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c_corpus

Id Subject Object Predicate Lexical cue
T2 0-11 GO:0004248 denotes Stromelysin
T4 0-13 P28863 denotes Stromelysin-1
T5 0-13 P08254 denotes Stromelysin-1
T6 0-13 Q28397 denotes Stromelysin-1
T7 0-13 Q6Y4Q5 denotes Stromelysin-1
T8 0-13 P28862 denotes Stromelysin-1
T9 0-13 PR:000010488 denotes Stromelysin-1
T10 0-13 P03957 denotes Stromelysin-1
T3 0-13 D019278 denotes Stromelysin-1
T13 18-30 P08253 denotes gelatinase A
T14 18-30 Q90611 denotes gelatinase A
T16 18-30 PR:000010479 denotes gelatinase A
T17 18-30 P33436 denotes gelatinase A
T18 18-30 P33434 denotes gelatinase A
T19 18-30 P50757 denotes gelatinase A
T15 18-30 D020778 denotes gelatinase A
T24 54-63 P19101 denotes TNF-alpha
T25 54-63 Q06599 denotes TNF-alpha
T26 54-63 O35734 denotes TNF-alpha
T27 54-63 Q8JFG3 denotes TNF-alpha
T30 54-63 PR:000000134 denotes TNF-alpha
T31 54-63 Q8MKG8 denotes TNF-alpha
T32 54-63 P29553 denotes TNF-alpha
T33 54-63 P23563 denotes TNF-alpha
T34 54-63 P33620 denotes TNF-alpha
T35 54-63 P06804 denotes TNF-alpha
T36 54-63 Q1WM27 denotes TNF-alpha
T37 54-63 Q539C2 denotes TNF-alpha
T38 54-63 P59695 denotes TNF-alpha
T39 54-63 Q8WNR1 denotes TNF-alpha
T40 54-63 Q8HZD9 denotes TNF-alpha
T41 54-63 Q75N23 denotes TNF-alpha
T42 54-63 O77764 denotes TNF-alpha
T43 54-63 P48094 denotes TNF-alpha
T44 54-63 P59694 denotes TNF-alpha
T45 54-63 P79374 denotes TNF-alpha
T46 54-63 Q9BEA1 denotes TNF-alpha
T47 54-63 Q2MH05 denotes TNF-alpha
T48 54-63 P23383 denotes TNF-alpha
T49 54-63 O77510 denotes TNF-alpha
T50 54-63 P59693 denotes TNF-alpha
T51 54-63 P51742 denotes TNF-alpha
T52 54-63 P59684 denotes TNF-alpha
T53 54-63 P04924 denotes TNF-alpha
T54 54-63 P51435 denotes TNF-alpha
T55 54-63 Q1G1A2 denotes TNF-alpha
T56 54-63 P01375 denotes TNF-alpha
T57 54-63 P13296 denotes TNF-alpha
T58 54-63 Q19LH4 denotes TNF-alpha
T59 54-63 P16599 denotes TNF-alpha
T60 54-63 P79337 denotes TNF-alpha
T61 54-63 P36939 denotes TNF-alpha
T62 54-63 P51743 denotes TNF-alpha
T28 54-63 D014409 denotes TNF-alpha
T29 54-63 D014409 denotes TNF-alpha
T65 67-70 PR:Q9QUK6 denotes LPS
T67 67-70 PR:000001155 denotes LPS
T64 67-70 CHEBI:89981 denotes LPS
T68 67-70 CHEBI:52603 denotes LPS
T69 67-70 CHEBI:16412 denotes LPS
T66 67-70 C536528 denotes LPS
T70 173-184 GO:0006508 denotes proteolysis
T71 195-220 D020782 denotes Matrix metalloproteinases
T73 222-226 D020782 denotes MMPs
T75 257-277 GO:0031012 denotes extracellular matrix
T76 271-277 UBERON:0027368 denotes matrix
T77 340-347 UBERON:0004111 denotes opening
T78 355-374 UBERON:0000120 denotes blood-brain barrier
T81 376-379 UBERON:0000120 denotes BBB
T82 406-424 CHEBI:89981 denotes lipopolysaccharide
T83 406-424 CHEBI:16412 denotes lipopolysaccharide
T85 426-429 PR:Q9QUK6 denotes LPS
