PubMed:11971862
Annnotations
Glycan-Motif
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 18-29 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | sialic acid |
GlyCosmos6-Glycan-Motif-Image
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 18-29 | Glycan_Motif | denotes | sialic acid | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| TextSentencer_T1 | 0-120 | Sentence | denotes | An O-glycoside of sialic acid derivative that inhibits both hemagglutinin and sialidase activities of influenza viruses. |
| TextSentencer_T2 | 121-332 | Sentence | denotes | The compound Neu5Ac3alphaF-DSPE (4), in which the C-3 position was modified with an axial fluorine atom, inhibited the catalytic hydrolysis of influenza virus sialidase and the binding activity of hemagglutinin. |
| TextSentencer_T3 | 333-417 | Sentence | denotes | The inhibitory activities to sialidases were independent of virus isolates examined. |
| TextSentencer_T4 | 418-729 | Sentence | denotes | With the positive results obtained for inhibition of hemagglutination and hemolysis induced by A/Aichi/2/68 virus, the inhibitory effect of Neu5Ac3alphaF-DSPE (4) against MDCK cells was examined, and it was found that 4 inhibits the viral infection with IC50 value of 5.6 microM based on the cytopathic effects. |
| TextSentencer_T5 | 730-996 | Sentence | denotes | The experimental results indicate that compound 4 not only inhibits the attachment of virus to the cell surface receptor but also disturbs the release of the progeny viruses from infected cells by inhibiting both hemagglutinin and sialidase of the influenza viruses. |
| TextSentencer_T6 | 997-1123 | Sentence | denotes | The study suggested that the compound is a new class of bifunctional drug candidates for the future chemotherapy of influenza. |
| T1 | 0-120 | Sentence | denotes | An O-glycoside of sialic acid derivative that inhibits both hemagglutinin and sialidase activities of influenza viruses. |
| T2 | 121-332 | Sentence | denotes | The compound Neu5Ac3alphaF-DSPE (4), in which the C-3 position was modified with an axial fluorine atom, inhibited the catalytic hydrolysis of influenza virus sialidase and the binding activity of hemagglutinin. |
| T3 | 333-417 | Sentence | denotes | The inhibitory activities to sialidases were independent of virus isolates examined. |
| T4 | 418-729 | Sentence | denotes | With the positive results obtained for inhibition of hemagglutination and hemolysis induced by A/Aichi/2/68 virus, the inhibitory effect of Neu5Ac3alphaF-DSPE (4) against MDCK cells was examined, and it was found that 4 inhibits the viral infection with IC50 value of 5.6 microM based on the cytopathic effects. |
| T5 | 730-996 | Sentence | denotes | The experimental results indicate that compound 4 not only inhibits the attachment of virus to the cell surface receptor but also disturbs the release of the progeny viruses from infected cells by inhibiting both hemagglutinin and sialidase of the influenza viruses. |
| T6 | 997-1123 | Sentence | denotes | The study suggested that the compound is a new class of bifunctional drug candidates for the future chemotherapy of influenza. |
| T1 | 0-120 | Sentence | denotes | An O-glycoside of sialic acid derivative that inhibits both hemagglutinin and sialidase activities of influenza viruses. |
| T2 | 121-332 | Sentence | denotes | The compound Neu5Ac3alphaF-DSPE (4), in which the C-3 position was modified with an axial fluorine atom, inhibited the catalytic hydrolysis of influenza virus sialidase and the binding activity of hemagglutinin. |
| T3 | 333-417 | Sentence | denotes | The inhibitory activities to sialidases were independent of virus isolates examined. |
| T4 | 418-729 | Sentence | denotes | With the positive results obtained for inhibition of hemagglutination and hemolysis induced by A/Aichi/2/68 virus, the inhibitory effect of Neu5Ac3alphaF-DSPE (4) against MDCK cells was examined, and it was found that 4 inhibits the viral infection with IC50 value of 5.6 microM based on the cytopathic effects. |
| T5 | 730-996 | Sentence | denotes | The experimental results indicate that compound 4 not only inhibits the attachment of virus to the cell surface receptor but also disturbs the release of the progeny viruses from infected cells by inhibiting both hemagglutinin and sialidase of the influenza viruses. |
| T6 | 997-1123 | Sentence | denotes | The study suggested that the compound is a new class of bifunctional drug candidates for the future chemotherapy of influenza. |
GlyCosmos6-Glycan-Motif-Structure
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 18-29 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | sialic acid |
