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PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 54-196 DRI_Challenge denotes MutL homolog 3 (Mlh3) is a member of a family of proteins conserved during evolution and having dual roles in DNA mismatch repair and meiosis.
T2 197-423 DRI_Background denotes The pathway in eukaryotes consists of the DNA-binding components, which are the homologs of the bacterial MutS protein (MSH 2 6), and the MutL homologs, which bind to the MutS homologs and are essential for the repair process.
T3 424-661 DRI_Approach denotes Three of the six homologs of MutS that function in these processes, Msh2, Msh3 and Msh6, are involved in the mismatch repair of mutations, frameshifts and replication errors, and two others, Msh4 and Msh5, have specific roles in meiosis.
T4 662-848 DRI_Outcome denotes Of the four MutL homologs, Mlh1, Mlh3, Pms1 and Pms2, three are involved in mismatch repair and at least two, Pms2 and Mlh1, are essential for meiotic progression in both yeast and mice.
T5 849-949 DRI_Approach denotes To assess the role of Mlh3 in mammalian meiosis, we have generated and characterized Mlh3(-/-) mice.
T6 950-1006 DRI_Outcome denotes Here we show that Mlh3(-/-) mice are viable but sterile.
T7 1007-1276 DRI_Approach denotes Mlh3 is required for Mlh1 binding to meiotic chromosomes and localizes to meiotic chromosomes from the mid pachynema stage of prophase I. Mlh3(-/-) spermatocytes reach metaphase before succumbing to apoptosis, but oocytes fail to complete meiosis I after fertilization.
T8 1277-1360 DRI_Outcome denotes Our results show that Mlh3 has an essential and distinct role in mammalian meiosis.

c_corpus

Id Subject Object Predicate Lexical cue
T1 19-29 D000782 denotes aneuploidy
T2 19-29 D000782 denotes aneuploidy
T3 33-37 PR:F4JN26 denotes MLH3
T4 33-37 PR:Q12083 denotes MLH3
T5 33-37 PR:000010443 denotes MLH3
T6 33-37 PR:Q9UHC1 denotes MLH3
T7 48-52 PR:000005054 denotes mice
T9 48-52 O89094 denotes mice
T8 48-52 D051379 denotes mice
T10 48-52 10095 denotes mice
T11 59-66 SO:0000853 denotes homolog
T12 70-74 PR:F4JN26 denotes Mlh3
T13 70-74 PR:Q12083 denotes Mlh3
T14 70-74 PR:000010443 denotes Mlh3
T15 70-74 PR:Q9UHC1 denotes Mlh3
T16 103-111 CHEBI:36080 denotes proteins
T17 112-121 SO:0000856 denotes conserved
T18 164-167 GO:0005574 denotes DNA
T20 164-167 SO:0000352 denotes DNA
T19 164-167 CHEBI:16991 denotes DNA
T21 164-167 D004247 denotes DNA
T22 168-183 GO:0006298 denotes mismatch repair
T23 188-195 GO:0051321 denotes meiosis
T24 201-208 CHEBI:34922 denotes pathway
T25 212-222 D056890 denotes eukaryotes
T28 239-242 SO:0000352 denotes DNA
T27 239-242 CHEBI:16991 denotes DNA
T29 239-242 D004247 denotes DNA
T26 239-242 GO:0005574 denotes DNA
T30 239-250 GO:0003677 denotes DNA-binding
T31 243-250 SO:0100018 denotes binding
T32 243-250 SO:0001091 denotes binding
T34 303-307 PR:000023326 denotes MutS
T35 303-307 PR:P23909 denotes MutS
T36 303-307 PR:Q2FYZ9 denotes MutS
