PubMed:12076079
Annnotations
c_corpus
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 14-20 | UBERON:0027368 | denotes | matrix |
| T2 | 14-39 | D020782 | denotes | matrix metalloproteinases |
| T4 | 50-60 | CHEBI:35222 | denotes | inhibitors |
| T5 | 77-84 | D012172 | denotes | retinal |
| T6 | 77-84 | CHEBI:17898 | denotes | retinal |
| T7 | 77-84 | D012172 | denotes | retinal |
| T8 | 77-84 | CHEBI:15035 | denotes | retinal |
| T9 | 77-84 | CHEBI:45487 | denotes | retinal |
| T12 | 85-112 | D015427 | denotes | ischemia-reperfusion injury |
| T13 | 85-112 | D015427 | denotes | ischemia-reperfusion injury |
| T16 | 116-120 | 10118 | denotes | rats |
| T17 | 116-120 | 10116 | denotes | rats |
| T18 | 116-120 | D051381 | denotes | rats |
| T19 | 129-147 | D045726 | denotes | metalloproteinases |
| T20 | 149-153 | D020782 | denotes | MMPs |
| T22 | 159-173 | 8031 | denotes | endopeptidases |
| T21 | 159-173 | D010450 | denotes | endopeptidases |
| T24 | 191-211 | GO:0031012 | denotes | extracellular matrix |
| T25 | 205-211 | UBERON:0027368 | denotes | matrix |
| T26 | 213-216 | PR:Q13201 | denotes | ECM |
| T28 | 213-216 | PR:000010492 | denotes | ECM |
| T27 | 213-216 | UBERON:4000022 | denotes | ECM |
| T29 | 242-254 | GO:0009405 | denotes | pathogenesis |
| T30 | 258-265 | D012172 | denotes | retinal |
| T31 | 258-265 | CHEBI:17898 | denotes | retinal |
| T32 | 258-265 | D012172 | denotes | retinal |
| T33 | 258-265 | CHEBI:15035 | denotes | retinal |
| T34 | 258-265 | CHEBI:45487 | denotes | retinal |
| T35 | 258-278 | D012162 | denotes | retinal degeneration |
| T36 | 258-278 | D012162 | denotes | retinal degeneration |
| T37 | 290-296 | UBERON:0000479 | denotes | tissue |
| T38 | 297-307 | CHEBI:35222 | denotes | inhibitors |
| T39 | 311-329 | D045726 | denotes | metalloproteinases |
| T40 | 423-427 | D020782 | denotes | MMPs |
| T41 | 429-432 | CHEBI:340824 | denotes | MMP |
| T44 | 429-432 | CHEBI:59761 | denotes | MMP |
| T45 | 429-434 | PR:P08253 | denotes | MMP-2 |
| T46 | 429-434 | Q9GLE5 | denotes | MMP-2 |
| T47 | 429-434 | P08253 | denotes | MMP-2 |
| T48 | 429-434 | Q90611 | denotes | MMP-2 |
| T50 | 429-434 | PR:Q8MPP3 | denotes | MMP-2 |
| T51 | 429-434 | P33436 | denotes | MMP-2 |
| T52 | 429-434 | PR:Q90611 | denotes | MMP-2 |
| T53 | 429-434 | PR:P33436 | denotes | MMP-2 |
| T54 | 429-434 | PR:000010479 | denotes | MMP-2 |
| T55 | 429-434 | PR:P33434 | denotes | MMP-2 |
| T56 | 429-434 | P33434 | denotes | MMP-2 |
| T57 | 429-434 | P50757 | denotes | MMP-2 |
| T49 | 429-434 | GO:0004228 | denotes | MMP-2 |
| T58 | 439-442 | CHEBI:340824 | denotes | MMP |
| T61 | 439-442 | CHEBI:59761 | denotes | MMP |
| T62 | 439-444 | PR:P50282 | denotes | MMP-9 |
| T63 | 439-444 | PR:P14780 | denotes | MMP-9 |
| T64 | 439-444 | P14780 | denotes | MMP-9 |
| T65 | 439-444 | PR:P41245 | denotes | MMP-9 |
| T66 | 439-444 | P41246 | denotes | MMP-9 |
| T67 | 439-444 | P41245 | denotes | MMP-9 |
| T68 | 439-444 | PR:P52176 | denotes | MMP-9 |
| T69 | 439-444 | P50282 | denotes | MMP-9 |
| T71 | 439-444 | PR:000010491 | denotes | MMP-9 |
| T72 | 439-444 | P52176 | denotes | MMP-9 |
| T73 | 439-444 | O18733 | denotes | MMP-9 |
| T70 | 439-444 | GO:0004229 | denotes | MMP-9 |
