> top > docs > PubMed:11851721 > annotations

PubMed:11851721 JSONTXT

Annnotations TAB JSON ListView MergeView

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-150 Sentence denotes PON1 L55M polymorphism is not a predictor of coronary atherosclerosis either alone or in combination with Q192R polymorphism in an Italian population.
TextSentencer_T2 151-162 Sentence denotes BACKGROUND:
TextSentencer_T3 163-356 Sentence denotes The present study evaluated the role of the PON1 L55M polymorphism independently and in conjunction with the Q192R polymorphism on the risk of coronary atherosclerosis in an Italian population.
TextSentencer_T4 357-379 Sentence denotes MATERIALS AND METHODS:
TextSentencer_T5 380-691 Sentence denotes Three hundred and ninety-one subjects with significant coronary stenosis (> 50%) (coronary artery disease-positive; CAD+), 196 subjects with normal coronary arteries (< 10% stenosis) (CAD-) and 178 healthy controls were screened using a combination of polymerase chain reaction and restriction enzyme digestion.
TextSentencer_T6 692-700 Sentence denotes RESULTS:
TextSentencer_T7 701-965 Sentence denotes In the pooled population, the frequencies of L and M alleles were 0.63 and 0.37, respectively; the most common haplotypes were QQ/LM (24.2%) and QR/LL (21.8%) and a strong linkage disequilibrium between L/55 and R/192 alleles was observed (D' = -0.91; P < 0.0001).
TextSentencer_T8 966-1137 Sentence denotes CAD+ subjects did not show any significant differences in the distribution of PON1-55 genotypes as compared to CAD- subjects and population controls (chi2 = 1.5, P = 0.8).
TextSentencer_T9 1138-1306 Sentence denotes After controlling for other risk factors, the low-concentration M allele was not associated with a significant change of CAD risk (OR 1.02; 95% CI 0.80-1.29; P = 0.87).
TextSentencer_T10 1307-1537 Sentence denotes Moreover, the L55M polymorphism did not show any interaction with other risk factors such as smoking, diabetes, hypertension, low levels of high-density lipoprotein (HDL) or high ratios of low-density to high-density lipoproteins.
TextSentencer_T11 1538-1626 Sentence denotes The combination of L55M with the Q192R polymorphism did not show any effect on CAD risk.
TextSentencer_T12 1627-1847 Sentence denotes However, a marginal decrease in myocardial infarction risk was detected when QQ/MM carriers (OR 0.51; 95% CI 0.26-0.99; P = 0.048), but not LL/RR carriers, were compared with subjects not homozygous for an L or R allele.
TextSentencer_T13 1848-1860 Sentence denotes CONCLUSIONS:
TextSentencer_T14 1861-2011 Sentence denotes These findings did not indicate a major effect of the PON1 L55M polymorphism, either alone or in combination with the Q192R polymorphism, on CAD risk.
TextSentencer_T15 2012-2152 Sentence denotes Additional studies are needed for a better evaluation of the role of the 55/192 PON1 genotypes in combination on myocardial infarction risk.
T1 0-150 Sentence denotes PON1 L55M polymorphism is not a predictor of coronary atherosclerosis either alone or in combination with Q192R polymorphism in an Italian population.
T2 151-162 Sentence denotes BACKGROUND:
T3 163-356 Sentence denotes The present study evaluated the role of the PON1 L55M polymorphism independently and in conjunction with the Q192R polymorphism on the risk of coronary atherosclerosis in an Italian population.
T4 357-379 Sentence denotes MATERIALS AND METHODS:
T5 380-691 Sentence denotes Three hundred and ninety-one subjects with significant coronary stenosis (> 50%) (coronary artery disease-positive; CAD+), 196 subjects with normal coronary arteries (< 10% stenosis) (CAD-) and 178 healthy controls were screened using a combination of polymerase chain reaction and restriction enzyme digestion.
T6 692-700 Sentence denotes RESULTS:
T7 701-965 Sentence denotes In the pooled population, the frequencies of L and M alleles were 0.63 and 0.37, respectively; the most common haplotypes were QQ/LM (24.2%) and QR/LL (21.8%) and a strong linkage disequilibrium between L/55 and R/192 alleles was observed (D' = -0.91; P < 0.0001).
T8 966-1137 Sentence denotes CAD+ subjects did not show any significant differences in the distribution of PON1-55 genotypes as compared to CAD- subjects and population controls (chi2 = 1.5, P = 0.8).
T9 1138-1306 Sentence denotes After controlling for other risk factors, the low-concentration M allele was not associated with a significant change of CAD risk (OR 1.02; 95% CI 0.80-1.29; P = 0.87).
T10 1307-1537 Sentence denotes Moreover, the L55M polymorphism did not show any interaction with other risk factors such as smoking, diabetes, hypertension, low levels of high-density lipoprotein (HDL) or high ratios of low-density to high-density lipoproteins.
T11 1538-1626 Sentence denotes The combination of L55M with the Q192R polymorphism did not show any effect on CAD risk.
T12 1627-1847 Sentence denotes However, a marginal decrease in myocardial infarction risk was detected when QQ/MM carriers (OR 0.51; 95% CI 0.26-0.99; P = 0.048), but not LL/RR carriers, were compared with subjects not homozygous for an L or R allele.
T13 1848-1860 Sentence denotes CONCLUSIONS:
T14 1861-2011 Sentence denotes These findings did not indicate a major effect of the PON1 L55M polymorphism, either alone or in combination with the Q192R polymorphism, on CAD risk.
T15 2012-2152 Sentence denotes Additional studies are needed for a better evaluation of the role of the 55/192 PON1 genotypes in combination on myocardial infarction risk.

