PubMed:11860278 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/11860278","sourcedb":"PubMed","sourceid":"11860278","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/11860278","text":"Dopamine D2 receptor signaling controls neuronal cell death induced by muscarinic and glutamatergic drugs.\nDopamine (DA), through D1/D2 receptor-mediated signaling, plays a major role in the control of epileptic seizures arising in the limbic system. Excitotoxicity leading to neuronal cell death in the affected areas is a major consequence of seizures at the cellular level. In this respect, little is known about the role of DA receptors in the occurrence of epilepsy-induced neuronal cell death. Here we analyze the occurrence of seizures and neurotoxicity in D2R -/- mice treated with the cholinergic agonist pilocarpine. We compared these results with those previously obtained with kainic acid (KA), a potent glutamate agonist. Importantly, D2R -/- mice develop seizures at doses of both drugs that are not epileptogenic for WT littermates and show greater neurotoxicity. However, pilocarpine-induced seizures result in a more widespread neuronal death in both WT and D2R -/- brains in comparison to KA. Thus, the absence of D2R lowers the threshold for seizures induced by both glutamate and acetylcholine. Moreover, the dopaminergic control of epilepsy-induced neurodegeneration seems to be mediated by distinct interactions of D2R signaling with these two neurotransmitters.","tracks":[{"project":"bc5cdr-valid-experiment","denotations":[{"id":"T1","span":{"begin":0,"end":8},"obj":"Chemical"},{"id":"T2","span":{"begin":107,"end":115},"obj":"Chemical"},{"id":"T3","span":{"begin":117,"end":119},"obj":"Chemical"},{"id":"T4","span":{"begin":202,"end":220},"obj":"Disease"},{"id":"T5","span":{"begin":251,"end":265},"obj":"Disease"},{"id":"T6","span":{"begin":345,"end":353},"obj":"Disease"},{"id":"T7","span":{"begin":428,"end":430},"obj":"Chemical"},{"id":"T8","span":{"begin":462,"end":470},"obj":"Disease"},{"id":"T9","span":{"begin":534,"end":542},"obj":"Disease"},{"id":"T10","span":{"begin":547,"end":560},"obj":"Disease"},{"id":"T11","span":{"begin":614,"end":625},"obj":"Chemical"},{"id":"T12","span":{"begin":689,"end":700},"obj":"Chemical"},{"id":"T13","span":{"begin":702,"end":704},"obj":"Chemical"},{"id":"T14","span":{"begin":716,"end":725},"obj":"Chemical"},{"id":"T15","span":{"begin":769,"end":777},"obj":"Disease"},{"id":"T16","span":{"begin":864,"end":877},"obj":"Disease"},{"id":"T17","span":{"begin":888,"end":899},"obj":"Chemical"},{"id":"T18","span":{"begin":908,"end":916},"obj":"Disease"},{"id":"T19","span":{"begin":1007,"end":1009},"obj":"Chemical"},{"id":"T20","span":{"begin":1061,"end":1069},"obj":"Disease"},{"id":"T21","span":{"begin":1086,"end":1095},"obj":"Chemical"},{"id":"T22","span":{"begin":1100,"end":1113},"obj":"Chemical"},{"id":"T23","span":{"begin":1153,"end":1161},"obj":"Disease"},{"id":"T24","span":{"begin":1170,"end":1187},"obj":"Disease"}],"attributes":[{"subj":"T1","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T2","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T3","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T4","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T5","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T6","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T7","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T8","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T9","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T10","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T11","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T12","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T13","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T14","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T15","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T16","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T17","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T18","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T19","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T20","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T21","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T22","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T23","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T24","pred":"source","obj":"bc5cdr-valid-experiment"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"bc5cdr-valid-experiment","color":"#ec9793","default":true}]}]}}