| T74 | 464-474 | CHEBI:35222 | denotes | inhibitors |
| T79 | 476-482 | P81546 | denotes | TIMP-1 |
| T80 | 476-482 | O02722 | denotes | TIMP-1 |
| T81 | 476-482 | P49061 | denotes | TIMP-1 |
| T82 | 476-482 | P50122 | denotes | TIMP-1 |
| T83 | 476-482 | P20614 | denotes | TIMP-1 |
| T84 | 476-482 | P12032 | denotes | TIMP-1 |
| T85 | 476-482 | P35624 | denotes | TIMP-1 |
| T86 | 476-482 | P20414 | denotes | TIMP-1 |
| T87 | 476-482 | Q95KL9 | denotes | TIMP-1 |
| T88 | 476-482 | Q5RC60 | denotes | TIMP-1 |
| T89 | 476-482 | PR:P30120 | denotes | TIMP-1 |
| T90 | 476-482 | P30120 | denotes | TIMP-1 |
| T91 | 476-482 | PR:000016352 | denotes | TIMP-1 |
| T93 | 476-482 | PR:P12032 | denotes | TIMP-1 |
| T94 | 476-482 | PR:P01033 | denotes | TIMP-1 |
| T95 | 476-482 | P01033 | denotes | TIMP-1 |
| T92 | 476-482 | D019715 | denotes | TIMP-1 |
| T100 | 487-493 | PR:P16035 | denotes | TIMP-2 |
| T101 | 487-493 | PR:000016353 | denotes | TIMP-2 |
| T102 | 487-493 | O42146 | denotes | TIMP-2 |
| T103 | 487-493 | Q9TRZ7 | denotes | TIMP-2 |
| T104 | 487-493 | Q9TTY1 | denotes | TIMP-2 |
| T105 | 487-493 | Q60453 | denotes | TIMP-2 |
| T106 | 487-493 | P16035 | denotes | TIMP-2 |
| T108 | 487-493 | P25785 | denotes | TIMP-2 |
| T109 | 487-493 | P16368 | denotes | TIMP-2 |
| T110 | 487-493 | O77717 | denotes | TIMP-2 |
| T111 | 487-493 | PR:P25785 | denotes | TIMP-2 |
| T112 | 487-493 | P30121 | denotes | TIMP-2 |
| T113 | 487-493 | Q9WUC6 | denotes | TIMP-2 |
| T114 | 487-493 | PR:P30121 | denotes | TIMP-2 |
| T115 | 487-493 | PR:O42146 | denotes | TIMP-2 |
| T107 | 487-493 | D019716 | denotes | TIMP-2 |
| T116 | 514-521 | D012172 | denotes | retinal |
| T117 | 514-521 | CHEBI:17898 | denotes | retinal |
| T118 | 514-521 | D012172 | denotes | retinal |
| T119 | 514-521 | CHEBI:15035 | denotes | retinal |
| T120 | 514-521 | CHEBI:45487 | denotes | retinal |
| T123 | 522-549 | D015427 | denotes | ischemia-reperfusion injury |
| T124 | 522-549 | D015427 | denotes | ischemia-reperfusion injury |
| T127 | 551-558 | D012172 | denotes | Retinal |
| T128 | 551-558 | CHEBI:17898 | denotes | Retinal |
| T129 | 551-558 | D012172 | denotes | Retinal |
| T130 | 551-558 | CHEBI:15035 | denotes | Retinal |
| T131 | 551-558 | CHEBI:45487 | denotes | Retinal |
| T134 | 559-586 | D015427 | denotes | ischemia-reperfusion injury |
| T135 | 559-586 | D015427 | denotes | ischemia-reperfusion injury |
| T138 | 609-614 | UBERON:0007023 | denotes | adult |
| T139 | 615-619 | 10118 | denotes | rats |
| T140 | 615-619 | 10116 | denotes | rats |
| T141 | 615-619 | D051381 | denotes | rats |
| T142 | 662-670 | D007511 | denotes | ischemia |
| T143 | 662-670 | D007511 | denotes | ischemia |
| T145 | 738-741 | PR:P63003-1 | denotes | rat |
| T146 | 738-741 | PR:Q2G0B1 | denotes | rat |
| T147 | 738-741 | PR:Q8VHJ4 | denotes | rat |
| T144 | 738-741 | 10116 | denotes | rat |
| T148 | 738-741 | D051381 | denotes | rat |
| T149 | 764-771 | D012172 | denotes | Retinal |
| T150 | 764-771 | CHEBI:17898 | denotes | Retinal |
| T151 | 764-771 | D012172 | denotes | Retinal |
| T152 | 764-771 | CHEBI:15035 | denotes | Retinal |
| T153 | 764-771 | CHEBI:45487 | denotes | Retinal |
| T154 | 839-842 | CHEBI:340824 | denotes | MMP |
