| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-89 |
Sentence |
denotes |
Pharmacodynamic assessment of clarithromycin in a murine model of pneumococcal pneumonia. |
| T2 |
90-189 |
Sentence |
denotes |
The pharmacodynamic profile of clarithromycin (CLR) was evaluated with a murine model of pneumonia. |
| T3 |
190-404 |
Sentence |
denotes |
Eight Streptococcus pneumoniae isolates, including three macrolide-sensitive and five macrolide-resistant strains, were inoculated intratracheally into immunocompromised ICR mice as 10(8)-CFU bacterial suspensions. |
| T4 |
405-551 |
Sentence |
denotes |
Orally administered CLR daily doses ranging from 5 to 600 mg/kg of body weight were given over 5 days, during which animal survival was monitored. |
| T5 |
552-653 |
Sentence |
denotes |
The bacterial density in lung tissues was examined after 24 h of CLR treatment and in control groups. |
| T6 |
654-892 |
Sentence |
denotes |
Pharmacokinetic analysis of CLR in mice demonstrated that the regimen of 150 mg/kg twice a day was representative of human pharmacokinetics and was used to compare the efficacy of CLR against sensitive and resistant S. pneumoniae strains. |
| T7 |
893-1070 |
Sentence |
denotes |
Immunocompetent CBA/J mice were also infected and treated as described above and evaluated for bacterial density and survival to assess the effect of the presence of leukocytes. |
| T8 |
1071-1447 |
Sentence |
denotes |
All three pharmacodynamic parameters, the duration (percent) of the time that serum CLR concentrations remain above the MIC (%T>MIC), the ratio of the area under the concentration-time curve from 0 to 24 h (AUC(0-24)) to the MIC, and the ratio of the maximum concentration of drug in serum to the MIC, were found to be closely correlated to CLR bacterial efficacy (P < 0.001). |
| T9 |
1448-1630 |
Sentence |
denotes |
Furthermore, all parameters had close correlation to bacterial density (r(2) = 0.72 to 0.82), median survival (r(2) = 0.93 to 0.94), and total percent survival (r(2) = 0.91 to 0.92). |
| T10 |
1631-1894 |
Sentence |
denotes |
These in vivo data suggest that the bacterial activity of CLR is closely correlated with all three parameters over a wide range of exposures and, as a consequence of parameter interdependency, AUC(0-24)/MIC is the most reasonable predictor of antibiotic efficacy. |
| T11 |
1895-2023 |
Sentence |
denotes |
In this neutropenic pneumonia model, CLR was less efficacious against S. pneumoniae strains for which MICs were >or=4 microg/ml. |
| T12 |
2024-2207 |
Sentence |
denotes |
However, the presence of leukocytes in the immunocompetent mice resulted in improved bactericidal activity, relative to that in the neutropenic animals, despite an MIC of 4 microg/ml. |