T41 308-315 SO:0000104 denotes protein
T38 308-315 CHEBI:36080 denotes protein
T39 308-315 CHEBI:11122 denotes protein
T37 308-315 GO:0003675 denotes protein
T42 308-320 Q03372 denotes protein (MSH
T44 317-320 CHEBI:16768 denotes MSH
T48 317-320 D009074 denotes MSH
T49 317-320 D009074 denotes MSH
T50 317-322 PR:000010666 denotes MSH 2
T51 317-322 PR:P25847 denotes MSH 2
T52 317-322 PR:P43246 denotes MSH 2
T53 317-322 P22711 denotes MSH 2
T54 317-322 PR:P22711 denotes MSH 2
T55 317-322 PR:P54275 denotes MSH 2
T56 317-322 PR:O74773 denotes MSH 2
T57 317-322 PR:P43247 denotes MSH 2
T58 317-322 PR:Q553L4 denotes MSH 2
T59 317-322 PR:O24617 denotes MSH 2
T60 335-339 PR:000023324 denotes MutL
T61 335-339 PR:Q93T05 denotes MutL
T62 335-339 PR:P23367 denotes MutL
T63 335-348 D000070956 denotes MutL homologs
T64 368-372 PR:000023326 denotes MutS
T65 368-372 PR:P23909 denotes MutS
T66 368-372 PR:Q2FYZ9 denotes MutS
T67 368-381 D000074080 denotes MutS homologs
T68 453-457 PR:000023326 denotes MutS
T69 453-457 PR:P23909 denotes MutS
T70 453-457 PR:Q2FYZ9 denotes MutS
T71 481-490 UBERON:0004529 denotes processes
T73 492-495 CHEBI:16768 denotes Msh
T77 492-495 D009074 denotes Msh
T78 492-495 D009074 denotes Msh
T79 492-496 PR:000010666 denotes Msh2
T80 492-496 PR:P25847 denotes Msh2
T81 492-496 PR:P43246 denotes Msh2
T82 492-496 P22711 denotes Msh2
T83 492-496 PR:P22711 denotes Msh2
T84 492-496 PR:P54275 denotes Msh2
T85 492-496 PR:O74773 denotes Msh2
T86 492-496 PR:P43247 denotes Msh2
T87 492-496 PR:Q553L4 denotes Msh2
T88 492-496 PR:O24617 denotes Msh2
T90 498-501 CHEBI:16768 denotes Msh
T94 498-501 D009074 denotes Msh
T95 498-501 D009074 denotes Msh
T96 498-502 PR:O65607 denotes Msh3
T97 498-502 PR:000010667 denotes Msh3
T98 498-502 PR:Q59Y41 denotes Msh3
T99 498-502 PR:P25336 denotes Msh3
T100 498-502 PR:P20585 denotes Msh3
T101 498-502 PR:P26359 denotes Msh3
T102 498-502 PR:P13705 denotes Msh3
T103 498-502 PR:Q1ZXH0 denotes Msh3
T105 507-510 CHEBI:16768 denotes Msh
T109 507-510 D009074 denotes Msh
T110 507-510 D009074 denotes Msh
T111 507-511 PR:P52701 denotes Msh6
T112 507-511 PR:P54276 denotes Msh6
T113 507-511 PR:Q9VUM0 denotes Msh6
T114 507-511 PR:Q55GU9 denotes Msh6
T115 507-511 PR:O04716 denotes Msh6
T116 507-511 PR:Q03834 denotes Msh6
T117 507-511 PR:O74502 denotes Msh6
T118 507-511 PR:000010670 denotes Msh6
T119 533-548 GO:0006298 denotes mismatch repair
T121 615-618 CHEBI:16768 denotes Msh
T125 615-618 D009074 denotes Msh
T126 615-618 D009074 denotes Msh
T127 615-619 PR:P40965 denotes Msh4
T128 615-619 PR:000010668 denotes Msh4
T129 615-619 PR:F4JP48 denotes Msh4
T130 615-619 PR:Q99MT2 denotes Msh4
T131 615-619 PR:O15457 denotes Msh4
T132 615-619 PR:Q23405 denotes Msh4
T134 624-627 CHEBI:16768 denotes Msh
T138 624-627 D009074 denotes Msh
T139 624-627 D009074 denotes Msh
T140 624-628 PR:Q6MG62 denotes Msh5
T141 624-628 PR:Q9QUM7 denotes Msh5
T142 624-628 PR:O43196 denotes Msh5
T143 624-628 PR:Q19272 denotes Msh5
T144 624-628 PR:F4JEP5 denotes Msh5
