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c_corpus

Id Subject Object Predicate Lexical cue
T2 41-65 350141 denotes Saccharomyces cerevisiae
T5 41-65 9511 denotes Saccharomyces cerevisiae
T3 41-65 D012441 denotes Saccharomyces cerevisiae
T4 41-65 4932 denotes Saccharomyces cerevisiae
T9 66-70 CVCL_G669 denotes MLH1
T6 66-70 PR:Q9ZRV4 denotes MLH1
T7 66-70 PR:P38920 denotes MLH1
T8 66-70 PR:Q54KD8 denotes MLH1
T10 66-70 PR:Q9JK91 denotes MLH1
T11 66-70 PR:P97679 denotes MLH1
T12 66-70 PR:Q9P7W6 denotes MLH1
T13 66-70 PR:000010442 denotes MLH1
T14 66-70 PR:P40692 denotes MLH1
T15 71-75 SO:0000704 denotes gene
T16 79-94 GO:0006298 denotes mismatch repair
T20 128-143 GO:0006298 denotes mismatch repair
T21 145-148 GO:0006298 denotes MMR
T22 145-148 CVCL_E779 denotes MMR
T23 145-148 P22897 denotes MMR
T24 145-148 PR:000002972 denotes MMR
T25 145-148 Q61830 denotes MMR
T26 170-174 SO:0000704 denotes gene
T27 277-287 SO:0001633 denotes downstream
T28 358-362 SO:0000704 denotes gene
T29 371-375 PR:Q9ZRV4 denotes MLH1
T30 371-375 PR:P38920 denotes MLH1
T31 371-375 PR:Q54KD8 denotes MLH1
T33 371-375 PR:Q9JK91 denotes MLH1
T34 371-375 PR:P97679 denotes MLH1
T35 371-375 PR:Q9P7W6 denotes MLH1
T36 371-375 PR:000010442 denotes MLH1
T37 371-375 PR:P40692 denotes MLH1
T32 371-375 CVCL_G669 denotes MLH1
T38 380-384 PR:F4JN26 denotes MLH3
T39 380-384 PR:Q12083 denotes MLH3
T40 380-384 PR:000010443 denotes MLH3
T41 380-384 PR:Q9UHC1 denotes MLH3
T42 520-528 CHEBI:33893 denotes reagents
T43 520-528 D007202 denotes reagents
T44 571-575 SO:0000704 denotes gene
T47 710-734 350141 denotes Saccharomyces cerevisiae
T50 710-734 9511 denotes Saccharomyces cerevisiae
T48 710-734 D012441 denotes Saccharomyces cerevisiae
T49 710-734 4932 denotes Saccharomyces cerevisiae
T54 739-743 CVCL_G669 denotes mlh1
T51 739-743 PR:Q9ZRV4 denotes mlh1
T52 739-743 PR:P38920 denotes mlh1
T53 739-743 PR:Q54KD8 denotes mlh1
T55 739-743 PR:Q9JK91 denotes mlh1
T56 739-743 PR:P97679 denotes mlh1
T57 739-743 PR:Q9P7W6 denotes mlh1
T58 739-743 PR:000010442 denotes mlh1
T59 739-743 PR:P40692 denotes mlh1
T60 749-757 SO:0000109 denotes mutation
T71 781-785 PR:P15436 denotes pol3
T72 781-785 PR:P30316 denotes pol3
T73 856-867 P00638 denotes exonuclease
T74 856-867 P20321 denotes exonuclease
T75 856-867 P03697 denotes exonuclease
T76 856-876 GO:0004527 denotes exonuclease activity
T77 924-928 PR:Q9ZRV4 denotes mlh1
T78 924-928 PR:P38920 denotes mlh1
T79 924-928 PR:Q54KD8 denotes mlh1
T81 924-928 PR:Q9JK91 denotes mlh1