T87 426-429 PR:000001155 denotes LPS
T84 426-429 CHEBI:89981 denotes LPS
T88 426-429 CHEBI:52603 denotes LPS
T89 426-429 CHEBI:16412 denotes LPS
T86 426-429 C536528 denotes LPS
T90 445-448 UBERON:0000120 denotes BBB
T94 471-483 P14780 denotes gelatinase B
T95 471-483 P41246 denotes gelatinase B
T96 471-483 P41245 denotes gelatinase B
T97 471-483 P50282 denotes gelatinase B
T98 471-483 PR:000010491 denotes gelatinase B
T99 471-483 P52176 denotes gelatinase B
T100 471-483 O18733 denotes gelatinase B
T93 471-483 D020780 denotes gelatinase B
T101 485-488 CHEBI:340824 denotes MMP
T104 485-488 CHEBI:59761 denotes MMP
T105 485-490 PR:P50282 denotes MMP-9
T106 485-490 PR:P14780 denotes MMP-9
T107 485-490 P14780 denotes MMP-9
T108 485-490 PR:P41245 denotes MMP-9
T109 485-490 P41246 denotes MMP-9
T110 485-490 P41245 denotes MMP-9
T111 485-490 PR:P52176 denotes MMP-9
T112 485-490 P50282 denotes MMP-9
T114 485-490 PR:000010491 denotes MMP-9
T115 485-490 P52176 denotes MMP-9
T116 485-490 O18733 denotes MMP-9
T113 485-490 GO:0004229 denotes MMP-9
T117 507-524 D002545 denotes cerebral ischemia
T118 507-524 D002545 denotes cerebral ischemia
T123 526-538 P08253 denotes gelatinase A
T124 526-538 Q90611 denotes gelatinase A
T126 526-538 PR:000010479 denotes gelatinase A
T127 526-538 P33436 denotes gelatinase A
T128 526-538 P33434 denotes gelatinase A
T129 526-538 P50757 denotes gelatinase A
T125 526-538 D020778 denotes gelatinase A
T130 540-543 CHEBI:340824 denotes MMP
T133 540-543 CHEBI:59761 denotes MMP
T134 540-545 PR:P08253 denotes MMP-2
T135 540-545 Q9GLE5 denotes MMP-2
T136 540-545 P08253 denotes MMP-2
T137 540-545 Q90611 denotes MMP-2
T139 540-545 PR:Q8MPP3 denotes MMP-2
T140 540-545 P33436 denotes MMP-2
T141 540-545 PR:Q90611 denotes MMP-2
T142 540-545 PR:P33436 denotes MMP-2
T143 540-545 PR:000010479 denotes MMP-2
T144 540-545 PR:P33434 denotes MMP-2
T145 540-545 P33434 denotes MMP-2
T146 540-545 P50757 denotes MMP-2
T138 540-545 GO:0004228 denotes MMP-2
T148 583-594 GO:0004248 denotes stromelysin
T150 583-596 P28863 denotes stromelysin-1
T151 583-596 P08254 denotes stromelysin-1
T152 583-596 Q28397 denotes stromelysin-1
T153 583-596 Q6Y4Q5 denotes stromelysin-1
T154 583-596 P28862 denotes stromelysin-1
T155 583-596 PR:000010488 denotes stromelysin-1
T156 583-596 P03957 denotes stromelysin-1
T149 583-596 D019278 denotes stromelysin-1
T157 595-601 PR:O23507 denotes 1 (MMP
T158 598-601 CHEBI:340824 denotes MMP
T161 598-601 CHEBI:59761 denotes MMP
T162 598-603 P28863 denotes MMP-3
T163 598-603 P08254 denotes MMP-3
T164 598-603 Q28397 denotes MMP-3
T165 598-603 PR:P08254 denotes MMP-3
T166 598-603 PR:P03957 denotes MMP-3
T167 598-603 Q6Y4Q5 denotes MMP-3
T168 598-603 P28862 denotes MMP-3
T170 598-603 PR:000010488 denotes MMP-3
T171 598-603 PR:P28862 denotes MMP-3
