PubMed:11919201
Annnotations
GlyCosmos6-Glycan-Motif-Image
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 42-51 | Glycan_Motif | denotes | galactose | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G68158BT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G65889KE |
| T3 | 52-73 | Glycan_Motif | denotes | N-acetylgalactosamine | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G27025MB |
| T4 | 493-500 | Glycan_Motif | denotes | mannose | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G70323CJ |
| T5 | 549-558 | Glycan_Motif | denotes | galactose | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G68158BT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G65889KE |
| T7 | 559-580 | Glycan_Motif | denotes | N-acetylgalactosamine | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G27025MB |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-154 | Sentence | denotes | The macrophage C-type lectin specific for galactose/N-acetylgalactosamine is an endocytic receptor expressed on monocyte-derived immature dendritic cells. |
| T2 | 155-283 | Sentence | denotes | Lectins on antigen presenting cells are potentially involved in the antigen uptake and the cellular recognition and trafficking. |
| T3 | 284-463 | Sentence | denotes | Serial analysis of gene expression in monocyte-derived dendritic cells (DCs), monocytes, and macrophages revealed that 7 of the 19 C-type lectin mRNA were present in immature DCs. |
| T4 | 464-692 | Sentence | denotes | Two of these, the macrophage mannose receptor and the macrophage lectin specific for galactose/N-acetylgalactosamine (MGL), were found only in immature DCs, as confirmed by reverse transcriptase-PCR and flow cytometric analysis. |
| T5 | 693-889 | Sentence | denotes | By subcloning and sequencing the amplified mRNA, we obtained nucleotide sequences encoding seven different human MGL (hMGL) subtypes, which were apparently derived from alternatively spliced mRNA. |
| T6 | 890-967 | Sentence | denotes | In addition, the hMGL gene locus on human chromosome 17p13 contains one gene. |
| T7 | 968-1120 | Sentence | denotes | A single nucleotide polymorphism was identified at a position in exon 3 that corresponds to the cytoplasmic region proximal to the transmembrane domain. |
| T8 | 1121-1246 | Sentence | denotes | Of all the splicing variants, the hMGL variant 6C was expressed at the highest levels on immature DCs from all donors tested. |
| T9 | 1247-1481 | Sentence | denotes | Immature DCs could incorporate alpha-GalNAc-modified soluble acrylamide polymers, and this was significantly inhibited by pretreatment of the cells with an anti-hMGL monoclonal antibody that blocks the lectin-carbohydrate interaction. |
| T10 | 1482-1597 | Sentence | denotes | We propose that hMGL is a marker of imDCs and that it functions as an endocytic receptor for glycosylated antigens. |
GlyCosmos6-Glycan-Motif-Structure
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 42-51 | https://glytoucan.org/Structures/Glycans/G65889KE | denotes | galactose |
| T2 | 42-51 | https://glytoucan.org/Structures/Glycans/G68158BT | denotes | galactose |
| T3 | 52-73 | https://glytoucan.org/Structures/Glycans/G27025MB | denotes | N-acetylgalactosamine |
| T4 | 493-500 | https://glytoucan.org/Structures/Glycans/G70323CJ | denotes | mannose |
| T5 | 549-558 | https://glytoucan.org/Structures/Glycans/G65889KE | denotes | galactose |
| T6 | 549-558 | https://glytoucan.org/Structures/Glycans/G68158BT | denotes | galactose |
| T7 | 559-580 | https://glytoucan.org/Structures/Glycans/G27025MB | denotes | N-acetylgalactosamine |
Glycosmos6-MAT
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 1083-1091 | http://purl.obolibrary.org/obo/MAT_0000491 | denotes | proximal |
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 1284-1290 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
GlyCosmos15-NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 800-805 | OrganismTaxon | denotes | human | 9606 |
| T2 | 926-931 | OrganismTaxon | denotes | human | 9606 |
GlyCosmos15-CL
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 4-14 | Cell | denotes | macrophage | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
| T3 | 112-120 | Cell | denotes | monocyte | http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054 |
| T5 | 138-153 | Cell | denotes | dendritic cells | http://purl.obolibrary.org/obo/CL:0000451|http://purl.obolibrary.org/obo/CL:0001056 |
| T7 | 322-354 | Cell | denotes | monocyte-derived dendritic cells | http://purl.obolibrary.org/obo/CL:0011031 |
| T8 | 322-330 | Cell | denotes | monocyte | http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054 |
| T10 | 356-359 | Cell | denotes | DCs | http://purl.obolibrary.org/obo/CL:0000451 |
| T11 | 362-371 | Cell | denotes | monocytes | http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054 |
| T13 | 377-388 | Cell | denotes | macrophages | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
| T15 | 459-462 | Cell | denotes | DCs | http://purl.obolibrary.org/obo/CL:0000451 |