T82 924-928 PR:P97679 denotes mlh1
T83 924-928 PR:Q9P7W6 denotes mlh1
T84 924-928 PR:000010442 denotes mlh1
T85 924-928 PR:P40692 denotes mlh1
T80 924-928 CVCL_G669 denotes mlh1
T96 1005-1009 PR:P15436 denotes pol3
T97 1005-1009 PR:P30316 denotes pol3
T98 1013-1020 D013180 denotes strains
T99 1013-1020 D013180 denotes strains
T100 1057-1064 D013180 denotes strains
T101 1057-1064 D013180 denotes strains
T102 1085-1089 PR:Q9ZRV4 denotes mlh1
T103 1085-1089 PR:P38920 denotes mlh1
T104 1085-1089 PR:Q54KD8 denotes mlh1
T106 1085-1089 PR:Q9JK91 denotes mlh1
T107 1085-1089 PR:P97679 denotes mlh1
T108 1085-1089 PR:Q9P7W6 denotes mlh1
T109 1085-1089 PR:000010442 denotes mlh1
T110 1085-1089 PR:P40692 denotes mlh1
T105 1085-1089 CVCL_G669 denotes mlh1
T111 1108-1117 SO:0000817 denotes wild-type
T112 1128-1137 SO:0000817 denotes wild-type
T113 1138-1146 SO:0000109 denotes mutation
T114 1189-1196 D013180 denotes strains
T115 1189-1196 D013180 denotes strains
T116 1207-1215 SO:0000109 denotes mutation
T117 1256-1260 PR:Q9ZRV4 denotes mlh1
T118 1256-1260 PR:P38920 denotes mlh1
T119 1256-1260 PR:Q54KD8 denotes mlh1
T121 1256-1260 PR:Q9JK91 denotes mlh1
T122 1256-1260 PR:P97679 denotes mlh1
T123 1256-1260 PR:Q9P7W6 denotes mlh1
T124 1256-1260 PR:000010442 denotes mlh1
T125 1256-1260 PR:P40692 denotes mlh1
T120 1256-1260 CVCL_G669 denotes mlh1
T126 1310-1314 PR:Q9ZRV4 denotes mlh1
T127 1310-1314 PR:P38920 denotes mlh1
T128 1310-1314 PR:Q54KD8 denotes mlh1
T130 1310-1314 PR:Q9JK91 denotes mlh1
T131 1310-1314 PR:P97679 denotes mlh1
T132 1310-1314 PR:Q9P7W6 denotes mlh1
T133 1310-1314 PR:000010442 denotes mlh1
T134 1310-1314 PR:P40692 denotes mlh1
T129 1310-1314 CVCL_G669 denotes mlh1
T135 1321-1328 D013180 denotes strains
T136 1321-1328 D013180 denotes strains
T142 1371-1375 PR:P39875 denotes EXO1
T143 1371-1375 PR:Q24558 denotes EXO1
T144 1371-1375 PR:Q54ED2 denotes EXO1
T145 1371-1375 PR:Q803U7 denotes EXO1
T146 1371-1375 PR:Q9UQ84 denotes EXO1
T147 1371-1375 PR:Q9QZ11 denotes EXO1
T148 1371-1375 PR:P53695 denotes EXO1
T149 1371-1375 PR:000007245 denotes EXO1
T150 1371-1375 PR:Q8L6Z7 denotes EXO1
T151 1396-1400 PR:Q9ZRV4 denotes mlh1
T152 1396-1400 PR:P38920 denotes mlh1
T153 1396-1400 PR:Q54KD8 denotes mlh1
T155 1396-1400 PR:Q9JK91 denotes mlh1
T156 1396-1400 PR:P97679 denotes mlh1
T157 1396-1400 PR:Q9P7W6 denotes mlh1
T158 1396-1400 PR:000010442 denotes mlh1
T159 1396-1400 PR:P40692 denotes mlh1
T154 1396-1400 CVCL_G669 denotes mlh1
T160 1476-1483 GO:0051321 denotes meiosis
T161 1490-1494 PR:Q9ZRV4 denotes mlh1