T172 598-603 P03957 denotes MMP-3
T169 598-603 GO:0004248 denotes MMP-3
T173 608-617 CL:0000129 denotes microglia
T174 631-635 D020782 denotes MMPs
T176 656-659 PR:Q9QUK6 denotes LPS
T178 656-659 PR:000001155 denotes LPS
T175 656-659 CHEBI:89981 denotes LPS
T179 656-659 CHEBI:52603 denotes LPS
T180 656-659 CHEBI:16412 denotes LPS
T177 656-659 C536528 denotes LPS
T181 691-695 SO:0000704 denotes gene
T182 696-709 GO:0006351 denotes transcription
T183 714-735 GO:0051641 denotes cellular localization
T185 747-751 D020782 denotes MMPs
T186 782-787 D009369 denotes tumor
T187 782-787 D009369 denotes tumor
T188 782-803 P19101 denotes tumor necrosis factor
T189 782-803 Q06599 denotes tumor necrosis factor
T190 782-803 O35734 denotes tumor necrosis factor
T191 782-803 Q8JFG3 denotes tumor necrosis factor
T194 782-803 PR:000000134 denotes tumor necrosis factor
T195 782-803 Q8MKG8 denotes tumor necrosis factor
T196 782-803 P29553 denotes tumor necrosis factor
T197 782-803 P23563 denotes tumor necrosis factor
T198 782-803 P33620 denotes tumor necrosis factor
T199 782-803 P06804 denotes tumor necrosis factor
T200 782-803 Q1WM27 denotes tumor necrosis factor
T201 782-803 Q539C2 denotes tumor necrosis factor
T202 782-803 P59695 denotes tumor necrosis factor
T203 782-803 Q8WNR1 denotes tumor necrosis factor
T204 782-803 Q8HZD9 denotes tumor necrosis factor
T205 782-803 Q75N23 denotes tumor necrosis factor
T206 782-803 O77764 denotes tumor necrosis factor
T207 782-803 P48094 denotes tumor necrosis factor
T208 782-803 P59694 denotes tumor necrosis factor
T209 782-803 P79374 denotes tumor necrosis factor
T210 782-803 Q9BEA1 denotes tumor necrosis factor
T211 782-803 Q2MH05 denotes tumor necrosis factor
T212 782-803 P23383 denotes tumor necrosis factor
T213 782-803 O77510 denotes tumor necrosis factor
T214 782-803 P59693 denotes tumor necrosis factor
T215 782-803 P51742 denotes tumor necrosis factor
T216 782-803 P59684 denotes tumor necrosis factor
T217 782-803 P04924 denotes tumor necrosis factor
T218 782-803 P51435 denotes tumor necrosis factor
T220 782-803 Q1G1A2 denotes tumor necrosis factor
T221 782-803 P01375 denotes tumor necrosis factor
T222 782-803 P13296 denotes tumor necrosis factor
T223 782-803 Q19LH4 denotes tumor necrosis factor
T224 782-803 P16599 denotes tumor necrosis factor
T225 782-803 P79337 denotes tumor necrosis factor
T226 782-803 P36939 denotes tumor necrosis factor
T227 782-803 P51743 denotes tumor necrosis factor
T192 782-803 D014409 denotes tumor necrosis factor
T193 782-803 D014409 denotes tumor necrosis factor
T219 782-803 GO:0005164 denotes tumor necrosis factor
T228 788-796 GO:0019835 denotes necrosis
T229 788-796 GO:0008219 denotes necrosis
T232 788-796 GO:0008220 denotes necrosis
T233 788-796 GO:0001906 denotes necrosis
