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PubMed:12007475 JSONTXT

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GlyCosmos6-CLO

Id Subject Object Predicate Lexical cue
T1 97-105 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T2 457-465 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T3 522-530 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T4 955-963 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T5 1136-1144 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T6 1192-1200 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 412-416 Disease denotes clam http://purl.obolibrary.org/obo/MONDO_0011948

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-106 Sentence denotes Effect of (1-->3)- and (1-->4)-linkages of fully sulfated polysaccharides on their anticoagulant activity.
TextSentencer_T2 107-483 Sentence denotes Chemically fully sulfated polysaccharides including xylan (-->4Xylbeta-(1-->4)Xylbeta1-->), amylose (-->4Glcalpha-(1-->4)Glcalpha1-->), cellulose (-->4Glcbeta-(1-->4)Glcbeta1-->), curdlan (-->3Glcbeta-(1-->3)Glcbeta1-->) and galactan (-->3Galbeta-(1-->3)Galbeta1-->), which have been isolated from Korean clam, were prepared, and their anticoagulant activity was investigated.
TextSentencer_T3 484-679 Sentence denotes The results strongly suggest that the activity might not be depending on anomeric configuration (alpha or beta) or monosaccharide species but on the glycosidic linkage, either (1-->3) or (1-->4).
TextSentencer_T4 680-887 Sentence denotes 1H NMR studies of these modified polysaccharides show that the neighboring sulfate groups at the C-2 and C-3 positions might have caused the conformational changes of each monosaccharide from 4C(1) to 1C(4).
TextSentencer_T5 888-1068 Sentence denotes Furthermore, the effect of 6-sulfate residues on the anticoagulant activity was investigated using a specific desulfated reaction for the chemically fully sulfated polysaccharides.
TextSentencer_T6 1069-1297 Sentence denotes The 6-sulfate group is very important in determining anticoagulant activity of (1-->3)-linked polysaccharides, whereas the activity is not affected by presence or absence of the 6-sulfate group in (1-->4)-linked polysaccharides.
T1 0-106 Sentence denotes Effect of (1-->3)- and (1-->4)-linkages of fully sulfated polysaccharides on their anticoagulant activity.
T2 107-483 Sentence denotes Chemically fully sulfated polysaccharides including xylan (-->4Xylbeta-(1-->4)Xylbeta1-->), amylose (-->4Glcalpha-(1-->4)Glcalpha1-->), cellulose (-->4Glcbeta-(1-->4)Glcbeta1-->), curdlan (-->3Glcbeta-(1-->3)Glcbeta1-->) and galactan (-->3Galbeta-(1-->3)Galbeta1-->), which have been isolated from Korean clam, were prepared, and their anticoagulant activity was investigated.
T3 484-679 Sentence denotes The results strongly suggest that the activity might not be depending on anomeric configuration (alpha or beta) or monosaccharide species but on the glycosidic linkage, either (1-->3) or (1-->4).
T4 680-887 Sentence denotes 1H NMR studies of these modified polysaccharides show that the neighboring sulfate groups at the C-2 and C-3 positions might have caused the conformational changes of each monosaccharide from 4C(1) to 1C(4).
T5 888-1068 Sentence denotes Furthermore, the effect of 6-sulfate residues on the anticoagulant activity was investigated using a specific desulfated reaction for the chemically fully sulfated polysaccharides.
T6 1069-1297 Sentence denotes The 6-sulfate group is very important in determining anticoagulant activity of (1-->3)-linked polysaccharides, whereas the activity is not affected by presence or absence of the 6-sulfate group in (1-->4)-linked polysaccharides.