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PubMed:11856738 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-118 Sentence denotes Suppression of androgen receptor transactivation by Pyk2 via interaction and phosphorylation of the ARA55 coregulator.
T2 119-304 Sentence denotes The proline-rich tyrosine kinase 2 (Pyk2) was first identified as a key kinase linked to the MAP kinase and JNK signaling pathways that play important roles in cell growth and adhesion.
T3 305-453 Sentence denotes The linkage between Pyk2 and the androgen receptor (AR), an important transcription factor in prostate cancer progression, however, remains unclear.
T4 454-708 Sentence denotes Here we report that using the full-length androgen receptor-associated protein, ARA55, coregulator as bait, we were able to isolate an ARA55-interacting protein, Pyk2, and demonstrated that Pyk2 could repress AR transactivation via inactivation of ARA55.
T5 709-907 Sentence denotes This inactivation may result from the direct phosphorylation of ARA55 by Pyk2 at tyrosine 43, impairing the coactivator activity of ARA55 and/or sequestering ARA55 to reduce its interaction with AR.
T6 908-1146 Sentence denotes Our finding that Pyk2 can indirectly modulate AR function via interaction and/or phosphorylation of ARA55 not only expands the role of Pyk2 in AR-mediated prostate cancer growth but also strengthens the role of ARA55 as an AR coregulator.
T1 0-118 Sentence denotes Suppression of androgen receptor transactivation by Pyk2 via interaction and phosphorylation of the ARA55 coregulator.
T2 119-304 Sentence denotes The proline-rich tyrosine kinase 2 (Pyk2) was first identified as a key kinase linked to the MAP kinase and JNK signaling pathways that play important roles in cell growth and adhesion.
T3 305-453 Sentence denotes The linkage between Pyk2 and the androgen receptor (AR), an important transcription factor in prostate cancer progression, however, remains unclear.
T4 454-708 Sentence denotes Here we report that using the full-length androgen receptor-associated protein, ARA55, coregulator as bait, we were able to isolate an ARA55-interacting protein, Pyk2, and demonstrated that Pyk2 could repress AR transactivation via inactivation of ARA55.
T5 709-907 Sentence denotes This inactivation may result from the direct phosphorylation of ARA55 by Pyk2 at tyrosine 43, impairing the coactivator activity of ARA55 and/or sequestering ARA55 to reduce its interaction with AR.
T6 908-1146 Sentence denotes Our finding that Pyk2 can indirectly modulate AR function via interaction and/or phosphorylation of ARA55 not only expands the role of Pyk2 in AR-mediated prostate cancer growth but also strengthens the role of ARA55 as an AR coregulator.

Glycosmos6-GlycoEpitope

Id Subject Object Predicate Lexical cue
T1 52-56 http://www.glycoepitope.jp/epitopes/AN0554 denotes Pyk2
T2 155-159 http://www.glycoepitope.jp/epitopes/AN0554 denotes Pyk2
T3 325-329 http://www.glycoepitope.jp/epitopes/AN0554 denotes Pyk2
T4 616-620 http://www.glycoepitope.jp/epitopes/AN0554 denotes Pyk2
T5 644-648 http://www.glycoepitope.jp/epitopes/AN0554 denotes Pyk2
T6 782-786 http://www.glycoepitope.jp/epitopes/AN0554 denotes Pyk2
T7 925-929 http://www.glycoepitope.jp/epitopes/AN0554 denotes Pyk2
T8 1043-1047 http://www.glycoepitope.jp/epitopes/AN0554 denotes Pyk2

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 399-407 http://purl.obolibrary.org/obo/MAT_0000078 denotes prostate
T2 1063-1071 http://purl.obolibrary.org/obo/MAT_0000078 denotes prostate

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 399-414 Disease denotes prostate cancer http://purl.obolibrary.org/obo/MONDO_0008315
T2 1063-1078 Disease denotes prostate cancer http://purl.obolibrary.org/obo/MONDO_0008315

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 399-414 Phenotype denotes prostate cancer HP:0012125
T2 1063-1078 Phenotype denotes prostate cancer HP:0012125

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 399-414 Phenotype denotes prostate cancer HP:0012125
T2 1063-1078 Phenotype denotes prostate cancer HP:0012125

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-118 Sentence denotes Suppression of androgen receptor transactivation by Pyk2 via interaction and phosphorylation of the ARA55 coregulator.
T2 119-304 Sentence denotes The proline-rich tyrosine kinase 2 (Pyk2) was first identified as a key kinase linked to the MAP kinase and JNK signaling pathways that play important roles in cell growth and adhesion.
T3 305-453 Sentence denotes The linkage between Pyk2 and the androgen receptor (AR), an important transcription factor in prostate cancer progression, however, remains unclear.
T4 454-708 Sentence denotes Here we report that using the full-length androgen receptor-associated protein, ARA55, coregulator as bait, we were able to isolate an ARA55-interacting protein, Pyk2, and demonstrated that Pyk2 could repress AR transactivation via inactivation of ARA55.
T5 709-907 Sentence denotes This inactivation may result from the direct phosphorylation of ARA55 by Pyk2 at tyrosine 43, impairing the coactivator activity of ARA55 and/or sequestering ARA55 to reduce its interaction with AR.
T6 908-1146 Sentence denotes Our finding that Pyk2 can indirectly modulate AR function via interaction and/or phosphorylation of ARA55 not only expands the role of Pyk2 in AR-mediated prostate cancer growth but also strengthens the role of ARA55 as an AR coregulator.

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 399-414 Disease denotes prostate cancer MONDO:0005159|MONDO:0008315
T3 1063-1078 Disease denotes prostate cancer MONDO:0005159|MONDO:0008315

GlyCosmos15-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 52-56 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes Pyk2 http://www.glycoepitope.jp/epitopes/AN0554
T2 155-159 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes Pyk2 http://www.glycoepitope.jp/epitopes/AN0554
T3 325-329 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes Pyk2 http://www.glycoepitope.jp/epitopes/AN0554
T4 616-620 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes Pyk2 http://www.glycoepitope.jp/epitopes/AN0554
T5 644-648 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes Pyk2 http://www.glycoepitope.jp/epitopes/AN0554
T6 782-786 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes Pyk2 http://www.glycoepitope.jp/epitopes/AN0554
T7 925-929 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes Pyk2 http://www.glycoepitope.jp/epitopes/AN0554
T8 1043-1047 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes Pyk2 http://www.glycoepitope.jp/epitopes/AN0554

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 399-407 Body_part denotes prostate http://purl.obolibrary.org/obo/UBERON_0002367
T2 1063-1071 Body_part denotes prostate http://purl.obolibrary.org/obo/UBERON_0002367

GlyCosmos15-FMA

Id Subject Object Predicate Lexical cue db_id
T1 399-407 Body_part denotes prostate FMA:9600
T2 1063-1071 Body_part denotes prostate FMA:9600

GlyCosmos15-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 399-407 Body_part denotes prostate http://purl.obolibrary.org/obo/MAT_0000078
T2 1063-1071 Body_part denotes prostate http://purl.obolibrary.org/obo/MAT_0000078

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 399-407 Body_part denotes prostate http://purl.obolibrary.org/obo/MAT_0000078
T2 1063-1071 Body_part denotes prostate http://purl.obolibrary.org/obo/MAT_0000078

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 399-407 Body_part denotes prostate http://purl.obolibrary.org/obo/UBERON_0002367
T2 1063-1071 Body_part denotes prostate http://purl.obolibrary.org/obo/UBERON_0002367