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PubMed:12058028 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-95 Sentence denotes The stress-activated protein kinases p38 alpha and JNK1 stabilize p21(Cip1) by phosphorylation.
T2 96-275 Sentence denotes Stress signals activate the SAPK/JNK and p38 MAPK classes of protein kinases, which mediate cellular responses, including steps in apoptosis and the maturation of some cell types.
T3 276-448 Sentence denotes We now show that stress signals initiated by transforming growth factor-beta 1 (TGF-beta 1) induce G(1) arrest through protein stabilization of the CDK inhibitor p21(Cip1).
T4 449-669 Sentence denotes TGF-beta 1 was previously shown to increase p21 protein levels, which in turn mediated G(1) arrest through inactivation of the CDK2-cyclin E complex in HD3 cells (Yan, Z., Kim, G.-Y., Deng, X., and Friedman, E. (2002) J.
T5 670-675 Sentence denotes Biol.
T6 676-681 Sentence denotes Chem.
T7 682-698 Sentence denotes 277, 9870-9879).
T8 699-817 Sentence denotes We now demonstrate that the increase in p21 abundance is caused by a post-transcriptional, SMAD-independent mechanism.
T9 818-901 Sentence denotes TGF-beta1 activated p38 alpha and JNK1, which initiated the phosphorylation of p21.
T10 902-965 Sentence denotes TGF-beta1 treatment increased the half-life of p21 by 3-4-fold.
T11 966-1265 Sentence denotes The increase in p21 stability was detected following activation of p38 alpha and JNK1, and treatment of cells with the p38 inhibitor SB203580 prevented this increase in p21 stability. p38 alpha and JNK1 phosphorylated p21 in vivo, and both p38 alpha and JNK1 phosphorylated p21 at Ser(130) in vitro.
T12 1266-1462 Sentence denotes Peptide mapping demonstrated that both TGF-beta 1 and p38 alpha induced phosphorylation of p21 at Ser(130) in vivo, and mutation of Ser(130) to alanine rendered p21 less stable than wild-type p21.
T13 1463-1545 Sentence denotes TGF-beta 1 increased the stability of wild-type p21, but not the p21-S130A mutant.
T14 1546-1661 Sentence denotes These findings demonstrate that SAPKs can mediate cell cycle arrest through post-translational modification of p21.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 633-637 HP_0011088 denotes Deng

FSU-PRGE

Id Subject Object Predicate Lexical cue
T1 4-36 protein denotes stress-activated protein kinases
T2 37-46 protein denotes p38 alpha
T3 51-55 protein denotes JNK1
T4 66-75 protein denotes p21(Cip1)
T5 124-128 protein denotes SAPK
T6 129-132 protein denotes JNK
T7 137-145 protein denotes p38 MAPK
T8 157-172 protein denotes protein kinases
T9 321-354 protein denotes transforming growth factor-beta 1
T10 356-366 protein denotes TGF-beta 1
T11 424-437 protein denotes CDK inhibitor
T12 438-447 protein denotes p21(Cip1)
T13 449-459 protein denotes TGF-beta 1
T14 493-496 protein denotes p21
T15 576-580 protein denotes CDK2
T16 581-589 protein denotes cyclin E
T17 739-742 protein denotes p21
T18 790-794 protein denotes SMAD
T19 818-827 protein denotes TGF-beta1
T20 838-847 protein denotes p38 alpha
T21 852-856 protein denotes JNK1
T22 897-900 protein denotes p21
T23 902-911 protein denotes TGF-beta1
T24 949-952 protein denotes p21
T25 982-985 protein denotes p21
T26 1033-1042 protein denotes p38 alpha
T27 1047-1051 protein denotes JNK1
T28 1085-1088 protein denotes p38
T29 1135-1138 protein denotes p21
T30 1150-1159 protein denotes p38 alpha
T31 1164-1168 protein denotes JNK1
T32 1184-1187 protein denotes p21
T33 1206-1215 protein denotes p38 alpha
T34 1220-1224 protein denotes JNK1
T35 1240-1243 protein denotes p21
T36 1305-1315 protein denotes TGF-beta 1
T37 1320-1329 protein denotes p38 alpha
T38 1357-1360 protein denotes p21
T39 1427-1430 protein denotes p21
T40 1458-1461 protein denotes p21
T41 1463-1473 protein denotes TGF-beta 1
T42 1511-1514 protein denotes p21
T43 1528-1531 protein denotes p21
T44 1578-1583 protein denotes SAPKs
T45 1657-1660 protein denotes p21

