Id |
Subject |
Object |
Predicate |
Lexical cue |
TextSentencer_T1 |
0-27 |
Sentence |
denotes |
[The Lesch-Nyhan syndrome]. |
TextSentencer_T2 |
28-62 |
Sentence |
denotes |
Les-Nijanov (Lesch-Nyhan) sindrom. |
TextSentencer_T3 |
63-355 |
Sentence |
denotes |
Deficiency of hypoxanthine phosphoribosyltransferase (HPRT) has a broad spectrum of clinical manifestations, from the complete enzyme defect, the Lesch-Nyhan syndrome with severe neurological deficiency to the partial defect associated only with uric acid overproduction and its consequences. |
TextSentencer_T4 |
356-410 |
Sentence |
denotes |
We present a 5-year old boy with Lesch-Nyhan syndrome. |
TextSentencer_T5 |
411-492 |
Sentence |
denotes |
He came to our hospital because of abdominal pain, vomiting and gross haematuria. |
TextSentencer_T6 |
493-642 |
Sentence |
denotes |
At the age of 8 months he was categorized as a "cerebral palsy" patient due to involuntary movements and high degree of spastically and tonic spasms. |
TextSentencer_T7 |
643-694 |
Sentence |
denotes |
He remained incapable of sitting or standing alone. |
TextSentencer_T8 |
695-814 |
Sentence |
denotes |
The patient's brother and two uncles were also categorized as "cerebral palsy" cases and died at the age of 8-14 years. |
TextSentencer_T9 |
815-926 |
Sentence |
denotes |
Clinical examination revealed hyperuricaemia and hyperuricosuria, radiolucent renal and urinary bladder stones. |
TextSentencer_T10 |
927-1052 |
Sentence |
denotes |
HPRT enzyme activity was totally absent, while adenine phosphoribosyl transferase activity was increased compared to control. |
TextSentencer_T11 |
1053-1181 |
Sentence |
denotes |
The patient was treated with allopurinol, urinary alkalization, low-purine diet and adequate hydration while he was in hospital. |
TextSentencer_T12 |
1182-1243 |
Sentence |
denotes |
However, his parents refused further treatment and follow-up. |
TextSentencer_T13 |
1244-1354 |
Sentence |
denotes |
The most important issue is whether the healthy sisters of the patients are heterozygotes for HPRT deficiency. |
TextSentencer_T14 |
1355-1392 |
Sentence |
denotes |
This DNA analysis is now in progress. |
T1 |
0-27 |
Sentence |
denotes |
[The Lesch-Nyhan syndrome]. |
T2 |
28-62 |
Sentence |
denotes |
Les-Nijanov (Lesch-Nyhan) sindrom. |
T3 |
63-355 |
Sentence |
denotes |
Deficiency of hypoxanthine phosphoribosyltransferase (HPRT) has a broad spectrum of clinical manifestations, from the complete enzyme defect, the Lesch-Nyhan syndrome with severe neurological deficiency to the partial defect associated only with uric acid overproduction and its consequences. |
T4 |
356-410 |
Sentence |
denotes |
We present a 5-year old boy with Lesch-Nyhan syndrome. |
T5 |
411-492 |
Sentence |
denotes |
He came to our hospital because of abdominal pain, vomiting and gross haematuria. |
T6 |
493-642 |
Sentence |
denotes |
At the age of 8 months he was categorized as a "cerebral palsy" patient due to involuntary movements and high degree of spastically and tonic spasms. |
T7 |
643-694 |
Sentence |
denotes |
He remained incapable of sitting or standing alone. |
T8 |
695-814 |
Sentence |
denotes |
The patient's brother and two uncles were also categorized as "cerebral palsy" cases and died at the age of 8-14 years. |
T9 |
815-926 |
Sentence |
denotes |
Clinical examination revealed hyperuricaemia and hyperuricosuria, radiolucent renal and urinary bladder stones. |
T10 |
927-1052 |
Sentence |
denotes |
HPRT enzyme activity was totally absent, while adenine phosphoribosyl transferase activity was increased compared to control. |
T11 |
1053-1181 |
Sentence |
denotes |
The patient was treated with allopurinol, urinary alkalization, low-purine diet and adequate hydration while he was in hospital. |
T12 |
1182-1243 |
Sentence |
denotes |
However, his parents refused further treatment and follow-up. |
T13 |
1244-1354 |
Sentence |
denotes |
The most important issue is whether the healthy sisters of the patients are heterozygotes for HPRT deficiency. |
T14 |
1355-1392 |
Sentence |
denotes |
This DNA analysis is now in progress. |