GlycoBiology-PACDB
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| _T1 | 102-119 | http://acgg.asia/db/diseases/pacdb/lec?ids=LEC780 | denotes | influenza viruses |
| _T2 | 264-279 | http://acgg.asia/db/diseases/pacdb/lec?ids=LEC780 | denotes | influenza virus |
| _T3 | 978-995 | http://acgg.asia/db/diseases/pacdb/lec?ids=LEC780 | denotes | influenza viruses |
ICD10
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 651-666 | http://purl.bioontology.org/ontology/ICD10/B34.9 | denotes | viral infection |
GlycoBiology-FMA
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| _T1 | 125-133 | FMAID:165656 | denotes | compound |
| _T2 | 125-133 | FMAID:67745 | denotes | compound |
| _T3 | 205-210 | FMAID:74547 | denotes | axial |
| _T4 | 205-210 | FMAID:179284 | denotes | axial |
| _T5 | 594-599 | FMAID:68646 | denotes | cells |
| _T6 | 594-599 | FMAID:169002 | denotes | cells |
| _T7 | 690-696 | FMAID:165145 | denotes | microM |
| _T8 | 769-777 | FMAID:165656 | denotes | compound |
| _T9 | 769-777 | FMAID:67745 | denotes | compound |
| _T10 | 829-841 | FMAID:200942 | denotes | cell surface |
| _T11 | 829-841 | FMAID:212684 | denotes | cell surface |
| _T12 | 834-841 | FMAID:146300 | denotes | surface |
| _T13 | 834-841 | FMAID:50594 | denotes | surface |
| _T14 | 918-923 | FMAID:169002 | denotes | cells |
| _T15 | 918-923 | FMAID:68646 | denotes | cells |
| _T16 | 1026-1034 | FMAID:67745 | denotes | compound |
| _T17 | 1026-1034 | FMAID:165656 | denotes | compound |
uniprot-human
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 829-850 | http://www.uniprot.org/uniprot/Q9UKJ1 | denotes | cell surface receptor |
| T2 | 829-850 | http://www.uniprot.org/uniprot/Q9UKJ0 | denotes | cell surface receptor |
GlycoBiology-NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 102-119 | http://purl.bioontology.org/ontology/NCBITAXON/11320 | denotes | influenza viruses |
| T2 | 264-279 | http://purl.bioontology.org/ontology/NCBITAXON/11520 | denotes | influenza virus |
| T3 | 264-279 | http://purl.bioontology.org/ontology/NCBITAXON/11320 | denotes | influenza virus |
| T4 | 274-279 | http://purl.bioontology.org/ontology/NCBITAXON/184751 | denotes | virus |
| T5 | 393-398 | http://purl.bioontology.org/ontology/NCBITAXON/184751 | denotes | virus |
| T6 | 526-531 | http://purl.bioontology.org/ontology/NCBITAXON/184751 | denotes | virus |
| T7 | 594-599 | http://purl.bioontology.org/ontology/STY/T025 | denotes | cells |
| T8 | 816-821 | http://purl.bioontology.org/ontology/NCBITAXON/184751 | denotes | virus |
| T9 | 918-923 | http://purl.bioontology.org/ontology/STY/T025 | denotes | cells |
| T10 | 978-995 | http://purl.bioontology.org/ontology/NCBITAXON/11320 | denotes | influenza viruses |
GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 78-98 | http://purl.obolibrary.org/obo/GO_0004308 | denotes | sialidase activities |
| T2 | 348-372 | http://purl.obolibrary.org/obo/GO_0004308 | denotes | activities to sialidases |
| T3 | 298-314 | http://purl.obolibrary.org/obo/GO_0051099 | denotes | binding activity |
| T4 | 651-666 | http://purl.obolibrary.org/obo/GO_0016032 | denotes | viral infection |
GO-MF
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 298-305 | http://purl.obolibrary.org/obo/GO_0070026 | denotes | binding |
| T2 | 298-305 | http://purl.obolibrary.org/obo/GO_0003680 | denotes | binding |
| T3 | 298-305 | http://purl.obolibrary.org/obo/GO_0017091 | denotes | binding |
| T4 | 298-305 | http://purl.obolibrary.org/obo/GO_0005488 | denotes | binding |
GO-CC
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 594-599 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T2 | 829-833 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T3 | 829-841 | http://purl.obolibrary.org/obo/GO_0009986 | denotes | cell surface |
EDAM-topics
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 112-119 | http://edamontology.org/topic_0781 | denotes | viruses |
| T2 | 896-903 | http://edamontology.org/topic_0781 | denotes | viruses |
| T3 | 988-995 | http://edamontology.org/topic_0781 | denotes | viruses |
| T4 | 1001-1006 | http://edamontology.org/topic_3678 | denotes | study |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 102-111 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T2 | 264-273 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T3 | 651-666 | Disease | denotes | viral infection | http://purl.obolibrary.org/obo/MONDO_0005108 |
| T4 | 978-987 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T5 | 1113-1122 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |