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PubMed:11948116 JSONTXT

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DisGeNET

Id Subject Object Predicate Lexical cue
T0 954-958 gene:4176 denotes Mcm2
T1 1024-1036 disease:C0022665 denotes renal tumors
T2 954-958 gene:4171 denotes Mcm2
T3 1024-1036 disease:C0022665 denotes renal tumors
T4 954-958 gene:4176 denotes Mcm2
T5 1095-1105 disease:C0949541 denotes oncocytoma
T6 954-958 gene:4176 denotes Mcm2
T7 1095-1105 disease:C1378050 denotes oncocytoma
T8 954-958 gene:4176 denotes Mcm2
T9 1095-1105 disease:C1510502 denotes oncocytoma
T10 954-958 gene:4171 denotes Mcm2
T11 1095-1105 disease:C0949541 denotes oncocytoma
T12 954-958 gene:4171 denotes Mcm2
T13 1095-1105 disease:C1378050 denotes oncocytoma
T14 954-958 gene:4171 denotes Mcm2
T15 1095-1105 disease:C1510502 denotes oncocytoma
T16 954-958 gene:4176 denotes Mcm2
T17 1117-1144 disease:C0007138 denotes transitional cell carcinoma
T18 954-958 gene:4171 denotes Mcm2
T19 1117-1144 disease:C0007138 denotes transitional cell carcinoma
T20 954-958 gene:4176 denotes Mcm2
T21 1424-1437 disease:C0022665 denotes kidney tumors
T22 954-958 gene:4171 denotes Mcm2
T23 1424-1437 disease:C0022665 denotes kidney tumors
T24 1363-1367 gene:4176 denotes Mcm2
T25 1024-1036 disease:C0022665 denotes renal tumors
T26 1363-1367 gene:4171 denotes Mcm2
T27 1024-1036 disease:C0022665 denotes renal tumors
T28 1363-1367 gene:4176 denotes Mcm2
T29 1095-1105 disease:C0949541 denotes oncocytoma
T30 1363-1367 gene:4176 denotes Mcm2
T31 1095-1105 disease:C1378050 denotes oncocytoma
T32 1363-1367 gene:4176 denotes Mcm2
T33 1095-1105 disease:C1510502 denotes oncocytoma
T34 1363-1367 gene:4171 denotes Mcm2
T35 1095-1105 disease:C0949541 denotes oncocytoma
T36 1363-1367 gene:4171 denotes Mcm2
T37 1095-1105 disease:C1378050 denotes oncocytoma
T38 1363-1367 gene:4171 denotes Mcm2
T39 1095-1105 disease:C1510502 denotes oncocytoma
T40 1363-1367 gene:4176 denotes Mcm2
T41 1117-1144 disease:C0007138 denotes transitional cell carcinoma
T42 1363-1367 gene:4171 denotes Mcm2
T43 1117-1144 disease:C0007138 denotes transitional cell carcinoma
T44 1363-1367 gene:4176 denotes Mcm2
T45 1424-1437 disease:C0022665 denotes kidney tumors
T46 1363-1367 gene:4171 denotes Mcm2
T47 1424-1437 disease:C0022665 denotes kidney tumors
R1 T0 T1 associated_with Mcm2,renal tumors
R2 T2 T3 associated_with Mcm2,renal tumors
R3 T4 T5 associated_with Mcm2,oncocytoma
R4 T6 T7 associated_with Mcm2,oncocytoma
R5 T8 T9 associated_with Mcm2,oncocytoma
R6 T10 T11 associated_with Mcm2,oncocytoma
R7 T12 T13 associated_with Mcm2,oncocytoma
R8 T14 T15 associated_with Mcm2,oncocytoma
R9 T16 T17 associated_with Mcm2,transitional cell carcinoma
R10 T18 T19 associated_with Mcm2,transitional cell carcinoma
R11 T20 T21 associated_with Mcm2,kidney tumors
R12 T22 T23 associated_with Mcm2,kidney tumors
R13 T24 T25 associated_with Mcm2,renal tumors
R14 T26 T27 associated_with Mcm2,renal tumors
R15 T28 T29 associated_with Mcm2,oncocytoma
R16 T30 T31 associated_with Mcm2,oncocytoma
R17 T32 T33 associated_with Mcm2,oncocytoma
R18 T34 T35 associated_with Mcm2,oncocytoma
R19 T36 T37 associated_with Mcm2,oncocytoma
R20 T38 T39 associated_with Mcm2,oncocytoma
R21 T40 T41 associated_with Mcm2,transitional cell carcinoma
R22 T42 T43 associated_with Mcm2,transitional cell carcinoma
R23 T44 T45 associated_with Mcm2,kidney tumors
R24 T46 T47 associated_with Mcm2,kidney tumors

