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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-147 Sentence denotes Possible activation of an intramyocardial inflammatory process ( Staphylococcus aureus)after treatment with infliximab in a boy with Crohn disease.
T2 148-159 Sentence denotes UNLABELLED:
T3 160-335 Sentence denotes In an 11-year old boy with Crohn disease, long-term therapy with prednisolone was decided to be augmented by infliximab, a monoclonal antibody to tumour necrosis factor alpha.
T4 336-552 Sentence denotes The patient, who was in a stable clinical condition with low signs of inflammation at that time, deteriorated 3 days after the first dose of 200 mg infliximab with fever, nausea, myalgia and signs of cardiac failure.
T5 553-646 Sentence denotes Echocardiography demonstrated destruction of the aortic valve with third grade insufficiency.
T6 647-728 Sentence denotes In the blood culture, a susceptible strain of Staphylococcus aureus was isolated.
T7 729-863 Sentence denotes Antibiotic therapy resulted in rapid improvement, but the aortic valve had to be replaced by a homograft due to massive insufficiency.
T8 864-1113 Sentence denotes At surgery, there were no signs of endocarditic vegetations, the aortic ring and the right coronary aortic cusp had been destroyed by a massive intramyocardial abscess, leading from close beneath the aortic ring in the direction of the right atrium.
T9 1114-1201 Sentence denotes The size of the process suggested chronic infection or reinfection after several weeks.
T10 1202-1429 Sentence denotes As clinical and laboratory signs as well as echocardiographic changes pointed to a dramatic flare-up shortly after the administration of infliximab, we suggest that this chronic inflammatory process was activated by infliximab.
T11 1430-1585 Sentence denotes CONCLUSION: when using infliximab, special awareness of potential risks is necessary in patients with chronic infections or in a state of immunodeficiency.
T1 0-147 Sentence denotes Possible activation of an intramyocardial inflammatory process ( Staphylococcus aureus)after treatment with infliximab in a boy with Crohn disease.
T2 148-159 Sentence denotes UNLABELLED:
T3 160-335 Sentence denotes In an 11-year old boy with Crohn disease, long-term therapy with prednisolone was decided to be augmented by infliximab, a monoclonal antibody to tumour necrosis factor alpha.
T4 336-552 Sentence denotes The patient, who was in a stable clinical condition with low signs of inflammation at that time, deteriorated 3 days after the first dose of 200 mg infliximab with fever, nausea, myalgia and signs of cardiac failure.
T5 553-646 Sentence denotes Echocardiography demonstrated destruction of the aortic valve with third grade insufficiency.
T6 647-728 Sentence denotes In the blood culture, a susceptible strain of Staphylococcus aureus was isolated.
T7 729-863 Sentence denotes Antibiotic therapy resulted in rapid improvement, but the aortic valve had to be replaced by a homograft due to massive insufficiency.
T8 864-1113 Sentence denotes At surgery, there were no signs of endocarditic vegetations, the aortic ring and the right coronary aortic cusp had been destroyed by a massive intramyocardial abscess, leading from close beneath the aortic ring in the direction of the right atrium.
T9 1114-1201 Sentence denotes The size of the process suggested chronic infection or reinfection after several weeks.
T10 1202-1429 Sentence denotes As clinical and laboratory signs as well as echocardiographic changes pointed to a dramatic flare-up shortly after the administration of infliximab, we suggest that this chronic inflammatory process was activated by infliximab.
T11 1430-1585 Sentence denotes CONCLUSION: when using infliximab, special awareness of potential risks is necessary in patients with chronic infections or in a state of immunodeficiency.

disease_gene_microbe_small

Id Subject Object Predicate Lexical cue
T0 133-146 DOID:8778 denotes Crohn disease
T1 188-201 DOID:8778 denotes rohn disease,
T2 65-86 taxonomy:1280 denotes Staphylococcus aureus
T3 694-715 taxonomy:1280 denotes taphylococcus aureus

PubCasesHPO

Id Subject Object Predicate Lexical cue
AB1 500-505 HP:0001945 denotes fever
AB2 507-513 HP:0002018 denotes nausea
AB3 515-522 HP:0003326 denotes myalgia
AB4 1148-1165 HP:0031035 denotes chronic infection
AB5 1532-1550 HP:0031035 denotes chronic infections
AB6 1568-1584 HP:0002721 denotes immunodeficiency