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bc5cdr-valid-experiment

Id Subject Object Predicate Lexical cue
T1 14-30 Chemical denotes poly(ADP-ribose)
T2 72-83 Chemical denotes doxorubicin
T3 92-105 Disease denotes heart failure
T4 140-156 Chemical denotes poly(ADP-ribose)
T5 379-393 Disease denotes cardiotoxicity
T6 397-408 Chemical denotes doxorubicin
T7 410-413 Chemical denotes DOX
T8 440-453 Chemical denotes anthracycline
T9 538-541 Chemical denotes DOX
T10 550-564 Disease denotes cardiotoxicity
T11 702-706 Chemical denotes PJ34
T12 766-785 Disease denotes cardiac dysfunction
T13 797-800 Chemical denotes DOX
T14 862-865 Chemical denotes DOX
T15 898-901 Chemical denotes DOX
T16 1105-1109 Chemical denotes PJ34
T17 1139-1143 Chemical denotes PJ34
T18 1167-1186 Disease denotes cardiac dysfunction
T19 1242-1246 Chemical denotes PJ34
T20 1273-1276 Chemical denotes DOX
T21 1307-1314 Chemical denotes lactate
T22 1333-1341 Chemical denotes creatine
T23 1452-1466 Disease denotes cardiotoxicity
T24 1470-1473 Chemical denotes DOX
T25 1554-1575 Disease denotes cardiac complications
T26 1596-1599 Chemical denotes DOX

bc5cdr-valid-deepseek-nr-ng

Id Subject Object Predicate Lexical cue
T1 0-13 Disease denotes Activation of
T2 14-41 Chemical denotes poly(ADP-ribose) polymerase
T3 41-71 Disease denotes contributes to development of
T4 72-83 Chemical denotes doxorubicin
T5 140-167 Chemical denotes poly(ADP-ribose) polymerase
T6 169-173 Chemical denotes PARP
T7 174-315 Disease denotes by oxidant-mediated DNA damage is an important pathway of cell dysfunction and tissue injury in conditions associated with oxidative stress.
T8 410-413 Chemical denotes DOX
T9 414-439 Disease denotes , a widely used antitumor
T10 440-453 Chemical denotes anthracycline
T11 454-464 Chemical denotes antibiotic
T12 464-510 Disease denotes . Thus, we hypothesized that the activation of
T13 511-515 Chemical denotes PARP
T14 515-537 Disease denotes may contribute to the
T15 538-541 Chemical denotes DOX
T16 541-590 Disease denotes -induced cardiotoxicity. Using a dual approach of
T17 591-597 Chemical denotes PARP-1
T18 609-686 Disease denotes , by genetic deletion or pharmacological inhibition with the phenanthridinone
T19 702-706 Chemical denotes PJ34
T20 797-800 Chemical denotes DOX
T21 802-806 Chemical denotes PARP
T22 816-820 Chemical denotes PARP
T23 825-861 Disease denotes mice received a single injection of
T24 862-865 Chemical denotes DOX
T25 865-897 Disease denotes (25 mg/kg i.p). Five days after
T26 898-901 Chemical denotes DOX
T27 1109-1138 Disease denotes or vehicle. Treatment with a
T28 1143-1241 Disease denotes significantly improved cardiac dysfunction and increased the survival of the animals. In addition
T29 1246-1272 Disease denotes significantly reduced the
T30 1276-1416 Disease denotes -induced increase in the serum lactate dehydrogenase and creatine kinase activities but not metalloproteinase activation in the heart. Thus,
T31 1421-1469 Disease denotes activation contributes to the cardiotoxicity of
T32 1473-1595 Disease denotes . PARP inhibitors may exert protective effects against the development of severe cardiac complications associated with the
T33 1599-1610 Disease denotes treatment.

