PubMed:12057899 / 341-615 JSONTXT

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{"project":"PubmedHPO","denotations":[{"id":"T4","span":{"begin":184,"end":191},"obj":"HP_0002664"}],"text":"As tumorigenesis in HNPCC is driven by deficient DNA mismatch repair (MMR), we compared its typical consequence, instability at microsatellite sequences, in colorectal and endometrial cancers from patients with identical predisposing mutations in the MMR genes MLH1 or MSH2."}

{"project":"UseCases_ArguminSci_Discourse","denotations":[{"id":"T3","span":{"begin":0,"end":274},"obj":"DRI_Outcome"}],"text":"As tumorigenesis in HNPCC is driven by deficient DNA mismatch repair (MMR), we compared its typical consequence, instability at microsatellite sequences, in colorectal and endometrial cancers from patients with identical predisposing mutations in the MMR genes MLH1 or MSH2."}

{"project":"DisGeNET","denotations":[{"id":"T0","span":{"begin":251,"end":254},"obj":"gene:4360"},{"id":"T1","span":{"begin":172,"end":191},"obj":"disease:C0476089"},{"id":"T2","span":{"begin":261,"end":265},"obj":"gene:4292"},{"id":"T3","span":{"begin":172,"end":191},"obj":"disease:C0476089"},{"id":"T4","span":{"begin":269,"end":273},"obj":"gene:4436"},{"id":"T5","span":{"begin":172,"end":191},"obj":"disease:C0476089"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T0","obj":"T1"},{"id":"R2","pred":"associated_with","subj":"T2","obj":"T3"},{"id":"R3","pred":"associated_with","subj":"T4","obj":"T5"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"text":"As tumorigenesis in HNPCC is driven by deficient DNA mismatch repair (MMR), we compared its typical consequence, instability at microsatellite sequences, in colorectal and endometrial cancers from patients with identical predisposing mutations in the MMR genes MLH1 or MSH2."}