DisGeNET5_variant_disease

Id Subject Object Predicate Lexical cue
11851721-0#106#111#geners778916575 1571-1576 geners778916575 denotes Q192R
11851721-0#106#111#geners662 1571-1576 geners662 denotes Q192R
11851721-0#5#9#geners854560 212-216 geners854560 denotes L55M
11851721-0#45#69#diseaseC0010054 643-1214 diseaseC0010054 denotes chain reaction and restriction enzyme digestion. RESULTS: In the pooled population, the frequencies of L and M alleles were 0.63 and 0.37, respectively; the most common haplotypes were QQ/LM (24.2%) and QR/LL (21.8%) and a strong linkage disequilibrium between L/55 and R/192 alleles was observed (D' = -0.91; P < 0.0001). CAD+ subjects did not show any significant differences in the distribution of PON1-55 genotypes as compared to CAD- subjects and population controls (chi2 = 1.5, P = 0.8). After controlling for other risk factors, the low-concentration M allele was
11851721-6#14#18#geners854560 1321-1325 geners854560 denotes L55M
11851721-6#102#110#diseaseC0011847 1409-1417 diseaseC0011847 denotes diabetes
11851721-6#102#110#diseaseC0011849 1409-1417 diseaseC0011849 denotes diabetes
106#111#geners77891657545#69#diseaseC0010054 11851721-0#106#111#geners778916575 11851721-0#45#69#diseaseC0010054 associated_with Q192R,"chain reaction and restriction enzyme digestion. RESULTS: In the pooled population, the frequencies of L and M alleles were 0.63 and 0.37, respectively; the most common haplotypes were QQ/LM (24.2%) and QR/LL (21.8%) and a strong linkage disequilibrium between L/55 and R/192 alleles was observed (D' = -0.91; P < 0.0001). CAD+ subjects did not show any significant differences in the distribution of PON1-55 genotypes as compared to CAD- subjects and population controls (chi2 = 1.5, P = 0.8). After controlling for other risk factors, the low-concentration M allele was"
106#111#geners66245#69#diseaseC0010054 11851721-0#106#111#geners662 11851721-0#45#69#diseaseC0010054 associated_with Q192R,"chain reaction and restriction enzyme digestion. RESULTS: In the pooled population, the frequencies of L and M alleles were 0.63 and 0.37, respectively; the most common haplotypes were QQ/LM (24.2%) and QR/LL (21.8%) and a strong linkage disequilibrium between L/55 and R/192 alleles was observed (D' = -0.91; P < 0.0001). CAD+ subjects did not show any significant differences in the distribution of PON1-55 genotypes as compared to CAD- subjects and population controls (chi2 = 1.5, P = 0.8). After controlling for other risk factors, the low-concentration M allele was"
5#9#geners85456045#69#diseaseC0010054 11851721-0#5#9#geners854560 11851721-0#45#69#diseaseC0010054 associated_with L55M,"chain reaction and restriction enzyme digestion. RESULTS: In the pooled population, the frequencies of L and M alleles were 0.63 and 0.37, respectively; the most common haplotypes were QQ/LM (24.2%) and QR/LL (21.8%) and a strong linkage disequilibrium between L/55 and R/192 alleles was observed (D' = -0.91; P < 0.0001). CAD+ subjects did not show any significant differences in the distribution of PON1-55 genotypes as compared to CAD- subjects and population controls (chi2 = 1.5, P = 0.8). After controlling for other risk factors, the low-concentration M allele was"
14#18#geners854560102#110#diseaseC0011847 11851721-6#14#18#geners854560 11851721-6#102#110#diseaseC0011847 associated_with L55M,diabetes
14#18#geners854560102#110#diseaseC0011849 11851721-6#14#18#geners854560 11851721-6#102#110#diseaseC0011849 associated_with L55M,diabetes