T162 1490-1494 PR:P38920 denotes mlh1
T163 1490-1494 PR:Q54KD8 denotes mlh1
T165 1490-1494 PR:Q9JK91 denotes mlh1
T166 1490-1494 PR:P97679 denotes mlh1
T167 1490-1494 PR:Q9P7W6 denotes mlh1
T168 1490-1494 PR:000010442 denotes mlh1
T169 1490-1494 PR:P40692 denotes mlh1
T164 1490-1494 CVCL_G669 denotes mlh1
T170 1512-1519 D013180 denotes strains
T171 1512-1519 D013180 denotes strains
T172 1548-1571 GO:0000710 denotes meiotic mismatch repair
T174 1590-1599 SO:0000817 denotes wild-type
T175 1691-1695 PR:Q9ZRV4 denotes MLH1
T176 1691-1695 PR:P38920 denotes MLH1
T177 1691-1695 PR:Q54KD8 denotes MLH1
T179 1691-1695 PR:Q9JK91 denotes MLH1
T180 1691-1695 PR:P97679 denotes MLH1
T181 1691-1695 PR:Q9P7W6 denotes MLH1
T182 1691-1695 PR:000010442 denotes MLH1
T183 1691-1695 PR:P40692 denotes MLH1
T178 1691-1695 CVCL_G669 denotes MLH1
T184 1758-1762 PR:Q9ZRV4 denotes mlh1
T185 1758-1762 PR:P38920 denotes mlh1
T186 1758-1762 PR:Q54KD8 denotes mlh1
T188 1758-1762 PR:Q9JK91 denotes mlh1
T189 1758-1762 PR:P97679 denotes mlh1
T190 1758-1762 PR:Q9P7W6 denotes mlh1
T191 1758-1762 PR:000010442 denotes mlh1
T192 1758-1762 PR:P40692 denotes mlh1
T187 1758-1762 CVCL_G669 denotes mlh1
T195 1801-1804 P22897 denotes MMR
T196 1801-1804 PR:000002972 denotes MMR
T197 1801-1804 Q61830 denotes MMR
T194 1801-1804 CVCL_E779 denotes MMR
T193 1801-1804 GO:0006298 denotes MMR
T198 1844-1848 PR:Q9ZRV4 denotes MLH1
T199 1844-1848 PR:P38920 denotes MLH1
T200 1844-1848 PR:Q54KD8 denotes MLH1
T202 1844-1848 PR:Q9JK91 denotes MLH1
T203 1844-1848 PR:P97679 denotes MLH1
T204 1844-1848 PR:Q9P7W6 denotes MLH1
T205 1844-1848 PR:000010442 denotes MLH1
T206 1844-1848 PR:P40692 denotes MLH1
T201 1844-1848 CVCL_G669 denotes MLH1
T207 1886-1890 PR:Q9ZRV4 denotes MLH1
T208 1886-1890 PR:P38920 denotes MLH1
T209 1886-1890 PR:Q54KD8 denotes MLH1
T211 1886-1890 PR:Q9JK91 denotes MLH1
T212 1886-1890 PR:P97679 denotes MLH1
T213 1886-1890 PR:Q9P7W6 denotes MLH1
T214 1886-1890 PR:000010442 denotes MLH1
T215 1886-1890 PR:P40692 denotes MLH1
T210 1886-1890 CVCL_G669 denotes MLH1
T216 1895-1905 SO:0001633 denotes downstream

PMID_GLOBAL

Id Subject Object Predicate Lexical cue
T1 0-124 Sentence denotes Analysis of conditional mutations in the Saccharomyces cerevisiae MLH1 gene in mismatch repair and in meiotic crossing over.
T2 125-337 Sentence denotes In mismatch repair (MMR), members of the MLH gene family have been proposed to act as key molecular matchmakers to coordinate mismatch recognition with downstream repair functions that result in mispair excision.
