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PubMed:12082094 JSONTXT

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Glycosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 52-58 Cell denotes type I http://purl.obolibrary.org/obo/CL:0004120|http://purl.obolibrary.org/obo/CL:0004138
T3 122-134 Cell denotes osteoblastic http://purl.obolibrary.org/obo/CL:0000062
T4 154-166 Cell denotes chondrocytes http://purl.obolibrary.org/obo/CL:0000138
T5 321-332 Cell denotes chondrocyte http://purl.obolibrary.org/obo/CL:0000138
T6 471-483 Cell denotes chondrocytes http://purl.obolibrary.org/obo/CL:0000138
T7 488-500 Cell denotes chondrocytic http://purl.obolibrary.org/obo/CL:0000138
T8 664-689 Cell denotes hypertrophic chondrocytes http://purl.obolibrary.org/obo/CL:0000743
T9 890-901 Cell denotes osteoblasts http://purl.obolibrary.org/obo/CL:0000062
T10 973-979 Cell denotes type I http://purl.obolibrary.org/obo/CL:0004120|http://purl.obolibrary.org/obo/CL:0004138
T12 1182-1194 Cell denotes chondrocytes http://purl.obolibrary.org/obo/CL:0000138
T13 1253-1265 Cell denotes osteoblastic http://purl.obolibrary.org/obo/CL:0000062
T14 1285-1297 Cell denotes chondrocytes http://purl.obolibrary.org/obo/CL:0000138
T15 1409-1421 Cell denotes chondrocytes http://purl.obolibrary.org/obo/CL:0000138
T16 1493-1505 Cell denotes chondrocytic http://purl.obolibrary.org/obo/CL:0000138
T17 1521-1533 Cell denotes osteoblastic http://purl.obolibrary.org/obo/CL:0000062
T18 1682-1693 Cell denotes chondrocyte http://purl.obolibrary.org/obo/CL:0000138
T19 1698-1708 Cell denotes osteoblast http://purl.obolibrary.org/obo/CL:0000062

sentences

Id Subject Object Predicate Lexical cue
T1 0-167 Sentence denotes Functions of transforming growth factor-beta family type I receptors and Smad proteins in the hypertrophic maturation and osteoblastic differentiation of chondrocytes.
T2 168-410 Sentence denotes We investigated the effects of bone morphogenetic protein (BMP)-2, a member of the transforming growth factor-beta superfamily, on the regulation of the chondrocyte phenotype, and we identified signaling molecules involved in this regulation.
T3 411-513 Sentence denotes BMP-2 triggers three concomitant responses in mouse primary chondrocytes and chondrocytic MC615 cells.
T4 514-582 Sentence denotes First, BMP-2 stimulates expression or synthesis of type II collagen.
T5 583-824 Sentence denotes Second, BMP-2 induces expression of molecular markers characteristic of pre- and hypertrophic chondrocytes, such as Indian hedgehog, parathyroid hormone/parathyroid hormone-related peptide receptor, type X collagen, and alkaline phosphatase.
T6 825-902 Sentence denotes Third, BMP-2 induces osteocalcin expression, a specific trait of osteoblasts.
T7 903-1065 Sentence denotes Constitutively active forms of transforming growth factor-beta family type I receptors and Smad proteins were overexpressed to address their role in this process.
T8 1066-1212 Sentence denotes Activin receptor-like kinase (ALK)-1, ALK-2, ALK-3, and ALK-6 were able to reproduce the hypertrophic maturation of chondrocytes induced by BMP-2.
T9 1213-1315 Sentence denotes In addition, ALK-2 mimicked further the osteoblastic differentiation of chondrocytes induced by BMP-2.
T10 1316-1467 Sentence denotes In the presence of BMP-2, Smad1, Smad5, and Smad8 potentiated the hypertrophic maturation of chondrocytes, but failed to induce osteocalcin expression.
T11 1468-1567 Sentence denotes Smad6 and Smad7 impaired chondrocytic expression and osteoblastic differentiation induced by BMP-2.
T12 1568-1807 Sentence denotes Thus, our results indicate that Smad-mediated pathways are essential for the regulation of the different steps of chondrocyte and osteoblast differentiation and suggest that additional Smad-independent pathways might be activated by ALK-2.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 199-203 http://purl.obolibrary.org/obo/MAT_0000299 denotes bone
T2 716-727 http://purl.obolibrary.org/obo/MAT_0000082 denotes parathyroid
T3 736-747 http://purl.obolibrary.org/obo/MAT_0000082 denotes parathyroid

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 890-901 HP_0011846 denotes osteoblasts
T2 1253-1265 HP_0011846 denotes osteoblastic
T3 1521-1533 HP_0011846 denotes osteoblastic
T4 1698-1708 HP_0011846 denotes osteoblast