bc5cdr-valid

Id Subject Object Predicate Lexical cue
T1 14-30 Chemical denotes poly(ADP-ribose)
T2 72-83 Chemical denotes doxorubicin
T3 92-105 Disease denotes heart failure
T4 140-156 Chemical denotes poly(ADP-ribose)
T5 379-393 Disease denotes cardiotoxicity
T6 397-408 Chemical denotes doxorubicin
T7 410-413 Chemical denotes DOX
T8 440-453 Chemical denotes anthracycline
T9 538-541 Chemical denotes DOX
T10 550-564 Disease denotes cardiotoxicity
T11 702-706 Chemical denotes PJ34
T12 766-785 Disease denotes cardiac dysfunction
T13 797-800 Chemical denotes DOX
T14 862-865 Chemical denotes DOX
T15 898-901 Chemical denotes DOX
T16 1105-1109 Chemical denotes PJ34
T17 1139-1143 Chemical denotes PJ34
T18 1167-1186 Disease denotes cardiac dysfunction
T19 1242-1246 Chemical denotes PJ34
T20 1273-1276 Chemical denotes DOX
T21 1307-1314 Chemical denotes lactate
T22 1333-1341 Chemical denotes creatine
T23 1452-1466 Disease denotes cardiotoxicity
T24 1470-1473 Chemical denotes DOX
T25 1554-1575 Disease denotes cardiac complications
T26 1596-1599 Chemical denotes DOX

bc5cdr-valid-gemini-r-g

Id Subject Object Predicate Lexical cue
T1 72-83 Chemical denotes doxorubicin
T2 92-105 Disease denotes heart failure
T3 379-393 Disease denotes cardiotoxicity
T4 397-408 Chemical denotes doxorubicin
T5 410-413 Chemical denotes DOX
T6 550-564 Disease denotes cardiotoxicity
T7 702-706 Chemical denotes PJ34
T8 766-785 Disease denotes cardiac dysfunction
T9 797-800 Chemical denotes DOX
T10 898-901 Chemical denotes DOX
T11 1105-1109 Chemical denotes PJ34
T12 1167-1186 Disease denotes cardiac dysfunction
T13 1273-1276 Chemical denotes DOX
T14 1452-1466 Disease denotes cardiotoxicity
T15 1470-1473 Chemical denotes DOX

bc5cdr-valid-gemini-r-ng

Id Subject Object Predicate Lexical cue
T1 14-41 Chemical denotes poly(ADP-ribose) polymerase
T2 72-83 Chemical denotes doxorubicin
T3 92-105 Disease denotes heart failure
T4 140-167 Chemical denotes poly(ADP-ribose) polymerase
T5 169-173 Chemical denotes PARP
T6 233-249 Disease denotes cell dysfunction
T7 254-267 Disease denotes tissue injury
T8 298-314 Disease denotes oxidative stress
T9 379-393 Disease denotes cardiotoxicity
T10 397-408 Chemical denotes doxorubicin
T11 410-413 Chemical denotes DOX
T12 440-464 Chemical denotes anthracycline antibiotic
T13 511-515 Chemical denotes PARP
T14 538-541 Chemical denotes DOX
T15 550-564 Disease denotes cardiotoxicity
T16 670-686 Chemical denotes phenanthridinone
T17 687-691 Chemical denotes PARP
T18 702-706 Chemical denotes PJ34
T19 766-785 Disease denotes cardiac dysfunction
T20 797-800 Chemical denotes DOX
T21 862-865 Chemical denotes DOX
T22 1105-1109 Chemical denotes PJ34
T23 1167-1186 Disease denotes cardiac dysfunction
T24 1273-1276 Chemical denotes DOX
T25 1307-1328 Chemical denotes lactate dehydrogenase
T26 1333-1348 Chemical denotes creatine kinase
T27 1368-1385 Chemical denotes metalloproteinase
T28 1417-1421 Chemical denotes PARP
T29 1452-1466 Disease denotes cardiotoxicity
T30 1470-1473 Chemical denotes DOX
T31 1554-1575 Disease denotes cardiac complications

bc5cdr-valid-gemini-nr-g

Id Subject Object Predicate Lexical cue
T1 14-41 Chemical denotes poly(ADP-ribose) polymerase
T2 72-83 Chemical denotes doxorubicin
T3 92-105 Disease denotes heart failure
T4 140-167 Chemical denotes poly(ADP-ribose) polymerase
T5 169-173 Chemical denotes PARP
T6 254-267 Disease denotes tissue injury
T7 298-314 Disease denotes oxidative stress
T8 316-342 Disease denotes Increased oxidative stress
T9 379-393 Disease denotes cardiotoxicity
T10 397-408 Chemical denotes doxorubicin
T11 410-413 Chemical denotes DOX
T12 430-439 Disease denotes antitumor
T13 440-464 Chemical denotes anthracycline antibiotic
T14 511-515 Chemical denotes PARP
T15 538-541 Chemical denotes DOX
T16 550-564 Disease denotes cardiotoxicity
T17 591-595 Chemical denotes PARP
T18 702-706 Chemical denotes PJ34
T19 766-785 Disease denotes cardiac dysfunction
T20 797-800 Chemical denotes DOX
T21 898-901 Chemical denotes DOX
T22 1026-1030 Chemical denotes PARP
T23 1105-1109 Chemical denotes PJ34
T24 1273-1276 Chemical denotes DOX
T25 1301-1328 Chemical denotes serum lactate dehydrogenase
T26 1333-1348 Chemical denotes creatine kinase
T27 1452-1466 Disease denotes cardiotoxicity
T28 1554-1575 Disease denotes cardiac complications

bc5cdr-valid-gemini-nr-ng

Id Subject Object Predicate Lexical cue
T1 72-83 Chemical denotes doxorubicin
T2 92-105 Disease denotes heart failure
T3 140-167 Chemical denotes poly(ADP-ribose) polymerase
T4 169-173 Chemical denotes PARP
T5 397-408 Chemical denotes doxorubicin
T6 410-413 Chemical denotes DOX
T7 511-515 Chemical denotes PARP
T8 538-541 Chemical denotes DOX
T9 591-595 Chemical denotes PARP
T10 702-706 Chemical denotes PJ34
T11 797-800 Chemical denotes DOX
T12 898-901 Chemical denotes DOX
T13 1026-1030 Chemical denotes PARP
T14 1273-1276 Chemical denotes DOX
T15 1307-1328 Chemical denotes lactate dehydrogenase
T16 1333-1348 Chemical denotes creatine kinase

bc5cdr-valid-gpt-r-ng

Id Subject Object Predicate Lexical cue
T1 72-83 Chemical denotes doxorubicin
T2 92-105 Disease denotes heart failure
T3 379-393 Disease denotes cardiotoxicity
T4 397-408 Chemical denotes doxorubicin
T5 410-413 Chemical denotes DOX
T6 440-464 Chemical denotes anthracycline antibiotic
T7 538-541 Chemical denotes DOX
T8 550-564 Disease denotes cardiotoxicity
T9 670-686 Chemical denotes phenanthridinone
T10 702-706 Chemical denotes PJ34
T11 766-785 Disease denotes cardiac dysfunction
T12 797-800 Chemical denotes DOX
T13 862-865 Chemical denotes DOX
T14 1105-1109 Chemical denotes PJ34
T15 1167-1186 Disease denotes cardiac dysfunction
T16 1242-1246 Chemical denotes PJ34
T17 1273-1276 Chemical denotes DOX
T18 1452-1466 Disease denotes cardiotoxicity
T19 1470-1473 Chemical denotes DOX
T20 1547-1575 Disease denotes severe cardiac complications
T21 1596-1599 Chemical denotes DOX

bc5cdr-valid-gpt-nr-ng

Id Subject Object Predicate Lexical cue
T1 72-83 Chemical denotes doxorubicin
T2 92-105 Disease denotes heart failure
T3 379-393 Disease denotes cardiotoxicity
T4 397-408 Chemical denotes doxorubicin
T5 410-413 Chemical denotes DOX
T6 538-541 Chemical denotes DOX
T7 550-564 Disease denotes cardiotoxicity
T8 670-686 Chemical denotes phenanthridinone
T9 702-706 Chemical denotes PJ34
T10 766-785 Disease denotes cardiac dysfunction
T11 797-800 Chemical denotes DOX
T12 862-865 Chemical denotes DOX
T13 1105-1109 Chemical denotes PJ34
T14 1167-1186 Disease denotes cardiac dysfunction
T15 1242-1246 Chemical denotes PJ34
T16 1273-1276 Chemical denotes DOX
T17 1307-1328 Chemical denotes lactate dehydrogenase
T18 1333-1348 Chemical denotes creatine kinase
T19 1368-1385 Chemical denotes metalloproteinase
T20 1452-1466 Disease denotes cardiotoxicity
T21 1470-1473 Chemical denotes DOX
T22 1554-1575 Disease denotes cardiac complications
T23 1596-1599 Chemical denotes DOX