T3 338-437 Sentence denotes Two members of this gene family, MLH1 and MLH3, have also been implicated in meiotic crossing over.
T4 438-678 Sentence denotes These diverse roles suggest that a mutational analysis of MLH genes could provide reagents required to identify interactions between gene products and to test whether the different roles ascribed to a subset of these genes can be separated.
T5 679-877 Sentence denotes In this report we show that in Saccharomyces cerevisiae the mlh1Delta mutation confers inviability in pol3-01 strain backgrounds that are defective in the Poldelta proofreading exonuclease activity.
T6 878-1021 Sentence denotes This phenotype was exploited to identify four mlh1 alleles that each confer a temperature-sensitive phenotype for viability in pol3-01 strains.
T7 1022-1167 Sentence denotes In three different mutator assays, strains bearing conditional mlh1 alleles displayed wild-type or nearly wild-type mutation rates at 26 degrees.
T8 1168-1274 Sentence denotes At 35 degrees, these strains exhibited mutation rates that approached those observed in mlh1Delta mutants.
T9 1275-1391 Sentence denotes The mutator phenotype exhibited in mlh1-I296S strains was partially suppressed at 35 degrees by EXO1 overexpression.
T10 1392-1706 Sentence denotes The mlh1-F228S and -I296S mutations conferred a separation-of-function phenotype in meiosis; both mlh1-F228S and -I296S strains displayed strong defects in meiotic mismatch repair but showed nearly wild-type levels of crossing over, suggesting that the conditional mutations differentially affected MLH1 functions.
T11 1707-1924 Sentence denotes These genetic studies suggest that the conditional mlh1 mutations can be used to separate the MMR and meiotic crossing-over functions of MLH1 and to identify interactions between MLH1 and downstream repair components.

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-124 DRI_Approach denotes Analysis of conditional mutations in the Saccharomyces cerevisiae MLH1 gene in mismatch repair and in meiotic crossing over.
T2 125-337 DRI_Background denotes In mismatch repair (MMR), members of the MLH gene family have been proposed to act as key molecular matchmakers to coordinate mismatch recognition with downstream repair functions that result in mispair excision.
T3 338-437 DRI_Background denotes Two members of this gene family, MLH1 and MLH3, have also been implicated in meiotic crossing over.
T4 438-678 DRI_Challenge denotes These diverse roles suggest that a mutational analysis of MLH genes could provide reagents required to identify interactions between gene products and to test whether the different roles ascribed to a subset of these genes can be separated.
T5 679-877 DRI_Outcome denotes In this report we show that in Saccharomyces cerevisiae the mlh1Delta mutation confers inviability in pol3-01 strain backgrounds that are defective in the Poldelta proofreading exonuclease activity.
T6 878-1021 DRI_Approach denotes This phenotype was exploited to identify four mlh1 alleles that each confer a temperature-sensitive phenotype for viability in pol3-01 strains.
T7 1022-1167 DRI_Outcome denotes In three different mutator assays, strains bearing conditional mlh1 alleles displayed wild-type or nearly wild-type mutation rates at 26 degrees.
T8 1168-1274 DRI_Background denotes At 35 degrees, these strains exhibited mutation rates that approached those observed in mlh1Delta mutants.
T9 1275-1391 DRI_Background denotes The mutator phenotype exhibited in mlh1-I296S strains was partially suppressed at 35 degrees by EXO1 overexpression.
T10 1392-1706 DRI_Outcome denotes The mlh1-F228S and -I296S mutations conferred a separation-of-function phenotype in meiosis; both mlh1-F228S and -I296S strains displayed strong defects in meiotic mismatch repair but showed nearly wild-type levels of crossing over, suggesting that the conditional mutations differentially affected MLH1 functions.
T11 1707-1924 DRI_Background denotes These genetic studies suggest that the conditional mlh1 mutations can be used to separate the MMR and meiotic crossing-over functions of MLH1 and to identify interactions between MLH1 and downstream repair components.