T145 624-628 PR:000010669 denotes Msh5
T146 624-628 PR:Q12175 denotes Msh5
T147 653-660 GO:0051321 denotes meiosis
T148 674-678 PR:000023324 denotes MutL
T149 674-678 PR:Q93T05 denotes MutL
T150 674-678 PR:P23367 denotes MutL
T151 674-687 D000070956 denotes MutL homologs
T152 689-693 PR:Q9ZRV4 denotes Mlh1
T153 689-693 PR:P38920 denotes Mlh1
T154 689-693 PR:Q54KD8 denotes Mlh1
T156 689-693 PR:Q9JK91 denotes Mlh1
T157 689-693 PR:P97679 denotes Mlh1
T158 689-693 PR:Q9P7W6 denotes Mlh1
T159 689-693 PR:000010442 denotes Mlh1
T160 689-693 PR:P40692 denotes Mlh1
T155 689-693 CVCL_G669 denotes Mlh1
T161 695-699 PR:F4JN26 denotes Mlh3
T162 695-699 PR:Q12083 denotes Mlh3
T163 695-699 PR:000010443 denotes Mlh3
T164 695-699 PR:Q9UHC1 denotes Mlh3
T171 701-705 PR:P14242 denotes Pms1
T172 701-705 PR:000012913 denotes Pms1
T175 701-705 PR:Q941I6 denotes Pms1
T176 701-705 PR:P54280 denotes Pms1
T177 701-705 PR:Q5NC83 denotes Pms1
T178 701-705 PR:P54277 denotes Pms1
T179 701-705 PR:Q54QA0 denotes Pms1
T173 701-705 C102203 denotes Pms1
T174 701-705 C102203 denotes Pms1
T180 710-713 CHEBI:53396 denotes Pms
T183 710-713 CHEBI:53430 denotes Pms
T185 710-713 CHEBI:8055 denotes Pms
T186 710-714 PR:P54279 denotes Pms2
T187 710-714 PR:F1NQJ3 denotes Pms2
T188 710-714 PR:P38920 denotes Pms2
T189 710-714 PR:000012914 denotes Pms2
T190 710-714 PR:P54278 denotes Pms2
T191 738-753 GO:0006298 denotes mismatch repair
T192 772-775 CHEBI:53396 denotes Pms
T195 772-775 CHEBI:53430 denotes Pms
T197 772-775 CHEBI:8055 denotes Pms
T198 772-776 PR:P54279 denotes Pms2
T199 772-776 PR:F1NQJ3 denotes Pms2
T200 772-776 PR:P38920 denotes Pms2
T201 772-776 PR:000012914 denotes Pms2
T202 772-776 PR:P54278 denotes Pms2
T203 781-785 PR:Q9ZRV4 denotes Mlh1
T204 781-785 PR:P38920 denotes Mlh1
T205 781-785 PR:Q54KD8 denotes Mlh1
T207 781-785 PR:Q9JK91 denotes Mlh1
T208 781-785 PR:P97679 denotes Mlh1
T209 781-785 PR:Q9P7W6 denotes Mlh1
T210 781-785 PR:000010442 denotes Mlh1
T211 781-785 PR:P40692 denotes Mlh1
T206 781-785 CVCL_G669 denotes Mlh1
T213 833-838 214355 denotes yeast
T212 833-838 D015003 denotes yeast
T215 843-847 D051379 denotes mice
T217 843-847 10095 denotes mice
T214 843-847 PR:000005054 denotes mice
T216 843-847 O89094 denotes mice
T218 871-875 PR:F4JN26 denotes Mlh3
T219 871-875 PR:Q12083 denotes Mlh3
T220 871-875 PR:000010443 denotes Mlh3
T221 871-875 PR:Q9UHC1 denotes Mlh3
T222 889-896 GO:0051321 denotes meiosis
T223 934-938 PR:F4JN26 denotes Mlh3
T224 934-938 PR:Q12083 denotes Mlh3
T225 934-938 PR:000010443 denotes Mlh3
T226 934-938 PR:Q9UHC1 denotes Mlh3
T227 944-948 PR:000005054 denotes mice
T229 944-948 O89094 denotes mice
T228 944-948 D051379 denotes mice
T230 944-948 10095 denotes mice
T231 968-972 PR:F4JN26 denotes Mlh3
T232 968-972 PR:Q12083 denotes Mlh3
T233 968-972 PR:000010443 denotes Mlh3
T234 968-972 PR:Q9UHC1 denotes Mlh3
T235 978-982 PR:000005054 denotes mice
T237 978-982 O89094 denotes mice
T236 978-982 D051379 denotes mice