T234 788-796 GO:0070265 denotes necrosis
T230 788-796 D009336 denotes necrosis
T231 788-796 D009336 denotes necrosis
T239 805-814 P19101 denotes TNF-alpha
T240 805-814 Q06599 denotes TNF-alpha
T241 805-814 O35734 denotes TNF-alpha
T242 805-814 Q8JFG3 denotes TNF-alpha
T245 805-814 PR:000000134 denotes TNF-alpha
T246 805-814 Q8MKG8 denotes TNF-alpha
T247 805-814 P29553 denotes TNF-alpha
T248 805-814 P23563 denotes TNF-alpha
T249 805-814 P33620 denotes TNF-alpha
T250 805-814 P06804 denotes TNF-alpha
T251 805-814 Q1WM27 denotes TNF-alpha
T252 805-814 Q539C2 denotes TNF-alpha
T253 805-814 P59695 denotes TNF-alpha
T254 805-814 Q8WNR1 denotes TNF-alpha
T255 805-814 Q8HZD9 denotes TNF-alpha
T256 805-814 Q75N23 denotes TNF-alpha
T257 805-814 O77764 denotes TNF-alpha
T258 805-814 P48094 denotes TNF-alpha
T259 805-814 P59694 denotes TNF-alpha
T260 805-814 P79374 denotes TNF-alpha
T261 805-814 Q9BEA1 denotes TNF-alpha
T262 805-814 Q2MH05 denotes TNF-alpha
T263 805-814 P23383 denotes TNF-alpha
T264 805-814 O77510 denotes TNF-alpha
T265 805-814 P59693 denotes TNF-alpha
T266 805-814 P51742 denotes TNF-alpha
T267 805-814 P59684 denotes TNF-alpha
T268 805-814 P04924 denotes TNF-alpha
T269 805-814 P51435 denotes TNF-alpha
T270 805-814 Q1G1A2 denotes TNF-alpha
T271 805-814 P01375 denotes TNF-alpha
T272 805-814 P13296 denotes TNF-alpha
T273 805-814 Q19LH4 denotes TNF-alpha
T274 805-814 P16599 denotes TNF-alpha
T275 805-814 P79337 denotes TNF-alpha
T276 805-814 P36939 denotes TNF-alpha
T277 805-814 P51743 denotes TNF-alpha
T243 805-814 D014409 denotes TNF-alpha
T244 805-814 D014409 denotes TNF-alpha
T279 846-851 SO:0000419 denotes chain
T280 846-860 MOP:0000635 denotes chain reaction
T281 862-865 Q41249 denotes PCR
T282 862-865 O66148 denotes PCR
T283 862-865 Q59987 denotes PCR
T284 862-865 Q01289 denotes PCR
T285 862-865 O80333 denotes PCR
T286 862-865 P15904 denotes PCR
T287 862-865 Q9SDT1 denotes PCR
T288 862-865 Q39617 denotes PCR
T289 933-936 CHEBI:340824 denotes MMP
T292 933-936 CHEBI:59761 denotes MMP
T293 933-938 PR:P08253 denotes MMP-2
T294 933-938 Q9GLE5 denotes MMP-2
T295 933-938 P08253 denotes MMP-2
T296 933-938 Q90611 denotes MMP-2
T298 933-938 PR:Q8MPP3 denotes MMP-2
T299 933-938 P33436 denotes MMP-2
T300 933-938 PR:Q90611 denotes MMP-2
T301 933-938 PR:P33436 denotes MMP-2
T302 933-938 PR:000010479 denotes MMP-2
T303 933-938 PR:P33434 denotes MMP-2
T304 933-938 P33434 denotes MMP-2
T305 933-938 P50757 denotes MMP-2
T297 933-938 GO:0004228 denotes MMP-2
T309 946-950 SO:0000234 denotes mRNA
T307 946-950 D012333 denotes mRNA
T308 946-950 CHEBI:33699 denotes mRNA
T311 968-971 PR:Q9QUK6 denotes LPS
T313 968-971 PR:000001155 denotes LPS
T310 968-971 CHEBI:89981 denotes LPS
T314 968-971 CHEBI:52603 denotes LPS
T315 968-971 CHEBI:16412 denotes LPS
T312 968-971 C536528 denotes LPS