| T16 | 482-492 | Cell | denotes | macrophage | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
| T18 | 518-528 | Cell | denotes | macrophage | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
| T20 | 616-619 | Cell | denotes | DCs | http://purl.obolibrary.org/obo/CL:0000451 |
| T21 | 1219-1222 | Cell | denotes | DCs | http://purl.obolibrary.org/obo/CL:0000451 |
| T22 | 1256-1259 | Cell | denotes | DCs | http://purl.obolibrary.org/obo/CL:0000451 |
GlyCosmos15-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 4-14 | Body_part | denotes | macrophage | http://purl.obolibrary.org/obo/CL_0000235 |
| T2 | 112-120 | Body_part | denotes | monocyte | http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054 |
| T4 | 138-153 | Body_part | denotes | dendritic cells | http://purl.obolibrary.org/obo/CL_0000451 |
| T5 | 322-330 | Body_part | denotes | monocyte | http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054 |
| T7 | 339-354 | Body_part | denotes | dendritic cells | http://purl.obolibrary.org/obo/CL_0000451 |
| T8 | 356-359 | Body_part | denotes | DCs | http://purl.obolibrary.org/obo/CL_0000451 |
| T9 | 362-371 | Body_part | denotes | monocytes | http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054 |
| T11 | 377-388 | Body_part | denotes | macrophages | http://purl.obolibrary.org/obo/CL_0000235 |
| T12 | 459-462 | Body_part | denotes | DCs | http://purl.obolibrary.org/obo/CL_0000451 |
| T13 | 482-492 | Body_part | denotes | macrophage | http://purl.obolibrary.org/obo/CL_0000235 |
| T14 | 518-528 | Body_part | denotes | macrophage | http://purl.obolibrary.org/obo/CL_0000235 |
| T15 | 616-619 | Body_part | denotes | DCs | http://purl.obolibrary.org/obo/CL_0000451 |
| T16 | 932-942 | Body_part | denotes | chromosome | http://purl.obolibrary.org/obo/GO_0005694 |
| T17 | 1064-1082 | Body_part | denotes | cytoplasmic region | http://purl.obolibrary.org/obo/GO_0099568 |
| T18 | 1099-1112 | Body_part | denotes | transmembrane | http://purl.obolibrary.org/obo/GO_0016020 |
| T19 | 1219-1222 | Body_part | denotes | DCs | http://purl.obolibrary.org/obo/CL_0000451 |
| T20 | 1256-1259 | Body_part | denotes | DCs | http://purl.obolibrary.org/obo/CL_0000451 |
GlyCosmos15-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 1083-1091 | Body_part | denotes | proximal | http://purl.obolibrary.org/obo/MAT_0000491 |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-154 | Sentence | denotes | The macrophage C-type lectin specific for galactose/N-acetylgalactosamine is an endocytic receptor expressed on monocyte-derived immature dendritic cells. |
| T2 | 155-283 | Sentence | denotes | Lectins on antigen presenting cells are potentially involved in the antigen uptake and the cellular recognition and trafficking. |
| T3 | 284-463 | Sentence | denotes | Serial analysis of gene expression in monocyte-derived dendritic cells (DCs), monocytes, and macrophages revealed that 7 of the 19 C-type lectin mRNA were present in immature DCs. |
| T4 | 464-692 | Sentence | denotes | Two of these, the macrophage mannose receptor and the macrophage lectin specific for galactose/N-acetylgalactosamine (MGL), were found only in immature DCs, as confirmed by reverse transcriptase-PCR and flow cytometric analysis. |
| T5 | 693-889 | Sentence | denotes | By subcloning and sequencing the amplified mRNA, we obtained nucleotide sequences encoding seven different human MGL (hMGL) subtypes, which were apparently derived from alternatively spliced mRNA. |
| T6 | 890-967 | Sentence | denotes | In addition, the hMGL gene locus on human chromosome 17p13 contains one gene. |
| T7 | 968-1120 | Sentence | denotes | A single nucleotide polymorphism was identified at a position in exon 3 that corresponds to the cytoplasmic region proximal to the transmembrane domain. |
| T8 | 1121-1246 | Sentence | denotes | Of all the splicing variants, the hMGL variant 6C was expressed at the highest levels on immature DCs from all donors tested. |
| T9 | 1247-1481 | Sentence | denotes | Immature DCs could incorporate alpha-GalNAc-modified soluble acrylamide polymers, and this was significantly inhibited by pretreatment of the cells with an anti-hMGL monoclonal antibody that blocks the lectin-carbohydrate interaction. |
| T10 | 1482-1597 | Sentence | denotes | We propose that hMGL is a marker of imDCs and that it functions as an endocytic receptor for glycosylated antigens. |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-154 | Sentence | denotes | The macrophage C-type lectin specific for galactose/N-acetylgalactosamine is an endocytic receptor expressed on monocyte-derived immature dendritic cells. |
| T2 | 155-283 | Sentence | denotes | Lectins on antigen presenting cells are potentially involved in the antigen uptake and the cellular recognition and trafficking. |
| T3 | 284-463 | Sentence | denotes | Serial analysis of gene expression in monocyte-derived dendritic cells (DCs), monocytes, and macrophages revealed that 7 of the 19 C-type lectin mRNA were present in immature DCs. |