T238 978-982 10095 denotes mice
T239 1007-1011 PR:F4JN26 denotes Mlh3
T240 1007-1011 PR:Q12083 denotes Mlh3
T241 1007-1011 PR:000010443 denotes Mlh3
T242 1007-1011 PR:Q9UHC1 denotes Mlh3
T243 1028-1032 PR:Q9ZRV4 denotes Mlh1
T244 1028-1032 PR:P38920 denotes Mlh1
T245 1028-1032 PR:Q54KD8 denotes Mlh1
T247 1028-1032 PR:Q9JK91 denotes Mlh1
T248 1028-1032 PR:P97679 denotes Mlh1
T249 1028-1032 PR:Q9P7W6 denotes Mlh1
T250 1028-1032 PR:000010442 denotes Mlh1
T251 1028-1032 PR:P40692 denotes Mlh1
T246 1028-1032 CVCL_G669 denotes Mlh1
T252 1033-1040 SO:0100018 denotes binding
T253 1033-1040 SO:0001091 denotes binding
T254 1033-1040 GO:0005488 denotes binding
T255 1133-1141 GO:0051324 denotes prophase
T256 1145-1149 PR:F4JN26 denotes Mlh3
T257 1145-1149 PR:Q12083 denotes Mlh3
T258 1145-1149 PR:000010443 denotes Mlh3
T259 1145-1149 PR:Q9UHC1 denotes Mlh3
T260 1175-1184 GO:0051323 denotes metaphase
T261 1206-1215 GO:0097194 denotes apoptosis
T262 1206-1215 GO:0006915 denotes apoptosis
T264 1246-1255 GO:0007127 denotes meiosis I
T265 1262-1275 GO:0009566 denotes fertilization
T266 1299-1303 PR:F4JN26 denotes Mlh3
T267 1299-1303 PR:Q12083 denotes Mlh3
T268 1299-1303 PR:000010443 denotes Mlh3
T269 1299-1303 PR:Q9UHC1 denotes Mlh3
T270 1352-1359 GO:0051321 denotes meiosis

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-53 DRI_Background denotes Meiotic arrest and aneuploidy in MLH3-deficient mice.
T2 54-196 DRI_Challenge denotes MutL homolog 3 (Mlh3) is a member of a family of proteins conserved during evolution and having dual roles in DNA mismatch repair and meiosis.
T3 197-423 DRI_Background denotes The pathway in eukaryotes consists of the DNA-binding components, which are the homologs of the bacterial MutS protein (MSH 2 6), and the MutL homologs, which bind to the MutS homologs and are essential for the repair process.
T4 424-661 DRI_Approach denotes Three of the six homologs of MutS that function in these processes, Msh2, Msh3 and Msh6, are involved in the mismatch repair of mutations, frameshifts and replication errors, and two others, Msh4 and Msh5, have specific roles in meiosis.
T5 662-848 DRI_Outcome denotes Of the four MutL homologs, Mlh1, Mlh3, Pms1 and Pms2, three are involved in mismatch repair and at least two, Pms2 and Mlh1, are essential for meiotic progression in both yeast and mice.
T6 849-949 DRI_Approach denotes To assess the role of Mlh3 in mammalian meiosis, we have generated and characterized Mlh3(-/-) mice.
T7 950-1006 DRI_Outcome denotes Here we show that Mlh3(-/-) mice are viable but sterile.
T8 1007-1276 DRI_Approach denotes Mlh3 is required for Mlh1 binding to meiotic chromosomes and localizes to meiotic chromosomes from the mid pachynema stage of prophase I. Mlh3(-/-) spermatocytes reach metaphase before succumbing to apoptosis, but oocytes fail to complete meiosis I after fertilization.
T9 1277-1360 DRI_Outcome denotes Our results show that Mlh3 has an essential and distinct role in mammalian meiosis.