| T157 | 839-842 | CHEBI:59761 | denotes | MMP |
| T158 | 839-844 | PR:P08253 | denotes | MMP-2 |
| T159 | 839-844 | Q9GLE5 | denotes | MMP-2 |
| T160 | 839-844 | P08253 | denotes | MMP-2 |
| T161 | 839-844 | Q90611 | denotes | MMP-2 |
| T163 | 839-844 | PR:Q8MPP3 | denotes | MMP-2 |
| T164 | 839-844 | P33436 | denotes | MMP-2 |
| T165 | 839-844 | PR:Q90611 | denotes | MMP-2 |
| T166 | 839-844 | PR:P33436 | denotes | MMP-2 |
| T167 | 839-844 | PR:000010479 | denotes | MMP-2 |
| T168 | 839-844 | PR:P33434 | denotes | MMP-2 |
| T169 | 839-844 | P33434 | denotes | MMP-2 |
| T170 | 839-844 | P50757 | denotes | MMP-2 |
| T162 | 839-844 | GO:0004228 | denotes | MMP-2 |
| T175 | 864-870 | P81546 | denotes | TIMP-1 |
| T176 | 864-870 | O02722 | denotes | TIMP-1 |
| T177 | 864-870 | P49061 | denotes | TIMP-1 |
| T178 | 864-870 | P50122 | denotes | TIMP-1 |
| T179 | 864-870 | P20614 | denotes | TIMP-1 |
| T180 | 864-870 | P12032 | denotes | TIMP-1 |
| T181 | 864-870 | P35624 | denotes | TIMP-1 |
| T182 | 864-870 | P20414 | denotes | TIMP-1 |
| T183 | 864-870 | Q95KL9 | denotes | TIMP-1 |
| T184 | 864-870 | Q5RC60 | denotes | TIMP-1 |
| T185 | 864-870 | PR:P30120 | denotes | TIMP-1 |
| T186 | 864-870 | P30120 | denotes | TIMP-1 |
| T187 | 864-870 | PR:000016352 | denotes | TIMP-1 |
| T189 | 864-870 | PR:P12032 | denotes | TIMP-1 |
| T190 | 864-870 | PR:P01033 | denotes | TIMP-1 |
| T191 | 864-870 | P01033 | denotes | TIMP-1 |
| T188 | 864-870 | D019715 | denotes | TIMP-1 |
| T196 | 875-881 | PR:P16035 | denotes | TIMP-2 |
| T197 | 875-881 | PR:000016353 | denotes | TIMP-2 |
| T198 | 875-881 | O42146 | denotes | TIMP-2 |
| T199 | 875-881 | Q9TRZ7 | denotes | TIMP-2 |
| T200 | 875-881 | Q9TTY1 | denotes | TIMP-2 |
| T201 | 875-881 | Q60453 | denotes | TIMP-2 |
| T202 | 875-881 | P16035 | denotes | TIMP-2 |
| T204 | 875-881 | P25785 | denotes | TIMP-2 |
| T205 | 875-881 | P16368 | denotes | TIMP-2 |
| T206 | 875-881 | O77717 | denotes | TIMP-2 |
| T207 | 875-881 | PR:P25785 | denotes | TIMP-2 |
| T208 | 875-881 | P30121 | denotes | TIMP-2 |
| T209 | 875-881 | Q9WUC6 | denotes | TIMP-2 |
| T210 | 875-881 | PR:P30121 | denotes | TIMP-2 |
| T211 | 875-881 | PR:O42146 | denotes | TIMP-2 |
| T203 | 875-881 | D019716 | denotes | TIMP-2 |
| T212 | 898-905 | SO:0001031 | denotes | reverse |
| T216 | 922-929 | PR:000000001 | denotes | protein |
| T214 | 922-929 | CHEBI:36080 | denotes | protein |
| T215 | 922-929 | CHEBI:11122 | denotes | protein |
| T217 | 922-929 | SO:0000104 | denotes | protein |
| T213 | 922-929 | GO:0003675 | denotes | protein |
| T218 | 1052-1055 | CHEBI:340824 | denotes | MMP |
| T221 | 1052-1055 | CHEBI:59761 | denotes | MMP |
| T222 | 1052-1057 | PR:P50282 | denotes | MMP-9 |
| T223 | 1052-1057 | PR:P14780 | denotes | MMP-9 |
| T224 | 1052-1057 | P14780 | denotes | MMP-9 |
| T225 | 1052-1057 | PR:P41245 | denotes | MMP-9 |
| T226 | 1052-1057 | P41246 | denotes | MMP-9 |
| T227 | 1052-1057 | P41245 | denotes | MMP-9 |
| T228 | 1052-1057 | PR:P52176 | denotes | MMP-9 |
| T229 | 1052-1057 | P50282 | denotes | MMP-9 |
| T231 | 1052-1057 | PR:000010491 | denotes | MMP-9 |
| T232 | 1052-1057 | P52176 | denotes | MMP-9 |
| T233 | 1052-1057 | O18733 | denotes | MMP-9 |