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
11851721-0#0#4#gene5444 207-211 gene5444 denotes PON1
11851721-0#45#69#diseaseC0010054 643-1214 diseaseC0010054 denotes chain reaction and restriction enzyme digestion. RESULTS: In the pooled population, the frequencies of L and M alleles were 0.63 and 0.37, respectively; the most common haplotypes were QQ/LM (24.2%) and QR/LL (21.8%) and a strong linkage disequilibrium between L/55 and R/192 alleles was observed (D' = -0.91; P < 0.0001). CAD+ subjects did not show any significant differences in the distribution of PON1-55 genotypes as compared to CAD- subjects and population controls (chi2 = 1.5, P = 0.8). After controlling for other risk factors, the low-concentration M allele was
11851721-10#80#84#gene5444 2092-2096 gene5444 denotes PON1
11851721-10#113#134#diseaseC0027051 2125-2146 diseaseC0027051 denotes myocardial infarction
11851721-2#116#119#gene790 496-499 gene790 denotes CAD
11851721-2#184#187#gene790 564-567 gene790 denotes CAD
11851721-2#116#119#gene790 496-499 gene790 denotes CAD
11851721-2#184#187#gene790 564-567 gene790 denotes CAD
11851721-2#82#105#diseaseC0010054 462-485 diseaseC0010054 denotes coronary artery disease
11851721-2#82#105#diseaseC0010068 462-485 diseaseC0010068 denotes coronary artery disease
11851721-2#82#105#diseaseC1956346 462-485 diseaseC1956346 denotes coronary artery disease
11851721-2#82#105#diseaseC0010054 462-485 diseaseC0010054 denotes coronary artery disease
11851721-2#82#105#diseaseC0010068 462-485 diseaseC0010068 denotes coronary artery disease
11851721-2#82#105#diseaseC1956346 462-485 diseaseC1956346 denotes coronary artery disease
11851721-2#55#72#diseaseC0242231 435-452 diseaseC0242231 denotes coronary stenosis
0#4#gene544445#69#diseaseC0010054 11851721-0#0#4#gene5444 11851721-0#45#69#diseaseC0010054 associated_with PON1,"chain reaction and restriction enzyme digestion. RESULTS: In the pooled population, the frequencies of L and M alleles were 0.63 and 0.37, respectively; the most common haplotypes were QQ/LM (24.2%) and QR/LL (21.8%) and a strong linkage disequilibrium between L/55 and R/192 alleles was observed (D' = -0.91; P < 0.0001). CAD+ subjects did not show any significant differences in the distribution of PON1-55 genotypes as compared to CAD- subjects and population controls (chi2 = 1.5, P = 0.8). After controlling for other risk factors, the low-concentration M allele was"
80#84#gene5444113#134#diseaseC0027051 11851721-10#80#84#gene5444 11851721-10#113#134#diseaseC0027051 associated_with PON1,myocardial infarction
116#119#gene79082#105#diseaseC0010054 11851721-2#116#119#gene790 11851721-2#82#105#diseaseC0010054 associated_with CAD,coronary artery disease
116#119#gene79082#105#diseaseC0010068 11851721-2#116#119#gene790 11851721-2#82#105#diseaseC0010068 associated_with CAD,coronary artery disease
116#119#gene79082#105#diseaseC1956346 11851721-2#116#119#gene790 11851721-2#82#105#diseaseC1956346 associated_with CAD,coronary artery disease
116#119#gene79082#105#diseaseC0010054 11851721-2#116#119#gene790 11851721-2#82#105#diseaseC0010054 associated_with CAD,coronary artery disease
116#119#gene79082#105#diseaseC0010068 11851721-2#116#119#gene790 11851721-2#82#105#diseaseC0010068 associated_with CAD,coronary artery disease
116#119#gene79082#105#diseaseC1956346 11851721-2#116#119#gene790 11851721-2#82#105#diseaseC1956346 associated_with CAD,coronary artery disease
116#119#gene79055#72#diseaseC0242231 11851721-2#116#119#gene790 11851721-2#55#72#diseaseC0242231 associated_with CAD,coronary stenosis
184#187#gene79082#105#diseaseC0010054 11851721-2#184#187#gene790 11851721-2#82#105#diseaseC0010054 associated_with CAD,coronary artery disease
184#187#gene79082#105#diseaseC0010068 11851721-2#184#187#gene790 11851721-2#82#105#diseaseC0010068 associated_with CAD,coronary artery disease
184#187#gene79082#105#diseaseC1956346 11851721-2#184#187#gene790 11851721-2#82#105#diseaseC1956346 associated_with CAD,coronary artery disease
184#187#gene79082#105#diseaseC0010054 11851721-2#184#187#gene790 11851721-2#82#105#diseaseC0010054 associated_with CAD,coronary artery disease
184#187#gene79082#105#diseaseC0010068 11851721-2#184#187#gene790 11851721-2#82#105#diseaseC0010068 associated_with CAD,coronary artery disease
184#187#gene79082#105#diseaseC1956346 11851721-2#184#187#gene790 11851721-2#82#105#diseaseC1956346 associated_with CAD,coronary artery disease
184#187#gene79055#72#diseaseC0242231 11851721-2#184#187#gene790 11851721-2#55#72#diseaseC0242231 associated_with CAD,coronary stenosis
116#119#gene79082#105#diseaseC0010054 11851721-2#116#119#gene790 11851721-2#82#105#diseaseC0010054 associated_with CAD,coronary artery disease
116#119#gene79082#105#diseaseC0010068 11851721-2#116#119#gene790 11851721-2#82#105#diseaseC0010068 associated_with CAD,coronary artery disease
116#119#gene79082#105#diseaseC1956346 11851721-2#116#119#gene790 11851721-2#82#105#diseaseC1956346 associated_with CAD,coronary artery disease
116#119#gene79082#105#diseaseC0010054 11851721-2#116#119#gene790 11851721-2#82#105#diseaseC0010054 associated_with CAD,coronary artery disease
116#119#gene79082#105#diseaseC0010068 11851721-2#116#119#gene790 11851721-2#82#105#diseaseC0010068 associated_with CAD,coronary artery disease
116#119#gene79082#105#diseaseC1956346 11851721-2#116#119#gene790 11851721-2#82#105#diseaseC1956346 associated_with CAD,coronary artery disease
116#119#gene79055#72#diseaseC0242231 11851721-2#116#119#gene790 11851721-2#55#72#diseaseC0242231 associated_with CAD,coronary stenosis
184#187#gene79082#105#diseaseC0010054 11851721-2#184#187#gene790 11851721-2#82#105#diseaseC0010054 associated_with CAD,coronary artery disease
184#187#gene79082#105#diseaseC0010068 11851721-2#184#187#gene790 11851721-2#82#105#diseaseC0010068 associated_with CAD,coronary artery disease
184#187#gene79082#105#diseaseC1956346 11851721-2#184#187#gene790 11851721-2#82#105#diseaseC1956346 associated_with CAD,coronary artery disease
184#187#gene79082#105#diseaseC0010054 11851721-2#184#187#gene790 11851721-2#82#105#diseaseC0010054 associated_with CAD,coronary artery disease
184#187#gene79082#105#diseaseC0010068 11851721-2#184#187#gene790 11851721-2#82#105#diseaseC0010068 associated_with CAD,coronary artery disease
184#187#gene79082#105#diseaseC1956346 11851721-2#184#187#gene790 11851721-2#82#105#diseaseC1956346 associated_with CAD,coronary artery disease
184#187#gene79055#72#diseaseC0242231 11851721-2#184#187#gene790 11851721-2#55#72#diseaseC0242231 associated_with CAD,coronary stenosis