T316 1039-1044 UBERON:6110636 denotes brain
T317 1039-1044 UBERON:0000955 denotes brain
T318 1045-1051 UBERON:0000479 denotes tissue
T320 1074-1077 PR:Q9QUK6 denotes LPS
T322 1074-1077 PR:000001155 denotes LPS
T319 1074-1077 CHEBI:89981 denotes LPS
T323 1074-1077 CHEBI:52603 denotes LPS
T324 1074-1077 CHEBI:16412 denotes LPS
T321 1074-1077 C536528 denotes LPS
T325 1089-1093 SO:0000704 denotes gene
T326 1089-1104 GO:0010467 denotes gene expression
T327 1108-1111 CHEBI:340824 denotes MMP
T330 1108-1111 CHEBI:59761 denotes MMP
T331 1108-1113 PR:P08253 denotes MMP-2
T332 1108-1113 Q9GLE5 denotes MMP-2
T333 1108-1113 P08253 denotes MMP-2
T334 1108-1113 Q90611 denotes MMP-2
T336 1108-1113 PR:Q8MPP3 denotes MMP-2
T337 1108-1113 P33436 denotes MMP-2
T338 1108-1113 PR:Q90611 denotes MMP-2
T339 1108-1113 PR:P33436 denotes MMP-2
T340 1108-1113 PR:000010479 denotes MMP-2
T341 1108-1113 PR:P33434 denotes MMP-2
T342 1108-1113 P33434 denotes MMP-2
T343 1108-1113 P50757 denotes MMP-2
T335 1108-1113 GO:0004228 denotes MMP-2
T346 1154-1157 PR:Q9QUK6 denotes LPS
T348 1154-1157 PR:000001155 denotes LPS
T345 1154-1157 CHEBI:89981 denotes LPS
T349 1154-1157 CHEBI:52603 denotes LPS
T350 1154-1157 CHEBI:16412 denotes LPS
T347 1154-1157 C536528 denotes LPS
T351 1167-1173 UBERON:0000479 denotes tissue
T356 1181-1190 P19101 denotes TNF-alpha
T357 1181-1190 Q06599 denotes TNF-alpha
T358 1181-1190 O35734 denotes TNF-alpha
T359 1181-1190 Q8JFG3 denotes TNF-alpha
T362 1181-1190 PR:000000134 denotes TNF-alpha
T363 1181-1190 Q8MKG8 denotes TNF-alpha
T364 1181-1190 P29553 denotes TNF-alpha
T365 1181-1190 P23563 denotes TNF-alpha
T366 1181-1190 P33620 denotes TNF-alpha
T367 1181-1190 P06804 denotes TNF-alpha
T368 1181-1190 Q1WM27 denotes TNF-alpha
T369 1181-1190 Q539C2 denotes TNF-alpha
T370 1181-1190 P59695 denotes TNF-alpha
T371 1181-1190 Q8WNR1 denotes TNF-alpha
T372 1181-1190 Q8HZD9 denotes TNF-alpha
T373 1181-1190 Q75N23 denotes TNF-alpha
T374 1181-1190 O77764 denotes TNF-alpha
T375 1181-1190 P48094 denotes TNF-alpha
T376 1181-1190 P59694 denotes TNF-alpha
T377 1181-1190 P79374 denotes TNF-alpha
T378 1181-1190 Q9BEA1 denotes TNF-alpha
T379 1181-1190 Q2MH05 denotes TNF-alpha
T380 1181-1190 P23383 denotes TNF-alpha
T381 1181-1190 O77510 denotes TNF-alpha
T382 1181-1190 P59693 denotes TNF-alpha
T383 1181-1190 P51742 denotes TNF-alpha
T384 1181-1190 P59684 denotes TNF-alpha
T385 1181-1190 P04924 denotes TNF-alpha
T386 1181-1190 P51435 denotes TNF-alpha
T387 1181-1190 Q1G1A2 denotes TNF-alpha
T388 1181-1190 P01375 denotes TNF-alpha
T389 1181-1190 P13296 denotes TNF-alpha
T390 1181-1190 Q19LH4 denotes TNF-alpha
T391 1181-1190 P16599 denotes TNF-alpha
T392 1181-1190 P79337 denotes TNF-alpha
T393 1181-1190 P36939 denotes TNF-alpha
T394 1181-1190 P51743 denotes TNF-alpha
