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PubMed:12094250 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-138 Sentence denotes Deletion analysis of chromosome 13q14.3 and characterisation of an alternative splice form of LEU1 in B cell chronic lymphocytic leukemia.
TextSentencer_T2 139-334 Sentence denotes Heterozygous and homozygous deletions of chromosome 13q14.3 are found in 50% of patients with B cell CLL, suggesting the presence of one or more tumour suppressor genes within the deleted region.
TextSentencer_T3 335-470 Sentence denotes To identify candidate genes from the region, we constructed a map of 13q14.3 using a combination of genomic and cDNA library screening.
TextSentencer_T4 471-608 Sentence denotes The incidence of deletions in CLL patients was 51.5% encompassing a 265 kb region of minimal deletion (RMD) telomeric to markers D13S319.
TextSentencer_T5 609-744 Sentence denotes Two CpG islands were identified within the RMD, the telomeric of which is fully methylated whilst the more centromeric is unmethylated.
TextSentencer_T6 745-848 Sentence denotes A novel transcript was identified within the RMD that represents an alternative splice version of Leu1.
TextSentencer_T7 849-956 Sentence denotes The nine exons of this transcript span a genomic of 436 kb with exon 1 of Leu1 being the common first exon.
TextSentencer_T8 957-1035 Sentence denotes The remaining exons were shown to be more frequently deleted than Leu1 itself.
TextSentencer_T9 1036-1163 Sentence denotes All splice forms of this transcript were detectable by RT-PCR but Leu1 detected the most abundant message on Northern blotting.
TextSentencer_T10 1164-1380 Sentence denotes Sequence analysis failed to reveal inactivating mutations in patients with heterozygous deletion of 13q14.3, although a polymorphic T to A variant was identified within exon 1 of Leu1 in leukemic and normal controls.
TextSentencer_T11 1381-1593 Sentence denotes As no mutations have been detected for Leu1 or any other transcript so far described, we cannot exclude the existence of control elements within the RMD that may regulate expression of genes lying in this region.
T1 0-138 Sentence denotes Deletion analysis of chromosome 13q14.3 and characterisation of an alternative splice form of LEU1 in B cell chronic lymphocytic leukemia.
T2 139-334 Sentence denotes Heterozygous and homozygous deletions of chromosome 13q14.3 are found in 50% of patients with B cell CLL, suggesting the presence of one or more tumour suppressor genes within the deleted region.
T3 335-470 Sentence denotes To identify candidate genes from the region, we constructed a map of 13q14.3 using a combination of genomic and cDNA library screening.
T4 471-608 Sentence denotes The incidence of deletions in CLL patients was 51.5% encompassing a 265 kb region of minimal deletion (RMD) telomeric to markers D13S319.
T5 609-744 Sentence denotes Two CpG islands were identified within the RMD, the telomeric of which is fully methylated whilst the more centromeric is unmethylated.
T6 745-848 Sentence denotes A novel transcript was identified within the RMD that represents an alternative splice version of Leu1.
T7 849-956 Sentence denotes The nine exons of this transcript span a genomic of 436 kb with exon 1 of Leu1 being the common first exon.
T8 957-1035 Sentence denotes The remaining exons were shown to be more frequently deleted than Leu1 itself.
T9 1036-1163 Sentence denotes All splice forms of this transcript were detectable by RT-PCR but Leu1 detected the most abundant message on Northern blotting.
T10 1164-1380 Sentence denotes Sequence analysis failed to reveal inactivating mutations in patients with heterozygous deletion of 13q14.3, although a polymorphic T to A variant was identified within exon 1 of Leu1 in leukemic and normal controls.
T11 1381-1593 Sentence denotes As no mutations have been detected for Leu1 or any other transcript so far described, we cannot exclude the existence of control elements within the RMD that may regulate expression of genes lying in this region.

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
12094250-0#94#98#gene921 94-98 gene921 denotes LEU1
12094250-0#94#98#gene10301 94-98 gene10301 denotes LEU1
12094250-0#102#137#diseaseC0023434 102-137 diseaseC0023434 denotes B cell chronic lymphocytic leukemia
94#98#gene921102#137#diseaseC0023434 12094250-0#94#98#gene921 12094250-0#102#137#diseaseC0023434 associated_with LEU1,B cell chronic lymphocytic leukemia
94#98#gene10301102#137#diseaseC0023434 12094250-0#94#98#gene10301 12094250-0#102#137#diseaseC0023434 associated_with LEU1,B cell chronic lymphocytic leukemia

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T1711 94-98 gene:921 denotes LEU1
T1712 102-137 disease:C0023434 denotes B cell chronic lymphocytic leukemia
R1 T1711 T1712 associated_with LEU1,B cell chronic lymphocytic leukemia
R2 T1711 T1712 associated_with LEU1,B cell chronic lymphocytic leukemia

DisGeNET

Id Subject Object Predicate Lexical cue
T0 94-98 gene:921 denotes LEU1
T1 102-137 disease:C0023434 denotes B cell chronic lymphocytic leukemia
T2 94-98 gene:10301 denotes LEU1
T3 102-137 disease:C0023434 denotes B cell chronic lymphocytic leukemia
R1 T0 T1 associated_with LEU1,B cell chronic lymphocytic leukemia
R2 T2 T3 associated_with LEU1,B cell chronic lymphocytic leukemia