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PubMed:12084720 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-132 Sentence denotes Identification of human male germ cell-associated kinase, a kinase transcriptionally activated by androgen in prostate cancer cells.
T2 133-228 Sentence denotes Androgen is involved in both normal development and malignant transformation of prostate cells.
T3 229-318 Sentence denotes The signal transduction pathways associated with these processes are not well understood.
T4 319-536 Sentence denotes Using a novel kinase display approach, we have identified a protein kinase, human male germ cell-associated kinase (hMAK), which is transcriptionally induced by the androgenic hormone 5alpha-dihydrotestosterone (DHT).
T5 537-652 Sentence denotes The kinetics of induction is rapid and dose-dependent, and the induction is not blocked by cycloheximide treatment.
T6 653-775 Sentence denotes Real time reverse transcription-PCR studies demonstrated a 9-fold induction of hMAK by 10 nm DHT at 24 h post-stimulation.
T7 776-905 Sentence denotes The expression levels of hMAK in prostate cancer cell lines are in general higher than those of normal prostate epithelial cells.
T8 906-1003 Sentence denotes A reverse transcription-PCR product encompassing the entire hMAK open reading frame was isolated.
T9 1004-1201 Sentence denotes The results from sequencing analysis showed that the hMAK protein is 623 amino acids in length and contains a kinase catalytic domain at its N terminus, followed by a proline/glutamine-rich domain.
T10 1202-1357 Sentence denotes The catalytic domain of this kinase contains sequence motifs related to both the cyclin-dependent kinase and the mitogen-activated protein kinase families.
T11 1358-1524 Sentence denotes When expressed in COS1 cells, hMAK is kinase-active as demonstrated by autophosphorylation and phosphorylation of exogenous substrate and is localized in the nucleus.
T12 1525-1685 Sentence denotes A 3.7-kilobase pair promoter of the hMAK locus was isolated from a human genomic DNA bacterial artificial chromosome clone and was shown to be activated by DHT.
T13 1686-1831 Sentence denotes This activation can be blocked by an anti-androgen drug bicalutamide (Casodex), implicating the involvement of androgen receptor in this process.
T14 1832-1995 Sentence denotes Taken together, these data suggest that hMAK is a protein kinase targeted by androgen that may participate in androgen-mediated signaling in prostate cancer cells.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 24-28 http://purl.obolibrary.org/obo/MAT_0000029 denotes male
T2 29-38 http://purl.obolibrary.org/obo/MAT_0000334 denotes germ cell
T3 110-118 http://purl.obolibrary.org/obo/MAT_0000078 denotes prostate
T4 213-221 http://purl.obolibrary.org/obo/MAT_0000078 denotes prostate
T5 401-405 http://purl.obolibrary.org/obo/MAT_0000029 denotes male
T6 406-415 http://purl.obolibrary.org/obo/MAT_0000334 denotes germ cell
T7 809-817 http://purl.obolibrary.org/obo/MAT_0000078 denotes prostate
T8 879-887 http://purl.obolibrary.org/obo/MAT_0000078 denotes prostate
T9 1973-1981 http://purl.obolibrary.org/obo/MAT_0000078 denotes prostate

FSU-PRGE

Id Subject Object Predicate Lexical cue
T1 24-56 protein denotes male germ cell-associated kinase
T2 60-66 protein denotes kinase
T3 333-339 protein denotes kinase
T4 379-393 protein denotes protein kinase
T5 401-433 protein denotes male germ cell-associated kinase
T6 435-439 protein denotes hMAK
T7 732-736 protein denotes hMAK
T8 801-805 protein denotes hMAK
T9 966-970 protein denotes hMAK
T10 1057-1061 protein denotes hMAK
T11 1114-1120 protein denotes kinase
T12 1231-1237 protein denotes kinase
T13 1283-1356 protein denotes cyclin-dependent kinase and the mitogen-activated protein kinase families
T14 1388-1392 protein denotes hMAK
T15 1396-1402 protein denotes kinase
T16 1561-1565 protein denotes hMAK
T17 1797-1814 protein denotes androgen receptor
T18 1872-1876 protein denotes hMAK
T19 1882-1896 protein denotes protein kinase