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
11948116-10#0#4#gene4171 1965-1969 gene4171 denotes Mcm2
11948116-10#82#110#diseaseC0007138 2047-2075 diseaseC0007138 denotes transitional cell carcinomas
11948116-10#138#159#diseaseC0007134 2103-2124 diseaseC0007134 denotes renal cell carcinomas
11948116-6#70#74#gene4171 954-958 gene4171 denotes Mcm2
11948116-6#479#483#gene4171 1363-1367 gene4171 denotes Mcm2
11948116-6#70#74#gene4171 954-958 gene4171 denotes Mcm2
11948116-6#479#483#gene4171 1363-1367 gene4171 denotes Mcm2
11948116-6#211#221#diseaseC0949541 1095-1105 diseaseC0949541 denotes oncocytoma
11948116-6#211#221#diseaseC1378050 1095-1105 diseaseC1378050 denotes oncocytoma
11948116-6#211#221#diseaseC1510502 1095-1105 diseaseC1510502 denotes oncocytoma
11948116-6#211#221#diseaseC0949541 1095-1105 diseaseC0949541 denotes oncocytoma
11948116-6#211#221#diseaseC1378050 1095-1105 diseaseC1378050 denotes oncocytoma
11948116-6#211#221#diseaseC1510502 1095-1105 diseaseC1510502 denotes oncocytoma
11948116-6#140#152#diseaseC0022665 1024-1036 diseaseC0022665 denotes renal tumors
11948116-6#540#553#diseaseC0022665 1424-1437 diseaseC0022665 denotes kidney tumors
11948116-6#140#152#diseaseC0022665 1024-1036 diseaseC0022665 denotes renal tumors
11948116-6#540#553#diseaseC0022665 1424-1437 diseaseC0022665 denotes kidney tumors
0#4#gene417182#110#diseaseC0007138 11948116-10#0#4#gene4171 11948116-10#82#110#diseaseC0007138 associated_with Mcm2,transitional cell carcinomas
0#4#gene4171138#159#diseaseC0007134 11948116-10#0#4#gene4171 11948116-10#138#159#diseaseC0007134 associated_with Mcm2,renal cell carcinomas
70#74#gene4171211#221#diseaseC0949541 11948116-6#70#74#gene4171 11948116-6#211#221#diseaseC0949541 associated_with Mcm2,oncocytoma
70#74#gene4171211#221#diseaseC1378050 11948116-6#70#74#gene4171 11948116-6#211#221#diseaseC1378050 associated_with Mcm2,oncocytoma
70#74#gene4171211#221#diseaseC1510502 11948116-6#70#74#gene4171 11948116-6#211#221#diseaseC1510502 associated_with Mcm2,oncocytoma
70#74#gene4171211#221#diseaseC0949541 11948116-6#70#74#gene4171 11948116-6#211#221#diseaseC0949541 associated_with Mcm2,oncocytoma
70#74#gene4171211#221#diseaseC1378050 11948116-6#70#74#gene4171 11948116-6#211#221#diseaseC1378050 associated_with Mcm2,oncocytoma
70#74#gene4171211#221#diseaseC1510502 11948116-6#70#74#gene4171 11948116-6#211#221#diseaseC1510502 associated_with Mcm2,oncocytoma
70#74#gene4171140#152#diseaseC0022665 11948116-6#70#74#gene4171 11948116-6#140#152#diseaseC0022665 associated_with Mcm2,renal tumors
70#74#gene4171540#553#diseaseC0022665 11948116-6#70#74#gene4171 11948116-6#540#553#diseaseC0022665 associated_with Mcm2,kidney tumors
70#74#gene4171140#152#diseaseC0022665 11948116-6#70#74#gene4171 11948116-6#140#152#diseaseC0022665 associated_with Mcm2,renal tumors
70#74#gene4171540#553#diseaseC0022665 11948116-6#70#74#gene4171 11948116-6#540#553#diseaseC0022665 associated_with Mcm2,kidney tumors
479#483#gene4171211#221#diseaseC0949541 11948116-6#479#483#gene4171 11948116-6#211#221#diseaseC0949541 associated_with Mcm2,oncocytoma
479#483#gene4171211#221#diseaseC1378050 11948116-6#479#483#gene4171 11948116-6#211#221#diseaseC1378050 associated_with Mcm2,oncocytoma
479#483#gene4171211#221#diseaseC1510502 11948116-6#479#483#gene4171 11948116-6#211#221#diseaseC1510502 associated_with Mcm2,oncocytoma
479#483#gene4171211#221#diseaseC0949541 11948116-6#479#483#gene4171 11948116-6#211#221#diseaseC0949541 associated_with Mcm2,oncocytoma
