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PubMed:11950392 JSONTXT

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FSU-PRGE

Id Subject Object Predicate Lexical cue
T1 0-3 protein denotes GGA
T2 95-119 protein denotes ADP-ribosylation factors
T3 121-145 protein denotes ADP-ribosylation factors
T4 147-151 protein denotes ARFs
T5 169-182 protein denotes small GTPases
T6 266-275 protein denotes ARF1-ARF6
T7 376-385 protein denotes ARF1-ARF3
T8 397-401 protein denotes ARF4
T9 406-410 protein denotes ARF5
T10 427-431 protein denotes ARF6
T11 489-492 protein denotes ARF
T12 511-520 protein denotes GGA1-GGA3
T13 565-569 protein denotes ARF1
T14 574-578 protein denotes ARF3
T15 661-664 protein denotes GGA
T16 688-760 protein denotes Golgi-localizing, gamma-adaptin ear homology domain, ARF-binding protein
T17 803-806 protein denotes ARF
T18 848-852 protein denotes ARF1
T19 854-858 protein denotes ARF5
T20 863-867 protein denotes ARF6
T21 891-894 protein denotes GGA
T22 971-974 protein denotes GGA
T23 1001-1004 protein denotes GGA
T24 1026-1029 protein denotes ARF
T25 1085-1088 protein denotes GGA
T26 1132-1142 protein denotes GGA family
T27 1161-1164 protein denotes ARF
T28 1197-1203 protein denotes GTPase
T29 1226-1230 protein denotes ARF1
T30 1235-1239 protein denotes ARF5
T31 1263-1266 protein denotes GGA
T32 1339-1342 protein denotes ARF
T33 1360-1363 protein denotes GGA
T34 1385-1388 protein denotes ARF
T35 1460-1464 protein denotes ARF1
T36 1479-1483 protein denotes ARF5
T37 1541-1544 protein denotes GGA
T38 1625-1629 protein denotes ARF6
T39 1676-1679 protein denotes GGA

PMID_GLOBAL

Id Subject Object Predicate Lexical cue
T1 0-120 Sentence denotes GGA proteins associate with Golgi membranes through interaction between their GGAH domains and ADP-ribosylation factors.
T2 121-251 Sentence denotes ADP-ribosylation factors (ARFs) are a family of small GTPases that are involved in various aspects of membrane trafficking events.
T3 252-366 Sentence denotes These include ARF1-ARF6, which are divided into three classes on the basis of similarity in the primary structure:
T4 367-432 Sentence denotes Class I, ARF1-ARF3; Class II, ARF4 and ARF5; and Class III, ARF6.
T5 433-762 Sentence denotes Previous studies identified a novel family of potential ARF effectors, termed GGA1-GGA3, which interact specifically with GTP-bound ARF1 and ARF3 and are localized to the trans-Golgi network (TGN) or its related compartment(s) (GGA is an abbreviation for Golgi-localizing, gamma-adaptin ear homology domain, ARF-binding protein).
T6 763-954 Sentence denotes In the present study we have shown that ARF proteins belonging to the three classes, ARF1, ARF5 and ARF6, can interact with all GGA proteins in a yeast two-hybrid assay, in vitro and in vivo.
T7 955-1173 Sentence denotes Segmentation of GGA proteins and isolation of GGA mutants defective in ARF binding have revealed that a limited region within the GGA homology domain, which is conserved in the GGA family, is essential for ARF binding.
T8 1174-1314 Sentence denotes Expression in cells of GTPase-restricted mutants of ARF1 and ARF5 blocks dissociation of GGA proteins from membranes induced by brefeldin A.
T9 1315-1397 Sentence denotes However, neither of the ARF mutants recruits GGA mutants defective in ARF binding.
T10 1398-1574 Sentence denotes On the basis of these observations, we conclude that at least ARF1 (Class I) and ARF5 (Class II) in their GTP-bound state cause recruitment of GGA proteins on to TGN membranes.
T11 1575-1737 Sentence denotes In contrast, on the basis of similar experiments, ARF6 (Class III) may be involved in recruitment of GGA proteins to other compartments, possibly early endosomes.