| T230 | 1052-1057 | GO:0004229 | denotes | MMP-9 |
| T234 | 1065-1071 | UBERON:0000966 | denotes | retina |
| T235 | 1114-1122 | C069860 | denotes | ProMMP-2 |
| T239 | 1175-1183 | C120487 | denotes | ProMMP-9 |
| T257 | 1376-1383 | D012172 | denotes | retinal |
| T258 | 1376-1383 | CHEBI:17898 | denotes | retinal |
| T259 | 1376-1383 | D012172 | denotes | retinal |
| T260 | 1376-1383 | CHEBI:15035 | denotes | retinal |
| T261 | 1376-1383 | CHEBI:45487 | denotes | retinal |
| T262 | 1429-1433 | D004492 | denotes | EDTA |
| T263 | 1429-1433 | CHEBI:42191 | denotes | EDTA |
| T264 | 1429-1433 | CHEBI:64755 | denotes | EDTA |
| T265 | 1429-1433 | D004492 | denotes | EDTA |
| T266 | 1497-1526 | C010024 | denotes | 4-aminophenylmercuric acetate |
| T267 | 1497-1526 | C010024 | denotes | 4-aminophenylmercuric acetate |
| T269 | 1519-1526 | 164 | denotes | acetate |
| T271 | 1528-1532 | PR:P54672 | denotes | APMA |
| T272 | 1620-1623 | CHEBI:340824 | denotes | MMP |
| T275 | 1620-1623 | CHEBI:59761 | denotes | MMP |
| T276 | 1620-1625 | PR:P08253 | denotes | MMP-2 |
| T277 | 1620-1625 | Q9GLE5 | denotes | MMP-2 |
| T278 | 1620-1625 | P08253 | denotes | MMP-2 |
| T279 | 1620-1625 | Q90611 | denotes | MMP-2 |
| T281 | 1620-1625 | PR:Q8MPP3 | denotes | MMP-2 |
| T282 | 1620-1625 | P33436 | denotes | MMP-2 |
| T283 | 1620-1625 | PR:Q90611 | denotes | MMP-2 |
| T284 | 1620-1625 | PR:P33436 | denotes | MMP-2 |
| T285 | 1620-1625 | PR:000010479 | denotes | MMP-2 |
| T286 | 1620-1625 | PR:P33434 | denotes | MMP-2 |
| T287 | 1620-1625 | P33434 | denotes | MMP-2 |
| T288 | 1620-1625 | P50757 | denotes | MMP-2 |
| T280 | 1620-1625 | GO:0004228 | denotes | MMP-2 |
| T292 | 1657-1664 | PR:000000001 | denotes | protein |
| T289 | 1657-1664 | GO:0003675 | denotes | protein |
| T293 | 1657-1664 | SO:0000104 | denotes | protein |
| T290 | 1657-1664 | CHEBI:36080 | denotes | protein |
| T291 | 1657-1664 | CHEBI:11122 | denotes | protein |
| T298 | 1724-1730 | P81546 | denotes | TIMP-1 |
| T299 | 1724-1730 | O02722 | denotes | TIMP-1 |
| T300 | 1724-1730 | P49061 | denotes | TIMP-1 |
| T301 | 1724-1730 | P50122 | denotes | TIMP-1 |
| T302 | 1724-1730 | P20614 | denotes | TIMP-1 |
| T303 | 1724-1730 | P12032 | denotes | TIMP-1 |
| T304 | 1724-1730 | P35624 | denotes | TIMP-1 |
| T305 | 1724-1730 | P20414 | denotes | TIMP-1 |
| T306 | 1724-1730 | Q95KL9 | denotes | TIMP-1 |
| T307 | 1724-1730 | Q5RC60 | denotes | TIMP-1 |
| T308 | 1724-1730 | PR:P30120 | denotes | TIMP-1 |
| T309 | 1724-1730 | P30120 | denotes | TIMP-1 |
| T310 | 1724-1730 | PR:000016352 | denotes | TIMP-1 |
| T312 | 1724-1730 | PR:P12032 | denotes | TIMP-1 |
| T313 | 1724-1730 | PR:P01033 | denotes | TIMP-1 |
| T314 | 1724-1730 | P01033 | denotes | TIMP-1 |
| T311 | 1724-1730 | D019715 | denotes | TIMP-1 |
| T319 | 1735-1741 | PR:P16035 | denotes | TIMP-2 |
| T320 | 1735-1741 | PR:000016353 | denotes | TIMP-2 |
| T321 | 1735-1741 | O42146 | denotes | TIMP-2 |
| T322 | 1735-1741 | Q9TRZ7 | denotes | TIMP-2 |
| T323 | 1735-1741 | Q9TTY1 | denotes | TIMP-2 |
| T324 | 1735-1741 | Q60453 | denotes | TIMP-2 |
| T325 | 1735-1741 | P16035 | denotes | TIMP-2 |
| T327 | 1735-1741 | P25785 | denotes | TIMP-2 |
| T328 | 1735-1741 | P16368 | denotes | TIMP-2 |