479#483#gene4171211#221#diseaseC1378050 11948116-6#479#483#gene4171 11948116-6#211#221#diseaseC1378050 associated_with Mcm2,oncocytoma
479#483#gene4171211#221#diseaseC1510502 11948116-6#479#483#gene4171 11948116-6#211#221#diseaseC1510502 associated_with Mcm2,oncocytoma
479#483#gene4171140#152#diseaseC0022665 11948116-6#479#483#gene4171 11948116-6#140#152#diseaseC0022665 associated_with Mcm2,renal tumors
479#483#gene4171540#553#diseaseC0022665 11948116-6#479#483#gene4171 11948116-6#540#553#diseaseC0022665 associated_with Mcm2,kidney tumors
479#483#gene4171140#152#diseaseC0022665 11948116-6#479#483#gene4171 11948116-6#140#152#diseaseC0022665 associated_with Mcm2,renal tumors
479#483#gene4171540#553#diseaseC0022665 11948116-6#479#483#gene4171 11948116-6#540#553#diseaseC0022665 associated_with Mcm2,kidney tumors
70#74#gene4171211#221#diseaseC0949541 11948116-6#70#74#gene4171 11948116-6#211#221#diseaseC0949541 associated_with Mcm2,oncocytoma
70#74#gene4171211#221#diseaseC1378050 11948116-6#70#74#gene4171 11948116-6#211#221#diseaseC1378050 associated_with Mcm2,oncocytoma
70#74#gene4171211#221#diseaseC1510502 11948116-6#70#74#gene4171 11948116-6#211#221#diseaseC1510502 associated_with Mcm2,oncocytoma
70#74#gene4171211#221#diseaseC0949541 11948116-6#70#74#gene4171 11948116-6#211#221#diseaseC0949541 associated_with Mcm2,oncocytoma
70#74#gene4171211#221#diseaseC1378050 11948116-6#70#74#gene4171 11948116-6#211#221#diseaseC1378050 associated_with Mcm2,oncocytoma
70#74#gene4171211#221#diseaseC1510502 11948116-6#70#74#gene4171 11948116-6#211#221#diseaseC1510502 associated_with Mcm2,oncocytoma
70#74#gene4171140#152#diseaseC0022665 11948116-6#70#74#gene4171 11948116-6#140#152#diseaseC0022665 associated_with Mcm2,renal tumors
70#74#gene4171540#553#diseaseC0022665 11948116-6#70#74#gene4171 11948116-6#540#553#diseaseC0022665 associated_with Mcm2,kidney tumors
70#74#gene4171140#152#diseaseC0022665 11948116-6#70#74#gene4171 11948116-6#140#152#diseaseC0022665 associated_with Mcm2,renal tumors
70#74#gene4171540#553#diseaseC0022665 11948116-6#70#74#gene4171 11948116-6#540#553#diseaseC0022665 associated_with Mcm2,kidney tumors
479#483#gene4171211#221#diseaseC0949541 11948116-6#479#483#gene4171 11948116-6#211#221#diseaseC0949541 associated_with Mcm2,oncocytoma
479#483#gene4171211#221#diseaseC1378050 11948116-6#479#483#gene4171 11948116-6#211#221#diseaseC1378050 associated_with Mcm2,oncocytoma
479#483#gene4171211#221#diseaseC1510502 11948116-6#479#483#gene4171 11948116-6#211#221#diseaseC1510502 associated_with Mcm2,oncocytoma
479#483#gene4171211#221#diseaseC0949541 11948116-6#479#483#gene4171 11948116-6#211#221#diseaseC0949541 associated_with Mcm2,oncocytoma
479#483#gene4171211#221#diseaseC1378050 11948116-6#479#483#gene4171 11948116-6#211#221#diseaseC1378050 associated_with Mcm2,oncocytoma
479#483#gene4171211#221#diseaseC1510502 11948116-6#479#483#gene4171 11948116-6#211#221#diseaseC1510502 associated_with Mcm2,oncocytoma
479#483#gene4171140#152#diseaseC0022665 11948116-6#479#483#gene4171 11948116-6#140#152#diseaseC0022665 associated_with Mcm2,renal tumors
479#483#gene4171540#553#diseaseC0022665 11948116-6#479#483#gene4171 11948116-6#540#553#diseaseC0022665 associated_with Mcm2,kidney tumors
479#483#gene4171140#152#diseaseC0022665 11948116-6#479#483#gene4171 11948116-6#140#152#diseaseC0022665 associated_with Mcm2,renal tumors
479#483#gene4171540#553#diseaseC0022665 11948116-6#479#483#gene4171 11948116-6#540#553#diseaseC0022665 associated_with Mcm2,kidney tumors