PIR-corpus2

Id Subject Object Predicate Lexical cue
T1 4-46 protein denotes stress-activated protein kinases p38 alpha
T2 51-55 protein denotes JNK1
T3 66-69 protein denotes p21
T4 70-74 protein denotes Cip1
T5 124-128 protein denotes SAPK
T6 129-132 protein denotes JNK
T7 137-145 protein denotes p38 MAPK
T8 157-164 protein denotes protein
T9 321-367 protein denotes transforming growth factor-beta 1 (TGF-beta 1)
T10 424-447 protein denotes CDK inhibitor p21(Cip1)
T11 449-459 protein denotes TGF-beta 1
T12 493-504 protein denotes p21 protein
T13 576-580 protein denotes CDK2
T14 581-589 protein denotes cyclin E
T15 739-742 protein denotes p21
T16 790-794 protein denotes SMAD
T17 818-827 protein denotes TGF-beta1
T18 838-847 protein denotes p38 alpha
T19 852-856 protein denotes JNK1
T20 897-900 protein denotes p21
T21 902-911 protein denotes TGF-beta1
T22 949-952 protein denotes p21
T23 982-985 protein denotes p21
T24 1033-1042 protein denotes p38 alpha
T25 1047-1051 protein denotes JNK1
T26 1085-1088 protein denotes p38
T27 1135-1138 protein denotes p21
T28 1150-1153 protein denotes p38
T29 1164-1168 protein denotes JNK1
T30 1184-1187 protein denotes p21
T31 1206-1215 protein denotes p38 alpha
T32 1220-1224 protein denotes JNK1
T33 1240-1243 protein denotes p21
T34 1305-1315 protein denotes TGF-beta 1
T35 1320-1329 protein denotes p38 alpha
T36 1357-1360 protein denotes p21
T37 1427-1430 protein denotes p21
T38 1458-1461 protein denotes p21
T39 1463-1473 protein denotes TGF-beta 1
T40 1511-1514 protein denotes p21
T41 1528-1531 protein denotes p21
T42 1578-1583 protein denotes SAPKs
T43 1657-1660 protein denotes p21

PIR-corpus1

Id Subject Object Predicate Lexical cue
T1 21-36 protein denotes protein kinases
T2 37-46 protein denotes p38 alpha
T3 51-55 protein denotes JNK1
T4 66-69 protein denotes p21
T5 70-74 protein denotes Cip1
T6 124-132 protein denotes SAPK/JNK
T7 137-145 protein denotes p38 MAPK
T8 157-164 protein denotes protein
T9 321-354 protein denotes transforming growth factor-beta 1
T10 356-366 acronym denotes TGF-beta 1
T11 424-441 protein denotes CDK inhibitor p21
T12 442-446 protein denotes Cip1
T13 449-459 protein denotes TGF-beta 1
T14 493-504 protein denotes p21 protein
T15 576-589 protein denotes CDK2-cyclin E
T16 739-742 protein denotes p21
T17 818-827 protein denotes TGF-beta1
T18 838-847 protein denotes p38 alpha
T19 852-856 protein denotes JNK1
T20 897-900 protein denotes p21
T21 902-911 protein denotes TGF-beta1
T22 949-952 protein denotes p21
T23 982-985 protein denotes p21
T24 1033-1042 protein denotes p38 alpha
T25 1047-1051 protein denotes JNK1
T26 1135-1138 protein denotes p21
T27 1150-1153 protein denotes p38
T28 1164-1168 protein denotes JNK1
T29 1184-1187 protein denotes p21
T30 1206-1215 protein denotes p38 alpha
T31 1220-1224 protein denotes JNK1
T32 1240-1243 protein denotes p21
T33 1305-1315 protein denotes TGF-beta 1
T34 1320-1329 protein denotes p38 alpha
T35 1357-1360 protein denotes p21
T36 1427-1430 protein denotes p21
T37 1458-1461 protein denotes p21
T38 1463-1473 protein denotes TGF-beta 1
T39 1511-1514 protein denotes p21
T40 1528-1544 protein denotes p21-S130A mutant
T41 1578-1583 protein denotes SAPKs
T42 1657-1660 protein denotes p21

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 1596-1606 Body_part denotes cell cycle http://purl.obolibrary.org/obo/UBERON_2000098