| T329 | 1735-1741 | O77717 | denotes | TIMP-2 |
| T330 | 1735-1741 | PR:P25785 | denotes | TIMP-2 |
| T331 | 1735-1741 | P30121 | denotes | TIMP-2 |
| T332 | 1735-1741 | Q9WUC6 | denotes | TIMP-2 |
| T333 | 1735-1741 | PR:P30121 | denotes | TIMP-2 |
| T334 | 1735-1741 | PR:O42146 | denotes | TIMP-2 |
| T326 | 1735-1741 | D019716 | denotes | TIMP-2 |
| T338 | 1742-1749 | PR:000000001 | denotes | protein |
| T335 | 1742-1749 | GO:0003675 | denotes | protein |
| T339 | 1742-1749 | SO:0000104 | denotes | protein |
| T336 | 1742-1749 | CHEBI:36080 | denotes | protein |
| T337 | 1742-1749 | CHEBI:11122 | denotes | protein |
| T343 | 1763-1770 | PR:000000001 | denotes | protein |
| T340 | 1763-1770 | GO:0003675 | denotes | protein |
| T344 | 1763-1770 | SO:0000104 | denotes | protein |
| T341 | 1763-1770 | CHEBI:36080 | denotes | protein |
| T342 | 1763-1770 | CHEBI:11122 | denotes | protein |
| T345 | 1793-1800 | SO:0001031 | denotes | reverse |
| T346 | 1849-1852 | CHEBI:340824 | denotes | MMP |
| T349 | 1849-1852 | CHEBI:59761 | denotes | MMP |
| T350 | 1849-1854 | PR:P50282 | denotes | MMP-9 |
| T351 | 1849-1854 | PR:P14780 | denotes | MMP-9 |
| T352 | 1849-1854 | P14780 | denotes | MMP-9 |
| T353 | 1849-1854 | PR:P41245 | denotes | MMP-9 |
| T354 | 1849-1854 | P41246 | denotes | MMP-9 |
| T355 | 1849-1854 | P41245 | denotes | MMP-9 |
| T356 | 1849-1854 | PR:P52176 | denotes | MMP-9 |
| T357 | 1849-1854 | P50282 | denotes | MMP-9 |
| T359 | 1849-1854 | PR:000010491 | denotes | MMP-9 |
| T360 | 1849-1854 | P52176 | denotes | MMP-9 |
| T361 | 1849-1854 | O18733 | denotes | MMP-9 |
| T358 | 1849-1854 | GO:0004229 | denotes | MMP-9 |
| T362 | 1879-1885 | UBERON:0000966 | denotes | retina |
| T363 | 1940-1943 | CHEBI:340824 | denotes | MMP |
| T366 | 1940-1943 | CHEBI:59761 | denotes | MMP |
| T367 | 1940-1945 | PR:P50282 | denotes | MMP-9 |
| T368 | 1940-1945 | PR:P14780 | denotes | MMP-9 |
| T369 | 1940-1945 | P14780 | denotes | MMP-9 |
| T370 | 1940-1945 | PR:P41245 | denotes | MMP-9 |
| T371 | 1940-1945 | P41246 | denotes | MMP-9 |
| T372 | 1940-1945 | P41245 | denotes | MMP-9 |
| T373 | 1940-1945 | PR:P52176 | denotes | MMP-9 |
| T374 | 1940-1945 | P50282 | denotes | MMP-9 |
| T376 | 1940-1945 | PR:000010491 | denotes | MMP-9 |
| T377 | 1940-1945 | P52176 | denotes | MMP-9 |
| T378 | 1940-1945 | O18733 | denotes | MMP-9 |
| T375 | 1940-1945 | GO:0004229 | denotes | MMP-9 |
| T380 | 1994-1997 | PR:P63003-1 | denotes | rat |
| T381 | 1994-1997 | PR:Q2G0B1 | denotes | rat |
| T382 | 1994-1997 | PR:Q8VHJ4 | denotes | rat |
| T379 | 1994-1997 | 10116 | denotes | rat |
| T383 | 1994-1997 | D051381 | denotes | rat |
| T384 | 1998-2004 | UBERON:0000966 | denotes | retina |
| T386 | 2073-2081 | C069860 | denotes | ProMMP-2 |
| T387 | 2086-2094 | C120487 | denotes | ProMMP-9 |
| T388 | 2149-2159 | CHEBI:35222 | denotes | inhibitors |
| T393 | 2161-2167 | P81546 | denotes | TIMP-1 |
| T394 | 2161-2167 | O02722 | denotes | TIMP-1 |
| T395 | 2161-2167 | P49061 | denotes | TIMP-1 |
| T396 | 2161-2167 | P50122 | denotes | TIMP-1 |
| T397 | 2161-2167 | P20614 | denotes | TIMP-1 |
| T398 | 2161-2167 | P12032 | denotes | TIMP-1 |
| T399 | 2161-2167 | P35624 | denotes | TIMP-1 |
| T400 | 2161-2167 | P20414 | denotes | TIMP-1 |
