PubMed:119407 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/119407","sourcedb":"PubMed","sourceid":"119407","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/119407","text":"Myeloproliferative disease of childhood associated with a trisomy 21 clone.\nMyeloproliferative disease of childhood is frequently associated with chromosomal anomalies, usually of the C group. Clinical features are similar to those of the juvenile type of chronic myeloid leukemia. A child with this disease is described. Marked myeloid proliferation, anemia, thrombocytopenia and hepatosplenomegaly were present; leukocyte alkaline phosphatase and fetal hemoglobin were moderately elevated. Chromosome analysis of bone marrow cells revealed a mosaicism 47,XX,+21/46,XX. Down's syndrome was ruled out by the child's normal phenotype and dermatoglyphic analysis. The cytogenetic finding is probably evidence for the clonal origin of the trisomy 21 cell line.","tracks":[{"project":"performance-test","denotations":[{"id":"PD-UBERON-AE-B_T1","span":{"begin":515,"end":526},"obj":"http://purl.obolibrary.org/obo/UBERON_0002371"}],"attributes":[{"subj":"PD-UBERON-AE-B_T1","pred":"source","obj":"performance-test"}]},{"project":"sentences","denotations":[{"id":"TextSentencer_T1","span":{"begin":0,"end":75},"obj":"Sentence"},{"id":"TextSentencer_T2","span":{"begin":76,"end":192},"obj":"Sentence"},{"id":"TextSentencer_T3","span":{"begin":193,"end":281},"obj":"Sentence"},{"id":"TextSentencer_T4","span":{"begin":282,"end":321},"obj":"Sentence"},{"id":"TextSentencer_T5","span":{"begin":322,"end":491},"obj":"Sentence"},{"id":"TextSentencer_T6","span":{"begin":492,"end":570},"obj":"Sentence"},{"id":"TextSentencer_T7","span":{"begin":571,"end":661},"obj":"Sentence"},{"id":"TextSentencer_T8","span":{"begin":662,"end":757},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":75},"obj":"Sentence"},{"id":"T2","span":{"begin":76,"end":192},"obj":"Sentence"},{"id":"T3","span":{"begin":193,"end":281},"obj":"Sentence"},{"id":"T4","span":{"begin":282,"end":321},"obj":"Sentence"},{"id":"T5","span":{"begin":322,"end":491},"obj":"Sentence"},{"id":"T6","span":{"begin":492,"end":570},"obj":"Sentence"},{"id":"T7","span":{"begin":571,"end":661},"obj":"Sentence"},{"id":"T8","span":{"begin":662,"end":757},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"TextSentencer_T1","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T2","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T3","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T4","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T5","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T6","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T7","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T8","pred":"source","obj":"sentences"},{"subj":"T1","pred":"source","obj":"sentences"},{"subj":"T2","pred":"source","obj":"sentences"},{"subj":"T3","pred":"source","obj":"sentences"},{"subj":"T4","pred":"source","obj":"sentences"},{"subj":"T5","pred":"source","obj":"sentences"},{"subj":"T6","pred":"source","obj":"sentences"},{"subj":"T7","pred":"source","obj":"sentences"},{"subj":"T8","pred":"source","obj":"sentences"}]},{"project":"UBERON-AE","denotations":[{"id":"PD-UBERON-AE-B_T1","span":{"begin":515,"end":526},"obj":"http://purl.obolibrary.org/obo/UBERON_0002371"}],"attributes":[{"subj":"PD-UBERON-AE-B_T1","pred":"source","obj":"UBERON-AE"}]},{"project":"PubCasesHPO","denotations":[{"id":"AB1","span":{"begin":264,"end":280},"obj":"HP:0012324"},{"id":"AB2","span":{"begin":352,"end":358},"obj":"HP:0001903"},{"id":"AB3","span":{"begin":360,"end":376},"obj":"HP:0001873"},{"id":"AB4","span":{"begin":381,"end":399},"obj":"HP:0001433"}],"attributes":[{"subj":"AB1","pred":"source","obj":"PubCasesHPO"},{"subj":"AB2","pred":"source","obj":"PubCasesHPO"},{"subj":"AB3","pred":"source","obj":"PubCasesHPO"},{"subj":"AB4","pred":"source","obj":"PubCasesHPO"}]},{"project":"PubCasesORDO","denotations":[{"id":"TI1","span":{"begin":58,"end":68},"obj":"ORDO:870"},{"id":"AB1","span":{"begin":256,"end":280},"obj":"ORDO:521"},{"id":"AB2","span":{"begin":736,"end":746},"obj":"ORDO:870"}],"namespaces":[{"prefix":"ORDO","uri":"http://www.orpha.net/ORDO/Orphanet_"}],"attributes":[{"subj":"TI1","pred":"source","obj":"PubCasesORDO"},{"subj":"AB1","pred":"source","obj":"PubCasesORDO"},{"subj":"AB2","pred":"source","obj":"PubCasesORDO"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"performance-test","color":"#939eec","default":true},{"id":"sentences","color":"#b8ec93"},{"id":"UBERON-AE","color":"#ec93d2"},{"id":"PubCasesHPO","color":"#93ecec"},{"id":"PubCasesORDO","color":"#ecd293"}]}]}}