T360 1181-1190 D014409 denotes TNF-alpha
T361 1181-1190 D014409 denotes TNF-alpha
T398 1191-1195 SO:0000234 denotes mRNA
T396 1191-1195 D012333 denotes mRNA
T397 1191-1195 CHEBI:33699 denotes mRNA
T399 1299-1302 CHEBI:340824 denotes MMP
T402 1299-1302 CHEBI:59761 denotes MMP
T403 1299-1304 PR:P08253 denotes MMP-2
T404 1299-1304 Q9GLE5 denotes MMP-2
T405 1299-1304 P08253 denotes MMP-2
T406 1299-1304 Q90611 denotes MMP-2
T408 1299-1304 PR:Q8MPP3 denotes MMP-2
T409 1299-1304 P33436 denotes MMP-2
T410 1299-1304 PR:Q90611 denotes MMP-2
T411 1299-1304 PR:P33436 denotes MMP-2
T412 1299-1304 PR:000010479 denotes MMP-2
T413 1299-1304 PR:P33434 denotes MMP-2
T414 1299-1304 P33434 denotes MMP-2
T415 1299-1304 P50757 denotes MMP-2
T407 1299-1304 GO:0004228 denotes MMP-2
T416 1325-1334 UBERON:0004529 denotes processes
T417 1353-1366 UBERON:0004537 denotes blood vessels
T419 1390-1393 PR:Q9QUK6 denotes LPS
T421 1390-1393 PR:000001155 denotes LPS
T418 1390-1393 CHEBI:89981 denotes LPS
T422 1390-1393 CHEBI:52603 denotes LPS
T423 1390-1393 CHEBI:16412 denotes LPS
T420 1390-1393 C536528 denotes LPS
T424 1423-1426 CHEBI:340824 denotes MMP
T427 1423-1426 CHEBI:59761 denotes MMP
T428 1423-1428 PR:P50282 denotes MMP-9
T429 1423-1428 PR:P14780 denotes MMP-9
T430 1423-1428 P14780 denotes MMP-9
T431 1423-1428 PR:P41245 denotes MMP-9
T432 1423-1428 P41246 denotes MMP-9
T433 1423-1428 P41245 denotes MMP-9
T434 1423-1428 PR:P52176 denotes MMP-9
T435 1423-1428 P50282 denotes MMP-9
T437 1423-1428 PR:000010491 denotes MMP-9
T438 1423-1428 P52176 denotes MMP-9
T439 1423-1428 O18733 denotes MMP-9
T436 1423-1428 GO:0004229 denotes MMP-9
T440 1433-1436 CHEBI:340824 denotes MMP
T443 1433-1436 CHEBI:59761 denotes MMP
T444 1433-1438 P28863 denotes MMP-3
T445 1433-1438 P08254 denotes MMP-3
T446 1433-1438 Q28397 denotes MMP-3
T447 1433-1438 PR:P08254 denotes MMP-3
T448 1433-1438 PR:P03957 denotes MMP-3
T449 1433-1438 Q6Y4Q5 denotes MMP-3
T450 1433-1438 P28862 denotes MMP-3
T452 1433-1438 PR:000010488 denotes MMP-3
T453 1433-1438 PR:P28862 denotes MMP-3
T454 1433-1438 P03957 denotes MMP-3
T451 1433-1438 GO:0004248 denotes MMP-3
T456 1489-1492 PR:Q9QUK6 denotes LPS
T458 1489-1492 PR:000001155 denotes LPS
T455 1489-1492 CHEBI:89981 denotes LPS
T459 1489-1492 CHEBI:52603 denotes LPS
T460 1489-1492 CHEBI:16412 denotes LPS
T457 1489-1492 C536528 denotes LPS
T461 1504-1509 UBERON:6110636 denotes brain
T462 1504-1509 UBERON:0000955 denotes brain
T463 1510-1516 UBERON:0000479 denotes tissue
T464 1565-1577 GO:0005604 denotes basal lamina
T465 1565-1577 UBERON:0000482 denotes basal lamina
T469 1620-1631 D010447 denotes proteinases
T471 1660-1663 PR:Q9QUK6 denotes LPS
T473 1660-1663 PR:000001155 denotes LPS
T470 1660-1663 CHEBI:89981 denotes LPS
T474 1660-1663 CHEBI:52603 denotes LPS
