> top > docs > PubMed:12039952 > annotations

PubMed:12039952 JSONTXT

Annnotations TAB JSON ListView MergeView

sentences

Id Subject Object Predicate Lexical cue
T1 0-100 Sentence denotes Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha.
T2 101-347 Sentence denotes In an attempt to isolate cofactors capable of influencing estrogen receptor alpha (ERalpha) transcriptional activity, we used yeast two-hybrid screening and identified protein arginine methyltransferase 2 (PRMT2) as a new ERalpha-binding protein.
T3 348-496 Sentence denotes PRMT2 interacted directly with three ERalpha regions including AF-1, DNA binding domain, and hormone binding domain in a ligand-independent fashion.
T4 497-598 Sentence denotes The ERalpha-interacting region on PRMT2 has been mapped to a region encompassing amino acids 133-275.
T5 599-704 Sentence denotes PRMT2 also binds to ERbeta, PR, TRbeta, RARalpha, PPARgamma, and RXRalpha in a ligand-independent manner.
T6 705-873 Sentence denotes PRMT2 enhanced both ERalpha AF-1 and AF-2 transcriptional activity, and the potential methyltransferase activity of PRMT2 appeared pivotal for its coactivator function.
T7 874-955 Sentence denotes In addition, PRMT2 enhanced PR, PPARgamma, and RARalpha-mediated transactivation.
T8 956-1273 Sentence denotes Although PRMT2 was found to interact with two other coactivators, the steroid receptor coactivator-1 (SRC-1) and the peroxisome proliferator-activated receptor-interacting protein (PRIP), no synergistic enhancement of ERalpha transcriptional activity was observed when PRMT2 was coexpressed with either PRIP or SRC-1.
T9 1274-1390 Sentence denotes In this respect PRMT2 differs from coactivators PRMT1 and CARM1 (coactivator-associated arginine methyltransferase).
T10 1391-1455 Sentence denotes These results suggest that PRMT2 is a novel ERalpha coactivator.

relna

Id Subject Object Predicate Lexical cue
T1 18-54 Protein denotes protein arginine methyltransferase 2
T2 76-99 DNA denotes estrogen receptor alpha
T3 159-182 DNA denotes estrogen receptor alpha
T4 184-191 DNA denotes ERalpha
T5 269-305 Protein denotes protein arginine methyltransferase 2
T6 307-312 Protein denotes PRMT2
T7 323-330 DNA denotes ERalpha
T8 348-353 Protein denotes PRMT2
T9 385-392 DNA denotes ERalpha
T10 411-415 Protein denotes AF-1
T11 501-508 DNA denotes ERalpha
T12 531-536 Protein denotes PRMT2
T13 599-604 Protein denotes PRMT2
T14 619-625 DNA denotes ERbeta
T15 631-637 Protein denotes TRbeta
T16 639-647 DNA denotes RARalpha
T17 649-658 DNA denotes PPARgamma
T18 664-672 DNA denotes RXRalpha
T19 705-710 Protein denotes PRMT2
T20 725-732 DNA denotes ERalpha
T21 733-737 Protein denotes AF-1
T22 821-826 Protein denotes PRMT2
T23 887-892 Protein denotes PRMT2
T24 906-915 DNA denotes PPARgamma
T25 921-929 DNA denotes RARalpha
T26 965-970 Protein denotes PRMT2
T27 1026-1056 Protein denotes steroid receptor coactivator-1
T28 1058-1063 Protein denotes SRC-1
T29 1073-1135 Protein denotes peroxisome proliferator-activated receptor-interacting protein
T30 1137-1141 Protein denotes PRIP
T31 1174-1181 DNA denotes ERalpha
T32 1225-1230 Protein denotes PRMT2
T33 1259-1263 Protein denotes PRIP
T34 1267-1272 Protein denotes SRC-1
T35 1290-1295 Protein denotes PRMT2
T36 1322-1327 Protein denotes PRMT1
T37 1332-1337 Protein denotes CARM1
T38 1418-1423 Protein denotes PRMT2
T39 1435-1442 DNA denotes ERalpha
R0 T6 T7 linked PRMT2,ERalpha
R1 T8 T9 linked PRMT2,ERalpha
R2 T13 T14 linked PRMT2,ERbeta
R3 T13 T16 linked PRMT2,RARalpha
R4 T13 T17 linked PRMT2,PPARgamma
R5 T13 T18 linked PRMT2,RXRalpha