosis pathways.
T3 168-323 Sentence denotes Previous findings have identified ganglioside GD3 (GD3) as an emerging apoptotic lipid intermediate that targets mitochondria in response to death signals.
T4 324-514 Sentence denotes Using immunoelectron and laser scanning confocal microscopy, we characterize the trafficking of GD3 to mitochondria in response to tumor necrosis factor-alpha (TNF-alpha) in rat hepatocytes.
T5 515-705 Sentence denotes In control hepatocytes, GD3 is present predominantly at the plasma membrane as well as in the endosomal/Golgi network, as verified by its colocalization with the asialoglycoprotein receptor.
T6 706-871 Sentence denotes Following TNF-alpha exposure, GD3 undergoes a rapid cellular redistribution with a gradual loss from the plasma membrane before its colocalization with mitochondria.
T7 872-999 Sentence denotes This process is mimicked by acidic sphingomyelinase and ionizing radiation but not by neutral sphingomyelinase or staurosporin.
T8 1000-1269 Sentence denotes TNF-alpha stimulated the colocalization of GD3 with early and late endosomal markers, Rab 5 and Rab 7, whereas perturbation of plasma membrane cholesterol or actin cytoskeleton or inhibition of glucosylceramide synthase prevented the trafficking of GD3 to mitochondria.
T9 1270-1451 Sentence denotes Finally, prevention of the TNF-alpha-stimulated neosynthesis of GD3, cyclosporin A, and latrunculin A or filipin protected sensitized hepatocytes from TNF-alpha-mediated cell death.
T10 1452-1673 Sentence denotes Thus, the intracellular redistribution and mitochondrial targeting of GD3 during TNF-alpha signaling occurs through actin cytoskeleton vesicular trafficking and contributes to TNF-alpha-mediated hepatocellular cell death.

GlyCosmos15-FMA

Id Subject Object Predicate Lexical cue db_id
T1 502-513 Body_part denotes hepatocytes FMA:14515
T2 526-537 Body_part denotes hepatocytes FMA:14515
T3 575-590 Body_part denotes plasma membrane FMA:63841
T4 609-618 Body_part denotes endosomal FMA:67180
T5 619-632 Body_part denotes Golgi network FMA:67108
T6 811-826 Body_part denotes plasma membrane FMA:63841
T7 1062-1076 Body_part denotes late endosomal FMA:67467
T8 1127-1142 Body_part denotes plasma membrane FMA:63841
T9 1158-1176 Body_part denotes actin cytoskeleton FMA:84684
T10 1404-1415 Body_part denotes hepatocytes FMA:14515
T11 1568-1586 Body_part denotes actin cytoskeleton FMA:84684

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 498-501 OrganismTaxon denotes rat 10114|10116

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 502-513 Body_part denotes hepatocytes http://purl.obolibrary.org/obo/CL_0000182
T2 526-537 Body_part denotes hepatocytes http://purl.obolibrary.org/obo/CL_0000182
T3 575-590 Body_part denotes plasma membrane http://purl.obolibrary.org/obo/GO_0005886
T4 619-624 Body_part denotes Golgi http://purl.obolibrary.org/obo/GO_0005794
T5 811-826 Body_part denotes plasma membrane http://purl.obolibrary.org/obo/GO_0005886
T6 1127-1142 Body_part denotes plasma membrane http://purl.obolibrary.org/obo/GO_0005886
T7 1158-1176 Body_part denotes actin cytoskeleton http://purl.obolibrary.org/obo/GO_0015629
T8 1404-1415 Body_part denotes hepatocytes http://purl.obolibrary.org/obo/CL_0000182
T9 1462-1475 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622
T10 1568-1586 Body_part denotes actin cytoskeleton http://purl.obolibrary.org/obo/GO_0015629

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 502-513 Cell denotes hepatocytes http://purl.obolibrary.org/obo/CL:0000182
T2 526-537 Cell denotes hepatocytes http://purl.obolibrary.org/obo/CL:0000182
T3 1404-1415 Cell denotes hepatocytes http://purl.obolibrary.org/obo/CL:0000182