| T401 | 2161-2167 | Q95KL9 | denotes | TIMP-1 |
| T402 | 2161-2167 | Q5RC60 | denotes | TIMP-1 |
| T403 | 2161-2167 | PR:P30120 | denotes | TIMP-1 |
| T404 | 2161-2167 | P30120 | denotes | TIMP-1 |
| T405 | 2161-2167 | PR:000016352 | denotes | TIMP-1 |
| T407 | 2161-2167 | PR:P12032 | denotes | TIMP-1 |
| T408 | 2161-2167 | PR:P01033 | denotes | TIMP-1 |
| T409 | 2161-2167 | P01033 | denotes | TIMP-1 |
| T406 | 2161-2167 | D019715 | denotes | TIMP-1 |
| T414 | 2172-2178 | PR:P16035 | denotes | TIMP-2 |
| T415 | 2172-2178 | PR:000016353 | denotes | TIMP-2 |
| T416 | 2172-2178 | O42146 | denotes | TIMP-2 |
| T417 | 2172-2178 | Q9TRZ7 | denotes | TIMP-2 |
| T418 | 2172-2178 | Q9TTY1 | denotes | TIMP-2 |
| T419 | 2172-2178 | Q60453 | denotes | TIMP-2 |
| T420 | 2172-2178 | P16035 | denotes | TIMP-2 |
| T422 | 2172-2178 | P25785 | denotes | TIMP-2 |
| T423 | 2172-2178 | P16368 | denotes | TIMP-2 |
| T424 | 2172-2178 | O77717 | denotes | TIMP-2 |
| T425 | 2172-2178 | PR:P25785 | denotes | TIMP-2 |
| T426 | 2172-2178 | P30121 | denotes | TIMP-2 |
| T427 | 2172-2178 | Q9WUC6 | denotes | TIMP-2 |
| T428 | 2172-2178 | PR:P30121 | denotes | TIMP-2 |
| T429 | 2172-2178 | PR:O42146 | denotes | TIMP-2 |
| T421 | 2172-2178 | D019716 | denotes | TIMP-2 |
| T430 | 2222-2228 | UBERON:0000966 | denotes | retina |
| T431 | 2243-2247 | 10118 | denotes | rats |
| T432 | 2243-2247 | 10116 | denotes | rats |
| T433 | 2243-2247 | D051381 | denotes | rats |
| T434 | 2276-2279 | CHEBI:340824 | denotes | MMP |
| T437 | 2276-2279 | CHEBI:59761 | denotes | MMP |
| T438 | 2276-2281 | PR:P08253 | denotes | MMP-2 |
| T439 | 2276-2281 | Q9GLE5 | denotes | MMP-2 |
| T440 | 2276-2281 | P08253 | denotes | MMP-2 |
| T441 | 2276-2281 | Q90611 | denotes | MMP-2 |
| T443 | 2276-2281 | PR:Q8MPP3 | denotes | MMP-2 |
| T444 | 2276-2281 | P33436 | denotes | MMP-2 |
| T445 | 2276-2281 | PR:Q90611 | denotes | MMP-2 |
| T446 | 2276-2281 | PR:P33436 | denotes | MMP-2 |
| T447 | 2276-2281 | PR:000010479 | denotes | MMP-2 |
| T448 | 2276-2281 | PR:P33434 | denotes | MMP-2 |
| T449 | 2276-2281 | P33434 | denotes | MMP-2 |
| T450 | 2276-2281 | P50757 | denotes | MMP-2 |
| T442 | 2276-2281 | GO:0004228 | denotes | MMP-2 |
| T451 | 2286-2289 | CHEBI:340824 | denotes | MMP |
| T454 | 2286-2289 | CHEBI:59761 | denotes | MMP |
| T455 | 2286-2291 | PR:P50282 | denotes | MMP-9 |
| T456 | 2286-2291 | PR:P14780 | denotes | MMP-9 |
| T457 | 2286-2291 | P14780 | denotes | MMP-9 |
| T458 | 2286-2291 | PR:P41245 | denotes | MMP-9 |
| T459 | 2286-2291 | P41246 | denotes | MMP-9 |
| T460 | 2286-2291 | P41245 | denotes | MMP-9 |
| T461 | 2286-2291 | PR:P52176 | denotes | MMP-9 |
| T462 | 2286-2291 | P50282 | denotes | MMP-9 |
| T464 | 2286-2291 | PR:000010491 | denotes | MMP-9 |
| T465 | 2286-2291 | P52176 | denotes | MMP-9 |
| T466 | 2286-2291 | O18733 | denotes | MMP-9 |
| T463 | 2286-2291 | GO:0004229 | denotes | MMP-9 |
| T467 | 2344-2351 | D012172 | denotes | retinal |
| T468 | 2344-2351 | CHEBI:17898 | denotes | retinal |
| T469 | 2344-2351 | D012172 | denotes | retinal |
| T470 | 2344-2351 | CHEBI:15035 | denotes | retinal |
| T471 | 2344-2351 | CHEBI:45487 | denotes | retinal |