PubMed_Structured_Abstracts

Id Subject Object Predicate Lexical cue
T1 164-862 OBJECTIVE denotes A major problem in the management of patients with renal cell carcinoma is predicting tumor behavior. In the search for more accurate markers of prognosis, tumor cell proliferation has been investigated. These studies have mostly used antibodies directed against Ki-67 or proliferating cell nuclear antigen and have given conflicting results, findings that are likely because of a combination of specificity and methodological differences. Minichromosome maintenance (Mcm) proteins are a series of closely related proteins that are components of the prereplicative complex. The Mcm proteins are essential for initiating eukaryotic DNA replication and serve as useful markers of proliferating cells.
T2 884-1636 METHODS denotes The aims of this study were to determine the frequency and pattern of Mcm2 expression by immunohistochemistry in normal kidney (n = 10) and renal tumors [n = 56; clear cell n = 36; chromophil (papillary) n = 7; oncocytoma n = 5; and transitional cell carcinoma n = 8], compare its sensitivity to the established proliferation marker Ki-67, examine for differences in tumors derived from stable and labile epithelial cell populations in the kidney, and assess the relationship of Mcm2 proliferation to clinicopathological characteristics of kidney tumors. In addition, to additionally investigate the issue of tumor dormancy we wished to assess the relationship between Mcm2 labeling index (LI) and the angiogenic factors angiopoietin-1 (Ang) and Ang-2.
T3 1646-2625 RESULTS denotes In normal tissues, Mcm2 nuclear labeling was identified in both glomeruli (LI median 0.35%; range 0-1.7) and renal tubules (LI median 0.3%; range 0.1-2.9%). In tumors Mcm2 labeling was predominantly at the periphery with LIs ranging from 0.2-91.5%, which was significantly greater than Ki-67 LI (0.2-40.5%; P < 0.001). Mcm2 LI was also significantly higher in tumors derived from a labile epithelium (transitional cell carcinomas) than a stable epithelium (renal cell carcinomas; P = 0.013). A significant association was also demonstrated between Mcm2 LI and tumor grade (P = 0.0006), and angiogenic phenotype (defined by Ang expression; P = 0.03) but not with patient age (P = 0.84), patient sex (P = 0.25), tumor size (P = 0.74), or stage (P = 0.33). Furthermore, although not significant, a survival analysis demonstrated that 100% of patients with a low Mcm2 LI survived compared with 84% of those with a high Mcm2 LI over the follow-up period (up to 53.2 months; P = 0.14).
T4 2639-3484 CONCLUSIONS denotes This is the first study examining Mcm2 protein in normal and tumor kidney samples, and the first to perform histological subgroup analysis. It shows that Mcm2 is a superior marker to Ki-67 in the assessment of cell cycle entry in histological archival material and that normal kidney has a subset of cells within the glomerular and tubular compartments that are in cycle. It demonstrates that the frequency of cells in cycle in tumors formed from stable or labile epithelial populations mirrors that in the nonneoplastic epithelium. This study additionally demonstrates that the number of cells in cycle in tumors is limited by the angiogenic phenotype and supports animal models that show angiogenesis determines the likelihood of tumor dormancy. Additional study to confirm the clinical utility of Mcm2 as a prognostic marker is now indicated.