FSU-PRGE

Id Subject Object Predicate Lexical cue
T1 13-68 protein denotes transforming growth factor-beta family type I receptors
T2 73-77 protein denotes Smad
T3 199-233 protein denotes bone morphogenetic protein (BMP)-2
T4 251-294 protein denotes transforming growth factor-beta superfamily
T5 411-416 protein denotes BMP-2
T6 521-526 protein denotes BMP-2
T7 565-581 protein denotes type II collagen
T8 591-596 protein denotes BMP-2
T9 699-714 protein denotes Indian hedgehog
T10 716-780 protein denotes parathyroid hormone/parathyroid hormone-related peptide receptor
T11 782-797 protein denotes type X collagen
T12 803-823 protein denotes alkaline phosphatase
T13 832-837 protein denotes BMP-2
T14 846-857 protein denotes osteocalcin
T15 934-989 protein denotes transforming growth factor-beta family type I receptors
T16 994-998 protein denotes Smad
T17 1066-1102 protein denotes Activin receptor-like kinase (ALK)-1
T18 1104-1109 protein denotes ALK-2
T19 1111-1116 protein denotes ALK-3
T20 1122-1127 protein denotes ALK-6
T21 1206-1211 protein denotes BMP-2
T22 1226-1231 protein denotes ALK-2
T23 1309-1314 protein denotes BMP-2
T24 1335-1340 protein denotes BMP-2
T25 1342-1347 protein denotes Smad1
T26 1349-1354 protein denotes Smad5
T27 1360-1365 protein denotes Smad8
T28 1444-1455 protein denotes osteocalcin
T29 1468-1473 protein denotes Smad6
T30 1478-1483 protein denotes Smad7
T31 1561-1566 protein denotes BMP-2
T32 1600-1604 protein denotes Smad
T33 1753-1757 protein denotes Smad
T34 1801-1806 protein denotes ALK-2

PIR-corpus2

Id Subject Object Predicate Lexical cue
T1 13-68 protein denotes transforming growth factor-beta family type I receptors
T2 73-86 protein denotes Smad proteins
T3 199-233 protein denotes bone morphogenetic protein (BMP)-2
T4 251-282 protein denotes transforming growth factor-beta
T5 411-416 protein denotes BMP-2
T6 521-526 protein denotes BMP-2
T7 565-581 protein denotes type II collagen
T8 591-596 protein denotes BMP-2
T9 699-714 protein denotes Indian hedgehog
T10 716-727 protein denotes parathyroid
T11 782-797 protein denotes type X collagen
T12 803-823 protein denotes alkaline phosphatase
T13 832-837 protein denotes BMP-2
T14 846-857 protein denotes osteocalcin
T15 934-946 protein denotes transforming
T16 994-1007 protein denotes Smad proteins
T17 1066-1087 protein denotes Activin receptor-like
T18 1104-1109 protein denotes ALK-2
T19 1111-1116 protein denotes ALK-3
T20 1122-1127 protein denotes ALK-6
T21 1206-1211 protein denotes BMP-2
T22 1226-1231 protein denotes ALK-2
T23 1309-1314 protein denotes BMP-2
T24 1335-1340 protein denotes BMP-2
T25 1342-1347 protein denotes Smad1
T26 1349-1354 protein denotes Smad5
T27 1360-1365 protein denotes Smad8
T28 1444-1455 protein denotes osteocalcin
T29 1468-1473 protein denotes Smad6
T30 1478-1483 protein denotes Smad7
T31 1561-1566 protein denotes BMP-2
T32 1600-1604 protein denotes Smad
T33 1753-1757 protein denotes Smad
T34 1801-1806 protein denotes ALK-2

2015-BEL-Sample-2

Id Subject Object Predicate Lexical cue
BEL:20048082 591-822 p(MGI:Bmp2) increases r(MGI:Alpl) denotes BMP-2 induces expression of molecular markers characteristic of pre- and hypertrophic chondrocytes, such as Indian hedgehog, parathyroid hormone/parathyroid hormone-related peptide receptor, type X collagen, and alkaline phosphatas
BEL:20048098 591-822 p(MGI:Bmp2) increases r(MGI:Col10a1) denotes BMP-2 induces expression of molecular markers characteristic of pre- and hypertrophic chondrocytes, such as Indian hedgehog, parathyroid hormone/parathyroid hormone-related peptide receptor, type X collagen, and alkaline phosphatas
BEL:20048112 591-822 p(MGI:Bmp2) increases r(MGI:Ihh) denotes BMP-2 induces expression of molecular markers characteristic of pre- and hypertrophic chondrocytes, such as Indian hedgehog, parathyroid hormone/parathyroid hormone-related peptide receptor, type X collagen, and alkaline phosphatas
BEL:20048122 591-822 p(MGI:Bmp2) increases r(MGI:Pth1r) denotes BMP-2 induces expression of molecular markers characteristic of pre- and hypertrophic chondrocytes, such as Indian hedgehog, parathyroid hormone/parathyroid hormone-related peptide receptor, type X collagen, and alkaline phosphatas