PubmedHPO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 258-278 | HP_0000546 | denotes | retinal degeneration |
UseCases_ArguminSci_Discourse
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-121 | DRI_Background | denotes | Expression of matrix metalloproteinases and their inhibitors in experimental retinal ischemia-reperfusion injury in rats. |
| T2 | 122-338 | DRI_Approach | denotes | Matrix metalloproteinases (MMPs) are endopeptidases that degrade the extracellular matrix (ECM) and are involved in the pathogenesis of retinal degeneration along with tissue inhibitors of metalloproteinases (TIMPs). |
| T3 | 339-550 | DRI_Background | denotes | The present study examined the expression and activation of two specific members of MMPs (MMP-2 and MMP-9) and their related inhibitors (TIMP-1 and TIMP-2) in an experimental retinal ischemia-reperfusion injury. |
| T4 | 551-643 | DRI_Background | denotes | Retinal ischemia-reperfusion injury (RIRI) was induced in adult rats with a ligation method. |
| T5 | 644-763 | DRI_Background | denotes | After one hour of ischemia and a varied reperfusion time (0, 3, 6, 12, 24, 48 and 76 hr), the rat eyes were enucleated. |
| T6 | 764-847 | DRI_Background | denotes | Retinal extracts underwent zymographic analysis to measure the activity of MMP-2/9. |
| T7 | 848-917 | DRI_Background | denotes | The activity of TIMP-1 and TIMP-2 was measured by reverse zymography. |
| T8 | 918-965 | DRI_Background | denotes | The protein level was examined by Western blot. |
| T9 | 966-1083 | DRI_Background | denotes | Immunohistochemistry analysis was undertaken to assess the anatomical distribution of MMP-9 in the retina after RIRI. |
| T10 | 1084-1174 | DRI_Background | denotes | The gelatinolytic activity of ProMMP-2 (72 kDa) was increased markedly at 6 hr after RIRI. |
| T11 | 1175-1338 | DRI_Approach | denotes | ProMMP-9 (92 kDa) was not detected in the control specimens, while it appeared at 3 hr, increased markedly at 6 hr, and reached maximal levels at 24 hr after RIRI. |
| T12 | 1339-1602 | DRI_Background | denotes | The gelatinolytic activity found ian retinal extracts was shown to be inhibited by 10 m M EDTA and activated in vitro by a known metalloproteinase activator (4-aminophenylmercuric acetate (APMA)), indicating that these enzymes were of the metalloproteinase class. |
| T13 | 1603-1694 | DRI_Background | denotes | By western blot, MMP-2/9 levels increased parallel to protein activity level in zymography. |
| T14 | 1695-1829 | DRI_Background | denotes | No corresponding increase in TIMP-1 and TIMP-2 protein activity and protein level was detected by reverse zymography and western blot. |
| T15 | 1830-1925 | DRI_Background | denotes | Elevated levels of MMP-9 and its distribution in retina were confirmed by immunohistochemistry. |
| T16 | 1926-2057 | DRI_Background | denotes | Expression of MMP-9 was detected in the inner and outer segments of rat retina, and the level becomes stronger at 24 hr after RIRI. |
| T17 | 2058-2248 | DRI_Background | denotes | In this study, ProMMP-2 and ProMMP-9 were expressed and increased significantly, but their inhibitors (TIMP-1 and TIMP-2) remained relatively unaltered in ischemic retina after RIRI in rats. |