bc5cdr-valid-gpt-r-g

Id Subject Object Predicate Lexical cue
T1 72-83 Chemical denotes doxorubicin
T2 92-105 Disease denotes heart failure
T3 379-393 Disease denotes cardiotoxicity
T4 397-408 Chemical denotes doxorubicin
T5 410-413 Chemical denotes DOX
T6 440-453 Chemical denotes anthracycline
T7 538-541 Chemical denotes DOX
T8 550-564 Disease denotes cardiotoxicity
T9 670-686 Chemical denotes phenanthridinone
T10 702-706 Chemical denotes PJ34
T11 766-785 Disease denotes cardiac dysfunction
T12 797-800 Chemical denotes DOX
T13 862-865 Chemical denotes DOX
T14 1105-1109 Chemical denotes PJ34
T15 1167-1186 Disease denotes cardiac dysfunction
T16 1242-1246 Chemical denotes PJ34
T17 1273-1276 Chemical denotes DOX
T18 1452-1466 Disease denotes cardiotoxicity
T19 1470-1473 Chemical denotes DOX
T20 1596-1599 Chemical denotes DOX

bc5cdr-valid-gpt-nr-g

Id Subject Object Predicate Lexical cue
T1 72-83 Chemical denotes doxorubicin
T2 92-105 Disease denotes heart failure
T3 379-393 Disease denotes cardiotoxicity
T4 397-408 Chemical denotes doxorubicin
T5 410-413 Chemical denotes DOX
T6 440-464 Chemical denotes anthracycline antibiotic
T7 538-541 Chemical denotes DOX
T8 550-564 Disease denotes cardiotoxicity
T9 670-686 Chemical denotes phenanthridinone
T10 702-706 Chemical denotes PJ34
T11 766-785 Disease denotes cardiac dysfunction
T12 797-800 Chemical denotes DOX

bc5cdr-valid-deepseek-r-ng

Id Subject Object Predicate Lexical cue
T1 14-41 Chemical denotes poly(ADP-ribose) polymerase
T2 72-83 Chemical denotes doxorubicin
T3 92-105 Disease denotes heart failure
T4 140-167 Chemical denotes poly(ADP-ribose) polymerase
T5 169-173 Chemical denotes PARP
T6 379-393 Disease denotes cardiotoxicity
T7 410-413 Chemical denotes DOX
T8 702-706 Chemical denotes PJ34
T9 766-785 Disease denotes cardiac dysfunction
T10 1307-1328 Chemical denotes lactate dehydrogenase
T11 1333-1348 Chemical denotes creatine kinase
T12 1368-1385 Chemical denotes metalloproteinase
T13 1547-1575 Disease denotes severe cardiac complications

bc5cdr-valid-gemini-r-m

Id Subject Object Predicate Lexical cue
T1 72-83 Chemical denotes doxorubicin
T2 92-105 Disease denotes heart failure
T3 379-393 Disease denotes cardiotoxicity
T4 397-408 Chemical denotes doxorubicin
T5 410-413 Chemical denotes DOX
T6 440-453 Chemical denotes anthracycline
T7 538-541 Chemical denotes DOX
T8 670-686 Chemical denotes phenanthridinone
T9 702-706 Chemical denotes PJ34
T10 766-785 Disease denotes cardiac dysfunction
T11 797-800 Chemical denotes DOX
T12 898-901 Chemical denotes DOX
T13 1105-1109 Chemical denotes PJ34
T14 1273-1276 Chemical denotes DOX
T15 1452-1466 Disease denotes cardiotoxicity