PIR-corpus1

Id Subject Object Predicate Lexical cue
T1 13-68 protein denotes transforming growth factor-beta family type I receptors
T2 73-86 protein denotes Smad proteins
T3 199-233 protein denotes bone morphogenetic protein (BMP)-2
T4 411-416 protein denotes BMP-2
T5 521-526 protein denotes BMP-2
T6 565-581 protein denotes type II collagen
T7 591-596 protein denotes BMP-2
T8 699-714 protein denotes Indian hedgehog
T9 716-727 protein denotes parathyroid
T10 782-797 protein denotes type X collagen
T11 803-823 protein denotes alkaline phosphatase
T12 832-837 protein denotes BMP-2
T13 846-857 protein denotes osteocalcin
T14 925-946 protein denotes forms of transforming
T15 994-1007 protein denotes Smad proteins
T16 1066-1087 protein denotes Activin receptor-like
T17 1104-1109 protein denotes ALK-2
T18 1111-1116 protein denotes ALK-3
T19 1122-1127 protein denotes ALK-6
T20 1206-1211 protein denotes BMP-2
T21 1226-1231 protein denotes ALK-2
T22 1309-1314 protein denotes BMP-2
T23 1335-1340 protein denotes BMP-2
T24 1342-1347 protein denotes Smad1
T25 1349-1354 protein denotes Smad5
T26 1360-1365 protein denotes Smad8
T27 1444-1455 protein denotes osteocalcin
T28 1468-1473 protein denotes Smad6
T29 1478-1483 protein denotes Smad7
T30 1561-1566 protein denotes BMP-2
T31 1600-1604 protein denotes Smad
T32 1753-1757 protein denotes Smad
T33 1801-1806 protein denotes ALK-2

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 199-203 Body_part denotes bone http://purl.obolibrary.org/obo/MAT_0000299
T2 716-727 Body_part denotes parathyroid http://purl.obolibrary.org/obo/MAT_0000082
T3 736-747 Body_part denotes parathyroid http://purl.obolibrary.org/obo/MAT_0000082

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 457-462 OrganismTaxon denotes mouse 10088|10090

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 122-134 Body_part denotes osteoblastic http://purl.obolibrary.org/obo/CL_0000062
T2 154-166 Body_part denotes chondrocytes http://purl.obolibrary.org/obo/CL_0000138
T3 199-203 Body_part denotes bone http://purl.obolibrary.org/obo/UBERON_0001474|http://purl.obolibrary.org/obo/UBERON_0002481
T5 321-332 Body_part denotes chondrocyte http://purl.obolibrary.org/obo/CL_0000138
T6 471-483 Body_part denotes chondrocytes http://purl.obolibrary.org/obo/CL_0000138
T7 488-500 Body_part denotes chondrocytic http://purl.obolibrary.org/obo/CL_0000138
T8 677-689 Body_part denotes chondrocytes http://purl.obolibrary.org/obo/CL_0000138
T9 716-727 Body_part denotes parathyroid http://purl.obolibrary.org/obo/UBERON_0001132
T10 736-747 Body_part denotes parathyroid http://purl.obolibrary.org/obo/UBERON_0001132
T11 890-901 Body_part denotes osteoblasts http://purl.obolibrary.org/obo/CL_0000062
T12 1182-1194 Body_part denotes chondrocytes http://purl.obolibrary.org/obo/CL_0000138
T13 1253-1265 Body_part denotes osteoblastic http://purl.obolibrary.org/obo/CL_0000062
T14 1285-1297 Body_part denotes chondrocytes http://purl.obolibrary.org/obo/CL_0000138
T15 1409-1421 Body_part denotes chondrocytes http://purl.obolibrary.org/obo/CL_0000138
T16 1493-1505 Body_part denotes chondrocytic http://purl.obolibrary.org/obo/CL_0000138
T17 1521-1533 Body_part denotes osteoblastic http://purl.obolibrary.org/obo/CL_0000062
T18 1682-1693 Body_part denotes chondrocyte http://purl.obolibrary.org/obo/CL_0000138
T19 1698-1708 Body_part denotes osteoblast http://purl.obolibrary.org/obo/CL_0000062