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T2313 496-499 gene:790 denotes CAD
T2314 462-485 disease:C0010054 denotes coronary artery disease
T2315 564-567 gene:790 denotes CAD
R1 T2313 T2314 associated_with CAD,coronary artery disease
R2 T2313 T2314 associated_with CAD,coronary artery disease
R3 T2313 T2314 associated_with CAD,coronary artery disease
R4 T2315 T2314 associated_with CAD,coronary artery disease
R5 T2315 T2314 associated_with CAD,coronary artery disease
R6 T2315 T2314 associated_with CAD,coronary artery disease

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 462-477 http://purl.obolibrary.org/obo/UBERON_0001621 denotes coronary artery
PD-UBERON-AE-B_T2 528-545 http://purl.obolibrary.org/obo/UBERON_0001621 denotes coronary arteries
PD-UBERON-AE-B_T3 471-477 http://purl.obolibrary.org/obo/UBERON_0001637 denotes artery
PD-UBERON-AE-B_T4 537-545 http://purl.obolibrary.org/obo/UBERON_0001637 denotes arteries

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 471-477 http://purl.obolibrary.org/obo/UBERON_0001637 denotes artery
PD-UBERON-AE-B_T2 537-545 http://purl.obolibrary.org/obo/UBERON_0001637 denotes arteries
PD-UBERON-AE-B_T3 462-477 http://purl.obolibrary.org/obo/UBERON_0001621 denotes coronary artery
PD-UBERON-AE-B_T4 528-545 http://purl.obolibrary.org/obo/UBERON_0001621 denotes coronary arteries

DisGeNET

Id Subject Object Predicate Lexical cue
T0 2092-2096 gene:5444 denotes PON1
T1 2125-2146 disease:C0027051 denotes myocardial infarction
R1 T0 T1 associated_with PON1,myocardial infarction