> top > docs > PubMed:11844822 > annotations

PubMed:11844822 JSONTXT

Annnotations TAB JSON ListView MergeView

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-96 Sentence denotes BRCA1 and BRCA2 mutation frequency in women evaluated in a breast cancer risk evaluation clinic.
TextSentencer_T2 97-105 Sentence denotes PURPOSE:
TextSentencer_T3 106-228 Sentence denotes To determine the prevalence of BRCA1 and BRCA2 mutations in families identified in a breast cancer risk evaluation clinic.
TextSentencer_T4 229-250 Sentence denotes PATIENTS AND METHODS:
TextSentencer_T5 251-447 Sentence denotes One hundred sixty-four families seeking breast cancer risk evaluation were screened for coding region mutations in BRCA1 and BRCA2 by conformation-sensitive gel electrophoresis and DNA sequencing.
TextSentencer_T6 448-456 Sentence denotes RESULTS:
TextSentencer_T7 457-574 Sentence denotes Mutations were identified in 37 families (22.6%); 28 (17.1%) had BRCA1 mutations and nine (5.5%) had BRCA2 mutations.
TextSentencer_T8 575-677 Sentence denotes The Ashkenazi Jewish founder mutations 185delAG and 5382insC (BRCA1) were found in 10 families (6.1%).
TextSentencer_T9 678-805 Sentence denotes However, 6174delT (BRCA2) was found in only one family (0.6%) despite estimates of equal frequency in the Ashkenazi population.
TextSentencer_T10 806-987 Sentence denotes In contrast to other series, the average age of breast cancer diagnosis was earlier in BRCA2 mutation carriers (32.1 years) than in women with BRCA1 mutations (37.6 years, P =.028).
TextSentencer_T11 988-1154 Sentence denotes BRCA1 mutations were detected in 20 (45.5%) of 44 families with ovarian cancer and 12 (75%) of 16 families with both breast and ovarian cancer in a single individual.
TextSentencer_T12 1155-1265 Sentence denotes Significantly fewer BRCA2 mutations (two [4.5%] of 44) were detected in families with ovarian cancer (P =.01).
TextSentencer_T13 1266-1360 Sentence denotes Eight families had male breast cancer; one had a BRCA1 mutation and three had BRCA2 mutations.
TextSentencer_T14 1361-1442 Sentence denotes CONCLUSION: BRCA1 mutations were three times more prevalent than BRCA2 mutations.
TextSentencer_T15 1443-1733 Sentence denotes Breast cancer diagnosis before 50 years of age, ovarian cancer, breast and ovarian cancer in a single individual, and male breast cancer were all significantly more common in families with BRCA1 and BRCA2 mutations, but none of these factors distinguished between BRCA1 and BRCA2 mutations.
TextSentencer_T16 1734-1834 Sentence denotes Evidence for reduced breast cancer penetrance associated with the BRCA2 mutation 6174delT was noted.
T1 0-96 Sentence denotes BRCA1 and BRCA2 mutation frequency in women evaluated in a breast cancer risk evaluation clinic.
T2 97-105 Sentence denotes PURPOSE:
T3 106-228 Sentence denotes To determine the prevalence of BRCA1 and BRCA2 mutations in families identified in a breast cancer risk evaluation clinic.
T4 229-250 Sentence denotes PATIENTS AND METHODS:
T5 251-447 Sentence denotes One hundred sixty-four families seeking breast cancer risk evaluation were screened for coding region mutations in BRCA1 and BRCA2 by conformation-sensitive gel electrophoresis and DNA sequencing.
T6 448-456 Sentence denotes RESULTS:
T7 457-574 Sentence denotes Mutations were identified in 37 families (22.6%); 28 (17.1%) had BRCA1 mutations and nine (5.5%) had BRCA2 mutations.
T8 575-677 Sentence denotes The Ashkenazi Jewish founder mutations 185delAG and 5382insC (BRCA1) were found in 10 families (6.1%).
T9 678-805 Sentence denotes However, 6174delT (BRCA2) was found in only one family (0.6%) despite estimates of equal frequency in the Ashkenazi population.
T10 806-987 Sentence denotes In contrast to other series, the average age of breast cancer diagnosis was earlier in BRCA2 mutation carriers (32.1 years) than in women with BRCA1 mutations (37.6 years, P =.028).
T11 988-1154 Sentence denotes BRCA1 mutations were detected in 20 (45.5%) of 44 families with ovarian cancer and 12 (75%) of 16 families with both breast and ovarian cancer in a single individual.
T12 1155-1265 Sentence denotes Significantly fewer BRCA2 mutations (two [4.5%] of 44) were detected in families with ovarian cancer (P =.01).
T13 1266-1360 Sentence denotes Eight families had male breast cancer; one had a BRCA1 mutation and three had BRCA2 mutations.
T14 1361-1442 Sentence denotes CONCLUSION: BRCA1 mutations were three times more prevalent than BRCA2 mutations.
T15 1443-1733 Sentence denotes Breast cancer diagnosis before 50 years of age, ovarian cancer, breast and ovarian cancer in a single individual, and male breast cancer were all significantly more common in families with BRCA1 and BRCA2 mutations, but none of these factors distinguished between BRCA1 and BRCA2 mutations.
T16 1734-1834 Sentence denotes Evidence for reduced breast cancer penetrance associated with the BRCA2 mutation 6174delT was noted.