T475 1660-1663 CHEBI:16412 denotes LPS
T472 1660-1663 C536528 denotes LPS
T477 1686-1689 CHEBI:340824 denotes MMP
T480 1686-1689 CHEBI:59761 denotes MMP
T481 1686-1691 PR:P08253 denotes MMP-2
T482 1686-1691 Q9GLE5 denotes MMP-2
T483 1686-1691 P08253 denotes MMP-2
T484 1686-1691 Q90611 denotes MMP-2
T486 1686-1691 PR:Q8MPP3 denotes MMP-2
T487 1686-1691 P33436 denotes MMP-2
T488 1686-1691 PR:Q90611 denotes MMP-2
T489 1686-1691 PR:P33436 denotes MMP-2
T490 1686-1691 PR:000010479 denotes MMP-2
T491 1686-1691 PR:P33434 denotes MMP-2
T492 1686-1691 P33434 denotes MMP-2
T493 1686-1691 P50757 denotes MMP-2
T485 1686-1691 GO:0004228 denotes MMP-2
T496 1726-1729 PR:O04529 denotes MMP
T494 1726-1729 CHEBI:340824 denotes MMP
T497 1726-1729 CHEBI:59761 denotes MMP
T495 1726-1729 GO:0004235 denotes MMP
T498 1743-1752 SO:0000119 denotes regulated
T499 1766-1788 GO:0042089 denotes induction of cytokines
T500 1779-1788 D016207 denotes cytokines
T501 1779-1788 D016207 denotes cytokines
T506 1797-1806 P19101 denotes TNF-alpha
T507 1797-1806 Q06599 denotes TNF-alpha
T508 1797-1806 O35734 denotes TNF-alpha
T509 1797-1806 Q8JFG3 denotes TNF-alpha
T512 1797-1806 PR:000000134 denotes TNF-alpha
T513 1797-1806 Q8MKG8 denotes TNF-alpha
T514 1797-1806 P29553 denotes TNF-alpha
T515 1797-1806 P23563 denotes TNF-alpha
T516 1797-1806 P33620 denotes TNF-alpha
T517 1797-1806 P06804 denotes TNF-alpha
T518 1797-1806 Q1WM27 denotes TNF-alpha
T519 1797-1806 Q539C2 denotes TNF-alpha
T520 1797-1806 P59695 denotes TNF-alpha
T521 1797-1806 Q8WNR1 denotes TNF-alpha
T522 1797-1806 Q8HZD9 denotes TNF-alpha
T523 1797-1806 Q75N23 denotes TNF-alpha
T524 1797-1806 O77764 denotes TNF-alpha
T525 1797-1806 P48094 denotes TNF-alpha
T526 1797-1806 P59694 denotes TNF-alpha
T527 1797-1806 P79374 denotes TNF-alpha
T528 1797-1806 Q9BEA1 denotes TNF-alpha
T529 1797-1806 Q2MH05 denotes TNF-alpha
T530 1797-1806 P23383 denotes TNF-alpha
T531 1797-1806 O77510 denotes TNF-alpha
T532 1797-1806 P59693 denotes TNF-alpha
T533 1797-1806 P51742 denotes TNF-alpha
T534 1797-1806 P59684 denotes TNF-alpha
T535 1797-1806 P04924 denotes TNF-alpha
T536 1797-1806 P51435 denotes TNF-alpha
T537 1797-1806 Q1G1A2 denotes TNF-alpha
T538 1797-1806 P01375 denotes TNF-alpha
T539 1797-1806 P13296 denotes TNF-alpha
T540 1797-1806 Q19LH4 denotes TNF-alpha
T541 1797-1806 P16599 denotes TNF-alpha
T542 1797-1806 P79337 denotes TNF-alpha
T543 1797-1806 P36939 denotes TNF-alpha
T544 1797-1806 P51743 denotes TNF-alpha
T510 1797-1806 D014409 denotes TNF-alpha
T511 1797-1806 D014409 denotes TNF-alpha
T548 1817-1820 PR:O04529 denotes MMP
T546 1817-1820 CHEBI:340824 denotes MMP
T549 1817-1820 CHEBI:59761 denotes MMP
T547 1817-1820 GO:0004235 denotes MMP
T550 1821-1829 CHEBI:36080 denotes proteins
T551 1851-1864 UBERON:0004537 denotes blood vessels
