PubMed:11933203 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/11933203","sourcedb":"PubMed","sourceid":"11933203","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/11933203","text":"An osteopontin (SPP1) polymorphism is associated with systemic lupus erythematosus.\nOsteopontin (SPP1) is a soluble ligand with pleomorphic immunologic activities including activation of macrophage chemotaxis, promotion of Th1 responses, and activation of B1 B cells. It has been implicated in the development of murine lupus and is overexpressed in humans with systemic lupus erythematosus (SLE). We examined a polymorphism of osteopontin for an association with lupus in humans in an effort to determine whether there is any evidence that a genetic predisposition to altered osteopontin expression might explain the overexpression seen in human SLE patients. A silent polymorphism (707C\u003eT, rs1126616) of osteopontin was significantly associated with SLE. Additional associations with renal disease and opportunisitic infections were suggested. This is the first phenotypic association with a polymorphic variant of osteopontin.","tracks":[{"project":"DisGeNET","denotations":[{"id":"T0","span":{"begin":16,"end":20},"obj":"gene:6696"},{"id":"T1","span":{"begin":54,"end":82},"obj":"disease:C0024141"},{"id":"T2","span":{"begin":3,"end":14},"obj":"gene:6696"},{"id":"T3","span":{"begin":54,"end":82},"obj":"disease:C0024141"},{"id":"T4","span":{"begin":577,"end":588},"obj":"gene:6696"},{"id":"T5","span":{"begin":464,"end":469},"obj":"disease:C0024138"},{"id":"T6","span":{"begin":428,"end":439},"obj":"gene:6696"},{"id":"T7","span":{"begin":464,"end":469},"obj":"disease:C0409974"},{"id":"T8","span":{"begin":428,"end":439},"obj":"gene:6696"},{"id":"T9","span":{"begin":647,"end":650},"obj":"disease:C0024141"},{"id":"T10","span":{"begin":577,"end":588},"obj":"gene:6696"},{"id":"T11","span":{"begin":464,"end":469},"obj":"disease:C0024131"},{"id":"T12","span":{"begin":428,"end":439},"obj":"gene:6696"},{"id":"T13","span":{"begin":464,"end":469},"obj":"disease:C0024141"},{"id":"T14","span":{"begin":577,"end":588},"obj":"gene:6696"},{"id":"T15","span":{"begin":464,"end":469},"obj":"disease:C0024141"},{"id":"T16","span":{"begin":577,"end":588},"obj":"gene:6696"},{"id":"T17","span":{"begin":464,"end":469},"obj":"disease:C0409974"},{"id":"T18","span":{"begin":577,"end":588},"obj":"gene:6696"},{"id":"T19","span":{"begin":647,"end":650},"obj":"disease:C0024141"},{"id":"T20","span":{"begin":428,"end":439},"obj":"gene:6696"},{"id":"T21","span":{"begin":464,"end":469},"obj":"disease:C0024138"},{"id":"T22","span":{"begin":428,"end":439},"obj":"gene:6696"},{"id":"T23","span":{"begin":464,"end":469},"obj":"disease:C0024131"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T0","obj":"T1"},{"id":"R2","pred":"associated_with","subj":"T2","obj":"T3"},{"id":"R3","pred":"associated_with","subj":"T4","obj":"T5"},{"id":"R4","pred":"associated_with","subj":"T6","obj":"T7"},{"id":"R5","pred":"associated_with","subj":"T8","obj":"T9"},{"id":"R6","pred":"associated_with","subj":"T10","obj":"T11"},{"id":"R7","pred":"associated_with","subj":"T12","obj":"T13"},{"id":"R8","pred":"associated_with","subj":"T14","obj":"T15"},{"id":"R9","pred":"associated_with","subj":"T16","obj":"T17"},{"id":"R10","pred":"associated_with","subj":"T18","obj":"T19"},{"id":"R11","pred":"associated_with","subj":"T20","obj":"T21"},{"id":"R12","pred":"associated_with","subj":"T22","obj":"T23"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"attributes":[{"subj":"T0","pred":"source","obj":"DisGeNET"},{"subj":"T1","pred":"source","obj":"DisGeNET"},{"subj":"T2","pred":"source","obj":"DisGeNET"},{"subj":"T3","pred":"source","obj":"DisGeNET"},{"subj":"T4","pred":"source","obj":"DisGeNET"},{"subj":"T5","pred":"source","obj":"DisGeNET"},{"subj":"T6","pred":"source","obj":"DisGeNET"},{"subj":"T7","pred":"source","obj":"DisGeNET"},{"subj":"T8","pred":"source","obj":"DisGeNET"},{"subj":"T9","pred":"source","obj":"DisGeNET"},{"subj":"T10","pred":"source","obj":"DisGeNET"},{"subj":"T11","pred":"source","obj":"DisGeNET"},{"subj":"T12","pred":"source","obj":"DisGeNET"},{"subj":"T13","pred":"source","obj":"DisGeNET"},{"subj":"T14","pred":"source","obj":"DisGeNET"},{"subj":"T15","pred":"source","obj":"DisGeNET"},{"subj":"T16","pred":"source","obj":"DisGeNET"},{"subj":"T17","pred":"source","obj":"DisGeNET"},{"subj":"T18","pred":"source","obj":"DisGeNET"},{"subj":"T19","pred":"source","obj":"DisGeNET"},{"subj":"T20","pred":"source","obj":"DisGeNET"},{"subj":"T21","pred":"source","obj":"DisGeNET"},{"subj":"T22","pred":"source","obj":"DisGeNET"},{"subj":"T23","pred":"source","obj":"DisGeNET"}]},{"project":"DisGeNET5_variant_disease","denotations":[{"id":"11933203-4#31#40#geners1126616","span":{"begin":692,"end":701},"obj":"geners1126616"},{"id":"11933203-4#91#94#diseaseC0024141","span":{"begin":752,"end":755},"obj":"diseaseC0024141"}],"relations":[{"id":"31#40#geners112661691#94#diseaseC0024141","pred":"associated_with","subj":"11933203-4#31#40#geners1126616","obj":"11933203-4#91#94#diseaseC0024141"}],"attributes":[{"subj":"11933203-4#31#40#geners1126616","pred":"source","obj":"DisGeNET5_variant_disease"},{"subj":"11933203-4#91#94#diseaseC0024141","pred":"source","obj":"DisGeNET5_variant_disease"}]},{"project":"DisGeNET5_gene_disease","denotations":[{"id":"11933203-0#3#14#gene6696","span":{"begin":3,"end":14},"obj":"gene6696"},{"id":"11933203-0#16#20#gene6696","span":{"begin":16,"end":20},"obj":"gene6696"},{"id":"11933203-0#54#82#diseaseC0024141","span":{"begin":54,"end":82},"obj":"diseaseC0024141"},{"id":"11933203-3#30#41#gene6696","span":{"begin":428,"end":439},"obj":"gene6696"},{"id":"11933203-3#179#190#gene6696","span":{"begin":577,"end":588},"obj":"gene6696"},{"id":"11933203-3#66#71#diseaseC0024131","span":{"begin":464,"end":469},"obj":"diseaseC0024131"},{"id":"11933203-3#66#71#diseaseC0024138","span":{"begin":464,"end":469},"obj":"diseaseC0024138"},{"id":"11933203-3#66#71#diseaseC0409974","span":{"begin":464,"end":469},"obj":"diseaseC0409974"},{"id":"11933203-3#66#71#diseaseC0024131","span":{"begin":464,"end":469},"obj":"diseaseC0024131"},{"id":"11933203-3#66#71#diseaseC0024138","span":{"begin":464,"end":469},"obj":"diseaseC0024138"},{"id":"11933203-3#66#71#diseaseC0409974","span":{"begin":464,"end":469},"obj":"diseaseC0409974"}],"relations":[{"id":"3#14#gene669654#82#diseaseC0024141","pred":"associated_with","subj":"11933203-0#3#14#gene6696","obj":"11933203-0#54#82#diseaseC0024141"},{"id":"16#20#gene669654#82#diseaseC0024141","pred":"associated_with","subj":"11933203-0#16#20#gene6696","obj":"11933203-0#54#82#diseaseC0024141"},{"id":"30#41#gene669666#71#diseaseC0024131","pred":"associated_with","subj":"11933203-3#30#41#gene6696","obj":"11933203-3#66#71#diseaseC0024131"},{"id":"30#41#gene669666#71#diseaseC0024138","pred":"associated_with","subj":"11933203-3#30#41#gene6696","obj":"11933203-3#66#71#diseaseC0024138"},{"id":"30#41#gene669666#71#diseaseC0409974","pred":"associated_with","subj":"11933203-3#30#41#gene6696","obj":"11933203-3#66#71#diseaseC0409974"},{"id":"30#41#gene669666#71#diseaseC0024131","pred":"associated_with","subj":"11933203-3#30#41#gene6696","obj":"11933203-3#66#71#diseaseC0024131"},{"id":"30#41#gene669666#71#diseaseC0024138","pred":"associated_with","subj":"11933203-3#30#41#gene6696","obj":"11933203-3#66#71#diseaseC0024138"},{"id":"30#41#gene669666#71#diseaseC0409974","pred":"associated_with","subj":"11933203-3#30#41#gene6696","obj":"11933203-3#66#71#diseaseC0409974"},{"id":"179#190#gene669666#71#diseaseC0024131","pred":"associated_with","subj":"11933203-3#179#190#gene6696","obj":"11933203-3#66#71#diseaseC0024131"},{"id":"179#190#gene669666#71#diseaseC0024138","pred":"associated_with","subj":"11933203-3#179#190#gene6696","obj":"11933203-3#66#71#diseaseC0024138"},{"id":"179#190#gene669666#71#diseaseC0409974","pred":"associated_with","subj":"11933203-3#179#190#gene6696","obj":"11933203-3#66#71#diseaseC0409974"},{"id":"179#190#gene669666#71#diseaseC0024131","pred":"associated_with","subj":"11933203-3#179#190#gene6696","obj":"11933203-3#66#71#diseaseC0024131"},{"id":"179#190#gene669666#71#diseaseC0024138","pred":"associated_with","subj":"11933203-3#179#190#gene6696","obj":"11933203-3#66#71#diseaseC0024138"},{"id":"179#190#gene669666#71#diseaseC0409974","pred":"associated_with","subj":"11933203-3#179#190#gene6696","obj":"11933203-3#66#71#diseaseC0409974"}],"attributes":[{"subj":"11933203-0#3#14#gene6696","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"11933203-0#16#20#gene6696","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"11933203-0#54#82#diseaseC0024141","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"11933203-3#30#41#gene6696","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"11933203-3#179#190#gene6696","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"11933203-3#66#71#diseaseC0024131","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"11933203-3#66#71#diseaseC0024138","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"11933203-3#66#71#diseaseC0409974","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"11933203-3#66#71#diseaseC0024131","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"11933203-3#66#71#diseaseC0024138","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"11933203-3#66#71#diseaseC0409974","pred":"source","obj":"DisGeNET5_gene_disease"}]},{"project":"PubTator4TogoVar","denotations":[{"id":"41","span":{"begin":692,"end":701},"obj":"SNP"}],"attributes":[{"id":"A41","pred":"resolved_to","subj":"41","obj":"tmVar:rs1126616;VariantGroup:0;CorrespondingGene:6696;RS#:1126616;CorrespondingSpecies:9606"},{"subj":"41","pred":"source","obj":"PubTator4TogoVar"}]},{"project":"PubTatorOnTogoVar","denotations":[{"id":"41","span":{"begin":692,"end":701},"obj":"SNP"},{"id":"T1","span":{"begin":692,"end":701},"obj":"SNP"}],"attributes":[{"id":"A41","pred":"resolved_to","subj":"41","obj":"tmVar:rs1126616;VariantGroup:0;CorrespondingGene:6696;RS#:1126616;CorrespondingSpecies:9606"},{"id":"A1","pred":"resolved_to","subj":"T1","obj":"tmVar:rs1126616;VariantGroup:0;CorrespondingGene:6696;RS#:1126616;CorrespondingSpecies:9606"},{"subj":"41","pred":"source","obj":"PubTatorOnTogoVar"},{"subj":"T1","pred":"source","obj":"PubTatorOnTogoVar"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"DisGeNET","color":"#ec93e2","default":true},{"id":"DisGeNET5_variant_disease","color":"#93ecdc"},{"id":"DisGeNET5_gene_disease","color":"#ecc293"},{"id":"PubTator4TogoVar","color":"#a893ec"},{"id":"PubTatorOnTogoVar","color":"#97ec93"}]}]}}