| T4 | 464-692 | Sentence | denotes | Two of these, the macrophage mannose receptor and the macrophage lectin specific for galactose/N-acetylgalactosamine (MGL), were found only in immature DCs, as confirmed by reverse transcriptase-PCR and flow cytometric analysis. |
| T5 | 693-889 | Sentence | denotes | By subcloning and sequencing the amplified mRNA, we obtained nucleotide sequences encoding seven different human MGL (hMGL) subtypes, which were apparently derived from alternatively spliced mRNA. |
| T6 | 890-967 | Sentence | denotes | In addition, the hMGL gene locus on human chromosome 17p13 contains one gene. |
| T7 | 968-1120 | Sentence | denotes | A single nucleotide polymorphism was identified at a position in exon 3 that corresponds to the cytoplasmic region proximal to the transmembrane domain. |
| T8 | 1121-1246 | Sentence | denotes | Of all the splicing variants, the hMGL variant 6C was expressed at the highest levels on immature DCs from all donors tested. |
| T9 | 1247-1481 | Sentence | denotes | Immature DCs could incorporate alpha-GalNAc-modified soluble acrylamide polymers, and this was significantly inhibited by pretreatment of the cells with an anti-hMGL monoclonal antibody that blocks the lectin-carbohydrate interaction. |
| T10 | 1482-1597 | Sentence | denotes | We propose that hMGL is a marker of imDCs and that it functions as an endocytic receptor for glycosylated antigens. |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 1284-1290 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 800-805 | OrganismTaxon | denotes | human | 9606 |
| T2 | 926-931 | OrganismTaxon | denotes | human | 9606 |
Anatomy-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 1083-1091 | Body_part | denotes | proximal | http://purl.obolibrary.org/obo/MAT_0000491 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 4-14 | Body_part | denotes | macrophage | http://purl.obolibrary.org/obo/CL_0000235 |
| T2 | 112-120 | Body_part | denotes | monocyte | http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054 |
| T4 | 138-153 | Body_part | denotes | dendritic cells | http://purl.obolibrary.org/obo/CL_0000451 |
| T5 | 322-330 | Body_part | denotes | monocyte | http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054 |
| T7 | 339-354 | Body_part | denotes | dendritic cells | http://purl.obolibrary.org/obo/CL_0000451 |
| T8 | 356-359 | Body_part | denotes | DCs | http://purl.obolibrary.org/obo/CL_0000451 |
| T9 | 362-371 | Body_part | denotes | monocytes | http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054 |
| T11 | 377-388 | Body_part | denotes | macrophages | http://purl.obolibrary.org/obo/CL_0000235 |
| T12 | 459-462 | Body_part | denotes | DCs | http://purl.obolibrary.org/obo/CL_0000451 |
| T13 | 482-492 | Body_part | denotes | macrophage | http://purl.obolibrary.org/obo/CL_0000235 |
| T14 | 518-528 | Body_part | denotes | macrophage | http://purl.obolibrary.org/obo/CL_0000235 |
| T15 | 616-619 | Body_part | denotes | DCs | http://purl.obolibrary.org/obo/CL_0000451 |
| T16 | 932-942 | Body_part | denotes | chromosome | http://purl.obolibrary.org/obo/GO_0005694 |
| T17 | 1064-1082 | Body_part | denotes | cytoplasmic region | http://purl.obolibrary.org/obo/GO_0099568 |
| T18 | 1099-1112 | Body_part | denotes | transmembrane | http://purl.obolibrary.org/obo/GO_0016020 |
| T19 | 1219-1222 | Body_part | denotes | DCs | http://purl.obolibrary.org/obo/CL_0000451 |
| T20 | 1256-1259 | Body_part | denotes | DCs | http://purl.obolibrary.org/obo/CL_0000451 |
CL-cell
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 4-14 | Cell | denotes | macrophage | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
| T3 | 112-120 | Cell | denotes | monocyte | http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054 |
| T5 | 138-153 | Cell | denotes | dendritic cells | http://purl.obolibrary.org/obo/CL:0000451|http://purl.obolibrary.org/obo/CL:0001056 |
| T7 | 322-354 | Cell | denotes | monocyte-derived dendritic cells | http://purl.obolibrary.org/obo/CL:0011031 |
| T8 | 322-330 | Cell | denotes | monocyte | http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054 |
| T10 | 356-359 | Cell | denotes | DCs | http://purl.obolibrary.org/obo/CL:0000451 |
| T11 | 362-371 | Cell | denotes | monocytes | http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054 |
| T13 | 377-388 | Cell | denotes | macrophages | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
| T15 | 459-462 | Cell | denotes | DCs | http://purl.obolibrary.org/obo/CL:0000451 |
| T16 | 482-492 | Cell | denotes | macrophage | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
| T18 | 518-528 | Cell | denotes | macrophage | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
| T20 | 616-619 | Cell | denotes | DCs | http://purl.obolibrary.org/obo/CL:0000451 |
| T21 | 1219-1222 | Cell | denotes | DCs | http://purl.obolibrary.org/obo/CL:0000451 |
| T22 | 1256-1259 | Cell | denotes | DCs | http://purl.obolibrary.org/obo/CL:0000451 |