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
11844822-0#0#5#gene672 0-5 gene672 denotes BRCA1
11844822-0#10#15#gene675 10-15 gene675 denotes BRCA2
11844822-0#59#72#diseaseC0006142 59-72 diseaseC0006142 denotes breast cancer
11844822-0#59#72#diseaseC0678222 59-72 diseaseC0678222 denotes breast cancer
11844822-0#59#72#diseaseC0006142 59-72 diseaseC0006142 denotes breast cancer
11844822-0#59#72#diseaseC0678222 59-72 diseaseC0678222 denotes breast cancer
11844822-11#189#194#gene672 1632-1637 gene672 denotes BRCA1
11844822-11#75#89#diseaseC0029925 1518-1532 diseaseC0029925 denotes ovarian cancer
11844822-11#75#89#diseaseC1140680 1518-1532 diseaseC1140680 denotes ovarian cancer
11844822-11#118#136#diseaseC0238033 1561-1579 diseaseC0238033 denotes male breast cancer
11844822-11#118#136#diseaseC0242787 1561-1579 diseaseC0242787 denotes male breast cancer
11844822-8#20#25#gene675 1175-1180 gene675 denotes BRCA2
11844822-8#86#100#diseaseC0029925 1241-1255 diseaseC0029925 denotes ovarian cancer
11844822-8#86#100#diseaseC1140680 1241-1255 diseaseC1140680 denotes ovarian cancer
0#5#gene67259#72#diseaseC0006142 11844822-0#0#5#gene672 11844822-0#59#72#diseaseC0006142 associated_with BRCA1,breast cancer
0#5#gene67259#72#diseaseC0678222 11844822-0#0#5#gene672 11844822-0#59#72#diseaseC0678222 associated_with BRCA1,breast cancer
0#5#gene67259#72#diseaseC0006142 11844822-0#0#5#gene672 11844822-0#59#72#diseaseC0006142 associated_with BRCA1,breast cancer
0#5#gene67259#72#diseaseC0678222 11844822-0#0#5#gene672 11844822-0#59#72#diseaseC0678222 associated_with BRCA1,breast cancer
10#15#gene67559#72#diseaseC0006142 11844822-0#10#15#gene675 11844822-0#59#72#diseaseC0006142 associated_with BRCA2,breast cancer
10#15#gene67559#72#diseaseC0678222 11844822-0#10#15#gene675 11844822-0#59#72#diseaseC0678222 associated_with BRCA2,breast cancer
10#15#gene67559#72#diseaseC0006142 11844822-0#10#15#gene675 11844822-0#59#72#diseaseC0006142 associated_with BRCA2,breast cancer
10#15#gene67559#72#diseaseC0678222 11844822-0#10#15#gene675 11844822-0#59#72#diseaseC0678222 associated_with BRCA2,breast cancer
189#194#gene67275#89#diseaseC0029925 11844822-11#189#194#gene672 11844822-11#75#89#diseaseC0029925 associated_with BRCA1,ovarian cancer
189#194#gene67275#89#diseaseC1140680 11844822-11#189#194#gene672 11844822-11#75#89#diseaseC1140680 associated_with BRCA1,ovarian cancer
189#194#gene672118#136#diseaseC0238033 11844822-11#189#194#gene672 11844822-11#118#136#diseaseC0238033 associated_with BRCA1,male breast cancer
189#194#gene672118#136#diseaseC0242787 11844822-11#189#194#gene672 11844822-11#118#136#diseaseC0242787 associated_with BRCA1,male breast cancer
20#25#gene67586#100#diseaseC0029925 11844822-8#20#25#gene675 11844822-8#86#100#diseaseC0029925 associated_with BRCA2,ovarian cancer
20#25#gene67586#100#diseaseC1140680 11844822-8#20#25#gene675 11844822-8#86#100#diseaseC1140680 associated_with BRCA2,ovarian cancer

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T1943 1175-1180 gene:675 denotes BRCA2
T1944 1241-1255 disease:C0029925 denotes ovarian cancer
R1 T1943 T1944 associated_with BRCA2,ovarian cancer
R2 T1943 T1944 associated_with BRCA2,ovarian cancer

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 59-65 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T2 191-197 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T3 291-297 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T4 854-860 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T5 1105-1111 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T6 1290-1296 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T7 1507-1513 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T8 1566-1572 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T9 1755-1761 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T10 1285-1296 http://purl.obolibrary.org/obo/UBERON_0016410 denotes male breast
PD-UBERON-AE-B_T11 1561-1572 http://purl.obolibrary.org/obo/UBERON_0016410 denotes male breast

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 59-65 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T2 191-197 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T3 291-297 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T4 854-860 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T5 1105-1111 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T6 1290-1296 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T7 1443-1449 http://purl.obolibrary.org/obo/UBERON_0000310 denotes Breast
PD-UBERON-AE-B_T8 1507-1513 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T9 1566-1572 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T10 1755-1761 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T11 1285-1296 http://purl.obolibrary.org/obo/UBERON_0016410 denotes male breast
PD-UBERON-AE-B_T12 1561-1572 http://purl.obolibrary.org/obo/UBERON_0016410 denotes male breast

DisGeNET

Id Subject Object Predicate Lexical cue
T0 1175-1180 gene:675 denotes BRCA2
T1 1241-1255 disease:C0029925 denotes ovarian cancer
T2 1175-1180 gene:675 denotes BRCA2
T3 1241-1255 disease:C1140680 denotes ovarian cancer
R1 T0 T1 associated_with BRCA2,ovarian cancer
R2 T2 T3 associated_with BRCA2,ovarian cancer