| T18 | 2249-2368 | DRI_Challenge | denotes | These results suggest that MMP-2 and MMP-9 may play an important role in the pathomechanism of retinal ischemic injury. |
PubMed_ArguminSci
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 122-338 | DRI_Approach | denotes | Matrix metalloproteinases (MMPs) are endopeptidases that degrade the extracellular matrix (ECM) and are involved in the pathogenesis of retinal degeneration along with tissue inhibitors of metalloproteinases (TIMPs). |
| T2 | 339-550 | DRI_Background | denotes | The present study examined the expression and activation of two specific members of MMPs (MMP-2 and MMP-9) and their related inhibitors (TIMP-1 and TIMP-2) in an experimental retinal ischemia-reperfusion injury. |
| T3 | 551-643 | DRI_Background | denotes | Retinal ischemia-reperfusion injury (RIRI) was induced in adult rats with a ligation method. |
| T4 | 644-763 | DRI_Background | denotes | After one hour of ischemia and a varied reperfusion time (0, 3, 6, 12, 24, 48 and 76 hr), the rat eyes were enucleated. |
| T5 | 764-847 | DRI_Background | denotes | Retinal extracts underwent zymographic analysis to measure the activity of MMP-2/9. |
| T6 | 848-917 | DRI_Background | denotes | The activity of TIMP-1 and TIMP-2 was measured by reverse zymography. |
| T7 | 918-965 | DRI_Background | denotes | The protein level was examined by Western blot. |
| T8 | 966-1083 | DRI_Background | denotes | Immunohistochemistry analysis was undertaken to assess the anatomical distribution of MMP-9 in the retina after RIRI. |
| T9 | 1084-1174 | DRI_Background | denotes | The gelatinolytic activity of ProMMP-2 (72 kDa) was increased markedly at 6 hr after RIRI. |
| T10 | 1175-1338 | DRI_Approach | denotes | ProMMP-9 (92 kDa) was not detected in the control specimens, while it appeared at 3 hr, increased markedly at 6 hr, and reached maximal levels at 24 hr after RIRI. |
| T11 | 1339-1602 | DRI_Background | denotes | The gelatinolytic activity found ian retinal extracts was shown to be inhibited by 10 m M EDTA and activated in vitro by a known metalloproteinase activator (4-aminophenylmercuric acetate (APMA)), indicating that these enzymes were of the metalloproteinase class. |
| T12 | 1603-1694 | DRI_Background | denotes | By western blot, MMP-2/9 levels increased parallel to protein activity level in zymography. |
| T13 | 1695-1829 | DRI_Background | denotes | No corresponding increase in TIMP-1 and TIMP-2 protein activity and protein level was detected by reverse zymography and western blot. |
| T14 | 1830-1925 | DRI_Background | denotes | Elevated levels of MMP-9 and its distribution in retina were confirmed by immunohistochemistry. |
| T15 | 1926-2057 | DRI_Background | denotes | Expression of MMP-9 was detected in the inner and outer segments of rat retina, and the level becomes stronger at 24 hr after RIRI. |
| T16 | 2058-2248 | DRI_Background | denotes | In this study, ProMMP-2 and ProMMP-9 were expressed and increased significantly, but their inhibitors (TIMP-1 and TIMP-2) remained relatively unaltered in ischemic retina after RIRI in rats. |
| T17 | 2249-2368 | DRI_Challenge | denotes | These results suggest that MMP-2 and MMP-9 may play an important role in the pathomechanism of retinal ischemic injury. |