T553 1868-1871 PR:Q9QUK6 denotes LPS
T555 1868-1871 PR:000001155 denotes LPS
T552 1868-1871 CHEBI:89981 denotes LPS
T556 1868-1871 CHEBI:52603 denotes LPS
T557 1868-1871 CHEBI:16412 denotes LPS
T554 1868-1871 C536528 denotes LPS

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-66 DRI_Approach denotes Stromelysin-1 and gelatinase A are upregulated before TNF-alpha in
T2 67-99 Token_Label.OUTSIDE denotes LPS-stimulated neuroinflammation
T3 99-100 DRI_Approach denotes .
T4 101-194 DRI_Approach denotes Neuroinflammation induces a complex molecular cascade that leads to the proteolysis of cells.
T5 195-381 DRI_Approach denotes Matrix metalloproteinases (MMPs) attack all components of the extracellular matrix in a number of neuroinflammatory diseases and cause a delayed opening of the blood-brain barrier (BBB).
T6 382-492 DRI_Approach denotes Earlier, we showed that lipopolysaccharide (LPS) disrupted the BBB through the action of gelatinase B (MMP-9).
T7 493-618 DRI_Background denotes In a study of cerebral ischemia, gelatinase A (MMP-2) was seen in astrocytic end-feet and stromelysin-1 (MMP-3) in microglia.
T8 619-899 DRI_Challenge denotes Since other MMPs may be important in LPS-induced injury, we studied the gene transcription and cellular localization of several MMPs and an inflammatory mediator, tumor necrosis factor (TNF-alpha), using competitive polymerase chain reaction (PCR) and immunohistochemical methods.
T9 900-1061 DRI_Approach denotes Significantly elevated levels of MMP-2 and -3 mRNA were observed in LPS-injected brains by 2 h after injection as compared to non-injected brain tissue (P<0.05).
T10 1062-1222 DRI_Background denotes By 8 h post-LPS injection, gene expression of MMP-2 and -3 had declined in both saline- and LPS-injected tissue, while TNF-alpha mRNA levels rose significantly.
T11 1223-1298 DRI_Background denotes Immunohistochemistry of control brains confirmed the earlier observation of
T12 1299-1321 Token_Label.OUTSIDE denotes MMP-2 immunoreactivity
T13 1322-1404 DRI_Background denotes in processes abutting cerebral blood vessels, which increased after LPS injection.
T14 1405-1605 DRI_Background denotes The expression of MMP-9 and MMP-3 was localized mainly to the cerebrovasculature in LPS-stimulated brain tissue, predominantly in the perivascular cells of the basal lamina near the site of injection.
T15 1606-1703 DRI_Approach denotes Both of these proteinases were present at the site of LPS injection at 8 h, but MMP-2 was absent.
T16 1704-1867 DRI_Outcome denotes Our results show that MMP genes are up-regulated prior to the induction of cytokines such as TNF-alpha, and that MMP proteins are prominent around blood vessels in
T17 1868-1897 Token_Label.OUTSIDE denotes LPS-induced neuroinflammation
T18 1897-1898 DRI_Outcome denotes .