PIR-corpus2

Id Subject Object Predicate Lexical cue
T1 18-56 protein denotes human male germ cell-associated kinase
T2 60-66 protein denotes kinase
T3 333-339 protein denotes kinase
T4 379-393 protein denotes protein kinase
T5 395-405 protein denotes human male
T6 732-736 protein denotes hMAK
T7 801-805 protein denotes hMAK
T8 966-970 protein denotes hMAK
T9 1057-1069 protein denotes hMAK protein
T10 1114-1120 protein denotes kinase
T11 1231-1237 protein denotes kinase
T12 1283-1306 protein denotes cyclin-dependent kinase
T13 1315-1347 protein denotes mitogen-activated protein kinase
T14 1388-1392 protein denotes hMAK
T15 1396-1402 protein denotes kinase
T16 1561-1565 protein denotes hMAK
T17 1797-1814 protein denotes androgen receptor
T18 1872-1876 protein denotes hMAK
T19 1882-1889 protein denotes protein

PIR-corpus1

Id Subject Object Predicate Lexical cue
T1 24-56 protein denotes male germ cell-associated kinase
T2 60-66 protein denotes kinase
T3 401-405 protein denotes male
T4 435-439 acronym denotes hMAK
T5 732-736 protein denotes hMAK
T6 801-805 protein denotes hMAK
T7 1057-1069 protein denotes hMAK protein
T8 1231-1237 protein denotes kinase
T9 1388-1392 protein denotes hMAK
T10 1797-1814 protein denotes androgen receptor
T11 1872-1876 protein denotes hMAK
T12 1882-1889 protein denotes protein

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 110-125 Phenotype denotes prostate cancer HP:0012125
T2 809-824 Phenotype denotes prostate cancer HP:0012125
T3 1973-1988 Phenotype denotes prostate cancer HP:0012125

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 110-125 Disease denotes prostate cancer http://purl.obolibrary.org/obo/MONDO_0008315
T2 809-824 Disease denotes prostate cancer http://purl.obolibrary.org/obo/MONDO_0008315
T3 1973-1988 Disease denotes prostate cancer http://purl.obolibrary.org/obo/MONDO_0008315

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 18-23 OrganismTaxon denotes human 9606
T2 395-400 OrganismTaxon denotes human 9606
T3 1592-1597 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 24-38 Body_part denotes male germ cell http://purl.obolibrary.org/obo/CL_0000015
T2 110-118 Body_part denotes prostate http://purl.obolibrary.org/obo/UBERON_0002367
T3 213-221 Body_part denotes prostate http://purl.obolibrary.org/obo/UBERON_0002367
T4 401-415 Body_part denotes male germ cell http://purl.obolibrary.org/obo/CL_0000015
T5 809-817 Body_part denotes prostate http://purl.obolibrary.org/obo/UBERON_0002367
T6 879-904 Body_part denotes prostate epithelial cells http://purl.obolibrary.org/obo/CL_0002231
T7 1516-1523 Body_part denotes nucleus http://purl.obolibrary.org/obo/GO_0005634|http://purl.obolibrary.org/obo/UBERON_0000125
T9 1631-1641 Body_part denotes chromosome http://purl.obolibrary.org/obo/GO_0005694
T10 1973-1981 Body_part denotes prostate http://purl.obolibrary.org/obo/UBERON_0002367

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 24-28 Body_part denotes male http://purl.obolibrary.org/obo/MAT_0000029
T2 29-38 Body_part denotes germ cell http://purl.obolibrary.org/obo/MAT_0000334
T3 110-118 Body_part denotes prostate http://purl.obolibrary.org/obo/MAT_0000078
T4 213-221 Body_part denotes prostate http://purl.obolibrary.org/obo/MAT_0000078
T5 401-405 Body_part denotes male http://purl.obolibrary.org/obo/MAT_0000029
T6 406-415 Body_part denotes germ cell http://purl.obolibrary.org/obo/MAT_0000334
T7 809-817 Body_part denotes prostate http://purl.obolibrary.org/obo/MAT_0000078
T8 879-887 Body_part denotes prostate http://purl.obolibrary.org/obo/MAT_0000078
T9 1973-1981 Body_part denotes prostate http://purl.obolibrary.org/obo/MAT_0000078

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 24-38 Cell denotes male germ cell http://purl.obolibrary.org/obo/CL:0000015
T2 29-38 Cell denotes germ cell http://purl.obolibrary.org/obo/CL:0000586
T3 119-131 Cell denotes cancer cells http://purl.obolibrary.org/obo/CL:0001064
T4 401-415 Cell denotes male germ cell http://purl.obolibrary.org/obo/CL:0000015
T5 406-415 Cell denotes germ cell http://purl.obolibrary.org/obo/CL:0000586
T6 818-829 Cell denotes cancer cell http://purl.obolibrary.org/obo/CL:0001064
T7 879-904 Cell denotes prostate epithelial cells http://purl.obolibrary.org/obo/CL:0002231
T8 1982-1994 Cell denotes cancer cells http://purl.obolibrary.org/obo/CL:0001064