bc5cdr-valid-gpt-r-m2

Id Subject Object Predicate Lexical cue
T1 72-83 Chemical denotes doxorubicin
T2 92-105 Disease denotes heart failure
T3 379-393 Disease denotes cardiotoxicity
T4 397-408 Chemical denotes doxorubicin
T5 410-413 Chemical denotes DOX
T6 440-464 Chemical denotes anthracycline antibiotic
T7 538-541 Chemical denotes DOX
T8 550-564 Disease denotes cardiotoxicity
T9 670-686 Chemical denotes phenanthridinone
T10 702-706 Chemical denotes PJ34
T11 766-785 Disease denotes cardiac dysfunction
T12 797-800 Chemical denotes DOX
T13 862-865 Chemical denotes DOX
T14 1105-1109 Chemical denotes PJ34
T15 1167-1186 Disease denotes cardiac dysfunction
T16 1242-1246 Chemical denotes PJ34
T17 1273-1276 Chemical denotes DOX
T18 1452-1466 Disease denotes cardiotoxicity
T19 1470-1473 Chemical denotes DOX
T20 1596-1599 Chemical denotes DOX

bc5cdr-valid-deepseek-r-g

Id Subject Object Predicate Lexical cue
T1 72-83 Chemical denotes doxorubicin
T2 92-105 Disease denotes heart failure
T3 379-393 Disease denotes cardiotoxicity
T4 410-413 Chemical denotes DOX
T5 538-541 Chemical denotes DOX
T6 550-564 Disease denotes cardiotoxicity
T7 702-706 Chemical denotes PJ34
T8 766-785 Disease denotes cardiac dysfunction
T9 797-800 Chemical denotes DOX

bc5cdr-valid-deepseek-nr-g

Id Subject Object Predicate Lexical cue
T1 14-41 Chemical denotes poly(ADP-ribose) polymerase
T2 72-105 Disease denotes doxorubicin-induced heart failure
T3 140-174 Chemical denotes poly(ADP-ribose) polymerase (PARP)
T4 298-314 Disease denotes oxidative stress
T5 379-393 Disease denotes cardiotoxicity
T6 397-408 Chemical denotes doxorubicin
T7 410-413 Chemical denotes DOX
T8 430-464 Chemical denotes antitumor anthracycline antibiotic
T9 511-515 Chemical denotes PARP
T10 538-541 Chemical denotes DOX
T11 550-564 Disease denotes cardiotoxicity
T12 591-597 Chemical denotes PARP-1
T13 687-691 Chemical denotes PARP
T14 702-706 Chemical denotes PJ34
T15 739-743 Chemical denotes PARP
T16 797-800 Chemical denotes DOX
T17 802-811 Chemical denotes PARP-1+/+
T18 816-825 Chemical denotes PARP-1-/-

bc5cdr-valid-deepseek-r-m

Id Subject Object Predicate Lexical cue
T1 72-83 Chemical denotes doxorubicin
T2 92-105 Disease denotes heart failure
T3 379-393 Disease denotes cardiotoxicity
T4 410-413 Chemical denotes DOX
T5 538-541 Chemical denotes DOX
T6 550-564 Disease denotes cardiotoxicity
T7 702-706 Chemical denotes PJ34
T8 766-785 Disease denotes cardiac dysfunction

bc5cdr-valid-gpt-r-m

Id Subject Object Predicate Lexical cue
T1 72-83 Chemical denotes doxorubicin
T2 92-105 Disease denotes heart failure
T3 379-393 Disease denotes cardiotoxicity
T4 397-408 Chemical denotes doxorubicin
T5 410-413 Chemical denotes DOX
T6 440-453 Chemical denotes anthracycline
T7 538-541 Chemical denotes DOX
T8 550-564 Disease denotes cardiotoxicity
T9 670-686 Chemical denotes phenanthridinone
T10 702-706 Chemical denotes PJ34
T11 797-800 Chemical denotes DOX
T12 862-865 Chemical denotes DOX
T13 1105-1109 Chemical denotes PJ34
T14 1242-1246 Chemical denotes PJ34
T15 1273-1276 Chemical denotes DOX
T16 1452-1466 Disease denotes cardiotoxicity
T17 1470-1473 Chemical denotes DOX
T18 1596-1599 Chemical denotes DOX