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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-80 Sentence denotes Cardiac troponin T is essential in sarcomere assembly and cardiac contractility.
TextSentencer_T2 81-307 Sentence denotes Mutations of the gene (TNNT2) encoding the thin-filament contractile protein cardiac troponin T are responsible for 15% of all cases of familial hypertrophic cardiomyopathy, the leading cause of sudden death in young athletes.
TextSentencer_T3 308-414 Sentence denotes Mutant proteins are thought to act through a dominant-negative mode that impairs function of heart muscle.
TextSentencer_T4 415-505 Sentence denotes TNNT2 mutations can also lead to dilated cardiomyopathy, a leading cause of heart failure.
TextSentencer_T5 506-623 Sentence denotes Despite the importance of cardiac troponin T in human disease, its loss-of-function phenotype has not been described.
TextSentencer_T6 624-702 Sentence denotes We show that the zebrafish silent heart (sih) mutation affects the gene tnnt2.
TextSentencer_T7 703-853 Sentence denotes We characterize two mutated alleles of sih that severely reduce tnnt2 expression: one affects mRNA splicing, and the other affects gene transcription.
TextSentencer_T8 854-1002 Sentence denotes Tnnt2, together with alpha-tropomyosin (Tpma) and cardiac troponins C and I (Tnni3), forms a calcium-sensitive regulatory complex within sarcomeres.
TextSentencer_T9 1003-1177 Sentence denotes Unexpectedly, in addition to loss of Tnnt2 expression in sih mutant hearts, we observed a significant reduction in Tpma and Tnni3, and consequently, severe sarcomere defects.
TextSentencer_T10 1178-1466 Sentence denotes This interdependence of thin-filament protein expression led us to postulate that some mutations in tnnt2 may trigger misregulation of thin-filament protein expression, resulting in sarcomere loss and myocyte disarray, the life-threatening hallmarks of TNNT2 mutations in mice and humans.
T1 0-80 Sentence denotes Cardiac troponin T is essential in sarcomere assembly and cardiac contractility.
T2 81-307 Sentence denotes Mutations of the gene (TNNT2) encoding the thin-filament contractile protein cardiac troponin T are responsible for 15% of all cases of familial hypertrophic cardiomyopathy, the leading cause of sudden death in young athletes.
T3 308-414 Sentence denotes Mutant proteins are thought to act through a dominant-negative mode that impairs function of heart muscle.
T4 415-505 Sentence denotes TNNT2 mutations can also lead to dilated cardiomyopathy, a leading cause of heart failure.
T5 506-623 Sentence denotes Despite the importance of cardiac troponin T in human disease, its loss-of-function phenotype has not been described.
T6 624-702 Sentence denotes We show that the zebrafish silent heart (sih) mutation affects the gene tnnt2.
T7 703-853 Sentence denotes We characterize two mutated alleles of sih that severely reduce tnnt2 expression: one affects mRNA splicing, and the other affects gene transcription.
T8 854-1002 Sentence denotes Tnnt2, together with alpha-tropomyosin (Tpma) and cardiac troponins C and I (Tnni3), forms a calcium-sensitive regulatory complex within sarcomeres.
T9 1003-1177 Sentence denotes Unexpectedly, in addition to loss of Tnnt2 expression in sih mutant hearts, we observed a significant reduction in Tpma and Tnni3, and consequently, severe sarcomere defects.
T10 1178-1466 Sentence denotes This interdependence of thin-filament protein expression led us to postulate that some mutations in tnnt2 may trigger misregulation of thin-filament protein expression, resulting in sarcomere loss and myocyte disarray, the life-threatening hallmarks of TNNT2 mutations in mice and humans.

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
11967535-1#23#28#gene7139 104-109 gene7139 denotes TNNT2
11967535-1#136#172#diseaseC0949658 217-253 diseaseC0949658 denotes familial hypertrophic cardiomyopathy
11967535-3#0#5#gene7139 415-420 gene7139 denotes TNNT2
11967535-3#0#5#gene7139 415-420 gene7139 denotes TNNT2
11967535-3#76#89#diseaseC0018801 491-504 diseaseC0018801 denotes heart failure
11967535-3#76#89#diseaseC0018802 491-504 diseaseC0018802 denotes heart failure
11967535-3#33#55#diseaseC0007193 448-470 diseaseC0007193 denotes dilated cardiomyopathy
23#28#gene7139136#172#diseaseC0949658 11967535-1#23#28#gene7139 11967535-1#136#172#diseaseC0949658 associated_with TNNT2,familial hypertrophic cardiomyopathy
0#5#gene713976#89#diseaseC0018801 11967535-3#0#5#gene7139 11967535-3#76#89#diseaseC0018801 associated_with TNNT2,heart failure
0#5#gene713976#89#diseaseC0018802 11967535-3#0#5#gene7139 11967535-3#76#89#diseaseC0018802 associated_with TNNT2,heart failure
0#5#gene713933#55#diseaseC0007193 11967535-3#0#5#gene7139 11967535-3#33#55#diseaseC0007193 associated_with TNNT2,dilated cardiomyopathy
0#5#gene713976#89#diseaseC0018801 11967535-3#0#5#gene7139 11967535-3#76#89#diseaseC0018801 associated_with TNNT2,heart failure
0#5#gene713976#89#diseaseC0018802 11967535-3#0#5#gene7139 11967535-3#76#89#diseaseC0018802 associated_with TNNT2,heart failure
0#5#gene713933#55#diseaseC0007193 11967535-3#0#5#gene7139 11967535-3#33#55#diseaseC0007193 associated_with TNNT2,dilated cardiomyopathy

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T2389 415-420 gene:7139 denotes TNNT2
T2390 491-504 disease:C0018801 denotes heart failure
R1 T2389 T2390 associated_with TNNT2,heart failure
R2 T2389 T2390 associated_with TNNT2,heart failure

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 401-406 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
PD-UBERON-AE-B_T2 491-496 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
PD-UBERON-AE-B_T3 658-663 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
PD-UBERON-AE-B_T4 1071-1077 http://purl.obolibrary.org/obo/UBERON_0000948 denotes hearts

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 401-406 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
PD-UBERON-AE-B_T2 491-496 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
PD-UBERON-AE-B_T3 658-663 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
PD-UBERON-AE-B_T4 1071-1077 http://purl.obolibrary.org/obo/UBERON_0000948 denotes hearts

DisGeNET

Id Subject Object Predicate Lexical cue
T0 104-109 gene:7139 denotes TNNT2
T1 217-253 disease:C0949658 denotes familial hypertrophic cardiomyopathy
T2 415-420 gene:7139 denotes TNNT2
T3 491-504 disease:C0018802 denotes heart failure
T4 415-420 gene:7139 denotes TNNT2
T5 491-504 disease:C0018801 denotes heart failure
T6 415-420 gene:7139 denotes TNNT2
T7 448-470 disease:C0007193 denotes dilated cardiomyopathy
R1 T0 T1 associated_with TNNT2,familial hypertrophic cardiomyopathy
R2 T2 T3 associated_with TNNT2,heart failure
R3 T4 T5 associated_with TNNT2,heart failure
R4 T6 T7 associated_with TNNT2,dilated cardiomyopathy